"TRPC6 Cation Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.
| Descriptor ID |
D000074287
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| MeSH Number(s) |
D12.776.157.530.400.150.850 D12.776.157.530.400.901.500.500 D12.776.543.550.450.150.900 D12.776.543.585.400.150.850 D12.776.543.585.400.901.500.500
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| Concept/Terms |
TRPC6 Cation Channel- TRPC6 Cation Channel
- Cation Channel, TRPC6
- Channel, TRPC6 Cation
- Transient Receptor Potential Cation Channel Subfamily C, Member 6
- TRPC6
|
Below are MeSH descriptors whose meaning is more general than "TRPC6 Cation Channel".
Below are MeSH descriptors whose meaning is more specific than "TRPC6 Cation Channel".
This graph shows the total number of publications written about "TRPC6 Cation Channel" by people in this website by year, and whether "TRPC6 Cation Channel" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "TRPC6 Cation Channel" by people in Profiles.
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The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5. Kidney Int. 2023 06; 103(6):1056-1062.
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Contribution of Coiled-Coil Assembly to Ca2+/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated Phenotypes. J Am Soc Nephrol. 2019 09; 30(9):1587-1603.
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The Use of Sildenafil for Glomerular Disease. J Am Soc Nephrol. 2017 05; 28(5):1329-1331.
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Synaptopodin Limits TRPC6 Podocyte Surface Expression and Attenuates Proteinuria. J Am Soc Nephrol. 2016 Nov; 27(11):3308-3319.
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Podocyte Purinergic P2X4 Channels Are Mechanotransducers That Mediate Cytoskeletal Disorganization. J Am Soc Nephrol. 2016 Mar; 27(3):848-62.
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Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease. J Biol Chem. 2013 Dec 20; 288(51):36598-609.
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Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway. Am J Pathol. 2011 Oct; 179(4):1719-32.
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TRPC channel modulation in podocytes-inching toward novel treatments for glomerular disease. Pediatr Nephrol. 2011 Jul; 26(7):1057-64.
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Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease. PLoS One. 2010 Sep 20; 5(9):e12859.
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TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology. Am J Physiol Renal Physiol. 2010 Oct; 299(4):F689-701.