Nedd4 Ubiquitin Protein Ligases
"Nedd4 Ubiquitin Protein Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.
| Descriptor ID |
D000075702
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| MeSH Number(s) |
D05.500.199.500 D08.811.464.938.750.257 D12.776.543.990.493.500
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| Concept/Terms |
Nedd4 Ubiquitin Protein Ligases- Nedd4 Ubiquitin Protein Ligases
- Nedd4 Proteins
- Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase
- Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 Ligase
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