"Calcium Channels, L-Type" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
| Descriptor ID |
D020746
|
| MeSH Number(s) |
D12.776.157.530.400.150.400 D12.776.543.550.450.150.400 D12.776.543.585.400.150.400
|
| Concept/Terms |
Calcium Channels, L-Type- Calcium Channels, L-Type
- Calcium Channels, L Type
- L-Type VDCC
- L Type VDCC
- VDCC, L-Type
- L-Type Calcium Channel
- Calcium Channel, L-Type
- L Type Calcium Channel
- L-Type Voltage-Dependent Calcium Channels
- L Type Voltage Dependent Calcium Channels
- L-Type Calcium Channels
- L Type Calcium Channels
- Long-Lasting Calcium Channels
- Calcium Channels, Long-Lasting
- Long Lasting Calcium Channels
Receptors, Dihydropyridine- Receptors, Dihydropyridine
- L-Type VDCC alpha-1 Subunit
- L Type VDCC alpha 1 Subunit
- Dihydropyridine Receptor
- Receptor, Dihydropyridine
- Dihydropyridine Receptors
|
Below are MeSH descriptors whose meaning is more general than "Calcium Channels, L-Type".
Below are MeSH descriptors whose meaning is more specific than "Calcium Channels, L-Type".
This graph shows the total number of publications written about "Calcium Channels, L-Type" by people in this website by year, and whether "Calcium Channels, L-Type" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 3 | 3 |
| 2000 | 1 | 0 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 0 | 1 |
| 2005 | 2 | 2 | 4 |
| 2006 | 0 | 2 | 2 |
| 2007 | 1 | 2 | 3 |
| 2008 | 1 | 1 | 2 |
| 2009 | 3 | 1 | 4 |
| 2010 | 1 | 1 | 2 |
| 2011 | 2 | 0 | 2 |
| 2012 | 1 | 0 | 1 |
| 2013 | 2 | 0 | 2 |
| 2014 | 1 | 1 | 2 |
| 2015 | 1 | 1 | 2 |
| 2016 | 2 | 0 | 2 |
| 2017 | 3 | 0 | 3 |
| 2019 | 1 | 1 | 2 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Calcium Channels, L-Type" by people in Profiles.
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Quantification of the calcium signaling deficit in muscles devoid of triadin. PLoS One. 2022; 17(2):e0264146.
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Ion Channel and Structural Remodeling in Obesity-Mediated Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2020 08; 13(8):e008296.
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Diminished inhibition and facilitated activation of RyR2-mediated Ca2+ release is a common defect of arrhythmogenic calmodulin mutations. FEBS J. 2019 11; 286(22):4554-4578.
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Metabolic Inhibition Induces Transient Increase of L-type Ca2+ Current in Human and Rat Cardiac Myocytes. Int J Mol Sci. 2019 Mar 26; 20(6).
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Aging alters voltage-gated calcium channels in prefrontal cortex pyramidal neurons in the HIV brain. J Neurovirol. 2018 02; 24(1):113-118.
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Metabolic inhibition reduces cardiac L-type Ca2+ channel current due to acidification caused by ATP hydrolysis. PLoS One. 2017; 12(8):e0184246.
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Membrane potential determines calcium alternans through modulation of SR Ca2+ load and L-type Ca2+ current. J Mol Cell Cardiol. 2017 04; 105:49-58.
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Combined chronic blockade of hyper-active L-type calcium channels and NMDA receptors ameliorates HIV-1 associated hyper-excitability of mPFC pyramidal neurons. Neurobiol Dis. 2016 Oct; 94:85-94.
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HIV-1 Tat-Mediated Calcium Dysregulation and Neuronal Dysfunction in Vulnerable Brain Regions. Curr Drug Targets. 2016; 17(1):4-14.
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Intact Heart Loose Patch Photolysis Reveals Ionic Current Kinetics During Ventricular Action Potentials. Circ Res. 2016 Jan 22; 118(2):203-15.