Ryanodine Receptor Calcium Release Channel
"Ryanodine Receptor Calcium Release Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tetrameric calcium release channel in the SARCOPLASMIC RETICULUM membrane of SMOOTH MUSCLE CELLS, acting oppositely to SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE. Abnormalities are implicated in CARDIAC ARRHYTHMIAS and MUSCULAR DISEASES.
| Descriptor ID |
D019837
|
| MeSH Number(s) |
D12.776.157.530.400.150.800 D12.776.210.500.800 D12.776.543.550.450.150.800 D12.776.543.585.400.150.800
|
| Concept/Terms |
Ryanodine Receptor Calcium Release Channel- Ryanodine Receptor Calcium Release Channel
- Receptor, Ryanodine
- Ca Release Channel-Ryanodine Receptor
- Ca Release Channel Ryanodine Receptor
- Calcium-Ryanodine Receptor Complex
- Calcium Ryanodine Receptor Complex
- Complex, Calcium-Ryanodine Receptor
- Receptor Complex, Calcium-Ryanodine
- Ryanodine Receptor
|
Below are MeSH descriptors whose meaning is more general than "Ryanodine Receptor Calcium Release Channel".
Below are MeSH descriptors whose meaning is more specific than "Ryanodine Receptor Calcium Release Channel".
This graph shows the total number of publications written about "Ryanodine Receptor Calcium Release Channel" by people in this website by year, and whether "Ryanodine Receptor Calcium Release Channel" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 3 | 3 |
| 1997 | 0 | 2 | 2 |
| 1998 | 2 | 2 | 4 |
| 1999 | 3 | 0 | 3 |
| 2000 | 1 | 0 | 1 |
| 2002 | 3 | 1 | 4 |
| 2003 | 3 | 0 | 3 |
| 2004 | 3 | 0 | 3 |
| 2005 | 3 | 1 | 4 |
| 2006 | 1 | 0 | 1 |
| 2007 | 2 | 1 | 3 |
| 2008 | 0 | 1 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 2 | 2 | 4 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ryanodine Receptor Calcium Release Channel" by people in Profiles.
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Diminished inhibition and facilitated activation of RyR2-mediated Ca2+ release is a common defect of arrhythmogenic calmodulin mutations. FEBS J. 2019 11; 286(22):4554-4578.
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Sarcoplasmic Reticulum Ca2+ Release Uses a?Cascading Network of Intra-SR and Channel Countercurrents. Biophys J. 2018 01 23; 114(2):462-473.
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Stress Signaling JNK2 Crosstalk With CaMKII Underlies Enhanced Atrial Arrhythmogenesis. Circ Res. 2018 03 16; 122(6):821-835.
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The voltage sensor of excitation-contraction coupling in mammals: Inactivation and interaction with Ca2. J Gen Physiol. 2017 Nov 06; 149(11):1041-1058.
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Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+ hypersensitivity. J Gen Physiol. 2017 Feb; 149(2):199-218.
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The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+ Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor. J Biol Chem. 2017 01 27; 292(4):1385-1395.
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Nebivolol suppresses cardiac ryanodine receptor-mediated spontaneous Ca2+ release and catecholaminergic polymorphic ventricular tachycardia. Biochem J. 2016 Nov 15; 473(22):4159-4172.
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Approaching ryanodine receptor therapeutics from the calcin angle. J Gen Physiol. 2016 05; 147(5):369-73.
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Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks. Biophys J. 2016 Jan 19; 110(2):382-390.
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The couplonopathies: A comparative approach to a class of diseases of skeletal and cardiac muscle. J Gen Physiol. 2015 Jun; 145(6):459-74.