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Jeffrey A. Borgia

TitleAssociate Professor
InstitutionRush University, Rush Medical College
DepartmentCell and Molecular Medicine
AddressChicago IL 60612
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    Collapse Overview 
    Collapse overview
    Director, Rush University Cancer Center Biorepository.
    Director, Rush Biomarker Development Core.
    Director, Rush Translational Cancer Research Graduate Program.

    My Scopus ID is 6602993443.
    My NIH COMMONS name is JBORGIA.

    Research Areas:
    My research is primarily focused on the development of novel diagnostic tests based on ‘Omic’-level profiling of patient specimens and/or mechanistic insights for pathophysiology. As the Director of Rush Cancer Center Biorepository, I oversee the collection and annotation of patient specimens to support translational research projects and clinical trials that are ongoing in the Rush University Cancer Center. My role at the Director of the Rush Biomarker Development Core has me overseeing a state of the art facility for the discovery and development of novel biomarkers for diagnostic applications. Platforms supported include quantitative mass spectrometry and custom Luminex immunoassays with accompanying laboratory automation and skilled personnel to permit very high-throughput biomarker discovery, assay development (with analytical validation), and routine specimen processing.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/jeffrey-borgia-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/office-associate-provost-research/core-research-facilities/rush-proteomics-core-facility

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40797756/?sort=date&direction=descending

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=6602993443

    Education:
    PhD, University of Minnesota, Twin Cities
    BS, Eckerd College


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Fidler MJ, Frankenberger C, Seto R, Lobato GC, Fhied CL, Sayidine S, Basu S, Pool M, Karmali R, Batus M, Lie WR, Hayes D, Mistry J, Bonomi P, Borgia JA. Differential expression of circulating biomarkers of tumor phenotype and outcomes in previously treated non-small cell lung cancer patients receiving erlotinib vs. cytotoxic chemotherapy. Oncotarget. 2017 Apr 28. PMID: 28514740.
      View in: PubMed
    2. Fidler MJ, Frankenberger C, Seto R, Lobato GC, Fhied CL, Sayidine S, Basu S, Pool M, Karmali R, Batus M, Lie WR, Hayes D, Mistry J, Bonomi P, Borgia JA. Differential expression of circulating biomarkers of tumor phenotype and outcomes in previously treated non-small cell lung cancer patients receiving erlotinib vs. cytotoxic chemotherapy. Oncotarget. 2017 Aug 29; 8(35):58108-58121. PMID: 28938541.
      View in: PubMed
    3. Karmali R, Alrifai T, Fughhi IAM, Ng R, Chukkapalli V, Shah P, Basu S, Nathan S, Szymanski-Grant K, Gordon LI, Venugopal P, Penedo FJ, Borgia JA. Impact of cachexia on outcomes in aggressive lymphomas. Ann Hematol. 2017 Jun; 96(6):951-956. PMID: 28417157.
      View in: PubMed
    4. Bonomi P, Batus M, Fidler MJ, Borgia JA. Practical and theoretical implications of weight gain in advanced non-small cell lung cancer patients. Ann Transl Med. 2017 Mar; 5(6):152. PMID: 28462232.
      View in: PubMed
    5. Derman BA, Macklis JN, Azeem MS, Sayidine S, Basu S, Batus M, Esmail F, Borgia JA, Bonomi P, Fidler MJ. Relationships between longitudinal neutrophil to lymphocyte ratios, body weight changes, and overall survival in patients with non-small cell lung cancer. BMC Cancer. 2017 Feb 16; 17(1):141. PMID: 28209123.
      View in: PubMed
    6. Tarhoni I, Fhied C, Pithadia R, Seder CW, Basu S, Liptay M, Borgia JA. MINI01.06: Circulating Angiogenesis Biomarkers are Predictive for Early Stage Non-Small Cell Lung Cancer Progression and Clinical Outcome: Topic: Pathology. J Thorac Oncol. 2016 Nov; 11(11S):S259-S260. PMID: 27969454.
      View in: PubMed
    7. Marwaha G, Blumenfeld P, Walker A, Sayidine S, Fhied C, Borgia JA. MINI01.12: Angiogenesis Biomarkers are Associated with Progression Free Survival in Non-Small Cell Lung Cancer Treated with SBRT: Topic: Radiation Oncology. J Thorac Oncol. 2016 Nov; 11(11S):S263-S264. PMID: 27969460.
      View in: PubMed
    8. Jeganathan N, Predescu D, Zhang J, Sha F, Bardita C, Patel M, Wood S, Borgia JA, Balk RA, Predescu S. Rac1-mediated cytoskeleton rearrangements induced by intersectin-1s deficiency promotes lung cancer cell proliferation, migration and metastasis. Mol Cancer. 2016 Sep 14; 15(1):59. PMID: 27629044.
      View in: PubMed
    9. Lopez-Soler RI, Borgia JA, Kanangat S, Fhied CL, Conti DJ, Constantino D, Ata A, Chan R, Wang Z. Anti-vimentin Antibodies Present at the Time of Transplantation May Predict Early Development of Interstitial Fibrosis/Tubular Atrophy. Transplant Proc. 2016 Jul-Aug; 48(6):2023-33. PMID: 27569939.
      View in: PubMed
    10. Medairos RA, Clark J, Holoubek S, Kubasiak JC, Pithadia R, Hamid F, Chmielewski GW, Warren WH, Basu S, Borgia JA, Liptay MJ, Seder CW. Metformin exposure is associated with improved progression-free survival in diabetic patients after resection for early-stage non-small cell lung cancer. J Thorac Cardiovasc Surg. 2016 Jul; 152(1):55-61.e1. PMID: 27157918.
      View in: PubMed
    11. Chen H, Liu H, Zou H, Chen R, Dou Y, Sheng S, Dai S, Ai J, Melson J, Kittles RA, Pirooznia M, Liptay MJ, Borgia JA, Deng Y. Evaluation of Plasma miR-21 and miR-152 as Diagnostic Biomarkers for Common Types of Human Cancers. J Cancer. 2016; 7(5):490-9. PMID: 26958084; PMCID: PMC4780124.
    12. Seder CW, Kubasiak JC, Pithadia R, Basu S, Fhied C, Tarhoni I, Davila E, Alnajjar H, Chmielewski GW, Warren WH, Liptay MJ, Borgia JA. Angiogenesis Biomarkers May Be Useful in the Management of Patients With Indeterminate Pulmonary Nodules. Ann Thorac Surg. 2015 Aug; 100(2):429-36. PMID: 26138771.
      View in: PubMed
    13. Karmali R, Larson ML, Shammo JM, Basu S, Christopherson K, Borgia JA, Venugopal P. Impact of insulin-like growth factor 1 and insulin-like growth factor binding proteins on outcomes in acute myeloid leukemia. Leuk Lymphoma. 2015; 56(11):3135-42. PMID: 25735964.
      View in: PubMed
    14. Avasarala S, Van Scoyk M, Karuppusamy Rathinam MK, Zerayesus S, Zhao X, Zhang W, Pergande MR, Borgia JA, DeGregori J, Port JD, Winn RA, Bikkavilli RK. PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer. J Biol Chem. 2015 May 22; 290(21):13479-89. PMID: 25847239; PMCID: PMC4505594.
    15. Li Y, Rouhi O, Chen H, Ramirez R, Borgia JA, Deng Y. RNA-Seq and Network Analysis Revealed Interacting Pathways in TGF-ß-Treated Lung Cancer Cell Lines. Cancer Inform. 2014; 13(Suppl 5):129-40. PMID: 25991908; PMCID: PMC4384765.
    16. Gu J, Lu Y, Li F, Qiao L, Wang Q, Li N, Borgia JA, Deng Y, Lei G, Zheng Q. Identification and characterization of the novel Col10a1 regulatory mechanism during chondrocyte hypertrophic differentiation. Cell Death Dis. 2014 Oct 16; 5:e1469. PMID: 25321476; PMCID: PMC4649528.
    17. Daly S, Kubasiak JC, Rinewalt D, Pithadia R, Basu S, Fhied C, Lobato GC, Seder CW, Hong E, Warren WH, Chmielewski G, Liptay MJ, Bonomi P, Borgia JA. Circulating angiogenesis biomarkers are associated with disease progression in lung adenocarcinoma. Ann Thorac Surg. 2014 Dec; 98(6):1968-75; discussion 1975. PMID: 25301368.
      View in: PubMed
    18. Karmali R, Dalovisio A, Borgia JA, Venugopal P, Kim BW, Grant-Szymanski K, Hari P, Lazarus H. All in the family: Clueing into the link between metabolic syndrome and hematologic malignancies. Blood Rev. 2015 Mar; 29(2):71-80. PMID: 25433571.
      View in: PubMed
    19. Kubasiak JC, Seder CW, Pithadia R, Basu S, Fhied C, Phillips WW, Daly S, Shersher DD, Yoder MA, Chmielewski G, Edell ES, Maldonado F, Liptay MJ, Borgia JA. Value of circulating insulin-like growth factor-associated proteins for the detection of stage I non-small cell lung cancer. J Thorac Cardiovasc Surg. 2015 Mar; 149(3):727-34.e1-3; discussion 734. PMID: 25312225.
      View in: PubMed
    20. Fhied C, Kanangat S, Borgia JA. Development of a bead-based immunoassay to routinely measure vimentin autoantibodies in the clinical setting. J Immunol Methods. 2014 May; 407:9-14. PMID: 24657702.
      View in: PubMed
    21. Gaynes JS, Micic C, Gaynes BI, Borgia JA. Quantitation of in vitro a-1 adrenergic receptor antagonist binding capacity to biologic melanin using tandem mass spectrometry. Curr Eye Res. 2013 Dec; 38(12):1214-20. PMID: 24047464.
      View in: PubMed
    22. Sutton P, Borgia JA, Bonomi P, Plate JM. Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells. Mol Cancer. 2013 Jul 16; 12:76. PMID: 23866081; PMCID: PMC3725175.
    23. Frankenberger C, Borgia JA, Edirisinghe PD, Oegema TR. Incomplete elongation of the chondroitin sulfate linkage region on aggrecan and response to interleukin-1ß. Connect Tissue Res. 2013; 54(2):123-31. PMID: 23237500.
      View in: PubMed
    24. Daly S, Rinewalt D, Fhied C, Basu S, Mahon B, Liptay MJ, Hong E, Chmielewski G, Yoder MA, Shah PN, Edell ES, Maldonado F, Bungum AO, Borgia JA. Development and validation of a plasma biomarker panel for discerning clinical significance of indeterminate pulmonary nodules. J Thorac Oncol. 2013 Jan; 8(1):31-6. PMID: 23201823.
      View in: PubMed
    25. Rinewalt D, Shersher DD, Daly S, Fhied C, Basu S, Mahon B, Hong E, Chmielewski G, Liptay MJ, Borgia JA. Development of a serum biomarker panel predicting recurrence in stage I non-small cell lung cancer patients. J Thorac Cardiovasc Surg. 2012 Dec; 144(6):1344-50; discussion 1350-1. PMID: 22982029.
      View in: PubMed
    26. Fidler MJ, Shersher DD, Borgia JA, Bonomi P. Targeting the insulin-like growth factor receptor pathway in lung cancer: problems and pitfalls. Ther Adv Med Oncol. 2012 Mar; 4(2):51-60. PMID: 22423264; PMCID: PMC3296080.
    27. Land WH, Qiao X, Margolis DE, Ford WS, Paquette CT, Perez-Rogers JF, Borgia JA, Yang JY, Deng Y. Kernelized partial least squares for feature reduction and classification of gene microarray data. BMC Syst Biol. 2011; 5 Suppl 3:S13. PMID: 22784619; PMCID: PMC3287568.
    28. Shersher DD, Vercillo MS, Fhied C, Basu S, Rouhi O, Mahon B, Coon JS, Warren WH, Faber LP, Hong E, Bonomi P, Liptay MJ, Borgia JA. Biomarkers of the insulin-like growth factor pathway predict progression and outcome in lung cancer. Ann Thorac Surg. 2011 Nov; 92(5):1805-11; discussion 1811. PMID: 21945224.
      View in: PubMed
    29. Chubinskaya S, Otten L, Soeder S, Borgia JA, Aigner T, Rueger DC, Loeser RF. Regulation of chondrocyte gene expression by osteogenic protein-1. Arthritis Res Ther. 2011 Mar 29; 13(2):R55. PMID: 21447156; PMCID: PMC3132046.
    30. Overk CR, Borgia JA, Mufson EJ. A novel approach for long-term oral drug administration in animal research. J Neurosci Methods. 2011 Feb 15; 195(2):194-9. PMID: 21163304; PMCID: PMC3026878.
    31. Kim JS, Ellman MB, An HS, van Wijnen AJ, Borgia JA, Im HJ. Insulin-like growth factor 1 synergizes with bone morphogenetic protein 7-mediated anabolism in bovine intervertebral disc cells. Arthritis Rheum. 2010 Dec; 62(12):3706-15. PMID: 20812336; PMCID: PMC2995823.
    32. Patel K, Farlow EC, Kim AW, Lee BS, Basu S, Coon JS, DeCresce D, Thimothy L, Walters KA, Fhied C, Chang C, Chen SH, Faber LP, Bonomi P, Liptay MJ, Borgia JA. Enhancement of a multianalyte serum biomarker panel to identify lymph node metastases in non-small cell lung cancer with circulating autoantibody biomarkers. Int J Cancer. 2011 Jul 01; 129(1):133-42. PMID: 20824709.
      View in: PubMed
    33. Farlow EC, Vercillo MS, Coon JS, Basu S, Kim AW, Faber LP, Warren WH, Bonomi P, Liptay MJ, Borgia JA. A multi-analyte serum test for the detection of non-small cell lung cancer. Br J Cancer. 2010 Oct 12; 103(8):1221-8. PMID: 20859284; PMCID: PMC2967050.
    34. Farlow EC, Patel K, Basu S, Lee BS, Kim AW, Coon JS, Faber LP, Bonomi P, Liptay MJ, Borgia JA. Development of a multiplexed tumor-associated autoantibody-based blood test for the detection of non-small cell lung cancer. Clin Cancer Res. 2010 Jul 01; 16(13):3452-62. PMID: 20570928.
      View in: PubMed
    35. Borgia JA, Basu S, Faber LP, Kim AW, Coon JS, Kaiser-Walters KA, Fhied C, Thomas S, Rouhi O, Warren WH, Bonomi P, Liptay MJ. Establishment of a multi-analyte serum biomarker panel to identify lymph node metastases in non-small cell lung cancer. J Thorac Oncol. 2009 Mar; 4(3):338-47. PMID: 19190517.
      View in: PubMed
    36. Lee BS, Jayathilaka GD, Huang JS, Decresce D, Borgia JA, Zhou X, Gupta S. Modification of the immobilized metal affinity electrophoresis using sodium dodecyl sulfate polyacrylamide gel electrophoresis. Electrophoresis. 2008 Aug; 29(15):3160-3. PMID: 18633940.
      View in: PubMed
    37. Baronas-Lowell D, Lauer-Fields JL, Borgia JA, Sferrazza GF, Al-Ghoul M, Minond D, Fields GB. Differential modulation of human melanoma cell metalloproteinase expression by alpha2beta1 integrin and CD44 triple-helical ligands derived from type IV collagen. J Biol Chem. 2004 Oct 15; 279(42):43503-13. PMID: 15292257.
      View in: PubMed
    38. Malkar NB, Lauer-Fields JL, Borgia JA, Fields GB. Modulation of triple-helical stability and subsequent melanoma cellular responses by single-site substitution of fluoroproline derivatives. Biochemistry. 2002 May 14; 41(19):6054-64. PMID: 11994000.
      View in: PubMed
    39. Borgia JA, Malkar NB, Abbasi HU, Fields GB. Difficulties encountered during glycopeptide syntheses. J Biomol Tech. 2001 Sep; 12(3):44-68. PMID: 19499072; PMCID: PMC2291655.
    40. Borgia JA, Fields GB. Chemical synthesis of proteins. Trends Biotechnol. 2000 Jun; 18(6):243-51. PMID: 10802559.
      View in: PubMed
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