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Ana Capuano

TitleVisiting Professor
InstitutionRush University, Rush Medical College
DepartmentRush Alzheimer's Disease Center
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    Ana W. Capuano, MPS, MS, PhD, is an Associate Professor of Neurological Sciences in Biostatistics. She leads the Data Management and Statistical Core of the Rush Alzheimer's Disease Research Center and is a faculty biostatistician of the Rush Alzheimer’s Disease Center. She joined Rush in 2012 after concluding her PhD at the University of Iowa. She is a visiting scholar at the State Government Employee Medical Assistance Institute (IAMSP) in Brazil and Harvard T.H. Chan School of Public Health.

    With hundreds of original peer-reviewed publications cited by over six thousand other scientific works, Dr. Capuano has been invited to lecture nationally and internationally, such as recent courses at South New Wales University in Australia, and Karolinska Institute in Sweden. She collaborated, consulted, and provided mentorship to several scientists on the application of modern statistical methods in epidemiological studies including the research on the association of molecular (e.g. proteomics), environmental factors (e.g. pollutants), psychiatric/psychosocial factors (e.g. stress, personality, neuropsychiatric symptoms), and comorbidities (e.g. diabetes, kidney) with age-related conditions. Capuano’s methodological interests include longitudinal models, non-linear mixed models, constrained ordinal class of models, and study design in comorbidities and disparity research. Some of the methodological developments are available in the R package nlive.

    She holds elected leadership positions in multiple professional groups including elected Educational Officer of the American Statistical Association (ASA) Statistics and Data Science in Aging (SDSA) American Statistical Association, and elected incoming chair of the National Alzheimer's Coordination Center (NACC) and immediate past elected chair for the Design and Data Analytics (DaDA) Professional Interest Areas, an assembly of The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART). In this role, she has fostered a collaborative platform for statisticians, data scientists, and aging researchers to share their insights and experiences, discuss best practices, and exchange innovative methods and scientific findings.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wilson RS, Yang J, Yu L, Leurgans SE, Capuano AW, Schneider JA, Bennett DA, Boyle PA. Postmortem neurodegenerative markers and trajectories of decline in cognitive systems. Neurology. 2019 02 19; 92(8):e831-e840. PMID: 30674595.
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    2. Mocco J, Brown RD, Torner JC, Capuano AW, Fargen KM, Raghavan ML, Piepgras DG, Meissner I, Huston J. Aneurysm Morphology and Prediction of Rupture: An International Study of Unruptured Intracranial Aneurysms Analysis. Neurosurgery. 2018 04 01; 82(4):491-496. PMID: 28605486.
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    3. Wilson RS, Capuano AW, Yu L, Yang J, Kim N, Leurgans SE, Lamar M, Schneider JA, Bennett DA, Boyle PA. Neurodegenerative disease and cognitive retest learning. Neurobiol Aging. 2018 06; 66:122-130. PMID: 29558667.
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    4. Jansen WJ, Wilson RS, Visser PJ, Nag S, Schneider JA, James BD, Leurgans SE, Capuano AW, Bennett DA, Boyle PA. Age and the association of dementia-related pathology with trajectories of cognitive decline. Neurobiol Aging. 2018 01; 61:138-145. PMID: 29078129.
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    5. Wilson RS, Capuano AW, James BD, Amofa P, Arvanitakis Z, Shah R, Bennett DA, Boyle PA. Purpose in Life and Hospitalization for Ambulatory Care-Sensitive Conditions in Old Age. Am J Geriatr Psychiatry. 2018 03; 26(3):364-374. PMID: 28780129.
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    6. Boyle PA, Yang J, Yu L, Leurgans SE, Capuano AW, Schneider JA, Wilson RS, Bennett DA. Varied effects of age-related neuropathologies on the trajectory of late life cognitive decline. Brain. 2017 03 01; 140(3):804-812. PMID: 28082297.
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    7. Arfanakis K, Wilson RS, Barth CM, Capuano AW, Vasireddi A, Zhang S, Fleischman DA, Bennett DA. Cognitive activity, cognitive function, and brain diffusion characteristics in old age. Brain Imaging Behav. 2016 06; 10(2):455-63. PMID: 25982658.
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    8. Capuano AW, Wilson RS, Leurgans SE, Dawson JD, Bennett DA, Hedeker D. Sigmoidal mixed models for longitudinal data. Stat Methods Med Res. 2018 03; 27(3):863-875. PMID: 27130491.
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    9. Wilson RS, Capuano AW, Bennett DA, Schneider JA, Boyle PA. Temporal course of neurodegenerative effects on cognition in old age. Neuropsychology. 2016 07; 30(5):591-9. PMID: 27111293.
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    10. Wilson RS, Boyle PA, Capuano AW, Shah RC, Hoganson GM, Nag S, Bennett DA. Late-life depression is not associated with dementia-related pathology. Neuropsychology. 2016 Feb; 30(2):135-42. PMID: 26237627.
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    11. Modeling Likert Scale Outcomes With Trend-Proportional Odds With and Without Cluster Data. Methodology. 2016; 12(2):33-43.
    12. Ahima RS, Capuano AW, Schneider JA, Bennett DA, Arnold SE, Arvanitakis Z. Brain insulin resistance and AD neuropathology among older autopsied persons with and without diabetes. Alzheimer's Association International Conference 2016. Alzheimer's & Dementia 2016. 2016.
    13. Barnes LL, Yumoto F, Capuano A, Wilson RS, Bennett DA, Tractenberg RE. Examination of the Factor Structure of a Global Cognitive Function Battery across Race and Time. J Int Neuropsychol Soc. 2016 Jan; 22(1):66-75. PMID: 26563713.
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    14. Wilson RS, Capuano AW, Marquez DX, Amofa P, Barnes LL, Bennett DA. Change in Cognitive Abilities in Older Latinos. J Int Neuropsychol Soc. 2016 Jan; 22(1):58-65. PMID: 26553103.
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    15. Wilson RS, Capuano AW, Sytsma J, Bennett DA, Barnes LL. Cognitive aging in older Black and White persons. Psychol Aging. 2015 Jun; 30(2):279-85. PMID: 25961876.
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    16. Nag S, Yu L, Capuano AW, Wilson RS, Leurgans SE, Bennett DA, Schneider JA. Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease. Ann Neurol. 2015 Jun; 77(6):942-52. PMID: 25707479.
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    17. Arvanitakis Z, Capuano AW, Leurgans Se, Bennett DA, Schneider JA. The relationship of cerebral vessel pathology to brain microinfarcts. Alzheimer's Association International Conference 2015. Alzheimer's & Dementia 2015 (platform). 2015.
    18. Capuano AW, Robert RS, Leurgans SE, Dawson JD, Hedeker D. Using the Sigmoid Mixed Models for Longitudinal Cognitive Decline. Eastern North American Region International Biometric Society (ENAR). March 15-18, 2015. Miama, USA. 2015.
    19. Capuano AW, Leurgans SE, Bennett DA, Robert RS. Modeling Longitudinal change in depressive symptoms: Constraint ordinal models versus generalized linear mixed models. Statistical Methods Conference on Alzheimer's and Dementia, September 24, 2015, Chicago, IL. 2015.
    20. Capuano AW. Global odds model with proportional odds and trends odds applied to gross and microscopic brain infarcts. Fall ADC Meeting presentations. September 26-28, 2015. Chicago, IL. 2015.
    21. Shah RC, Matthews DC, Andrews RD, Capuano AW, Fleischman DA, VanderLugt JT, Colca JR. An evaluation of MSDC-0160, a prototype mTOT modulating insulin sensitizer, in patients with mild Alzheimer's disease. Curr Alzheimer Res. 2014; 11(6):564-73. PMID: 24931567.
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    22. Blair PJ, Putnam SD, Krueger WS, Chum C, Wierzba TF, Heil GL, Yasuda CY, Williams M, Kasper MR, Friary JA, Capuano AW, Saphonn V, Peiris M, Shao H, Perez DR, Gray GC. Evidence for avian H9N2 influenza virus infections among rural villagers in Cambodia. J Infect Public Health. 2013 Apr; 6(2):69-79. PMID: 23537819.
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    23. Capuano AW, Field RW, Marizen RR, Dawson JD. Using the Constrained Ordinal Models for Likert-Based Outcomes. Joint Statistical Meetings (JSM). August 3-8, 2013. Montreal, Quebec, Canada. 2013.
    24. Turner AD, Capuano AW. Comparing Two Validated Depression Scales as Predictors of Cognitive Decline in African Americans. Gerontological Society of America Annual Scientific Meeting. November 20-24, 2013. New Orleans, LA. 2013.
    25. Schenider JA, Capuano AW, Leurgans SE, Arvanitakis Z, Levine SR, Bennett DA. Brain microinfarcts: The role of atherosclerosis and arteriosclerosis and vascular risk factors. 6th International Society of Vascular Behavioural and Cognitive Disorders (VAS COG). July 25-28, 2013. Toronto, Ontario, Canada. 2013.
    26. Dlouhy BJ, Capuano AW, Madhavan K, Torner JC, Greenlee JD. Preoperative third ventricular bowing as a predictor of endoscopic third ventriculostomy success. J Neurosurg Pediatr. 2012 Feb; 9(2):182-90. PMID: 22295925.
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    27. Dlouhy BJ, Capuano AW, Madhavan KH, Torner J, Greenlee JDW. Pre-operative Anatomic Features of the Third Ventricle and Implications on Endoscopic Third Ventriculostomy Outcome. Congress of Neurological Surgeons. October 1-6, 2011. Washington, DC. 2011.
    28. Kung DK, Policeni BA, Capuano AW, Rossen JD, Jabbour PM, Torner JC, Howard MA, Hasan D. Risk of ventriculostomy-related hemorrhage in patients with acutely ruptured aneurysms treated using stent-assisted coiling. J Neurosurg. 2011 Apr; 114(4):1021-7. PMID: 20950080.
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    29. Capuano AW, Gray GC, Dawson JD, Field RW. Using the Trend Odds Model in Seroepidemiological Studies. Joint Statistical Meetings (JSM). July 31-August 5, 2010. Vancouver, British Columbia, Canada. 2010.
    30. Gray GC, Bender JB, Bridges CB, Daly RF, Baker WS, Heil GL, Capuano AW, Gramer MR, Schmitt BJ, Swenson SL, Cox NJ. Pandemic Influenza Virus Among Healthy US Swine Show Pigs. International Symposium on Neglected Influenza Viruses, February 3-5, 2010. Amelia Island, FL. 2010.
    31. Landry ML, Lebeck MG, Capuano AW, McCarthy T, Gray GC. Adenovirus type 3 outbreak in connecticut associated with a novel variant. J Med Virol. 2009 Aug; 81(8):1380-4. PMID: 19551823.
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    32. Rainwater KK, Ijdo J, Capuano A, Gilchrist MJ, Gill JS. Serosurveillance for Anaplasma phagocytophilum antibodies in white-tailed deer (Odocoileus virginianus) in Iowa, USA. Vector Borne Zoonotic Dis. 2006; 6(3):275-82. PMID: 16989567.
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    33. Capuano AW, Dawson AW, Gray GC. Maximizing the Statistical Assessment of Antibody Titer Data: The Proportional Odds Model. University of Iowa Research Week Mar 28-31, 2006, Iowa City, IA. 2006.
    34. Gray GC, McCarthy T, Capuano AW, Lynch CF, Wellman DA, Lesher KA, Setterquist SF, Miller NJ, Gillette PAP, Olson CW, Klimov AI, Alavanja MC, Katz JM. Population-based Surveillance for Zoontonic Influenza A in Agricultural Workers. International Conference on Emerging Infectious Diseases, Mar 19-22, 2006, Atlanta, GA. 2006.
    35. Gray GC, Capuano AW, Setterquist SF, Erdman DD, Newell ND, Abed Y, Doern GC, Sarah SE, Boivin G. Risk factors for Human Metapneumovirus Infection and Genomic Variation at a US Midwestern Referral Laboratory. International Conference on Emerging Infectious Diseases, Mar 19-22, 2006, Atlanta, GA. 2006.
    36. Ramirez A, Capuano AW, Wellman DA, Setterquist SF, Gray GC. Zootonic Influenza Risk and Personal Protective Devices. International Conference on Emerging Infectious Diseases, Mar 19-22, 2006, Atlanta, GA. 2006.
    37. Gray GC, Capuano AW, Setterquist SF, Erdman DD, Newell DD, Abed Y, Doern GC, Sarah SE, Boivin G. Risk Factors for Human Metapneumovirus Infection and Genomic Variation at a US Midwestern Referral Laboratory. University of Iowa Research Week Mar 28-31, 2006, Iowa City, IA. 2006.
    38. Gray GC, McCarthy T, Capuano AW, Lynch CF, Wellman DA, Lesher KA, Setterquist SF, Miller NJ, Gillette PAP, Olson CW, Klimov AI, Alavanja MC, Katz JM. Population-based Surveillance for Zootonic Influenza A in Agricultural Workers. University of Iowa Research Week Mar 28-31, 2006, Iowa City, IA. 2006.
    39. Gray GC, McCarthy T, Capuano AW, Lynch CF, Wellman DA, Lesher KA, Setterquist Sf, Miller NJ, Gillette PAP, Olson CW, Klimov AI, Alavanja MC, Katz JM. Population-based Surveillance for Zootonic Influenza A in Agricultural Workers. Second North American Congress on Epidemiology, June 21-24, 2006, Seattle Washington. 2006.
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