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Lei Yu

TitleAssociate Professor
InstitutionRush University, Rush Medical College
DepartmentRush Alzheimer's Disease Center
Address
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    Collapse Biography 
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    2007R. L. Anderson, Summer Research Conference on Statistics , Southern Regional Council on Statistics and American Statistical Association

    Collapse Overview 
    Collapse overview
    Lei Yu is a statistician with Rush Alzheimer’s Disease Center, and associate professor, neurological sciences with Rush University Medical Center. His current research activities focus on providing statistical advice on design and analysis to RADC investigators, and developing methods and applications tailored to the studies on aging and Alzheimer’s disease.
    Yu received his PhD in statistics from the University of Kentucky. He has a particular interest in longitudinal data analysis and statistical modeling of late life cognitive trajectories. Yu has also been actively involved in projects that leverage multi-level omics data to explore the associations between genetic risk factors and aging-related traits.

    My Scopus ID is 56497341800.
    My NIH COMMONS name is LEIYU123.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ross RD, Dulion B, Wong J, Gritsenko MA, Day LZ, McDermott JE, Jacobs JM, Leurgans SE, Yu L, Bennett DA. Establishing bone tissue level changes associated with cognitive impairment. J Gerontol A Biol Sci Med Sci. 2026 Jun 06; 81(7). PMID: 42172587.
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    2. Zammit AR, Klein HU, Yu L, Levey AI, Seyfried NT, Wingo AP, Wingo TS, Schneider JA, Bennett DA, Buchman AS. Proteome-wide Analyses Identified Cortical Proteins Associated With Resilience for Varied Cognitive Abilities. Neurology. 2024 Jan 09; 102(1):e207816. PMID: 38165375.
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    3. Zammit AR, Yu L, Buchman AS, Lange-Maia BS, Bennett DA, Grodstein F. A prospective study of the association of cognitive and motor function with odds of life space constriction in older adults. J Am Geriatr Soc. 2023 Oct 31. PMID: 37905593.
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    4. Yu L, Mottola G, Kieffer CN, Mascio R, Valdes O, Bennett DA, Boyle PA. Vulnerability of Older Adults to Government Impersonation Scams. JAMA Netw Open. 2023 09 05; 6(9):e2335319. PMID: 37738048.
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    5. Lamar M, Arfanakis K, Yu L, Kapasi A, Duke Han S, Fleischman DA, Bennett DA, Boyle P. The Relationship of MRI-Derived Alzheimer's and Cerebrovascular-Related Signatures With Level of and Change in Health and Financial Literacy. Am J Geriatr Psychiatry. 2023 12; 31(12):1129-1139. PMID: 37541932.
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    6. Yu L, Petyuk VA, Lopes KP, Tasaki S, Menon V, Wang Y, Schneider JA, De Jager PL, Bennett DA. Associations of VGF with Neuropathologies and Cognitive Health in Older Adults. Ann Neurol. 2023 08; 94(2):232-244. PMID: 37177846.
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    7. Buchman AS, Wang T, Oveisgharan S, Zammit AR, Yu L, Li P, Hu K, Hausdorff JM, Lim ASP, Bennett DA. Correlates of Person-Specific Rates of Change in Sensor-Derived Physical Activity Metrics of Daily Living in the Rush Memory and Aging Project. Sensors (Basel). 2023 Apr 21; 23(8). PMID: 37112493.
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    8. Buchman AS, Yu L, Klein HU, Zammit AR, Oveisgharan S, Grodstein F, Tasaki S, Levey AI, Seyfried NT, Bennett DA. Proteome-Wide Discovery of Cortical Proteins That May Provide Motor Resilience to Offset the Negative Effects of Pathologies in Older Adults. J Gerontol A Biol Sci Med Sci. 2023 03 01; 78(3):494-503. PMID: 35512265.
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    9. Oveisgharan S, Yu L, Wang T, Schneider JA, Bennett DA, Buchman AS. Neurodegenerative and Cerebrovascular Brain Pathologies Are Differentially Associated With Declining Grip Strength and Gait In Older Adults. J Gerontol A Biol Sci Med Sci. 2023 03 01; 78(3):504-513. PMID: 35675284.
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    10. McSorley VE, Lamar M, Yu L, Bennett DA, Barnes LL, Boyle PA. Decision Making and Blood Sugar Indicators in Older African American Adults. J Aging Health. 2023 03; 35(3-4):221-229. PMID: 35997533.
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    11. Yu L, Hsieh YC, Pearse RV, Wang Y, Petyuk VA, Schneider JA, Buchman AS, Seyfried NT, De Jager PL, Young-Pearse TL, Bennett DA. Association of AK4 Protein From Stem Cell-Derived Neurons With Cognitive Reserve: An Autopsy Study. Neurology. 2022 11 15; 99(20):e2264-e2274. PMID: 35948448.
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    12. Lamar M, Yu L, Leurgans S, Aggarwal NT, Wilson RS, Han SD, Bennett DA, Boyle P. Self-reported fraud victimization and objectively measured blood pressure: Sex differences in post-fraud cardiovascular health. J Am Geriatr Soc. 2022 11; 70(11):3185-3194. PMID: 35920078.
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    13. Yu L, Mottola G, Barnes LL, Valdes O, Wilson RS, Bennett DA, Boyle PA. Financial fragility and scam susceptibility in community dwelling older adults. J Elder Abuse Negl. 2022 Mar-May; 34(2):93-108. PMID: 35484831.
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    14. Boyle PA, Yu L, Mottola G, Innes K, Bennett DA. Degraded Rationality and Suboptimal Decision-Making in Old Age: A Silent Epidemic With Major Economic and Public Health Implications. Public Policy Aging Rep. 2022; 32(2):45-50. PMID: 35607367.
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    15. Zammit AR, Yu L, Petyuk V, Schneider JA, De Jager PL, Klein HU, Bennett DA, Buchman AS. Cortical Proteins and Individual Differences in Cognitive Resilience in Older Adults. Neurology. 2022 03 29; 98(13):e1304-e1314. PMID: 35241503.
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    16. Yu L, Mottola G, Wilson RS, Valdes O, Bennett DA, Boyle PA. Metamemory and financial decision making in older adults without dementia. Neuropsychology. 2022 Jan; 36(1):35-43. PMID: 34726461.
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    17. Boyle PA, Wang T, Yu L, Wilson RS, Dawe R, Arfanakis K, Schneider JA, Bennett DA. To what degree is late life cognitive decline driven by age-related neuropathologies? Brain. 2021 08 17; 144(7):2166-2175. PMID: 33742668.
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    18. Wilson RS, Wang T, Yu L, Grodstein F, Bennett DA, Boyle PA. Cognitive Activity and Onset Age of Incident Alzheimer Disease Dementia. Neurology. 2021 08 31; 97(9):e922-e929. PMID: 34261788.
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    19. Dawe RJ, Yu L, Leurgans SE, James BD, Poole VN, Arfanakis K, Schneider JA, Bennett DA, Buchman AS. Physical activity, brain tissue microstructure, and cognition in older adults. PLoS One. 2021; 16(7):e0253484. PMID: 34232955.
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    20. Grodstein F, Lemos B, Yu L, Klein HU, Iatrou A, Buchman AS, Shireby GL, Mill J, Schneider JA, De Jager PL, Bennett DA. The association of epigenetic clocks in brain tissue with brain pathologies and common aging phenotypes. Neurobiol Dis. 2021 09; 157:105428. PMID: 34153464.
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    21. Nag S, Barnes LL, Yu L, Buchman AS, Bennett DA, Schneider JA, Wilson RS. Association of Lewy Bodies With Age-Related Clinical Characteristics in Black and White Decedents. Neurology. 2021 08 24; 97(8):e825-e835. PMID: 34088871.
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    22. Kim N, Arfanakis K, Leurgans SE, Yang J, Fleischman DA, Han SD, Aggarwal NT, Lamar M, Yu L, Poole VN, Bennett DA, Barnes LL. Bootstrap approach for meta-synthesis of MRI findings from multiple scanners. J Neurosci Methods. 2021 08 01; 360:109229. PMID: 34052288.
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    23. Boyle PA, Wang T, Yu L, Barnes LL, Wilson RS, Bennett DA. Purpose in Life May Delay Adverse Health Outcomes in Old Age. Am J Geriatr Psychiatry. 2022 Feb; 30(2):174-181. PMID: 34175231.
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    24. Oveisgharan S, Yu L, Capuano A, Arvanitakis Z, Barnes LL, Schneider JA, Bennett DA, Buchman AS. Late-Life Vascular Risk Score in Association With Postmortem Cerebrovascular Disease Brain Pathologies. Stroke. 2021 06; 52(6):2060-2067. PMID: 33840227.
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    25. Buchman AS, Yu L, Oveisgharan S, Farfel JM, Schneider JA, Bennett DA. Person-Specific Contributions of Brain Pathologies to Progressive Parkinsonism in Older Adults. J Gerontol A Biol Sci Med Sci. 2021 03 31; 76(4):615-621. PMID: 32720690.
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    26. Yu L, Mottola G, Bennett DA, Boyle PA. Adverse Impacts of Declining Financial and Health Literacy in Old Age. Am J Geriatr Psychiatry. 2021 11; 29(11):1129-1139. PMID: 33676832.
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    27. Oveisgharan S, Yu L, Bennett DA, Buchman AS. Incident mobility disability, parkinsonism, and mortality in community-dwelling older adults. PLoS One. 2021; 16(2):e0246206. PMID: 33534811.
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    28. Grodstein F, Lemos B, Yu L, Iatrou A, De Jager PL, Bennett DA. Characteristics of Epigenetic Clocks Across Blood and Brain Tissue in Older Women and Men. Front Neurosci. 2020; 14:555307. PMID: 33488342.
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    29. Kapasi A, Yu L, Stewart C, Schneider JA, Bennett DA, Boyle PA. Association of Amyloid-? Pathology with Decision Making and Scam Susceptibility. J Alzheimers Dis. 2021; 83(2):879-887. PMID: 34366345.
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    30. Yu L, Tasaki S, Schneider JA, Arfanakis K, Duong DM, Wingo AP, Wingo TS, Kearns N, Thatcher GRJ, Seyfried NT, Levey AI, De Jager PL, Bennett DA. Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons. JAMA Psychiatry. 2020 11 01; 77(11):1172-1180. PMID: 32609320.
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    31. Yu L, Schneider JA, Kapasi A, Bennett DA, Boyle PA. Limbic-predominant Age-related TDP-43 Encephalopathy and Distinct Longitudinal Profiles of Domain-specific Literacy. Alzheimer Dis Assoc Disord. 2020 Oct-Dec; 34(4):299-305. PMID: 32452861.
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    32. Lamar M, Arfanakis K, Yu L, Zhang S, Han SD, Fleischman DA, Bennett DA, Boyle PA. White matter correlates of scam susceptibility in community-dwelling older adults. Brain Imaging Behav. 2020 Oct; 14(5):1521-1530. PMID: 30895444.
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    33. Buchman AS, Wang T, Yu L, Leurgans SE, Schneider JA, Bennett DA. Brain pathologies are associated with both the rate and variability of declining motor function in older adults. Acta Neuropathol. 2020 10; 140(4):587-589. PMID: 32803349.
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    34. Glover CM, Yu L, Stewart CC, Wilson RS, Bennett DA, Boyle PA. The Association of Late Life Cognitive Activity with Healthcare and Financial Decision-Making in Community-Dwelling, Nondemented Older Adults. Am J Geriatr Psychiatry. 2021 02; 29(2):117-125. PMID: 32646635.
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    35. Yang HS, White CC, Klein HU, Yu L, Gaiteri C, Ma Y, Felsky D, Mostafavi S, Petyuk VA, Sperling RA, Ertekin-Taner N, Schneider JA, Bennett DA, De Jager PL. Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology. Neuron. 2020 08 05; 107(3):496-508.e6. PMID: 32526197.
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    36. Wilson RS, Wang T, Yu L, Bennett DA, Boyle PA. Normative Cognitive Decline in Old Age. Ann Neurol. 2020 06; 87(6):816-829. PMID: 32144793.
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    37. Oveisgharan S, Yu L, Dawe RJ, Bennett DA, Buchman AS. Total Daily Physical Activity and the Risk of Parkinsonism in Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2020 03 09; 75(4):702-711. PMID: 31046115.
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    38. Yu L, Mottola G, Bennett DA, Boyle PA. Confidence in Financial and Health Literacy and Cognitive Health in Older Persons J Alzheimers Dis. 2020; 75(4):1229-1240. PMID: 32176649.
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    39. Dawe RJ, Yu L, Arfanakis K, Schneider JA, Bennett DA, Boyle PA. Late-life cognitive decline is associated with hippocampal volume, above and beyond its associations with traditional neuropathologic indices. Alzheimers Dement. 2020 01; 16(1):209-218. PMID: 31914231.
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    40. Wilson RS, Yu L, Leurgans SE, Bennett DA, Boyle PA. Proportion of cognitive loss attributable to terminal decline. Neurology. 2020 01 07; 94(1):e42-e50. PMID: 31792096.
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    41. Kapasi A, Yu L, Stewart CC, Schneider JA, Bennett DA, Boyle PA. Association of TDP-43 Pathology With Domain-specific Literacy in Older Persons. Alzheimer Dis Assoc Disord. 2019 Oct-Dec; 33(4):315-320. PMID: 31305319.
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    42. Yu L, Wang T, Wilson RS, Leurgans S, Schneider JA, Bennett DA, Boyle PA. Common age-related neuropathologies and yearly variability in cognition. Ann Clin Transl Neurol. 2019 11; 6(11):2140-2149. PMID: 31568713.
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    43. Nag S, Yu L, VanderHorst VG, Schneider JA, Bennett DA, Buchman AS, Wilson RS. Neocortical Lewy bodies are associated with impaired odor identification in community-dwelling elders without clinical PD. J Neurol. 2019 Dec; 266(12):3108-3118. PMID: 31535271.
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    44. Li P, Yu L, Yang J, Lo MT, Hu C, Buchman AS, Bennett DA, Hu K. Interaction between the progression of Alzheimer's disease and fractal degradation. Neurobiol Aging. 2019 11; 83:21-30. PMID: 31585364.
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    45. Buchman AS, Yu L, Petyuk VA, Gaiteri C, Tasaki S, Blizinsky KD, Schneider JA, De Jager PL, Bennett DA. Cognition may link cortical IGFBP5 levels with motor function in older adults. PLoS One. 2019; 14(8):e0220968. PMID: 31404102.
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    46. Gaiteri C, Dawe R, Mostafavi S, Blizinsky KD, Tasaki S, Komashko V, Yu L, Wang Y, Schneider JA, Arfanakis K, De Jager PL, Bennett DA. Gene expression and DNA methylation are extensively coordinated with MRI-based brain microstructural characteristics. Brain Imaging Behav. 2019 Aug; 13(4):963-972. PMID: 29934819.
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    47. Kim N, Yu L, Dawe R, Petyuk VA, Gaiteri C, De Jager PL, Schneider JA, Arfanakis K, Bennett DA. Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline. Neurobiol Aging. 2019 12; 84:17-25. PMID: 31479860.
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    48. Farfel JM, Yu L, Boyle PA, Leurgans S, Shah RC, Schneider JA, Bennett DA. Alzheimer's disease frequency peaks in the tenth decade and is lower afterwards. Acta Neuropathol Commun. 2019 07 03; 7(1):104. PMID: 31269985.
      Citations:    
    49. Dawe RJ, Yu L, Leurgans SE, Truty T, Curran T, Hausdorff JM, Wimmer MA, Block JA, Bennett DA, Buchman AS. Expanding instrumented gait testing in the community setting: A portable, depth-sensing camera captures joint motion in older adults. PLoS One. 2019; 14(5):e0215995. PMID: 31091267.
      Citations:    
    50. Buchman AS, Yu L, Wilson RS, Leurgans SE, Nag S, Shulman JM, Barnes LL, Schneider JA, Bennett DA. Progressive parkinsonism in older adults is related to the burden of mixed brain pathologies. Neurology. 2019 04 16; 92(16):e1821-e1830. PMID: 30894446.
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    51. Capuano AW, Wilson RS, Honer WG, Petyuk VA, Leurgans SE, Yu L, Gatchel JR, Arnold S, Bennett DA, Arvanitakis Z. Brain IGFBP-5 modifies the relation of depressive symptoms to decline in cognition in older persons. J Affect Disord. 2019 05 01; 250:313-318. PMID: 30875674.
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    52. Karasik D, Zillikens MC, Hsu YH, Aghdassi A, Akesson K, Amin N, Barroso I, Bennett DA, Bertram L, Bochud M, Borecki IB, Broer L, Buchman AS, Byberg L, Campbell H, Campos-Obando N, Cauley JA, Cawthon PM, Chambers JC, Chen Z, Cho NH, Choi HJ, Chou WC, Cummings SR, de Groot LCPGM, De Jager PL, Demuth I, Diatchenko L, Econs MJ, Eiriksdottir G, Enneman AW, Eriksson J, Eriksson JG, Estrada K, Evans DS, Feitosa MF, Fu M, Gieger C, Grallert H, Gudnason V, Lenore LJ, Hayward C, Hofman A, Homuth G, Huffman KM, Husted LB, Illig T, Ingelsson E, Ittermann T, Jansson JO, Johnson T, Biffar R, Jordan JM, Jula A, Karlsson M, Khaw KT, Kilpel?inen TO, Klopp N, Kloth JSL, Koller DL, Kooner JS, Kraus WE, Kritchevsky S, Kutalik Z, Kuulasmaa T, Kuusisto J, Laakso M, Lahti J, Lang T, Langdahl BL, Lerch MM, Lewis JR, Lill C, Lind L, Lindgren C, Liu Y, Livshits G, Ljunggren ?, Loos RJF, Lorentzon M, Luan J, Luben RN, Malkin I, McGuigan FE, Medina-Gomez C, Meitinger T, Melhus H, Mellstr?m D, Micha?lsson K, Mitchell BD, Morris AP, Mosekilde L, Nethander M, Newman AB, O'Connell JR, Oostra BA, Orwoll ES, Palotie A, Peacock M, Perola M, Peters A, Prince RL, Psaty BM, R?ikk?nen K, Ralston SH, Ripatti S, Rivadeneira F, Robbins JA, Rotter JI, Rudan I, Salomaa V, Satterfield S, Schipf S, Shin CS, Smith AV, Smith SB, Soranzo N, Spector TD, Stanc?kov? A, Stefansson K, Steinhagen-Thiessen E, Stolk L, Streeten EA, Styrkarsdottir U, Swart KMA, Thompson P, Thomson CA, Thorleifsson G, Thorsteinsdottir U, Tikkanen E, Tranah GJ, Uitterlinden AG, van Duijn CM, van Schoor NM, Vandenput L, Vollenweider P, V?lzke H, Wactawski-Wende J, Walker M, J Wareham N, Waterworth D, Weedon MN, Wichmann HE, Widen E, Williams FMK, Wilson JF, Wright NC, Yerges-Armstrong LM, Yu L, Zhang W, Zhao JH, Zhou Y, Nielson CM, Harris TB, Demissie S, Kiel DP, Ohlsson C. Disentangling the genetics of lean mass. Am J Clin Nutr. 2019 02 01; 109(2):276-287. PMID: 30721968.
      Citations:    
    53. Wilson RS, Yang J, Yu L, Leurgans SE, Capuano AW, Schneider JA, Bennett DA, Boyle PA. Postmortem neurodegenerative markers and trajectories of decline in cognitive systems. Neurology. 2019 02 19; 92(8):e831-e840. PMID: 30674595.
      Citations:    
    54. Buchman AS, Yu L, Wilson RS, Lim A, Dawe RJ, Gaiteri C, Leurgans SE, Schneider JA, Bennett DA. Physical activity, common brain pathologies, and cognition in community-dwelling older adults. Neurology. 2019 02 19; 92(8):e811-e822. PMID: 30651386.
      Citations:    
    55. Boyle PA, Yu L, Leurgans SE, Wilson RS, Brookmeyer R, Schneider JA, Bennett DA. Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies. Ann Neurol. 2019 01; 85(1):114-124. PMID: 30421454.
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    56. Oveisgharan S, Arvanitakis Z, Yu L, Farfel J, Schneider JA, Bennett DA. Sex differences in Alzheimer's disease and common neuropathologies of aging. Acta Neuropathol. 2018 12; 136(6):887-900. PMID: 30334074.
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    57. Lamar M, Yu L, Rubin LH, James BD, Barnes LL, Farfel JM, Gaiteri C, Buchman AS, Bennett DA, Schneider JA. APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults. Alzheimers Dement. 2019 02; 15(2):258-266. PMID: 30321502.
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    58. Yu L, Petyuk VA, Gaiteri C, Mostafavi S, Young-Pearse T, Shah RC, Buchman AS, Schneider JA, Piehowski PD, Sontag RL, Fillmore TL, Shi T, Smith RD, De Jager PL, Bennett DA. Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia. Ann Neurol. 2018 07; 84(1):78-88. PMID: 29908079.
      Citations:    
    59. James BD, Wilson RS, Shah RC, Yu L, Arvanitakis Z, Bennett DA, Boyle PA. Association of Financial Literacy With Hospitalization in Community-dwelling Older Adults. Med Care. 2018 07; 56(7):596-602. PMID: 29901572.
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    60. Dawe RJ, Yu L, Schneider JA, Arfanakis K, Bennett DA, Boyle PA. Postmortem brain MRI is related to cognitive decline, independent of cerebral vessel disease in older adults. Neurobiol Aging. 2018 09; 69:177-184. PMID: 29908416.
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    61. Li P, Yu L, Lim ASP, Buchman AS, Scheer FAJL, Shea SA, Schneider JA, Bennett DA, Hu K. Fractal regulation and incident Alzheimer's disease in elderly individuals. Alzheimers Dement. 2018 09; 14(9):1114-1125. PMID: 29733807.
      Citations:    
    62. Nag S, Yu L, Boyle PA, Leurgans SE, Bennett DA, Schneider JA. TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer's disease. Acta Neuropathol Commun. 2018 05 01; 6(1):33. PMID: 29716643.
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    63. Wilson RS, Capuano AW, Yu L, Yang J, Kim N, Leurgans SE, Lamar M, Schneider JA, Bennett DA, Boyle PA. Neurodegenerative disease and cognitive retest learning. Neurobiol Aging. 2018 06; 66:122-130. PMID: 29558667.
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    64. Boyle PA, Yu L, Wilson RS, Leurgans SE, Schneider JA, Bennett DA. Person-specific contribution of neuropathologies to cognitive loss in old age. Ann Neurol. 2018 01; 83(1):74-83. PMID: 29244218.
      Citations:    
    65. Yu L, Dawe RJ, Boyle PA, Gaiteri C, Yang J, Buchman AS, Schneider JA, Arfanakis K, De Jager PL, Bennett DA. Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline. JAMA Neurol. 2017 12 01; 74(12):1473-1480. PMID: 29084334.
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    66. Yu L, Lutz MW, Wilson RS, Burns DK, Roses AD, Saunders AM, Yang J, Gaiteri C, De Jager PL, Barnes LL, Bennett DA. APOE e4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans. PLoS One. 2017; 12(7):e0180356. PMID: 28672022.
      Citations:    
    67. Yu L, Wilson RS, Han SD, Leurgans S, Bennett DA, Boyle PA. Decline in Literacy and Incident AD Dementia Among Community-Dwelling Older Persons. J Aging Health. 2018 10; 30(9):1389-1405. PMID: 28645223.
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    68. Yu L, Lutz MW, Farfel JM, Wilson RS, Burns DK, Saunders AM, De Jager PL, Barnes LL, Schneider JA, Bennett DA. Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline. Alzheimers Dement. 2017 Dec; 13(12):1380-1388. PMID: 28624335.
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    69. Boyle PA, Yang J, Yu L, Leurgans SE, Capuano AW, Schneider JA, Wilson RS, Bennett DA. Varied effects of age-related neuropathologies on the trajectory of late life cognitive decline. Brain. 2017 03 01; 140(3):804-812. PMID: 28082297.
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    70. Yu L, Lutz MW, Wilson RS, Burns DK, Roses AD, Saunders AM, Gaiteri C, De Jager PL, Barnes LL, Bennett DA. TOMM40'523 variant and cognitive decline in older persons with APOE e3/3 genotype. Neurology. 2017 Feb 14; 88(7):661-668. PMID: 28108637.
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    71. Nag S, Yu L, Wilson RS, Chen EY, Bennett DA, Schneider JA. TDP-43 pathology and memory impairment in elders without pathologic diagnoses of AD or FTLD. Neurology. 2017 Feb 14; 88(7):653-660. PMID: 28087828.
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    72. Yu L, Wilson RS, Schneider JA, Bennett DA, Boyle PA. Financial and Health Literacy Predict Incident Alzheimer's Disease Dementia and Pathology. J Alzheimers Dis. 2017; 56(4):1485-1493. PMID: 28157101.
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    73. Raj T, Chibnik LB, McCabe C, Wong A, Replogle JM, Yu L, Gao S, Unverzagt FW, Stranger B, Murrell J, Barnes L, Hendrie HC, Foroud T, Krichevsky A, Bennett DA, Hall KS, Evans DA, De Jager PL. Genetic architecture of age-related cognitive decline in African Americans. Neurol Genet. 2017 Feb; 3(1):e125. PMID: 28078323.
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    74. Boyle PA, Yu L, Fleischman DA, Leurgans S, Yang J, Wilson RS, Schneider JA, Arvanitakis Z, Arfanakis K, Bennett DA. White matter hyperintensities, incident mild cognitive impairment, and cognitive decline in old age. Ann Clin Transl Neurol. 2016 10; 3(10):791-800. PMID: 27752514.
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    75. Buchman AS, Leurgans SE, Yu L, Wilson RS, Lim AS, James BD, Shulman JM, Bennett DA. Incident parkinsonism in older adults without Parkinson disease. Neurology. 2016 Sep 06; 87(10):1036-44. PMID: 27488597.
      Citations:    
    76. Farfel JM, Yu L, Buchman AS, Schneider JA, De Jager PL, Bennett DA. Relation of genomic variants for Alzheimer disease dementia to common neuropathologies. Neurology. 2016 Aug 02; 87(5):489-96. PMID: 27371493.
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    77. Dawe RJ, Yu L, Leurgans SE, Schneider JA, Buchman AS, Arfanakis K, Bennett DA, Boyle PA. Postmortem MRI: a novel window into the neurobiology of late life cognitive decline. Neurobiol Aging. 2016 09; 45:169-177. PMID: 27459937.
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    78. Wilson RS, Yu L, James BD, Bennett DA, Boyle PA. Association of financial and health literacy with cognitive health in old age. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2017 Mar; 24(2):186-197. PMID: 27263546.
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    79. Yu L, Chibnik LB, Yang J, McCabe C, Xu J, Schneider JA, De Jager PL, Bennett DA. Methylation profiles in peripheral blood CD4+ lymphocytes versus brain: The relation to Alzheimer's disease pathology. Alzheimers Dement. 2016 09; 12(9):942-951. PMID: 27016692.
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    80. Boyle PA, Yu L, Nag S, Leurgans S, Wilson RS, Bennett DA, Schneider JA. Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons. Neurology. 2015 Dec 01; 85(22):1930-6. PMID: 26537052.
      Citations:    
    81. Buchman AS, Wilson RS, Yu L, Boyle PA, Bennett DA, Barnes LL. Motor Function Is Associated With Incident Disability in Older African Americans. J Gerontol A Biol Sci Med Sci. 2016 May; 71(5):696-702. PMID: 26525087.
      Citations:    
    82. Dong J, Yang J, Tranah G, Franceschini N, Parimi N, Alkorta-Aranburu G, Xu Z, Alonso A, Cummings SR, Fornage M, Huang X, Kritchevsky S, Liu Y, London S, Niu L, Wilson RS, De Jager PL, Yu L, Singleton AB, Harris T, Mosley TH, Pinto JM, Bennett DA, Chen H. Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults. Medicine (Baltimore). 2015 Nov; 94(47):e1892. PMID: 26632684.
      Citations:    
    83. Buchman AS, Yu L, Wilson RS, Dawe RJ, VanderHorst V, Schneider JA, Bennett DA. Post-mortem brain pathology is related to declining respiratory function in community-dwelling older adults. Front Aging Neurosci. 2015; 7:197. PMID: 26539108.
      Citations:    
    84. Wilson RS, Boyle PA, Yu L, Barnes LL, Sytsma J, Buchman AS, Bennett DA, Schneider JA. Temporal course and pathologic basis of unawareness of memory loss in dementia. Neurology. 2015 Sep 15; 85(11):984-91. PMID: 26311746.
      Citations:    
    85. Yu L, Boyle PA, Nag S, Leurgans S, Buchman AS, Wilson RS, Arvanitakis Z, Farfel JM, De Jager PL, Bennett DA, Schneider JA. APOE and cerebral amyloid angiopathy in community-dwelling older persons. Neurobiol Aging. 2015 Nov; 36(11):2946-2953. PMID: 26341746.
      Citations:    
    86. Han SD, Boyle PA, James BD, Yu L, Barnes LL, Bennett DA. Discrepancies between cognition and decision making in older adults. Aging Clin Exp Res. 2016 Feb; 28(1):99-108. PMID: 25995167.
      Citations:    
    87. Yang J, Yu L, Gaiteri C, Srivastava GP, Chibnik LB, Leurgans SE, Schneider JA, Meissner A, De Jager PL, Bennett DA. Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies. Int J Biochem Cell Biol. 2015 Oct; 67:58-64. PMID: 26003740.
      Citations:    
    88. Chibnik LB, Yu L, Eaton ML, Srivastava G, Schneider JA, Kellis M, Bennett DA, De Jager PL. Alzheimer's loci: epigenetic associations and interaction with genetic factors. Ann Clin Transl Neurol. 2015 Jun; 2(6):636-47. PMID: 26125039.
      Citations:    
    89. Yu L, Boyle PA, Leurgans S, Schneider JA, Kryscio RJ, Wilson RS, Bennett DA. Effect of common neuropathologies on progression of late life cognitive impairment. Neurobiol Aging. 2015 Jul; 36(7):2225-2231. PMID: 25976345.
      Citations:    
    90. Nag S, Yu L, Capuano AW, Wilson RS, Leurgans SE, Bennett DA, Schneider JA. Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease. Ann Neurol. 2015 Jun; 77(6):942-52. PMID: 25707479.
      Citations:    
    91. Yu L, Boyle PA, Wilson RS, Levine SR, Schneider JA, Bennett DA. Purpose in life and cerebral infarcts in community-dwelling older people. Stroke. 2015 Apr; 46(4):1071-6. PMID: 25791714.
      Citations:    
    92. Wilson RS, Boyle PA, Yu L, Segawa E, Sytsma J, Bennett DA. Conscientiousness, dementia related pathology, and trajectories of cognitive aging. Psychol Aging. 2015 Mar; 30(1):74-82. PMID: 25664558.
      Citations:    
    93. Yu L, De Jager PL, Yang J, Trojanowski JQ, Bennett DA, Schneider JA. The TMEM106B locus and TDP-43 pathology in older persons without FTLD. Neurology. 2015 Mar 03; 84(9):927-34. PMID: 25653292.
      Citations:    
    94. Yu L, Chibnik LB, Srivastava GP, Pochet N, Yang J, Xu J, Kozubek J, Obholzer N, Leurgans SE, Schneider JA, Meissner A, De Jager PL, Bennett DA. Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease. JAMA Neurol. 2015 Jan; 72(1):15-24. PMID: 25365775.
      Citations:    
    95. Bihlmeyer NA, Brody JA, Smith AV, Lunetta KL, Nalls M, Smith JA, Tanaka T, Davies G, Yu L, Mirza SS, Teumer A, Coresh J, Pankow JS, Franceschini N, Scaria A, Oshima J, Psaty BM, Gudnason V, Eiriksdottir G, Harris TB, Li H, Karasik D, Kiel DP, Garcia M, Liu Y, Faul JD, Kardia SL, Zhao W, Ferrucci L, Allerhand M, Liewald DC, Redmond P, Starr JM, De Jager PL, Evans DA, Direk N, Ikram MA, Uitterlinden A, Homuth G, Lorbeer R, Grabe HJ, Launer L, Murabito JM, Singleton AB, Weir DR, Bandinelli S, Deary IJ, Bennett DA, Tiemeier H, Kocher T, Lumley T, Arking DE. Genetic diversity is a predictor of mortality in humans. BMC Genet. 2014 Dec 29; 15:159. PMID: 25543667.
      Citations:    
    96. Yu L, Boyle PA, Segawa E, Leurgans S, Schneider JA, Wilson RS, Bennett DA. Residual decline in cognition after adjustment for common neuropathologic conditions. Neuropsychology. 2015 May; 29(3):335-43. PMID: 25495832.
      Citations:    
    97. Arvanitakis Z, Brey RL, Rand JH, Schneider JA, Capuano AW, Yu L, Leurgans SE, Bennett DA, Levine SR. Relation of antiphospholipid antibodies to postmortem brain infarcts in older people. Circulation. 2015 Jan 13; 131(2):182-9. PMID: 25301832.
      Citations:    
    98. Buchman AS, Yu L, Wilson RS, Boyle PA, Schneider JA, Bennett DA. Brain pathology contributes to simultaneous change in physical frailty and cognition in old age. J Gerontol A Biol Sci Med Sci. 2014 Dec; 69(12):1536-44. PMID: 25136002.
      Citations:    
    99. Bennett DA, Yu L, Yang J, Srivastava GP, Aubin C, De Jager PL. Epigenomics of Alzheimer's disease. Transl Res. 2015 Jan; 165(1):200-20. PMID: 24905038.
      Citations:    
    100. Bennett DA, Yu L, De Jager PL. Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease. Biochem Pharmacol. 2014 Apr 15; 88(4):617-30. PMID: 24508835.
      Citations:    
    101. Wilson RS, Nag S, Boyle PA, Hizel LP, Yu L, Buchman AS, Shah RC, Schneider JA, Arnold SE, Bennett DA. Brainstem aminergic nuclei and late-life depressive symptoms. JAMA Psychiatry. 2013 Dec; 70(12):1320-8. PMID: 24132763.
      Citations:    
    102. James BD, Boyle PA, Yu L, Bennett DA. Internet use and decision making in community-based older adults. Front Psychol. 2013; 4:605. PMID: 24578696.
      Citations:    
    103. Boyle PA, Yu L, Wilson RS, Schneider JA, Bennett DA. Relation of neuropathology with cognitive decline among older persons without dementia. Front Aging Neurosci. 2013; 5:50. PMID: 24058343.
      Citations:    
    104. Buchman AS, Wilson RS, Yu L, James BD, Boyle PA, Bennett DA. Total daily activity declines more rapidly with increasing age in older adults. Arch Gerontol Geriatr. 2014 Jan-Feb; 58(1):74-9. PMID: 24007938.
      Citations:    
    105. Wilson RS, Boyle PA, Yu L, Barnes LL, Schneider JA, Bennett DA. Life-span cognitive activity, neuropathologic burden, and cognitive aging. Neurology. 2013 Jul 23; 81(4):314-21. PMID: 23825173.
      Citations:    
    106. Shah RC, Janos AL, Kline JE, Yu L, Leurgans SE, Wilson RS, Wei P, Bennett DA, Heilman KM, Tsao JW. Cognitive decline in older persons initiating anticholinergic medications. PLoS One. 2013; 8(5):e64111. PMID: 23741303.
      Citations:    
    107. Yu L, Boyle P, Schneider JA, Segawa E, Wilson RS, Leurgans S, Bennett DA. APOE e4, Alzheimer's disease pathology, cerebrovascular disease, and cognitive change over the years prior to death. Psychol Aging. 2013 Dec; 28(4):1015-23. PMID: 23647000.
      Citations:    
    108. Kotrotsou A, Bennett DA, Schneider JA, Dawe RJ, Golak T, Leurgans SE, Yu L, Arfanakis K. Ex vivo MR volumetry of human brain hemispheres. Magn Reson Med. 2014 Jan; 71(1):364-74. PMID: 23440751.
      Citations:    
    109. Buchman AS, Yu L, Boyle PA, Levine SR, Nag S, Schneider JA, Bennett DA. Microvascular brain pathology and late-life motor impairment. Neurology. 2013 Feb 19; 80(8):712-8. PMID: 23365057.
      Citations:    
    110. Boyle PA, Wilson RS, Yu L, Buchman AS, Bennett DA. Poor decision making is associated with an increased risk of mortality among community-dwelling older persons without dementia. Neuroepidemiology. 2013; 40(4):247-52. PMID: 23364306.
      Citations:    
    111. Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, Amin N, Bakshis E, Baumert J, Ding J, Liu Y, Marciante K, Meirelles O, Nalls MA, Sun YV, Vogelzangs N, Yu L, Bandinelli S, Benjamin EJ, Bennett DA, Boomsma D, Cannas A, Coker LH, de Geus E, De Jager PL, Diez-Roux AV, Purcell S, Hu FB, Rimma EB, Hunter DJ, Jensen MK, Curhan G, Rice K, Penman AD, Rotter JI, Sotoodehnia N, Emeny R, Eriksson JG, Evans DA, Ferrucci L, Fornage M, Gudnason V, Hofman A, Illig T, Kardia S, Kelly-Hayes M, Koenen K, Kraft P, Kuningas M, Massaro JM, Melzer D, Mulas A, Mulder CL, Murray A, Oostra BA, Palotie A, Penninx B, Petersmann A, Pilling LC, Psaty B, Rawal R, Reiman EM, Schulz A, Shulman JM, Singleton AB, Smith AV, Sutin AR, Uitterlinden AG, V?lzke H, Widen E, Yaffe K, Zonderman AB, Cucca F, Harris T, Ladwig KH, Llewellyn DJ, R?ikk?nen K, Tanaka T, van Duijn CM, Grabe HJ, Launer LJ, Lunetta KL, Mosley TH, Newman AB, Tiemeier H, Murabito J. A genome-wide association study of depressive symptoms. Biol Psychiatry. 2013 Apr 01; 73(7):667-78. PMID: 23290196.
      Citations:    
    112. Arvanitakis Z, Brey RL, Rand JH, Schneider JA, Leurgans SE, Yu L, Buchman AS, Arfanakis K, Fleischman DA, Boyle PA, Bennett DA, Levine SR. Antiphospholipid antibodies, brain infarcts, and cognitive and motor decline in aging (ABICMA): design of a community-based, longitudinal, clinical-pathological study. Neuroepidemiology. 2013; 40(2):73-84. PMID: 23095514.
      Citations:    
    113. Boyle PA, Yu L, Segawa E, Wilson RS, Buchman AS, Laibson DI, Bennett DA. Association of cognition with temporal discounting in community based older persons. BMC Geriatr. 2012 Aug 31; 12:48. PMID: 22938391.
      Citations:    
    114. Boyle PA, Yu L, Wilson RS, Gamble K, Buchman AS, Bennett DA. Poor decision making is a consequence of cognitive decline among older persons without Alzheimer's disease or mild cognitive impairment. PLoS One. 2012; 7(8):e43647. PMID: 22916287.
      Citations:    
    115. Yu L, Boyle P, Wilson RS, Segawa E, Leurgans S, De Jager PL, Bennett DA. A random change point model for cognitive decline in Alzheimer's disease and mild cognitive impairment. Neuroepidemiology. 2012; 39(2):73-83. PMID: 22814083.
      Citations:    
    116. Lim AS, Yu L, Costa MD, Leurgans SE, Buchman AS, Bennett DA, Saper CB. Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals. Sleep. 2012 May 01; 35(5):633-40B. PMID: 22547889.
      Citations:    
    117. Yu L, Shulman JM, Chibnik L, Leurgans S, Schneider JA, De Jager PL, Bennett DA. The CETP I405V polymorphism is associated with an increased risk of Alzheimer's disease. Aging Cell. 2012 Apr; 11(2):228-33. PMID: 22122979.
      Citations:    
    118. Lim AS, Yu L, Costa MD, Buchman AS, Bennett DA, Leurgans SE, Saper CB. Quantification of the fragmentation of rest-activity patterns in elderly individuals using a state transition analysis. Sleep. 2011 Nov 01; 34(11):1569-81. PMID: 22043128.
      Citations:    
    119. Han SD, Boyle PA, Arfanakis K, Fleischman DA, Yu L, Edmonds EC, Bennett DA. Neural intrinsic connectivity networks associated with risk aversion in old age. Behav Brain Res. 2012 Feb 01; 227(1):233-40. PMID: 22044475.
      Citations:    
    120. Wilson RS, Boyle PA, Buchman AS, Yu L, Arnold SE, Bennett DA. Harm avoidance and risk of Alzheimer's disease. Psychosom Med. 2011 Oct; 73(8):690-6. PMID: 21949425.
      Citations:    
    121. Boyle PA, Yu L, Buchman AS, Laibson DI, Bennett DA. Cognitive function is associated with risk aversion in community-based older persons. BMC Geriatr. 2011 Sep 11; 11:53. PMID: 21906402.
      Citations:    
    122. Wilson RS, Yu L, Schneider JA, Arnold SE, Buchman AS, Bennett DA. Lewy bodies and olfactory dysfunction in old age. Chem Senses. 2011 May; 36(4):367-73. PMID: 21257733.
      Citations:    
    123. Wilson RS, Yu L, Bennett DA. Odor identification and mortality in old age. Chem Senses. 2011 Jan; 36(1):63-7. PMID: 20923931.
      Citations:    
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