Header Logo

Michael Fill

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentPhysiology and Biophysics
Address1750 West Harrison St
Chicago IL 60612
vCardDownload vCard

    Collapse Biography 
    Collapse awards and honors
    2016Chair of the NIH MOSS-V02 Study Section, NIH
    2015The Francis & Catherine Bard Endowed Chair of Physiology, Rush University
    2014Ad Hoc member NIH MOSS-C02 Study Section, NIH
    2014Member NIH Director’s Early Independence DP5 Award Panel, NIH
    2009Member Journal General Physiology Editorial Advisory Board, Journal General Physiology, Journal General Physiology
    2008Ad Hoc reviewer NIH Study Section, NIH

    Collapse Overview 
    Collapse overview
    Chair and The Francis N. and Catherine O. Bard Professor of Physiology, Department of Physiology & Biophysics, Rush Medical College, Rush University Medical Center.

    The research of Michael Fill, PhD, explores the local control of intracellular Ca signals mediated by the ryanodine receptor (RyR) Ca release channel in excitable cells. These control mechanisms are fundamental to many cellular phenomena and, thus, are often sites of pathological failure and potential targets for therapeutic intervention.

    Dr. Fill’s laboratory at Rush University is internationally recognized for its world-class RyR experimental expertise. The Ca signals generated by RyRs are known to modulate a myriad of physiological functions. Our lab details clinically significant structure-function attributes of single RyR function in health and disease, including local RyR control by Ca, closely regulatory proteins and post-translational modifications. This provides a strong mechanistic foundation for our group’s ongoing work toward developing new RyR-targeted drugs that will hopefully be applied to limit/treat diseases exacerbated or caused by hyperactive RyR Ca signaling.

    My Scopus ID is 7003468631.
    My NIH COMMONS name is MFILL2005.

    Research Areas:
    Ryanodine receptor calcium release channel, calcium signaling.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/michael-fill-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/physiology-and-biophysics-research/laboratory-michael-fill-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/45353019/?sort=date&direction=descending

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=7003468631

    Education:
    PhD, University of Illinois at Urbana-Champaign
    MS, University of Illinois at Urbana-Champaign
    BS, University of Illinois at Urbana-Champaign

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Carvajal C, Yan J, Nani A, DeSantiago J, Wan X, Deschenes I, Ai X, Fill M. Isolated Cardiac Ryanodine Receptor Function Varies Between Mammals. J Membr Biol. 2024 Jan 29. PMID: 38285125.
      Citations:    
    2. S?ndergaard MT, Liu Y, Brohus M, Guo W, Nani A, Carvajal C, Fill M, Overgaard MT, Chen SRW. Diminished inhibition and facilitated activation of RyR2-mediated Ca2+ release is a common defect of arrhythmogenic calmodulin mutations. FEBS J. 2019 11; 286(22):4554-4578. PMID: 31230402.
      Citations:    
    3. Gao X, Wu X, Yan J, Zhang J, Zhao W, DeMarco D, Zhang Y, Bakhos M, Mignery G, Sun J, Li Z, Fill M, Ai X. Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIId expression in the aged atrium. Cardiovasc Res. 2018 04 01; 114(5):737-746. PMID: 29360953.
      Citations:    
    4. Zsolnay V, Fill M, Gillespie D. Sarcoplasmic Reticulum Ca2+ Release Uses a?Cascading Network of Intra-SR and Channel Countercurrents. Biophys J. 2018 01 23; 114(2):462-473. PMID: 29401443.
      Citations:    
    5. Yan J, Zhao W, Thomson JK, Gao X, DeMarco DM, Carrillo E, Chen B, Wu X, Ginsburg KS, Bakhos M, Bers DM, Anderson ME, Song LS, Fill M, Ai X. Stress Signaling JNK2 Crosstalk With CaMKII Underlies Enhanced Atrial Arrhythmogenesis. Circ Res. 2018 03 16; 122(6):821-835. PMID: 29352041.
      Citations:    
    6. Uehara A, Murayama T, Yasukochi M, Fill M, Horie M, Okamoto T, Matsuura Y, Uehara K, Fujimoto T, Sakurai T, Kurebayashi N. Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+ hypersensitivity. J Gen Physiol. 2017 Feb; 149(2):199-218. PMID: 28082361.
      Citations:    
    7. S?ndergaard MT, Liu Y, Larsen KT, Nani A, Tian X, Holt C, Wang R, Wimmer R, Van Petegem F, Fill M, Chen SR, Overgaard MT. The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+ Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor. J Biol Chem. 2017 01 27; 292(4):1385-1395. PMID: 27927985.
      Citations:    
    8. Berti C, Zsolnay V, Shannon TR, Fill M, Gillespie D. Sarcoplasmic reticulum Ca2+, Mg2+, K+, and Cl- concentrations adjust quickly as heart rate changes. J Mol Cell Cardiol. 2017 02; 103:31-39. PMID: 27914790.
      Citations:    
    9. Tan Z, Xiao Z, Wei J, Zhang J, Zhou Q, Smith CD, Nani A, Wu G, Song LS, Back TG, Fill M, Chen SR. Nebivolol suppresses cardiac ryanodine receptor-mediated spontaneous Ca2+ release and catecholaminergic polymorphic ventricular tachycardia. Biochem J. 2016 Nov 15; 473(22):4159-4172. PMID: 27623776.
      Citations:    
    10. Ramos-Franco J, Fill M. Approaching ryanodine receptor therapeutics from the calcin angle. J Gen Physiol. 2016 05; 147(5):369-73. PMID: 27114611.
      Citations:    
    11. Zoghbi ME, Copello JA, Villalba-Galea CA, V?lez P, Diaz Sylvester PL, Bola?os P, Marcano A, Fill M, Escobar AL. Differential Ca2+ and Sr2+ regulation of intracellular divalent cations release in ventricular myocytes. Cell Calcium. 2004 Aug; 36(2):119-34. PMID: 15193860.
      Citations:    
    12. Fill M. Mechanisms that turn-off intracellular calcium release channels. Front Biosci. 2003 Jan 01; 8:d46-54. PMID: 12456314.
      Citations:    
    13. Fill M, Copello JA. Ryanodine receptor calcium release channels. Physiol Rev. 2002 Oct; 82(4):893-922. PMID: 12270947.
      Citations:    
    14. Copello JA, Barg S, Sonnleitner A, Porta M, Diaz-Sylvester P, Fill M, Schindler H, Fleischer S. Differential activation by Ca2+, ATP and caffeine of cardiac and skeletal muscle ryanodine receptors after block by Mg2+. J Membr Biol. 2002 May 01; 187(1):51-64. PMID: 12029377.
      Citations:    
    15. Fill M, Zahradn?kov? A, Villalba-Galea CA, Zahradn?k I, Escobar AL, Gy?rke S. Ryanodine receptor adaptation. J Gen Physiol. 2000 Dec; 116(6):873-82. PMID: 11099353.
      Citations:    
    16. Olson RD, Li X, Palade P, Shadle SE, Mushlin PS, Gambliel HA, Fill M, Boucek RJ, Cusack BJ. Sarcoplasmic reticulum calcium release is stimulated and inhibited by daunorubicin and daunorubicinol. Toxicol Appl Pharmacol. 2000 Dec 01; 169(2):168-76. PMID: 11097869.
      Citations:    
    17. Ramos-Franco J, Bare D, Caenepeel S, Nani A, Fill M, Mignery G. Single-channel function of recombinant type 2 inositol 1,4, 5-trisphosphate receptor. Biophys J. 2000 Sep; 79(3):1388-99. PMID: 10969001.
      Citations:    
    18. Zoghbi ME, Bola?os P, Villalba-Galea C, Marcano A, Hern?ndez E, Fill M, Escobar AL. Spatial Ca(2+) distribution in contracting skeletal and cardiac muscle cells. Biophys J. 2000 Jan; 78(1):164-73. PMID: 10620283.
      Citations:    
    19. Ramos-Franco J, Galvan D, Mignery GA, Fill M. Location of the permeation pathway in the recombinant type 1 inositol 1,4,5-trisphosphate receptor. J Gen Physiol. 1999 Aug; 114(2):243-50. PMID: 10436000.
      Citations:    
    20. Fill M, Mej?a-Alvarez R, Kettlun C, Escobar A. Ryanodine receptor permeation and gating: glowing cinders that underlie the Ca2+ spark. J Gen Physiol. 1999 Jul; 114(1):159-61. PMID: 10447409.
      Citations:    
    21. Minn AJ, Kettlun CS, Liang H, Kelekar A, Vander Heiden MG, Chang BS, Fesik SW, Fill M, Thompson CB. Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms. EMBO J. 1999 Feb 01; 18(3):632-43. PMID: 9927423.
      Citations:    
    22. Mej?a-Alvarez R, Kettlun C, R?os E, Stern M, Fill M. Unitary Ca2+ current through cardiac ryanodine receptor channels under quasi-physiological ionic conditions. J Gen Physiol. 1999 Feb; 113(2):177-86. PMID: 9925817.
      Citations:    
    23. Satoh H, Katoh H, Velez P, Fill M, Bers DM. Bay K 8644 increases resting Ca2+ spark frequency in ferret ventricular myocytes independent of Ca influx: contrast with caffeine and ryanodine effects. Circ Res. 1998 Dec 14-28; 83(12):1192-204. PMID: 9851936.
      Citations:    
    24. Ramos-Franco J, Caenepeel S, Fill M, Mignery G. Single channel function of recombinant type-1 inositol 1,4,5-trisphosphate receptor ligand binding domain splice variants. Biophys J. 1998 Dec; 75(6):2783-93. PMID: 9826600.
      Citations:    
    25. Bers DM, Fill M. Coordinated feet and the dance of ryanodine receptors. Science. 1998 Aug 07; 281(5378):790-1. PMID: 9714684.
      Citations:    
    26. Ramos-Franco J, Fill M, Mignery GA. Isoform-specific function of single inositol 1,4,5-trisphosphate receptor channels. Biophys J. 1998 Aug; 75(2):834-9. PMID: 9675184.
      Citations:    
    27. Perez PJ, Ramos-Franco J, Fill M, Mignery GA. Identification and functional reconstitution of the type 2 inositol 1,4,5-trisphosphate receptor from ventricular cardiac myocytes. J Biol Chem. 1997 Sep 19; 272(38):23961-9. PMID: 9295347.
      Citations:    
    28. Escobar AL, Velez P, Kim AM, Cifuentes F, Fill M, Vergara JL. Kinetic properties of DM-nitrophen and calcium indicators: rapid transient response to flash photolysis. Pflugers Arch. 1997 Sep; 434(5):615-31. PMID: 9242727.
      Citations:    
    29. V?lez P, Gy?rke S, Escobar AL, Vergara J, Fill M. Adaptation of single cardiac ryanodine receptor channels. Biophys J. 1997 Feb; 72(2 Pt 1):691-7. PMID: 9017196.
      Citations:    
    30. Minn AJ, V?lez P, Schendel SL, Liang H, Muchmore SW, Fesik SW, Fill M, Thompson CB. Bcl-x(L) forms an ion channel in synthetic lipid membranes. Nature. 1997 Jan 23; 385(6614):353-7. PMID: 9002522.
      Citations:    
    31. Uehara A, Fill M, V?lez P, Yasukochi M, Imanaga I. Rectification of rabbit cardiac ryanodine receptor current by endogenous polyamines. Biophys J. 1996 Aug; 71(2):769-77. PMID: 8842215.
      Citations:    
    32. Sierralta J, Fill M, Su?rez-Isla BA. Functionally heterogenous ryanodine receptors in avian cerebellum. J Biol Chem. 1996 Jul 19; 271(29):17028-34. PMID: 8663321.
      Citations:    
    33. Cheng H, Fill M, Valdivia H, Lederer WJ. Models of Ca2+ release channel adaptation. Science. 1995 Mar 31; 267(5206):2009-10. PMID: 7701326.
      Citations:    
    34. Tu Q, V?lez P, Brodwick M, Fill M. Streaming potentials reveal a short ryanodine-sensitive selectivity filter in cardiac Ca2+ release channel. Biophys J. 1994 Dec; 67(6):2280-5. PMID: 7696468.
      Citations:    
    35. Gy?rke S, V?lez P, Su?rez-Isla B, Fill M. Activation of single cardiac and skeletal ryanodine receptor channels by flash photolysis of caged Ca2+. Biophys J. 1994 Jun; 66(6):1879-86. PMID: 8075325.
      Citations:    
    36. Tu Q, Velez P, Cortes-Gutierrez M, Fill M. Surface charge potentiates conduction through the cardiac ryanodine receptor channel. J Gen Physiol. 1994 May; 103(5):853-67. PMID: 8035165.
      Citations:    
    37. Gy?rke S, Fill M. Response. Science. 1994 Feb 18; 263(5149):987-8. PMID: 17758643.
      Citations:    
    38. Chu A, Fill M, Stefani E, Entman ML. Cytoplasmic Ca2+ does not inhibit the cardiac muscle sarcoplasmic reticulum ryanodine receptor Ca2+ channel, although Ca(2+)-induced Ca2+ inactivation of Ca2+ release is observed in native vesicles. J Membr Biol. 1993 Jul; 135(1):49-59. PMID: 8411131.
      Citations:    
    39. Gy?rke S, Fill M. Ryanodine receptor adaptation: control mechanism of Ca(2+)-induced Ca2+ release in heart. Science. 1993 May 07; 260(5109):807-9. PMID: 8387229.
      Citations:    
    40. Shomer NH, Louis CF, Fill M, Litterer LA, Mickelson JR. Reconstitution of abnormalities in the malignant hyperthermia-susceptible pig ryanodine receptor. Am J Physiol. 1993 Jan; 264(1 Pt 1):C125-35. PMID: 7679249.
      Citations:    
    41. Fill M, Stefani E, Nelson TE. Abnormal human sarcoplasmic reticulum Ca2+ release channels in malignant hyperthermic skeletal muscle. Biophys J. 1991 May; 59(5):1085-90. PMID: 1651122.
      Citations:    
    42. Mej?a-Alvarez R, Fill M, Stefani E. Voltage-dependent inactivation of T-tubular skeletal calcium channels in planar lipid bilayers. J Gen Physiol. 1991 Feb; 97(2):393-412. PMID: 1849962.
      Citations:    
    43. Fill M, Mejia-Alvarez R, Zorzato F, Volpe P, Stefani E. Antibodies as probes for ligand gating of single sarcoplasmic reticulum Ca2(+)-release channels. Biochem J. 1991 Jan 15; 273(Pt 2):449-57. PMID: 1703762.
      Citations:    
    44. Garc?a J, Fill M, Toro L, Stefani E. Functional studies of Ca2+ channels from plasmalemma and sarcoplasmic reticulum membranes in muscle cells. Semin Cell Biol. 1990 Aug; 1(4):255-64. PMID: 1966494.
      Citations:    
    45. Fill M, Coronado R, Mickelson JR, Vilven J, Ma JJ, Jacobson BA, Louis CF. Abnormal ryanodine receptor channels in malignant hyperthermia. Biophys J. 1990 Mar; 57(3):471-5. PMID: 2306496.
      Citations:    
    46. Fill M, Best PM. Effect of perchlorate on calcium release in skinned fibres stimulated by ionic substitution and caffeine. Pflugers Arch. 1990 Mar; 415(6):688-92. PMID: 2159617.
      Citations:    
    47. Hamilton SL, Alvarez RM, Fill M, Hawkes MJ, Brush KL, Schilling WP, Stefani E. [3H]PN200-110 and [3H]ryanodine binding and reconstitution of ion channel activity with skeletal muscle membranes. Anal Biochem. 1989 Nov 15; 183(1):31-41. PMID: 2559627.
      Citations:    
    48. Fill MD, Best PM. Block of contracture in skinned frog skeletal muscle fibers by calcium antagonists. J Gen Physiol. 1989 Mar; 93(3):429-49. PMID: 2539431.
      Citations:    
    49. Fill M, Ma JJ, Knudson CM, Imagawa T, Campbell KP, Coronado R. Role of the ryanodine receptor of skeletal muscle in excitation-contraction coupling. Ann N Y Acad Sci. 1989; 560:155-62. PMID: 2662857.
      Citations:    
    50. Ma J, Fill M, Knudson CM, Campbell KP, Coronado R. Ryanodine receptor of skeletal muscle is a gap junction-type channel. Science. 1988 Oct 07; 242(4875):99-102. PMID: 2459777.
      Citations:    
    51. Fill M, Coronado R. Ryanodine receptor channel of sarcoplasmic reticulum. Trends Neurosci. 1988 Oct; 11(10):453-7. PMID: 2469164.
      Citations:    
    52. Smith JS, Imagawa T, Ma J, Fill M, Campbell KP, Coronado R. Purified ryanodine receptor from rabbit skeletal muscle is the calcium-release channel of sarcoplasmic reticulum. J Gen Physiol. 1988 Jul; 92(1):1-26. PMID: 2459298.
      Citations:    
    53. Best PM, Fill M. Calcium release rate in skinned skeletal muscle fibers measured with arsenazo III. Am J Physiol. 1986 Feb; 250(2 Pt 1):C245-55. PMID: 3485383.
      Citations:    
    Fill's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (241)
    Explore
    _
    Co-Authors (1)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _