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Dirk Gillespie

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentPhysiology and Biophysics
Address1750 West Harrison St
Chicago IL 60612
ORCID ORCID Icon0000-0003-0802-5352 Additional info
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    Collapse Overview 
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    My ORCID is 0000-0003-0802-5352
    My Scopus ID is 7201826968
    My NIH COMMONS name is DGILLESP

    Research Areas:
    Cardiac excitation/contraction coupling, calcium-induced calcium release, calcium channel selectivity, nanofluidics, classical density functional theory of electrolytes.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/dirk-gillespie-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/physiology-and-biophysics-research/laboratory-dirk-gillespie-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/pubmed?term=Dirk%20Gillespie%5BAuthor%20-%20Full%5D

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=7201826968

    Education:
    PhD, Rush University
    MS, Northwestern University
    BA, Johns Hopkins University

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lakics EM, Valisk? M, Hat? Z, Gillespie D, Boda D. Cation/anion and monovalent/divalent selectivity in negatively charged nanopores: The effect of modeling the charged surface groups. J Chem Phys. 2026 Jun 14; 164(22). PMID: 42257311.
      Citations:    
    2. Vernin NS, Gillespie D. Ionic Rearrangements Lead to Like-Charge Attraction in a Nanoslit. J Phys Chem B. 2026 Mar 12; 130(10):2924-2935. PMID: 41769912.
      Citations:    
    3. Szarvas J, Valisk? M, Gillespie D, Boda D. Combined effect of confinement and dielectric exclusion on ion adsorption in slits, pores, and cavities. AIP Adv. 2024 Dec; 14(12):125323. PMID: 39735684; PMCID: PMC11672205.
      Citations:    
    4. Gillespie D. Blink nadir measurements of sarcoplasmic reticulum are consistent with strong local Ca2+ depletion. Biophys J. 2025 Jan 21; 124(2):245-255. PMID: 39604260; PMCID: PMC11788478.
      Citations:    
    5. Vernin NS, do Amaral Soares E, Tavares FW, Gillespie D. Charge Inversion in 1:1 Electrolytes: Analyzing the Energetics. J Phys Chem B. 2023 May 18; 127(19):4318-4327. PMID: 37145090.
      Citations:    
    6. R?os E, Gillespie D, Franzini-Armstrong C. The binding interactions that maintain excitation-contraction coupling junctions in skeletal muscle. J Gen Physiol. 2019 04 01; 151(4):593-605. PMID: 30728215.
      Citations:    
    7. Zsolnay V, Fill M, Gillespie D. Sarcoplasmic Reticulum Ca2+ Release Uses a?Cascading Network of Intra-SR and Channel Countercurrents. Biophys J. 2018 01 23; 114(2):462-473. PMID: 29401443.
      Citations:    
    8. Hat? Z, Valisk? M, Krist?f T, Gillespie D, Boda D. Multiscale modeling of a rectifying bipolar nanopore: explicit-water versus implicit-water simulations. Phys Chem Chem Phys. 2017 Jul 21; 19(27):17816-17826. PMID: 28657634.
      Citations:    
    9. Manno C, Figueroa LC, Gillespie D, Fitts R, Kang C, Franzini-Armstrong C, Rios E, Manno C, Figueroa LC, Gillespie D, Fitts R, Kang C, Franzini-Armstrong C, Rios E. Calsequestrin depolymerizes when calcium is depleted in the sarcoplasmic reticulum of working muscle. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):E638-E647. PMID: 28069951; PMCID: PMC5278470.
      Citations:    
    10. Berti C, Zsolnay V, Shannon TR, Fill M, Gillespie D. Sarcoplasmic reticulum Ca2+, Mg2+, K+, and Cl- concentrations adjust quickly as heart rate changes. J Mol Cell Cardiol. 2017 02; 103:31-39. PMID: 27914790.
      Citations:    
    11. Improving charge-sensitive biomolecule sensors with the right choice of electrolyte. Sensors and Actuators B: Chemical. 2016; 230:281-288.
    12. . Simulation study of a rectifying bipolar ion channel: Detailed model versus reduced model. Condensed Matter Physics. 2016; 19:13802.
    13. A review of steric interactions of ions: Why some theories succeed and others fail to acount for ion size. Microfluidics and Nanofluidics. 2015; 18:717-738.
    14. Berti C, Furini S, Gillespie D, Boda D, Eisenberg RS, Sangiorgi E, Fiegna C. Three-Dimensional Brownian Dynamics Simulator for the Study of Ion Permeation through Membrane Pores. J Chem Theory Comput. 2014 Aug 12; 10(8):2911-26. PMID: 26588267.
      Citations:    
    15. . Dynamic Monte Carlo simulation of coupled transport through a narrow multiply-occupied pore. Journal of Chemical Physics. 2014; 118:700-707.
    16. . Selective transport through a model calcium channel studied by Local Equilibrium Monte Carlo simulations coupled to the Nernst-Planck equation. Journal of Molecular Liquids. 2014; 189:100-112.
    17. Berti C, Gillespie D, Bardhan JP, Eisenberg RS, Fiegna C. Comparison of three-dimensional poisson solution methods for particle-based simulation and inhomogeneous dielectrics. Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Jul; 86(1 Pt 1):011912. PMID: 23005457.
      Citations:    
    18. Berti C, Gillespie D, Eisenberg RS, Fiegna C. Particle-based simulation of charge transport in discrete-charge nano-scale systems: the electrostatic problem. Nanoscale Res Lett. 2012 Feb 16; 7:135. PMID: 22338640.
      Citations:    
    19. Knepley MG, Karpeev DA, Davidovits S, Eisenberg RS, Gillespie D. An efficient algorithm for classical density functional theory in three dimensions: ionic solutions. J Chem Phys. 2010 Mar 28; 132(12):124101. PMID: 20370108.
      Citations:    
    20. Bardhan JP, Eisenberg RS, Gillespie D. Discretization of the induced-charge boundary integral equation. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Jul; 80(1 Pt 1):011906. PMID: 19658728.
      Citations:    
    21. He Y, Gillespie D, Boda D, Vlassiouk I, Eisenberg RS, Siwy ZS. Tuning transport properties of nanofluidic devices with local charge inversion. J Am Chem Soc. 2009 Apr 15; 131(14):5194-202. PMID: 19317490.
      Citations:    
    22. Roth R, Gillespie D, Nonner W, Eisenberg RE. Bubbles, gating, and anesthetics in ion channels. Biophys J. 2008 Jun; 94(11):4282-98. PMID: 18234836.
      Citations:    
    23. . Singular perturbation analysis of the steady state Poisson-Nernst-Planck system: Applications to ion channels. European Journal of Applied Mathematics. 2008; 19:541-560.
    24. . Selective adsorption of ions with different diameter and valence at highly-charged interfaces. Journal of Physical Chemistry C. 2007; 111:15575-15585.
    25. . Density functional theory of the electrical double layer: the RFD functional. Journal of Physics: Condensed Matter. 2005; 17:6609-6626.
    26. . Monte Carlo simulation of the electric double layer: dielectric boundaries and the effects of induced charge. Molecular Physics. 2005; 103:2851-2861.
    27. Miedema H, Meter-Arkema A, Wierenga J, Tang J, Eisenberg B, Nonner W, Hektor H, Gillespie D, Meijberg W. Permeation properties of an engineered bacterial OmpF porin containing the EEEE-locus of Ca2+ channels. Biophys J. 2004 Nov; 87(5):3137-47. PMID: 15326033.
      Citations:    
    28. . Monte Carlo simulation study of a system with a dielectric boundary: Application to calcium channel selectivity. Molecular Simulation. 2004; 30:89-96.
    29. Gillespie D, Nonner W, Eisenberg RS. Density functional theory of charged, hard-sphere fluids. Phys Rev E Stat Nonlin Soft Matter Phys. 2003 Sep; 68(3 Pt 1):031503. PMID: 14524773.
      Citations:    
    30. Gillespie D, Eisenberg RS. Physical descriptions of experimental selectivity measurements in ion channels. Eur Biophys J. 2002 Oct; 31(6):454-66. PMID: 12355255.
      Citations:    
    31. . Coupling Poisson-Nernst-Planck and density functional theory to calculate ion flux. Journal of Physics: Condensed Matter. 2002; 14:12129-12145.
    32. . A physical mechanism for large-ion selectivity in ion channels. Physical Chemistry Chemical Physics. 2002; 4:4763-4769.
    33. . Ion accumulation in a biological calcium channel: effects of solvent and confining pressure. Journal of Physical Chemistry B. 2001; 105:6427-6436.
    34. . Modified Donnan potentials for ion transport through biological ion channels. Physical Review E. 2001; 62:061902.
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