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Frank C Ko

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentAnatomy and Cell Biology
AddressChicago IL 60612
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    Frank C. Ko, PhD, completed his graduate training in musculoskeletal biomechanics at Cornell University. He subsequently pursued postdoctoral training at Massachusetts General Hospital and Beth Israel Deaconess Medical Center in musculoskeletal biology and mechanics. Dr. Ko’s current interest is in determining the molecular basis of intramembranous bone regeneration. He is a member of Orthopaedic Research Society and American Society for Bone and Mineral Research.

    Research Areas:
    Musculoskeletal homeostasis, disease, and repair.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/frank-c-ko-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/anatomy-cell-biology-research/laboratory-frank-ko-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/myncbi/1dqanars5t55i/bibliography/public/

    Education:
    PhD, Cornell University

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Obeidat AM, Newton MD, Li J, Hu B, Ishihara S, Lammlin L, Junginger LM, Farrell EC, Ko FC, Miller RJ, Scanzello CR, Maerz T, Miller RE, Malfait AM. NERVE GROWTH FACTOR IS SUFFICIENT TO CAUSE MULTIPLE OSTEOARTHRITIS-RELEVANT PATHOLOGICAL FEATURES IN NA?VE MURINE KNEE JOINTS. bioRxiv. 2025 Jun 26. PMID: 40666997; PMCID: PMC12262356.
      Citations:    
    2. Geraghty T, Ishihara S, Obeidat AM, Adamczyk NS, Hunter RS, Li J, Wang L, Lee H, Ko FC, Malfait AM, Miller RE. Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage. Arthritis Res Ther. 2024 Dec 20; 26(1):224. PMID: 39707543; PMCID: PMC11660666.
      Citations:    
    3. Ko FC, Fullam S, Lee H, Chan K, Ishihara S, Adamczyk NS, Obeidat AM, Soorya S, Miller RJ, Malfait AM, Miller RE. Clearing-enabled light sheet microscopy as a novel method for three-dimensional mapping of the sensory innervation of the mouse knee. J Orthop Res. 2025 Mar; 43(3):632-639. PMID: 39547819; PMCID: PMC11806991.
      Citations:    
    4. Geraghty T, Ishihara S, Obeidat AM, Adamczyk NS, Hunter RS, Li J, Wang L, Lee H, Ko FC, Malfait AM, Miller RE. Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage. bioRxiv. 2024 Aug 19. PMID: 39229102; PMCID: PMC11370380.
      Citations:    
    5. Ko FC, Fullam S, Lee H, Ishihara S, Adamczyk NS, Obeidat AM, Soorya S, Miller RJ, Malfait AM, Miller RE. Clearing-enabled light sheet microscopy as a novel method for three-dimensional mapping of the sensory innervation of the mouse knee. bioRxiv. 2024 Jun 01. PMID: 38853939; PMCID: PMC11160612.
      Citations:    
    6. Anderson KD, Ko FC, Virdi AS, Sumner DR, Ross RD, Anderson KD, Ko FC, Virdi AS, Sumner DR, Ross RD. Biomechanics of Implant Fixation in Osteoporotic Bone. Curr Osteoporos Rep. 2020 10; 18(5):577-586. PMID: 32734511; PMCID: PMC7541774.
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    7. Ko FC, Sumner DR, Ko FC, Sumner DR. How faithfully does intramembranous bone regeneration recapitulate embryonic skeletal development? Dev Dyn. 2021 03; 250(3):377-392. PMID: 32813296.
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    8. Ko FC, Mortreux M, Riveros D, Nagy JA, Rutkove SB, Bouxsein ML. Dose-dependent skeletal deficits due to varied reductions in mechanical loading in rats. NPJ Microgravity. 2020; 6:15. PMID: 32435691.
      Citations:    
    9. Wang W, Li J, Ko FC, Zhao X, Qiao Y, Lu RS, Sumner DR, Wang T, Chen D. CHIP regulates skeletal development and postnatal bone growth. J Cell Physiol. 2020 06; 235(6):5378-5385. PMID: 31898815.
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    10. Ko FC, Meagher MJ, Mashiatulla M, Ross RD, Virdi AS, Sumner DR. Implant surface alters compartmental-specific contributions to fixation strength in rats. J Orthop Res. 2020 06; 38(6):1208-1215. PMID: 31821588.
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    11. Morse A, Ko FC, McDonald MM, Lee LR, Schindeler A, van der Meulen MCH, Little DG. Increased anabolic bone response in Dkk1 KO mice following tibial compressive loading. Bone. 2020 02; 131:115054. PMID: 31521827.
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    12. Kuehn F, Adiliaghdam F, Hamarneh SR, Vasan R, Liu E, Liu Y, Ramirez JM, Hoda RS, Munoz AR, Ko FC, Armanini M, Brooks DJ, Bouxsein ML, Demay MB, Hodin RA. Loss of Intestinal Alkaline Phosphatase Leads to Distinct Chronic Changes in Bone Phenotype. J Surg Res. 2018 12; 232:325-331. PMID: 30463736.
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    13. Ko FC, Li J, Brooks DJ, Rutkove SB, Bouxsein ML. Structural and functional properties of bone are compromised in amyotrophic lateral sclerosis mice. Amyotroph Lateral Scler Frontotemporal Degener. 2018 08; 19(5-6):457-462. PMID: 29569488.
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    14. Mortreux M, Nagy JA, Ko FC, Bouxsein ML, Rutkove SB. A novel partial gravity ground-based analog for rats via quadrupedal unloading. J Appl Physiol (1985). 2018 07 01; 125(1):175-182. PMID: 29565773.
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    15. Ko FC, Van Vliet M, Ellman R, Grasso D, Brooks DJ, Spatz JM, Conlon C, Aguirre JI, Wronski TJ, Bouxsein ML. Treatment With a Soluble Bone Morphogenetic Protein Type 1A Receptor (BMPR1A) Fusion Protein Increases Bone Mass and Bone Formation in Mice Subjected to Hindlimb Unloading. JBMR Plus. 2017 Oct; 1(2):66-72. PMID: 30283882.
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    16. Adebayo OO, Ko FC, Wan PT, Goldring SR, Goldring MB, Wright TM, van der Meulen MCH. Role of subchondral bone properties and changes in development of load-induced osteoarthritis in mice. Osteoarthritis Cartilage. 2017 12; 25(12):2108-2118. PMID: 28919430.
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    17. Ko FC, Karim L, Brooks DJ, Bouxsein ML, Demay MB. Bisphosphonate Withdrawal: Effects on Bone Formation and Bone Resorption in Maturing Male Mice. J Bone Miner Res. 2017 04; 32(4):814-820. PMID: 27925290.
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    18. Ko FC, Martins JS, Reddy P, Bragdon B, Hussein AI, Gerstenfeld LC, Demay MB. Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice. J Bone Miner Res. 2016 12; 31(12):2204-2214. PMID: 27324177.
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    19. Ko FC, Dragomir CL, Plumb DA, Hsia AW, Adebayo OO, Goldring SR, Wright TM, Goldring MB, van der Meulen MC. Progressive cell-mediated changes in articular cartilage and bone in mice are initiated by a single session of controlled cyclic compressive loading. J Orthop Res. 2016 11; 34(11):1941-1949. PMID: 26896841.
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    20. Ko FC, Dragomir C, Plumb DA, Goldring SR, Wright TM, Goldring MB, van der Meulen MC. In vivo cyclic compression causes cartilage degeneration and subchondral bone changes in mouse tibiae. Arthritis Rheum. 2013 Jun; 65(6):1569-78. PMID: 23436303.
      Citations:    
    21. Fahlgren A, Yang X, Ciani C, Ryan JA, Kelly N, Ko FC, van der Meulen MC, Bostrom MP. The effects of PTH, loading and surgical insult on cancellous bone at the bone-implant interface in the rabbit. Bone. 2013 Feb; 52(2):718-24. PMID: 22613252.
      Citations:    
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