Proto-Oncogene Proteins c-cbl
"Proto-Oncogene Proteins c-cbl" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proto-oncogene proteins that negatively regulate RECEPTOR PROTEIN-TYROSINE KINASE signaling. It is a UBIQUITIN-PROTEIN LIGASE and the cellular homologue of ONCOGENE PROTEIN V-CBL.
| Descriptor ID |
D050721
|
| MeSH Number(s) |
D08.811.464.938.750.374 D12.776.624.664.700.172
|
| Concept/Terms |
Proto-Oncogene Proteins c-cbl- Proto-Oncogene Proteins c-cbl
- Proto Oncogene Proteins c cbl
- c-cbl, Proto-Oncogene Proteins
- RING Finger Protein 55
- c-cbl Protein
- cbl Proto-Oncogene Protein
- Proto-Oncogene Protein, cbl
- cbl Proto Oncogene Protein
- CBL E3 Ubiquitin Protein Ligase
- c-cbl Proto-Oncogene Protein
- Proto-Oncogene Protein, c-cbl
- c cbl Proto Oncogene Protein
- RNF55 Protein
- Proto-Oncogene Protein c-cbl
- Proto Oncogene Protein c cbl
- c-cbl, Proto-Oncogene Protein
|
Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-cbl".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-cbl".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-cbl" by people in this website by year, and whether "Proto-Oncogene Proteins c-cbl" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2007 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-cbl" by people in Profiles.
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ZAP-70 Regulates Autoimmune Arthritis via Alterations in T Cell Activation and Apoptosis. Cells. 2019 05 24; 8(5).
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Rac1-mediated cytoskeleton rearrangements induced by intersectin-1s deficiency promotes lung cancer cell proliferation, migration and metastasis. Mol Cancer. 2016 09 14; 15(1):59.
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Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration. J Biol Chem. 2011 Jan 07; 286(1):620-33.
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Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation. J Biol Chem. 2007 Oct 05; 282(40):29336-47.
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A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5413-8.
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Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation. J Immunol. 2004 Dec 15; 173(12):7135-9.
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The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling. Immunity. 2004 Jul; 21(1):7-17.
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Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis. J Biol Chem. 2003 Aug 01; 278(31):28950-60.
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Cutting edge: regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination. J Immunol. 2002 Sep 01; 169(5):2236-40.