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Ali Keshavarzian

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentDigestive Diseases and Nutrition
Address1725 W. Harrison St.
Chicago IL 60612
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    Collapse Overview 
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    Other Positions:
    Josephine M. Dyrenforth Chair of Gastroenterology
    Professor of Medicine, Rush Medical College
    Professor, Graduate College
    Director, Division of Digestive Diseases & Nutrition
    Director, Institute for Advanced Study of the Gut, Chronobiology and Inflammation

    My Scopus ID is 7006447140.
    My NIH COMMONS name is AKESHAVARZIAN.

    Education:
    MD, Tehran University School of Medical Sciences, Iran, 1976

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Aboushaala K, Chee AV, Adnan D, Toro SJ, Singh H, Savoia A, Dhillon ES, Yuh C, Dourdourekas J, Patel IK, Vucicevic R, Espinoza-Orias AA, Martin JT, Oh C, Keshavarzian A, Albert HB, Karppinen J, Kocak M, Wong AYL, Goldberg EJ, Phillips FM, Colman MW, Williams FMK, Borgia JA, Naqib A, Green SJ, Forsyth CB, An HS, Samartzis D. Gut microbiome dysbiosis is associated with lumbar degenerative spondylolisthesis in symptomatic patients. JOR Spine. 2024 Dec; 7(4):e70005. PMID: 39398942; PMCID: PMC11467165.
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    2. Bishehsari F, Drees M, Adnan D, Sharma D, Green S, Koshy J, Giron LB, Goldman A, Abdel-Mohsen M, Rasmussen HE, Miller GE, Keshavarzian A. Multi-omics approach to socioeconomic disparity in metabolic syndrome reveals roles of diet and microbiome. Proteomics. 2023 10; 23(19):e2300023. PMID: 37525324.
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    3. Ko FC, Jochum SB, Wilson BM, Adra A, Patel N, Lee H, Wilber S, Shaikh M, Forsyth C, Keshavarzian A, Swanson GR, Sumner DR. Colon epithelial cell-specific Bmal1 deletion impairs bone formation in mice. Bone. 2023 03; 168:116650. PMID: 36584784; PMCID: PMC9911378.
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    4. Jedel S, Beck T, Swanson G, Hood MM, Voigt RM, Gorenz A, Jakate S, Raeisi S, Hobfoll S, Keshavarzian A. Mindfulness Intervention Decreases Frequency and Severity of Flares in Inactive Ulcerative Colitis Patients: Results of a Phase II, Randomized, Placebo-Controlled Trial. Inflamm Bowel Dis. 2022 12 01; 28(12):1872-1892. PMID: 35661212.
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    5. Forsyth CB, Zhang L, Bhushan A, Swanson B, Zhang L, Mamede JI, Voigt RM, Shaikh M, Engen PA, Keshavarzian A, Forsyth CB, Zhang L, Bhushan A, Swanson B, Zhang L, Mamede JI, Voigt RM, Shaikh M, Engen PA, Keshavarzian A. The SARS-CoV-2 S1 Spike Protein Promotes MAPK and NF-kB Activation in Human Lung Cells and Inflammatory Cytokine Production in Human Lung and Intestinal Epithelial Cells. Microorganisms. 2022 Oct 10; 10(10). PMID: 36296272; PMCID: PMC9607240.
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    6. Manfready RA, Goetz CG, Keshavarzian A. Intestinal microbiota and neuroinflammation in Parkinson's disease: At the helm of the gut-brain axis. Int Rev Neurobiol. 2022; 167:81-99. PMID: 36427960.
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    7. Wilson BM, Witkiewics BR, Voigt RM, Forysth CB, Keshavarzian A, Ko FC, Virdi AS, Sumner DR. Alcohol and Circadian Disruption Minimally Impact Bone Properties in Two Cohorts of Male Mice While Between-Cohort Differences Predominate: Association With Season of Birth? JBMR Plus. 2022 Mar; 6(3):e10591. PMID: 35309863; PMCID: PMC8914150.
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    8. Szklany K, Engen PA, Naqib A, Green SJ, Keshavarzian A, Lopez Rincon A, Siebrand CJ, Diks MAP, van de Kaa M, Garssen J, Knippels LMJ, Kraneveld AD. Dietary Supplementation throughout Life with Non-Digestible Oligosaccharides and/or n-3 Poly-Unsaturated Fatty Acids in Healthy Mice Modulates the Gut-Immune System-Brain Axis. Nutrients. 2021 Dec 30; 14(1). PMID: 35011046.
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    9. Pal G, Ramirez V, Engen PA, Naqib A, Forsyth CB, Green SJ, Mahdavinia M, Batra PS, Tajudeen BA, Keshavarzian A. Deep nasal sinus cavity microbiota dysbiosis in Parkinson's disease. NPJ Parkinsons Dis. 2021 Dec 08; 7(1):111. PMID: 34880258.
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    10. Moran MM, Wessman P, Rolfson O, Bohl DD, K?rrholm J, Keshavarzian A, Sumner DR. The risk of revision following total hip arthroplasty in patients with inflammatory bowel disease, a registry based study. PLoS One. 2021; 16(11):e0257310. PMID: 34735461; PMCID: PMC8568118.
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    11. Giron LB, Dweep H, Yin X, Wang H, Damra M, Goldman AR, Gorman N, Palmer CS, Tang HY, Shaikh MW, Forsyth CB, Balk RA, Zilberstein NF, Liu Q, Kossenkov A, Keshavarzian A, Landay A, Abdel-Mohsen M. Corrigendum: Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients. Front Immunol. 2021; 12:779064. PMID: 34671365.
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    12. Alsayid M, Khan MO, Adnan D, Rasmussen HE, Keshavarzian A, Bishehsari F. Behavioral circadian phenotypes are associated with the risk of elevated body mass index. Eat Weight Disord. 2022 May; 27(4):1395-1403. PMID: 34355307.
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    13. Giron LB, Dweep H, Yin X, Wang H, Damra M, Goldman AR, Gorman N, Palmer CS, Tang HY, Shaikh MW, Forsyth CB, Balk RA, Zilberstein NF, Liu Q, Kossenkov A, Keshavarzian A, Landay A, Abdel-Mohsen M. Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients. Front Immunol. 2021; 12:686240. PMID: 34177935.
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    14. van Kessel SP, de Jong HR, Winkel SL, van Leeuwen SS, Nelemans SA, Permentier H, Keshavarzian A, El Aidy S. Gut bacterial deamination of residual levodopa medication for Parkinson's disease. BMC Biol. 2020 10 20; 18(1):137. PMID: 33076930.
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    15. Moran MM, Wilson BM, Li J, Engen PA, Naqib A, Green SJ, Virdi AS, Plaas A, Forsyth CB, Keshavarzian A, Sumner DR. The gut microbiota may be a novel pathogenic mechanism in loosening of orthopedic implants in rats. FASEB J. 2020 11; 34(11):14302-14317. PMID: 32931052; PMCID: PMC8025663.
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    16. Engen PA, Zaferiou A, Rasmussen H, Naqib A, Green SJ, Fogg LF, Forsyth CB, Raeisi S, Hamaker B, Keshavarzian A. Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis. Front Neurol. 2020; 11:978. PMID: 33013647.
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    17. Bishehsari F, Preuss F, Mirbagheri SS, Zhang L, Shaikh M, Keshavarzian A. Interaction of alcohol with time of eating on markers of circadian dyssynchrony and colon tissue injury. Chem Biol Interact. 2020 Jul 01; 325:109132. PMID: 32437693.
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    18. Bishehsari F, Zhang L, Voigt RM, Maltby N, Semsarieh B, Zorub E, Shaikh M, Wilber S, Armstrong AR, Mirbagheri SS, Preite NZ, Song P, Stornetta A, Balbo S, Forsyth CB, Keshavarzian A. Alcohol Effects on Colon Epithelium are Time-Dependent. Alcohol Clin Exp Res. 2019 09; 43(9):1898-1908. PMID: 31237690.
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    19. Mazzoccoli G, Keshavarzian A, Vinciguerra M. Hedgehog signaling keeps liver clock in check. J Hepatol. 2019 06; 70(6):1054-1056. PMID: 30826121.
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    20. Chen D, Xie R, Shu B, Landay AL, Wei C, Reiser J, Spagnoli A, Torquati A, Forsyth CB, Keshavarzian A, Sumner DR. Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging. Ann N Y Acad Sci. 2019 04; 1442(1):48-60. PMID: 30101565.
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    21. Das V, Kc R, Li X, Varma D, Qiu S, Kroin JS, Forsyth CB, Keshavarzian A, van Wijnen AJ, Park TJ, Stein GS, O-Sullivan I, Burris TP, Im HJ. Corrigendum to "Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain" [GENE 655 (2018) 1-12]. Gene. 2019 01 05; 680:105. PMID: 29890121.
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    22. Das V, Kc R, Li X, Varma D, Qiu S, Kroin JS, Forsyth CB, Keshavarzian A, van Wijnen AJ, Park TJ, Stein GS, O-Sullivan I, Burris TP, Im HJ. Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain. Gene. 2018 May 20; 655:1-12. PMID: 29474860.
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    23. Mahdavinia M, Engen PA, LoSavio PS, Naqib A, Khan RJ, Tobin MC, Mehta A, Kota R, Preite NZ, Codispoti CD, Tajudeen BA, Schleimer RP, Green SJ, Keshavarzian A, Batra PS. The nasal microbiome in patients with chronic rhinosinusitis: Analyzing the effects of atopy and bacterial functional pathways in 111 patients. J Allergy Clin Immunol. 2018 07; 142(1):287-290.e4. PMID: 29452201.
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    24. Rossi M, Jahanzaib Anwar M, Usman A, Keshavarzian A, Bishehsari F. Colorectal Cancer and Alcohol Consumption-Populations to Molecules. Cancers (Basel). 2018 Jan 30; 10(2). PMID: 29385712.
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    25. Davis BT, Voigt RM, Shaikh M, Forsyth CB, Keshavarzian A. CREB Protein Mediates Alcohol-Induced Circadian Disruption and Intestinal Permeability. Alcohol Clin Exp Res. 2017 Dec; 41(12):2007-2014. PMID: 28960346.
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    26. Gianella S, Chaillon A, Mutlu EA, Engen PA, Voigt RM, Keshavarzian A, Losurdo J, Chakradeo P, Lada SM, Nakazawa M, Landay AL. Effect of cytomegalovirus and Epstein-Barr virus replication on intestinal mucosal gene expression and microbiome composition of HIV-infected and uninfected individuals. AIDS. 2017 09 24; 31(15):2059-2067. PMID: 28906277.
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    27. Krarup AR, Abdel-Mohsen M, Schleimann MH, Vibholm L, Engen PA, Dige A, Wittig B, Schmidt M, Green SJ, Naqib A, Keshavarzian A, Deng X, Olesen R, Petersen AM, Benfield T, ?stergaard L, Rasmussen TA, Agnholt J, Nyengaard JR, Landay A, S?gaard OS, Pillai SK, Tolstrup M, Denton PW. The TLR9 agonist MGN1703 triggers a potent type I interferon response in the sigmoid colon. Mucosal Immunol. 2018 03; 11(2):449-461. PMID: 28766555.
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    28. Mahdavinia M, Rasmussen HE, Engen P, Van den Berg JP, Davis E, Engen K, Green SJ, Naqib A, Botha M, Gray C, Lunjani N, Hlela C, Basera W, Hobane L, Watkins A, Tobin MC, Landay A, Keshavarzian A, Levin ME. Atopic dermatitis and food sensitization in South African toddlers: Role of fiber and gut microbiota. Ann Allergy Asthma Immunol. 2017 06; 118(6):742-743.e3. PMID: 28583264.
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    29. Engen PA, Dodiya HB, Naqib A, Forsyth CB, Green SJ, Voigt RM, Kordower JH, Mutlu EA, Shannon KM, Keshavarzian A. The Potential Role of Gut-Derived Inflammation in Multiple System Atrophy. J Parkinsons Dis. 2017; 7(2):331-346. PMID: 28234259.
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    30. Voigt RM, Forsyth CB, Green SJ, Engen PA, Keshavarzian A. Circadian Rhythm and the Gut Microbiome. Int Rev Neurobiol. 2016; 131:193-205. PMID: 27793218.
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    31. Burgess HJ, Rizvydeen M, Fogg LF, Keshavarzian A. A single dose of alcohol does not meaningfully alter circadian phase advances and phase delays to light in humans. Am J Physiol Regul Integr Comp Physiol. 2016 Apr 15; 310(8):R759-65. PMID: 26936778.
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    32. Summa KC, Jiang P, Fitzpatrick K, Voigt RM, Bowers SJ, Forsyth CB, Vitaterna MH, Keshavarzian A, Turek FW. Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon. Alcohol Clin Exp Res. 2015 Oct; 39(10):1917-29. PMID: 26332085.
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    33. Kc R, Voigt R, Li X, Forsyth CB, Ellman MB, Summa KC, Turek FW, Keshavarzian A, Kim JS, Im HJ. Induction of Osteoarthritis-like Pathologic Changes by Chronic Alcohol Consumption in an Experimental Mouse Model. Arthritis Rheumatol. 2015 Jun; 67(6):1678-80. PMID: 25708245.
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    34. Keerthivasan S, Aghajani K, Dose M, Molinero L, Khan MW, Venkateswaran V, Weber C, Emmanuel AO, Sun T, Bentrem DJ, Mulcahy M, Keshavarzian A, Ramos EM, Blatner N, Khazaie K, Gounari F. ?-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells. Sci Transl Med. 2014 Feb 26; 6(225):225ra28. PMID: 24574339.
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    35. Gandhi S, Jedel S, Hood MM, Mutlu E, Swanson G, Keshavarzian A. The relationship between coping, health competence and patient participation among patients with inactive inflammatory bowel disease. J Crohns Colitis. 2014 05; 8(5):401-8. PMID: 24230968.
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    36. Kelly LP, Carvey PM, Keshavarzian A, Shannon KM, Shaikh M, Bakay RA, Kordower JH. Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease. Mov Disord. 2014 Jul; 29(8):999-1009. PMID: 24898698.
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    37. Yazici C, Losurdo J, Brown MD, Oosterveen S, Rahimi R, Keshavarzian A, Bozorgnia L, Mutlu E. Inpatient capsule endoscopy leads to frequent incomplete small bowel examinations. World J Gastroenterol. 2012 Sep 28; 18(36):5051-7. PMID: 23049213.
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    38. Mutlu EA, Engen PA, Soberanes S, Urich D, Forsyth CB, Nigdelioglu R, Chiarella SE, Radigan KA, Gonzalez A, Jakate S, Keshavarzian A, Budinger GR, Mutlu GM. Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice. Part Fibre Toxicol. 2011 Jun 09; 8:19. PMID: 21658250.
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    39. Singhal S, Dian D, Keshavarzian A, Fogg L, Fields JZ, Farhadi A. The role of oral hygiene in inflammatory bowel disease. Dig Dis Sci. 2011 Jan; 56(1):170-5. PMID: 20458622.
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    40. Melson J, Jakate S, Fung H, Arai S, Keshavarzian A. Crypt loss is a marker of clinical severity of acute gastrointestinal graft-versus-host disease. Am J Hematol. 2007 Oct; 82(10):881-6. PMID: 17570511.
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    41. Banan A, Keshavarzian A, Zhang L, Shaikh M, Forsyth CB, Tang Y, Fields JZ. NF-kappaB activation as a key mechanism in ethanol-induced disruption of the F-actin cytoskeleton and monolayer barrier integrity in intestinal epithelium. Alcohol. 2007 Sep; 41(6):447-60. PMID: 17869053.
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    42. Farhadi A, Keshavarzian A, Fields JZ, Jakate S, Shaikh M, Banan A. Reduced immunostaining for c-kit receptors in mucosal mast cells in inflammatory bowel disease. J Gastroenterol Hepatol. 2007 Dec; 22(12):2338-43. PMID: 17645464.
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    43. Farhadi A, Forsyth C, Banan A, Shaikh M, Engen P, Fields JZ, Keshavarzian A. Evidence for non-chemical, non-electrical intercellular signaling in intestinal epithelial cells. Bioelectrochemistry. 2007 Nov; 71(2):142-8. PMID: 17428745.
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    44. Mutlu EA, Keshavarzian A, Mutlu GM. Hyperalbuminemia and elevated transaminases associated with high-protein diet. Scand J Gastroenterol. 2006 Jun; 41(6):759-60. PMID: 16716979.
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    45. Frantzides CT, Madan AK, Moore RE, Zografakis JG, Carlson MA, Keshavarzian A. Laparoscopic transgastric esophageal mucosal resection for high-grade dysplasia. J Laparoendosc Adv Surg Tech A. 2004 Oct; 14(5):261-5. PMID: 15630939.
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    46. Keshavarzian A, Fields J. Alcoholic liver disease: is it an "extraintestinal" complication of alcohol-induced intestinal injury? J Lab Clin Med. 2003 Nov; 142(5):285-7. PMID: 14647031.
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    47. Banan A, Fields JZ, Zhang LJ, Shaikh M, Farhadi A, Keshavarzian A. Zeta isoform of protein kinase C prevents oxidant-induced nuclear factor-kappaB activation and I-kappaBalpha degradation: a fundamental mechanism for epidermal growth factor protection of the microtubule cytoskeleton and intestinal barrier integrity. J Pharmacol Exp Ther. 2003 Oct; 307(1):53-66. PMID: 12893839.
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    48. Bu P, Keshavarzian A, Stone DD, Liu J, Le PT, Fisher S, Qiao L. Apoptosis: one of the mechanisms that maintains unresponsiveness of the intestinal mucosal immune system. J Immunol. 2001 May 15; 166(10):6399-403. PMID: 11342665.
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    49. Kennedy M, Bruninga K, Mutlu EA, Losurdo J, Choudhary S, Keshavarzian A. Successful and sustained treatment of chronic radiation proctitis with antioxidant vitamins E and C. Am J Gastroenterol. 2001 Apr; 96(4):1080-4. PMID: 11316150.
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    50. Keshavarzian A, Fusunyan RD, Jacyno M, Winship D, MacDermott RP, Sanderson IR. Increased interleukin-8 (IL-8) in rectal dialysate from patients with ulcerative colitis: evidence for a biological role for IL-8 in inflammation of the colon. Am J Gastroenterol. 1999 Mar; 94(3):704-12. PMID: 10086655.
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    51. Holmes EW, Yong SL, Eiznhamer D, Keshavarzian A. Glutathione content of colonic mucosa: evidence for oxidative damage in active ulcerative colitis. Dig Dis Sci. 1998 May; 43(5):1088-95. PMID: 9590426.
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    52. Aranha GV, Walsh RM, Jacobs HK, Freeark RJ, Harford FJ, Keshavarzian A, Zarling EJ. Factors influencing bowel function following total abdominal colectomy. Dis Colon Rectum. 1996 Dec; 39(12):1418-22. PMID: 8969669.
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    53. Haydek JM, Keshavarzian A. Circulating neutrophils from patients with ulcerative colitis have a normal respiratory burst. Inflammation. 1995 Dec; 19(6):701-15. PMID: 8595936.
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    54. Keshavarzian A, Zorub O, Sayeed M, Urban G, Sweeney C, Winship D, Fields J. Acute ethanol inhibits calcium influxes into esophageal smooth but not striated muscle: a possible mechanism for ethanol-induced inhibition of esophageal contractility. J Pharmacol Exp Ther. 1994 Sep; 270(3):1057-62. PMID: 7932153.
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    55. Keshavarzian A, Doria MI, Sedghi S, Kanofsky JR, Hecht D, Holmes EW, Ibrahim C, List T, Urban G, Gaginella T, et al. Mitomycin C-induced colitis in rats: a new animal model of acute colonic inflammation implicating reactive oxygen species. J Lab Clin Med. 1992 Nov; 120(5):778-91. PMID: 1431507.
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    56. Keshavarzian A, Sedghi S, Kanofsky J, List T, Robinson C, Ibrahim C, Winship D. Excessive production of reactive oxygen metabolites by inflamed colon: analysis by chemiluminescence probe. Gastroenterology. 1992 Jul; 103(1):177-85. PMID: 1612325.
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    57. Keshavarzian A, Gordon JH, Willson C, Urban G, Fields JZ. Chronic ethanol feeding produces a muscarinic receptor upregulation, but not a muscarinic supersensitivity in lower esophageal sphincter muscle. J Pharmacol Exp Ther. 1992 Feb; 260(2):601-7. PMID: 1346638.
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    58. Keshavarzian A, Bushnell DL, Sontag S, Yegelwel EJ, Smid K. Gastric emptying in patients with severe reflux esophagitis. Am J Gastroenterol. 1991 Jun; 86(6):738-42. PMID: 2038997.
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    59. Chadwick VS, Mellor DM, Myers DB, Selden AC, Keshavarzian A, Broom MF, Hobson CH. Production of peptides inducing chemotaxis and lysosomal enzyme release in human neutrophils by intestinal bacteria in vitro and in vivo. Scand J Gastroenterol. 1988 Jan; 23(1):121-8. PMID: 3278364.
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    60. Keshavarzian A, Iber FL, Greer P, Wobbleton J. Gastric emptying of solid meal in male chronic alcoholics. Alcohol Clin Exp Res. 1986 Aug; 10(4):432-5. PMID: 3530022.
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    61. Keshavarzian A, Iber FL. Intestinal transit in insulin-requiring diabetics. Am J Gastroenterol. 1986 Apr; 81(4):257-60. PMID: 3962951.
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    62. Keshavarzian A, Gibson R, Guest J, Spencer J, Lavender JP, Hodgson HJ. Granulocyte migration in uncomplicated intestinal anastomosis in man. Dig Dis Sci. 1986 Mar; 31(3):268-72. PMID: 3948630.
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