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Antonio C Bianco

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentEndocrinology
Address1735 W. Harrison St.
Chicago IL 60612
Phone312-942-7131
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    My ORCID is 0000-0001-7737-6813.
    My Scopus ID is 7203005318.
    My NIH COMMONS name is ACB123.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ettleson MD, Ibarra S, Wan W, Peterson S, Laiteerapong N, Bianco AC. Demographic, Healthcare Access, and Dietary Factors Associated With Thyroid Hormone Treatments for Hypothyroidism. J Clin Endocrinol Metab. 2023 Nov 17; 108(12):e1614-e1623. PMID: 37327351.
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    2. Batistuzzo A, Salas-Lucia F, Gereben B, Ribeiro MO, Bianco AC. Sustained Pituitary T3 Production Explains the T4-mediated TSH Feedback Mechanism. Endocrinology. 2023 11 02; 164(12). PMID: 37864846.
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    3. Penna GC, Salas-Lucia F, Ribeiro MO, Bianco AC. Gene polymorphisms and thyroid hormone signaling: implication for the treatment of hypothyroidism. Endocrine. 2023 Sep 23. PMID: 37740833.
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    4. Bianco AC. Emerging Therapies in Hypothyroidism. Annu Rev Med. 2023 Sep 22. PMID: 37738506.
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    5. Casula S, Ettleson MD, Bianco AC. Are We Restoring Thyroid Hormone Signaling in Levothyroxine-Treated Patients With Residual Symptoms of Hypothyroidism? Endocr Pract. 2023 Jul; 29(7):581-588. PMID: 37419565.
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    6. Ettleson MD, Prieto WH, Russo PST, de Sa J, Wan W, Laiteerapong N, Maciel RMB, Bianco AC. Serum Thyrotropin and Triiodothyronine Levels in Levothyroxine-treated Patients. J Clin Endocrinol Metab. 2023 05 17; 108(6):e258-e266. PMID: 36515655.
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    7. Gambardella J, Fiordelisi A, Cerasuolo FA, Buonaiuto A, Avvisato R, Viti A, Sommella E, Merciai F, Salviati E, Campiglia P, D'Argenio V, Parisi S, Bianco A, Spinelli L, Di Vaia E, Cuocolo A, Pisani A, Riccio E, Di Risi T, Ciccarelli M, Santulli G, Sorriento D, Iaccarino G. Experimental evidence and clinical implications of Warburg effect in the skeletal muscle of Fabry disease. iScience. 2023 Mar 17; 26(3):106074. PMID: 36879801.
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    8. Sink? R, Moh?csik P, Kov?ri D, Penksza V, Wittmann G, M?csai L, Fonseca TL, Bianco AC, Fekete C, Gereben B. Different Hypothalamic Mechanisms Control Decreased Circulating Thyroid Hormone Levels in Infection and Fasting-Induced Non-Thyroidal Illness Syndrome in Male Thyroid Hormone Action Indicator Mice. Thyroid. 2023 01; 33(1):109-118. PMID: 36322711.
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    9. Capuano I, Buonanno P, Riccio E, Bianco A, Pisani A. Randomized Controlled Trials on Renin Angiotensin Aldosterone System Inhibitors in Chronic Kidney Disease Stages 3-5: Are They Robust? A Fragility Index Analysis. J Clin Med. 2022 Oct 20; 11(20). PMID: 36294504.
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    10. Ettleson MD, Bianco AC, Wan W, Laiteerapong N. Suboptimal Thyroid Hormone Replacement Is Associated With Worse Hospital Outcomes. J Clin Endocrinol Metab. 2022 07 14; 107(8):e3411-e3419. PMID: 35472082.
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    11. Lorena FB, Sato JM, Coviello BM, Arnold AJT, Batistuzzo A, Yamanouchi LM, Dias Junior E, do Nascimento BPP, Fonseca TL, Bianco AC, Ribeiro MO. Age Worsens the Cognitive Phenotype in Mice Carrying the Thr92Ala-DIO2 Polymorphism. Metabolites. 2022 Jul 08; 12(7). PMID: 35888752.
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    12. Boucai L, Salas-Lucia F, Krishnamoorthy GP, Sherman E, Rudin CM, Drilon A, Bianco AC, Fagin JA. Selpercatinib-Induced Hypothyroidism Through Off-Target Inhibition of Type 2 Iodothyronine Deiodinase. JCO Precis Oncol. 2022 06; 6:e2100496. PMID: 35704797.
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    13. de Lima Beltr?o FE, de Almeida Beltr?o DC, Carvalhal G, de Lima Beltr?o FE, de Souza Braga Filho J, de Brito Oliveira J, de Jesus JDS, Machado GJR, Dos Santos Silva H, Teixeira HMP, Rodrigues JL, de Figueiredo CAV, Dos Santos Costa R, Hecht F, Bianco AC, da Concei??o Rodrigues Gon?alves M, Ramos HE. Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19. J Clin Endocrinol Metab. 2022 05 17; 107(6):e2488-e2501. PMID: 35137147.
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    14. Fonseca TL, Russo SC, Luongo C, Salvatore D, Bianco AC. Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse. Endocrinology. 2022 05 01; 163(5). PMID: 35238380.
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    15. Ettleson MD, Raine A, Batistuzzo A, Batista SP, McAninch E, Teixeira MCTV, Jonklaas J, Laiteerapong N, Ribeiro MO, Bianco AC. Brain Fog in Hypothyroidism: Understanding the Patient's Perspective. Endocr Pract. 2022 Mar; 28(3):257-264. PMID: 34890786.
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    16. Idrees T, Bianco AC. Letter to the Editor from Idrees and Bianco: "Treatment of Thyroid Dysfunction and Serum Lipids: A Systematic Review and Meta-analysis". J Clin Endocrinol Metab. 2021 08 18; 106(9):e3785-e3786. PMID: 33837396.
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    17. Russo SC, Salas-Lucia F, Bianco AC. Deiodinases and the Metabolic Code for Thyroid Hormone Action. Endocrinology. 2021 08 01; 162(8). PMID: 33720335.
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    18. Ettleson MD, Bianco AC, Zhu M, Laiteerapong N. Sociodemographic Disparities in the Treatment of Hypothyroidism: NHANES 2007-2012. J Endocr Soc. 2021 Jul 01; 5(7):bvab041. PMID: 34104843.
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    19. Jonklaas J, Bianco AC, Cappola AR, Celi FS, Fliers E, Heuer H, McAninch EA, Moeller LC, Nygaard B, Sawka AM, Watt T, Dayan CM. Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document. Eur Thyroid J. 2021 Mar; 10(1):10-38. PMID: 33777817.
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    20. Jonklaas J, Bianco AC, Cappola AR, Celi FS, Fliers E, Heuer H, McAninch EA, Moeller LC, Nygaard B, Sawka AM, Watt T, Dayan CM. Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document. Thyroid. 2021 02; 31(2):156-182. PMID: 33276704.
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    21. Butterfield NC, Curry KF, Steinberg J, Dewhurst H, Komla-Ebri D, Mannan NS, Adoum AT, Leitch VD, Logan JG, Waung JA, Ghirardello E, Southam L, Youlten SE, Wilkinson JM, McAninch EA, Vancollie VE, Kussy F, White JK, Lelliott CJ, Adams DJ, Jacques R, Bianco AC, Boyde A, Zeggini E, Croucher PI, Williams GR, Bassett JHD. Accelerating functional gene discovery in osteoarthritis. Nat Commun. 2021 01 20; 12(1):467. PMID: 33473114.
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    22. E Marcondes AA, Gomez TGB, Ravache TT, Batistuzzo A, Lorena FB, de Paula CS, Lowenthal R, Bianco AC, Ribeiro MO. Assessment of children in the autistic spectrum disorder that carry the Thr92Ala-DIO2 polymorphism. J Endocrinol Invest. 2021 Aug; 44(8):1775-1782. PMID: 33449341.
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    23. Sawka AM, Alexander EK, Bianco AC, Chou R, Haugen BR, Kopp PA, Pearce EN, Ross DS, Smallridge RC, Jonklaas J. Challenges in Developing Recommendations Based on Low-Quality Evidence in Thyroid Guidelines. Thyroid. 2021 01; 31(1):3-7. PMID: 32900277.
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    24. Marcelino CP, McAninch EA, Fernandes GW, Bocco BMLC, Ribeiro MO, Bianco AC. Temporal Pole Responds to Subtle Changes in Local Thyroid Hormone Signaling. J Endocr Soc. 2020 Nov 01; 4(11):bvaa136. PMID: 33123655.
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    25. Ettleson MD, Bianco AC. Individualized Therapy for Hypothyroidism: Is T4 Enough for Everyone? J Clin Endocrinol Metab. 2020 09 01; 105(9). PMID: 32614450.
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    26. Idrees T, Palmer S, Maciel RMB, Bianco AC. Liothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism. Thyroid. 2020 10; 30(10):1399-1413. PMID: 32279609.
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    27. Bianco AC. We All Know We Need Them, We Hope They Are Coming, But When? Thyroid. 2020 06; 30(6):791-793. PMID: 32228170.
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    28. Bianco AC, Dumitrescu A, Gereben B, Ribeiro MO, Fonseca TL, Fernandes GW, Bocco BMLC. Paradigms of Dynamic Control of Thyroid Hormone Signaling. Endocr Rev. 2019 08 01; 40(4):1000-1047. PMID: 31033998.
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    29. McAninch EA, Bianco AC. The Swinging Pendulum in Treatment for Hypothyroidism: From (and Toward?) Combination Therapy. Front Endocrinol (Lausanne). 2019; 10:446. PMID: 31354624.
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    30. Fonseca TL, Fernandes GW, Bocco BMLC, Keshavarzian A, Jakate S, Donohue TM, Gereben B, Bianco AC. Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis. Alcohol Clin Exp Res. 2019 07; 43(7):1376-1383. PMID: 30908637.
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    31. Da Concei??o RR, Fernandes GW, Fonseca TL, Bocco BMLC, Bianco AC. Metal Coordinated Poly-Zinc-Liothyronine Provides Stable Circulating Triiodothyronine Levels in Hypothyroid Rats. Thyroid. 2018 11; 28(11):1425-1433. PMID: 30301431.
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    32. Bianco AC, Kim BS. Pathophysiological relevance of deiodinase polymorphism. Curr Opin Endocrinol Diabetes Obes. 2018 10; 25(5):341-346. PMID: 30063552.
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    33. McAninch EA, Glueck JS, Bianco AC. Does Sex Bias Play a Role for Dissatisfied Patients With Hypothyroidism? J Endocr Soc. 2018 Aug 01; 2(8):970-973. PMID: 30094410.
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    34. McAninch EA, Rajan KB, Evans DA, Jo S, Chaker L, Peeters RP, Bennett DA, Mash DC, Bianco AC. A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans. J Clin Endocrinol Metab. 2018 05 01; 103(5):1818-1826. PMID: 29481662.
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    35. Peterson SJ, Cappola AR, Castro MR, Dayan CM, Farwell AP, Hennessey JV, Kopp PA, Ross DS, Samuels MH, Sawka AM, Taylor PN, Jonklaas J, Bianco AC. An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction. Thyroid. 2018 06; 28(6):707-721. PMID: 29620972.
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    36. de Blasio F, Santaniello MG, de Blasio F, Mazzarella G, Bianco A, Lionetti L, Franssen FME, Scalfi L. Raw BIA variables are predictors of muscle strength in patients with chronic obstructive pulmonary disease. Eur J Clin Nutr. 2017 11; 71(11):1336-1340. PMID: 28901331.
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    37. Del Prete M, Di Sarno A, Modica R, Lassandro F, Giorgio A, Bianco A, Muto M, Gasperi M, Del Prete F, Colao A, Montesarchio V, Faggiano A. Role of contrast-enhanced ultrasound to define prognosis and predict response to biotherapy in pancreatic neuroendocrine tumors. J Endocrinol Invest. 2017 Dec; 40(12):1373-1380. PMID: 28667452.
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    38. Paolino BS, Pomerantzeff PM, Dallan LAO, Gaiotto FA, Preite NZ, Latr?nico AC, Nicolau JC, Bianco AC, Giraldez RRCV. Myocardial Inactivation of Thyroid Hormones in Patients with Aortic Stenosis. Thyroid. 2017 05; 27(5):738-745. PMID: 28095748.
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    39. Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. Lancet. 2017 Sep 23; 390(10101):1550-1562. PMID: 28336049.
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    40. Ignacio DL, Silvestre DH, Anne-Palmer E, Bocco BM, Fonseca TL, Ribeiro MO, Gereben B, Bianco AC, Werneck-de-Castro JP. Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function. Thyroid. 2017 04; 27(4):577-586. PMID: 27967605.
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    41. Preite NZ, Nascimento BP, Muller CR, Am?rico AL, Higa TS, Evangelista FS, Lancellotti CL, Henriques FS, Batista ML, Bianco AC, Ribeiro MO. Disruption of beta3 adrenergic receptor increases susceptibility to DIO in mouse. J Endocrinol. 2016 12; 231(3):259-269. PMID: 27672060.
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    42. Rajan KB, Arvanitakis Z, Lynch EB, McAninch EA, Wilson RS, Weuve J, Barnes LL, Bianco AC, Evans DA. Cognitive decline following incident and preexisting diabetes mellitus in a population sample. Neurology. 2016 Oct 18; 87(16):1681-1687. PMID: 27655734.
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    43. Lowe K, Bianco AC, Canar J, Kasdorf K, Mantei B, Smith BT. The Relationship Between Work Relative Value Unit Awareness and Work Relative Value Unit Accumulation Among Physicians. J Med Pract Manage. 2016 09; 32(2):86-91. PMID: 29944795.
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    44. McAninch EA, Bianco AC. The History and Future of Treatment of Hypothyroidism. Ann Intern Med. 2016 Jan 05; 164(1):50-6. PMID: 26747302.
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    45. McAninch EA, Bianco AC. Of rats and men: thyroid homeostasis in rodents and human beings - Authors' reply. Lancet Diabetes Endocrinol. 2015 Dec; 3(12):933. PMID: 26590685.
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    46. Fonseca TL, Fernandes GW, McAninch EA, Bocco BM, Abdalla SM, Ribeiro MO, Moh?csik P, Fekete C, Li D, Xing X, Wang T, Gereben B, Bianco AC. Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):14018-23. PMID: 26508642.
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    47. Lartey LJ, Werneck-de-Castro JP, O-Sullivan I, Unterman TG, Bianco AC. Coupling between Nutrient Availability and Thyroid Hormone Activation. J Biol Chem. 2015 Dec 18; 290(51):30551-61. PMID: 26499800.
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    48. Gereben B, McAninch EA, Ribeiro MO, Bianco AC. Scope and limitations of iodothyronine deiodinases in hypothyroidism. Nat Rev Endocrinol. 2015 Nov; 11(11):642-652. PMID: 26416219.
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    49. McAninch EA, Bianco AC. New insights into the variable effectiveness of levothyroxine monotherapy for hypothyroidism. Lancet Diabetes Endocrinol. 2015 Oct; 3(10):756-8. PMID: 26362364.
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    50. McAninch EA, Fonseca TL, Poggioli R, Panos AL, Salerno TA, Deng Y, Li Y, Bianco AC, Iacobellis G. Epicardial adipose tissue has a unique transcriptome modified in severe coronary artery disease. Obesity (Silver Spring). 2015 Jun; 23(6):1267-78. PMID: 25959145.
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    51. Werneck de Castro JP, Fonseca TL, Ueta CB, McAninch EA, Abdalla S, Wittmann G, Lechan RM, Gereben B, Bianco AC. Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine. J Clin Invest. 2015 Feb; 125(2):769-81. PMID: 25555216.
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    52. Abdalla SM, Bianco AC. Defending plasma T3 is a biological priority. Clin Endocrinol (Oxf). 2014 Nov; 81(5):633-41. PMID: 25040645.
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    53. Fernandes GW, Ueta CB, Fonseca TL, Gouveia CH, Lancellotti CL, Brum PC, Christoffolete MA, Bianco AC, Ribeiro MO. Inactivation of the adrenergic receptor ?2 disrupts glucose homeostasis in mice. J Endocrinol. 2014 Jun; 221(3):381-90. PMID: 24868110.
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    54. Bianco AC, Anderson G, Forrest D, Galton VA, Gereben B, Kim BW, Kopp PA, Liao XH, Obregon MJ, Peeters RP, Refetoff S, Sharlin DS, Simonides WS, Weiss RE, Williams GR. American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models. Thyroid. 2014 Jan; 24(1):88-168. PMID: 24001133.
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    55. Poggioli R, Ueta CB, Drigo RA, Castillo M, Fonseca TL, Bianco AC. Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice. Obesity (Silver Spring). 2013 Sep; 21(9):E415-20. PMID: 23408649.
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    56. Hong EG, Kim BW, Jung DY, Kim JH, Yu T, Seixas Da Silva W, Friedline RH, Bianco SD, Seslar SP, Wakimoto H, Berul CI, Russell KS, Lee KW, Larsen PR, Bianco AC, Kim JK. Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice. Endocrinology. 2013 Oct; 154(10):3937-46. PMID: 23861374.
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    57. Sampaio MC, M?ximo CA, Montenegro CM, Mota DM, Fernandes TR, Bianco AC, Amodeo C, Cordeiro AC. Comparison of diagnostic criteria for acute kidney injury in cardiac surgery. Arq Bras Cardiol. 2013 Jul; 101(1):18-25. PMID: 23752340.
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    58. Quintavalle C, Fiore D, De Micco F, Visconti G, Focaccio A, Golia B, Ricciardelli B, Donnarumma E, Bianco A, Zabatta MA, Troncone G, Colombo A, Briguori C, Condorelli G. Impact of a high loading dose of atorvastatin on contrast-induced acute kidney injury. Circulation. 2012 Dec 18; 126(25):3008-16. PMID: 23147173.
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    59. Ueta CB, Fernandes GW, Capelo LP, Fonseca TL, Maculan FD, Gouveia CH, Brum PC, Christoffolete MA, Aoki MS, Lancellotti CL, Kim B, Bianco AC, Ribeiro MO. ?(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice. J Endocrinol. 2012 Sep; 214(3):359-65. PMID: 22728333.
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    60. Kall? I, Moh?csik P, Vida B, Ze?ld A, Bard?czi Z, Zavacki AM, Farkas E, K?d?r A, Hrabovszky E, Arrojo E Drigo R, Dong L, Barna L, Palkovits M, Borsay BA, Herczeg L, Lechan RM, Bianco AC, Liposits Z, Fekete C, Gereben B. A novel pathway regulates thyroid hormone availability in rat and human hypothalamic neurosecretory neurons. PLoS One. 2012; 7(6):e37860. PMID: 22719854.
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    61. Ueta CB, Oskouei BN, Olivares EL, Pinto JR, Correa MM, Simovic G, Simonides WS, Hare JM, Bianco AC. Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice. Mol Endocrinol. 2012 May; 26(5):809-18. PMID: 22403173.
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    62. Arrojo E Drigo R, Fonseca TL, Castillo M, Salathe M, Simovic G, Moh?csik P, Gereben B, Bianco AC. Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis. Mol Endocrinol. 2011 Dec; 25(12):2065-75. PMID: 22053000.
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    63. Colucci A, Bianco A, Pomara F, Petrucci M, Grosso F, De Vita A, Adamo V, Palma A. Disease management of type 2 diabetes: a follow-up analysis in a sanitary district of Sicily. Minerva Gastroenterol Dietol. 2011 Sep; 57(3):241-6. PMID: 21769074.
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    64. Moh?csik P, Ze?ld A, Bianco AC, Gereben B. Thyroid hormone and the neuroglia: both source and target. J Thyroid Res. 2011; 2011:215718. PMID: 21876836.
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    65. Medina MC, Molina J, Gadea Y, Fachado A, Murillo M, Simovic G, Pileggi A, Hern?ndez A, Edlund H, Bianco AC. The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion. Endocrinology. 2011 Oct; 152(10):3717-27. PMID: 21828183.
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    66. Ueta CB, Olivares EL, Bianco AC. Responsiveness to thyroid hormone and to ambient temperature underlies differences between brown adipose tissue and skeletal muscle thermogenesis in a mouse model of diet-induced obesity. Endocrinology. 2011 Sep; 152(9):3571-81. PMID: 21771890.
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    67. Quintavalle C, Brenca M, De Micco F, Fiore D, Romano S, Romano MF, Apone F, Bianco A, Zabatta MA, Troncone G, Briguori C, Condorelli G. In vivo and in vitro assessment of pathways involved in contrast media-induced renal cells apoptosis. Cell Death Dis. 2011 May 12; 2:e155. PMID: 21562587.
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    68. Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ. Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev. 2010 Jul 15; 24(14):1507-18. PMID: 20634317.
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    69. Ribeiro MO, Bianco SD, Kaneshige M, Schultz JJ, Cheng SY, Bianco AC, Brent GA. Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis. Endocrinology. 2010 Jan; 151(1):432-40. PMID: 19906816.
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    70. Gereben B, Bianco AC. Covering the base-pairs in iodothyronine deiodinase-1 biology: holes remain in the lineup. Thyroid. 2009 Oct; 19(10):1027-9. PMID: 19803788.
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    71. Kang HW, Ribich S, Kim BW, Hagen SJ, Bianco AC, Cohen DE. Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue. J Lipid Res. 2009 Nov; 50(11):2212-21. PMID: 19502644.
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    72. Grozovsky R, Ribich S, Rosene ML, Mulcahey MA, Huang SA, Patti ME, Bianco AC, Kim BW. Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes. Endocrinology. 2009 Apr; 150(4):1976-83. PMID: 19036883.
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    73. Gereben B, Zavacki AM, Ribich S, Kim BW, Huang SA, Simonides WS, Ze?ld A, Bianco AC. Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev. 2008 Dec; 29(7):898-938. PMID: 18815314.
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    74. Gereben B, Ze?ld A, Dentice M, Salvatore D, Bianco AC. Activation and inactivation of thyroid hormone by deiodinases: local action with general consequences. Cell Mol Life Sci. 2008 Feb; 65(4):570-90. PMID: 17989921.
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    75. Adams BA, Gray SL, Isaac ER, Bianco AC, Vidal-Puig AJ, Sherwood NM. Feeding and metabolism in mice lacking pituitary adenylate cyclase-activating polypeptide. Endocrinology. 2008 Apr; 149(4):1571-80. PMID: 18162530.
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    76. Dentice M, Luongo C, Huang S, Ambrosio R, Elefante A, Mirebeau-Prunier D, Zavacki AM, Fenzi G, Grachtchouk M, Hutchin M, Dlugosz AA, Bianco AC, Missero C, Larsen PR, Salvatore D. Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes. Proc Natl Acad Sci U S A. 2007 Sep 04; 104(36):14466-71. PMID: 17720805.
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    77. Fekete C, Freitas BC, Ze?ld A, Wittmann G, K?d?r A, Liposits Z, Christoffolete MA, Singru P, Lechan RM, Bianco AC, Gereben B. Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain. Endocrinology. 2007 Oct; 148(10):4865-74. PMID: 17628004.
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    78. Wajner SM, dos Santos Wagner M, Melo RC, Parreira GG, Chiarini-Garcia H, Bianco AC, Fekete C, Sanchez E, Lechan RM, Maia AL. Type 2 iodothyronine deiodinase is highly expressed in germ cells of adult rat testis. J Endocrinol. 2007 Jul; 194(1):47-54. PMID: 17592020.
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    79. Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME. Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem. 2007 May 25; 282(21):15439-50. PMID: 17416903.
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    80. Villicev CM, Freitas FR, Aoki MS, Taffarel C, Scanlan TS, Moriscot AS, Ribeiro MO, Bianco AC, Gouveia CH. Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J Endocrinol. 2007 Apr; 193(1):21-9. PMID: 17400799.
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    81. Souza SC, Christoffolete MA, Ribeiro MO, Miyoshi H, Strissel KJ, Stancheva ZS, Rogers NH, D'Eon TM, Perfield JW, Imachi H, Obin MS, Bianco AC, Greenberg AS. Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue. J Lipid Res. 2007 Jun; 48(6):1273-9. PMID: 17401109.
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    82. Bianco AC, Kim BW. Deiodinases: implications of the local control of thyroid hormone action. J Clin Invest. 2006 Oct; 116(10):2571-9. PMID: 17016550.
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    83. Ze?ld A, Doleschall M, Haffner MC, Capelo LP, Menyh?rt J, Liposits Z, da Silva WS, Bianco AC, Kacskovics I, Fekete C, Gereben B. Characterization of the nuclear factor-kappa B responsiveness of the human dio2 gene. Endocrinology. 2006 Sep; 147(9):4419-29. PMID: 16728495.
      Citations:    
    84. Miyoshi H, Souza SC, Zhang HH, Strissel KJ, Christoffolete MA, Kovsan J, Rudich A, Kraemer FB, Bianco AC, Obin MS, Greenberg AS. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. J Biol Chem. 2006 Jun 09; 281(23):15837-44. PMID: 16595669.
      Citations:    
    85. Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature. 2006 Jan 26; 439(7075):484-9. PMID: 16400329.
      Citations:    
    86. Christoffolete MA, Ribeiro R, Singru P, Fekete C, da Silva WS, Gordon DF, Huang SA, Crescenzi A, Harney JW, Ridgway EC, Larsen PR, Lechan RM, Bianco AC. Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism. Endocrinology. 2006 Apr; 147(4):1735-43. PMID: 16396983.
      Citations:    
    87. Monte O, Zyngier S, Kimura ET, Bianco AC. [Dopaminergic and somatostatinergic pathways decrease serum thyrotropin in rats bearing the 256-Walker mammary carcinoma]. Arq Bras Endocrinol Metabol. 2005 Apr; 49(2):253-64. PMID: 16184254.
      Citations:    
    88. Dentice M, Bandyopadhyay A, Gereben B, Callebaut I, Christoffolete MA, Kim BW, Nissim S, Mornon JP, Zavacki AM, Ze?ld A, Capelo LP, Curcio-Morelli C, Ribeiro R, Harney JW, Tabin CJ, Bianco AC. The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. Nat Cell Biol. 2005 Jul; 7(7):698-705. PMID: 15965468.
      Citations:    
    89. Bianco AC, Maia AL, da Silva WS, Christoffolete MA. Adaptive activation of thyroid hormone and energy expenditure. Biosci Rep. 2005 Jun-Aug; 25(3-4):191-208. PMID: 16283553.
      Citations:    
    90. Canani LH, Capp C, Dora JM, Meyer EL, Wagner MS, Harney JW, Larsen PR, Gross JL, Bianco AC, Maia AL. The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2005 Jun; 90(6):3472-8. PMID: 15797963.
      Citations:    
    91. Gouveia CH, Christoffolete MA, Zaitune CR, Dora JM, Harney JW, Maia AL, Bianco AC. Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation. Endocrinology. 2005 Jan; 146(1):195-200. PMID: 15471965.
      Citations:    
    92. Bianco AC. Triplets! Unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects. Arq Bras Endocrinol Metabol. 2004 Feb; 48(1):16-24. PMID: 15611815.
      Citations:    
    93. Fekete C, Gereben B, Doleschall M, Harney JW, Dora JM, Bianco AC, Sarkar S, Liposits Z, Rand W, Emerson C, Kacskovics I, Larsen PR, Lechan RM. Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome. Endocrinology. 2004 Apr; 145(4):1649-55. PMID: 14684601.
      Citations:    
    94. Citro R, Galderisi M, Guarini P, Cicala S, Mattioli D, Bianco A, de Divitiis O, Gregorio G. Left bundle branch block with and without coronary artery disease: which value for a tissue Doppler-derived post-systolic motion? Ital Heart J. 2003 Oct; 4(10):706-12. PMID: 14664284.
      Citations:    
    95. Callebaut I, Curcio-Morelli C, Mornon JP, Gereben B, Buettner C, Huang S, Castro B, Fonseca TL, Harney JW, Larsen PR, Bianco AC. The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure. J Biol Chem. 2003 Sep 19; 278(38):36887-96. PMID: 12847093.
      Citations:    
    96. Baqui M, Botero D, Gereben B, Curcio C, Harney JW, Salvatore D, Sorimachi K, Larsen PR, Bianco AC. Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes. J Biol Chem. 2003 Jan 10; 278(2):1206-11. PMID: 12419801.
      Citations:    
    97. Fekete C, Sarkar S, Rand WM, Harney JW, Emerson CH, Bianco AC, Lechan RM. Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis. Endocrinology. 2002 Oct; 143(10):3846-53. PMID: 12239096.
      Citations:    
    98. Cohen WM, Bianco A, Connan F, Camoin L, Dalod M, Lauvau G, Ferri?s E, Culmann-Penciolelli B, van Endert PM, Briand JP, Choppin J, Guillet JG. Study of antigen-processing steps reveals preferences explaining differential biological outcomes of two HLA-A2-restricted immunodominant epitopes from human immunodeficiency virus type 1. J Virol. 2002 Oct; 76(20):10219-25. PMID: 12239297.
      Citations:    
    99. Botero D, Gereben B, Goncalves C, De Jesus LA, Harney JW, Bianco AC. Ubc6p and ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase. Mol Endocrinol. 2002 Sep; 16(9):1999-2007. PMID: 12198238.
      Citations:    
    100. Cristovão FC, Bisi H, Mendonça BB, Bianco AC, Bloise W. Severe and mild neonatal hypothyroidism mediate opposite effects on Leydig cells of rats. Thyroid. 2002 Jan; 12(1):13-8. PMID: 11838725.
      Citations:    
    101. Gouveia CH, Schultz JJ, Bianco AC, Brent GA. Thyroid hormone stimulation of osteocalcin gene expression in ROS 17/2.8 cells is mediated by transcriptional and post-transcriptional mechanisms. J Endocrinol. 2001 Sep; 170(3):667-75. PMID: 11524248.
      Citations:    
    102. Peeters R, Fekete C, Goncalves C, Legradi G, Tu HM, Harney JW, Bianco AC, Lechan RM, Larsen PR. Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency. Am J Physiol Endocrinol Metab. 2001 Jul; 281(1):E54-61. PMID: 11404222.
      Citations:    
    103. Choppin J, Cohen W, Bianco A, Briand JP, Connan F, Dalod M, Guillet JG. Characteristics of HIV-1 Nef regions containing multiple CD8+ T cell epitopes: wealth of HLA-binding motifs and sensitivity to proteasome degradation. J Immunol. 2001 May 15; 166(10):6164-9. PMID: 11342637.
      Citations:    
    104. Joseph C, Stier G, O'Brien R, Politou AS, Atkinson RA, Bianco A, Ladbury JE, Martin SR, Pastore A. A structural characterization of the interactions between titin Z-repeats and the alpha-actinin C-terminal domain. Biochemistry. 2001 Apr 24; 40(16):4957-65. PMID: 11305911.
      Citations:    
    105. Vianna CR, Hagen T, Zhang CY, Bachman E, Boss O, Gereben B, Moriscot AS, Lowell BB, Bicudo JE, Bianco AC. Cloning and functional characterization of an uncoupling protein homolog in hummingbirds. Physiol Genomics. 2001 Apr 02; 5(3):137-45. PMID: 11285367.
      Citations:    
    106. Bianco A, Furrer J, Limal D, Guichard G, Elbayed K, Raya J, Piotto M, Briand JP. Multistep synthesis of 2,5-diketopiperazines on different solid supports monitored by high resolution magic angle spinning NMR spectroscopy. J Comb Chem. 2000 Nov-Dec; 2(6):681-90. PMID: 11126296.
      Citations:    
    107. Ribeiro MO, Lebrun FL, Christoffolete MA, Branco M, Crescenzi A, Carvalho SD, Negr?o N, Bianco AC. Evidence of UCP1-independent regulation of norepinephrine-induced thermogenesis in brown fat. Am J Physiol Endocrinol Metab. 2000 Aug; 279(2):E314-22. PMID: 10913031.
      Citations:    
    108. Curcio C, Lopes AM, Ribeiro MO, Francoso OA, Carvalho SD, Lima FB, Bicudo JE, Bianco AC. Development of compensatory thermogenesis in response to overfeeding in hypothyroid rats. Endocrinology. 1999 Aug; 140(8):3438-43. PMID: 10433198.
      Citations:    
    109. Branco M, Ribeiro M, Negr?o N, Bianco AC. 3,5,3'-Triiodothyronine actively stimulates UCP in brown fat under minimal sympathetic activity. Am J Physiol. 1999 01; 276(1):E179-87. PMID: 9886965.
      Citations:    
    110. Pessoa JH, Lewin S, Longui CA, Mendon?a BB, Bianco AC. [Bone mineral density: correlation with body weight, height, bone age and insulin-like growth factor]. J Pediatr (Rio J). 1997 Jul-Aug; 73(4):259-64. PMID: 14685400.
      Citations:    
    111. Comella P, Frasci G, De Cataldis G, Panza N, Cioffi R, Curcio C, Belli M, Bianco A, Ianniello G, Maiorino L, Della Vittoria M, Perchard J, Comella G. Cisplatin/carboplatin + etoposide + vinorelbine in advanced non-small-cell lung cancer: a multicentre randomised trial. Gruppo Oncologico Campano. Br J Cancer. 1996 Dec; 74(11):1805-11. PMID: 8956797.
      Citations:    
    112. Gun C, Piegas LS, Bianco AC, Freire RB, Ramos RF, Timerman A. [Value of the use of milrinone in the treatment of acute crisis in patients with congestive heart failure]. Arq Bras Cardiol. 1995 Sep; 65(3):255-8. PMID: 8579514.
      Citations:    
    113. Latronico AC, Mendon?a BB, Bianco AC, Villares SM, Lucon MA, Nicolau W, Wajchenberg BL. Calcium-dependent protein kinase-C activity in human adrenocortical neoplasms, hyperplastic adrenals, and normal adrenocortical tissue. J Clin Endocrinol Metab. 1994 Sep; 79(3):736-9. PMID: 7521351.
      Citations:    
    114. Moriscot A, Rabelo R, Bianco AC. Corticosterone inhibits uncoupling protein gene expression in brown adipose tissue. Am J Physiol. 1993 Jul; 265(1 Pt 1):E81-7. PMID: 8338156.
      Citations:    
    115. Carvalho SD, Negr?o N, Bianco AC. Hormonal regulation of malic enzyme and glucose-6-phosphate dehydrogenase in brown adipose tissue. Am J Physiol. 1993 Jun; 264(6 Pt 1):E874-81. PMID: 8333512.
      Citations:    
    116. Bianco AC, Kieffer JD, Silva JE. Adenosine 3',5'-monophosphate and thyroid hormone control of uncoupling protein messenger ribonucleic acid in freshly dispersed brown adipocytes. Endocrinology. 1992 May; 130(5):2625-33. PMID: 1374009.
      Citations:    
    117. Carvalho SD, Kimura ET, Bianco AC, Silva JE. Central role of brown adipose tissue thyroxine 5'-deiodinase on thyroid hormone-dependent thermogenic response to cold. Endocrinology. 1991 Apr; 128(4):2149-59. PMID: 2004619.
      Citations:    
    118. Dorgan Neto V, Saad J?nior R, Hell NS, Bianco AC, Santo GC, Rasslan S. [Gastrin changes in the gastric antrum G-cells and in serum gastrin levels after 80% jejunoileal resection in rats]. Rev Paul Med. 1991 Mar-Apr; 109(2):71-6. PMID: 1887181.
      Citations:    
    119. Bianco AC, Sheng XY, Silva JE. Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis. J Biol Chem. 1988 Dec 05; 263(34):18168-75. PMID: 3192531.
      Citations:    
    120. Bianco AC, Silva JE. Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation. Am J Physiol. 1987 Sep; 253(3 Pt 1):E255-63. PMID: 3631256.
      Citations:    
    121. Bianco AC, Silva JE. Nuclear 3,5,3'-triiodothyronine (T3) in brown adipose tissue: receptor occupancy and sources of T3 as determined by in vivo techniques. Endocrinology. 1987 Jan; 120(1):55-62. PMID: 3780570.
      Citations:    
    122. Nunes MT, Bianco AC, Migala A, Agostini B, Hasselbach W. Thyroxine induced transformation in sarcoplasmic reticulum of rabbit soleus and psoas muscles. Z Naturforsch C Biosci. 1985 Sep-Oct; 40(9-10):726-34. PMID: 2934902.
      Citations:    
    123. Saad Júnior R, Bianco AC, de Minas RM, Chazanas JC, de Oliveira AM, Hell NS, Rasslan S. [Metabolic changes in rats subjected to massive intestinal resection or jejunoileal bypass]. Rev Paul Med. 1985 Jul-Aug; 103(4):171-5. PMID: 3914047.
      Citations:    
    124. Bianco AC, Nunes MT, Martins O, Roesner I, Douglas RA, Pereira RC, Douglas CR. Possible mechanism of action of cholesterol enriched diet on the thyroid. Endocrinol Exp. 1981 Dec; 15(4):277-85. PMID: 6976263.
      Citations:    
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