Inositol 1,4,5-Trisphosphate Receptors
"Inositol 1,4,5-Trisphosphate Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracellular receptors that bind to INOSITOL 1,4,5-TRISPHOSPHATE and play an important role in its intracellular signaling. Inositol 1,4,5-trisphosphate receptors are calcium channels that release CALCIUM in response to increased levels of inositol 1,4,5-trisphosphate in the CYTOPLASM.
| Descriptor ID |
D053496
|
| MeSH Number(s) |
D12.776.157.530.400.150.760 D12.776.543.550.450.150.760 D12.776.543.585.400.150.760 D12.776.826.179
|
| Concept/Terms |
Inositol 1,4,5-Trisphosphate Receptors- Inositol 1,4,5-Trisphosphate Receptors
- INSP3 Receptor
- Receptor, INSP3
- IP3 Receptor
- Receptor, IP3
- Inositol 1,4,5-Triphosphate Receptors
- Receptor, Inositol-1,4,5-triphosphate
- Inositol-1,4,5-Triphosphate Receptor
- 1,4,5-INTP Receptor
- Inositol Triphosphate Receptor
- Receptor, Inositol Triphosphate
- Triphosphate Receptor, Inositol
|
Below are MeSH descriptors whose meaning is more general than "Inositol 1,4,5-Trisphosphate Receptors".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Membrane Transport Proteins [D12.776.157.530]
- Ion Channels [D12.776.157.530.400]
- Calcium Channels [D12.776.157.530.400.150]
- Inositol 1,4,5-Trisphosphate Receptors [D12.776.157.530.400.150.760]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Ion Channels [D12.776.543.550.450]
- Calcium Channels [D12.776.543.550.450.150]
- Inositol 1,4,5-Trisphosphate Receptors [D12.776.543.550.450.150.760]
- Membrane Transport Proteins [D12.776.543.585]
- Ion Channels [D12.776.543.585.400]
- Calcium Channels [D12.776.543.585.400.150]
- Inositol 1,4,5-Trisphosphate Receptors [D12.776.543.585.400.150.760]
- Receptors, Cytoplasmic and Nuclear [D12.776.826]
- Inositol 1,4,5-Trisphosphate Receptors [D12.776.826.179]
Below are MeSH descriptors whose meaning is more specific than "Inositol 1,4,5-Trisphosphate Receptors".
This graph shows the total number of publications written about "Inositol 1,4,5-Trisphosphate Receptors" by people in this website by year, and whether "Inositol 1,4,5-Trisphosphate Receptors" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Inositol 1,4,5-Trisphosphate Receptors" by people in Profiles.
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Increased Risk for Atrial Alternans in Rabbit Heart Failure: The Role of Ca2+/Calmodulin-Dependent Kinase II and Inositol-1,4,5-trisphosphate Signaling. Biomolecules. 2023 Dec 30; 14(1).
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Ligand sensitivity of type-1 inositol 1,4,5-trisphosphate receptor is enhanced by the D2594K mutation. Pflugers Arch. 2023 05; 475(5):569-581.
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A gain-of-function mutation in the ITPR1 gating domain causes male infertility in mice. J Cell Physiol. 2022 08; 237(8):3305-3316.
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Inositol 1,4,5-trisphosphate receptor - reactive oxygen signaling domain regulates excitation-contraction coupling in atrial myocytes. J Mol Cell Cardiol. 2022 02; 163:147-155.
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Spatially defined InsP3-mediated signaling in embryonic stem cell-derived cardiomyocytes. PLoS One. 2014; 9(1):e83715.
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Role of inositol 1,4,5-trisphosphate in the regulation of ventricular Ca(2+) signaling in intact mouse heart. J Mol Cell Cardiol. 2012 Dec; 53(6):768-79.
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IP3-dependent nuclear Ca2+ signalling in the mammalian heart. J Physiol. 2007 Oct 15; 584(Pt 2):601-11.
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Inositol-1,4,5-trisphosphate-mediated spontaneous activity in mouse embryonic stem cell-derived cardiomyocytes. J Physiol. 2007 Jun 15; 581(Pt 3):1113-27.
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Cell cycle-dependent calcium oscillations in mouse embryonic stem cells. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1510-8.
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Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res. 2005 Dec 09; 97(12):1314-22.