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Raj Shah

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentFamily and Preventive Medicine
Address600 S. Paulina St.
Chicago IL 60612
Phone312-563-2902
Fax312-942-4154
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    Collapse Biography 
    Collapse awards and honors
    2000Golden Apple Outstanding Resident Teaching Award, West Suburban Medical Center
    1997William J Grove Outstanding Student Award, University of Illinois Chicago
    1996Alpha Omega Alpha, University of Illinois Chicago
    2019 - 2020Rush Excellence Award, Mentoring, Rush University
    2020President’s Award, Illinois Academy of Family Physicians

    Collapse Overview 
    Collapse overview
    Professor, Family & Preventive Medicine and the Rush Alzheimer’s Disease Center

    Overview:
    My academic career interest is the design of team-based, collaborative science infrastructures that generate impactful knowledge through clinical trials and other discovery research. My overall goal is to develop dynamic and adaptive systems to conduct clinical trials with diverse communities for the maintenance of disability-free survival.

    I am also the Rush site principal investigator for the Chicago Area Patient-Centered Outcomes Research Network (CAPriCORN), a consortium of academic health systems and other partners working to develop, test and implement strategies to improve care for diverse residents in the Chicago region to improve health care quality, health outcomes and health equity. I am the Rush site principal investigator for the All of Us Research Program of the NIH’s Precision Medicine Initiative. I also am an Associate Director of the Institute for Translational Medicine (ITM) as Cluster Leader for the Network Capacity Cluster. In this NIH funded CTSA program, I oversee the work to streamline clinical research startup and achieve more rapid recruitment at multiple ITM academic institutions. I was a member of the Rush Institutional Review Board for almost 15 years and has served on various other research-focused committees and leadership roles at Rush including the Assistant Vice-Provost, Clinical Research, Rush University.

    I have been the overall principal investigator for two investigator initiated clinical trials and one SBIR clinical trial. I am on the international steering committee investigator for the recently completed ASPirin in Reducing Events in the Elderly (ASPREE now ASPREE-XT) clinical trial and for the recently funded PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adults (PREVENTABLE) clinical trial. I have been the Rush site principal investigator for federally sponsored, foundation sponsored, and industry sponsored Alzheimer’s disease related (over 25) and other common age-related conditions such as COVID-19 along with being a Rush sub-investigator on many other clinical trials.

    My research manuscripts focus on non-neurological, modifiable factors associated with disability-free longevity in aging, novel clinical trial design and implementation, and health equity. I also was an editor of the book Community Health Equity: A Chicago Reader published by the University of Chicago Press in 2019.

    I also have provided support for ongoing longitudinal research and infrastructure projects on memory and aging, including the Chicago Health and Aging Project, the Rush Memory and Aging Project, the Rush Religious Orders Study, the Rush Minority Aging and Research Study, the Rush Alzheimer’s Disease Core Center, the Rush Alzheimer’s Disease Assistance Center, the Rush Center of Excellence on Disparities in HIV and Aging, and the Rush Memory Clinic Data and Specimen Repository.

    I have led education, community engagement and recruitment efforts of the Rush Alzheimer’s Disease Center, especially in communities under-represented in aging research. I am the co-Director of the Center for Community Health Equity, an initiative jointly led by Rush University Medical Center and DePaul University designed to reduce hardship and improve health outcomes in Chicago. I also have provided mentorship to diverse students interested in the health sciences at the high school, college, graduate and post-graduate levels, especially through two well-established summer internship program he co-designed with other faculty. I have been an Executive Committee member of the Rush Mentoring Program and have served as a thesis advisor in the Master of Science in Clinical Research of The Graduate College. I have served as faculty on federally funded institutional (T32) training grants and have been a co-mentor and/or advisor on federally funded career development (K series) grants. He has developed and taught curriculum for the Family Medicine Leadership Program and the Master of Science in Clinical Research at Rush.

    Education:
    BS, Northwestern University – Evanston, Illinois (Chemical Engineering)
    MD, University of Illinois at Chicago College of Medicine – Chicago, Illinois (Medicine)
    Residency, West Suburban Hospital & Medical Center – Oak Park, Illinois (Family Medicine)
    Fellowship, Rush University Medical Center – Chicago, Illinois (Geriatric Medicine)

    My ORCID is 0000-0001-9706-9730.
    My Scopus ID is 10046255700.
    My NIH COMMONS name is rshah1

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wilson RS, Capuano AW, James BD, Amofa P, Arvanitakis Z, Shah R, Bennett DA, Boyle PA. Purpose in Life and Hospitalization for Ambulatory Care-Sensitive Conditions in Old Age. Am J Geriatr Psychiatry. 2018 03; 26(3):364-374. PMID: 28780129.
      Citations:    
    2. Urinary Incontinence, incident parkinsonism, and Parkinson's disease pathology in older adults. J Gerontol A Biol Sci Med Sci. 2016.
    3. Lamotte G, Shah RC, Lazarov O, Corcos DM. Exercise Training for Persons with Alzheimer's Disease and Caregivers: A Review of Dyadic Exercise Interventions. J Mot Behav. 2017 Jul-Aug; 49(4):365-377. PMID: 27870597.
      Citations:    
    4. Berk M, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald SM, Lockery JE, Wolfe R, Mohebbi M, murray AM, Kirpach B, Grimm R, McNeil JJ. ASPREE-D: Aspirin for the prevention of depression in the elderly. Int. Psychogeriatr. 2016; 28(10):1741-8.
    5. Debrey SM, Leehey MA, Klepitskaya O, Filley CM, Shah RC, kluger B, Berry-Kravis E, Spector E, Tassone F, Hall DA. Clinical Phenotype of Adult Fragile X Gray Zone Allele carriers; a Case Series. Cerebellum. 2016; 15(5):623-31.
    6. Farran CJ, Etkin CD, Eisenstein A, Paun O, Rajan KB, Sweet CMC, McCann JJ, Barnes LL, Shah RC, Evans DA. Effect of Moderate to Vigorous Physical Activity Intervention on Improving Dementia Family Caregiver Physical Function: A Randomized Controlled Trial. J Alzheimers Dis Parkinsonism. 2016 Aug; 6(4). PMID: 28752016.
      Citations:    
    7. Langbaum JB, Hendrix S, Ayutyanont N, Bennett DA, Shah RC, Barnes LL, Lopera F, Reiman EM, Tariot PN. Establishing Composite Cognitive Endpoints for Use in Preclinical Alzheimer's Disease Trials. J Prev Alzheimers Dis. 2015 Mar; 2(1):2-3. PMID: 26273569.
      Citations:    
    8. Gustafson DR, Clare Morris M, Scarmeas N, Shah RC, Sijben J, Yaffe K, Zhu X. New Perspectives on Alzheimer's Disease and Nutrition. J Alzheimers Dis. 2015; 46(4):1111-27. PMID: 26402637.
      Citations:    
    9. Shah RC, Matthews DC, Andrews RD, Capuano AW, Fleischman DA, VanderLugt JT, Colca JR. An evaluation of MSDC-0160, a prototype mTOT modulating insulin sensitizer, in patients with mild Alzheimer's disease. Curr Alzheimer Res. 2014; 11(6):564-73. PMID: 24931567.
      Citations:    
    10. Gaynes BI, Shah R, Leurgans S, Bennett D. Neuroticism modifies the association of vision impairment and cognition among community-dwelling older adults. Neuroepdemiology. 2013; 40:142-146.
    11. Rogalski E, Stebbins GT, Barnes CA, Murphy CM, Stoub TR, George S, Ferrari C, Shah RC, deToledo-Morrell L. Age-related changes in parahippocampal white matter integrity: a diffusion tensor imaging study. Neuropsychologia. 2012 Jul; 50(8):1759-65. PMID: 22561887.
      Citations:    
    12. Buchman AS, Boyle PA, Yu L, Shah RC, Wilson RS, Bennett DA. Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology. 2012 Apr 24; 78(17):1323-9. PMID: 22517108.
      Citations:    
    13. Dickerson BC, Stoub TR, Shah RC, Sperling RA, Killiany RJ, Albert MS, Hyman BT, Blacker D, Detoledo-Morrell L. Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults. Neurology. 2011 Apr 19; 76(16):1395-402. PMID: 21490323.
      Citations:    
    14. Hebert LE, Bienias JL, Aggarwal NT, Wilson RS, Bennett DA, Shah RC, Evans DA. Change in risk of Alzheimer disease over time. Neurology. 2010 Aug 31; 75(9):786-91. PMID: 20805524.
      Citations:    
    15. George S, Mufson EJ, Leurgans S, Shah RC, Ferrari C, deToledo-Morrell L. MRI-based volumetric measurement of the substantia innominata in amnestic MCI and mild AD. Neurobiol Aging. 2011 Oct; 32(10):1756-64. PMID: 20005600.
      Citations:    
    16. Buchman AS, Tanne D, Boyle PA, Shah RC, Leurgans SE, Bennett DA. Kidney function is associated with the rate of cognitive decline in the elderly. Neurology. 2009 Sep 22. 2009; 73(12):920-7.
    17. Rogalski EJ, Murphy CM, deToledo-Morrell L, Shah RC, Moseley ME, Bammer R, Stebbins GT. Changes in parahippocampal white matter integrity in amnestic mild cognitive impairment: a diffusion tensor imaging study. Behav Neurol. 2009; 32(1):40-6.
    18. Buchman AS, Boyle PA, Wilson RS, Leurgans S, Shah RC, Bennett DA. Respiratory Muscle Strength Predicts Decline in Mobility in Older Persons. Neuroepidemiology. 2008; 31(3):174-180.
    19. Dong X, Mendes de Leon C, Tang Y, Artz A, Gobrien M, Shah R, Evans D. A Population-Based Study of Hemoglobin, Race, and Mortality in the Elderly. J Gerontol A Biol Sci. 2008; 63(8):873-8.
    20. Shah RC. Shift shown in influenza A adamantane resistance. JAMA. 2006 Oct 04; 296(13):1585-6; author reply 1586-7. PMID: 17018799.
      Citations:    
    21. Bennett DA, Schneider JA, Arvanitakis Z, Kelly JF, Aggarwal NT, Shah RC, Wilson RS. Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology. 2006 Jun 27; 66(12):1837-44. PMID: 16801647.
      Citations:    
    22. Buchman AS, Wilson RS, Bienias JL, Shah RC, Evans DA, Bennett DA. Change in body mass index and risk of incident Alzheimer disease. Neurology. 2005 Sep 27; 65(6):892-7. PMID: 16186530.
      Citations:    
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