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Al-Harthi, Lena
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overview Chairperson, The Thomas J. Coogan Sr., MD, Chair of Immunology, Department of Microbial Pathogens and Immunity (formerly, Immunology/Microbiology), RUSH Medical College, RUSH University Medical Center. Director of RUSH Initiative to Maximize Student Development (RUSH-IMSD). RUSH Medical College Acting Vice Dean for Research. My ORCID is 0000-0003-3915-3904. My Scopus ID is 7004503402. My NIH COMMONS name is LALHARTHI. Research Areas: HIV/AIDS, HIV/host interactions. Articles in the press and media coverage highlight my recent work: https://journals.plos.org/plospathogens/article/related?id=10.1371/journal.ppat.1008381 https://docs.google.com/document/d/1qfXvONEL91j15nVIcrpE4ZcnE4uJ0mm2KNQvfEnbVvo/edit?usp=sharing My Faculty Profile at RUSH University Medical Center: https://www.rushu.rush.edu/faculty/lena-al-harthi-phd My Laboratory: https://www.rushu.rush.edu/research/departmental-research/microbial-pathogens-and-immunity-research/laboratory-lena-al-harthi-phd My NCBI Bibliography: https://www.ncbi.nlm.nih.gov/pubmed/?term=Al-Harthi+L My ORCID: http://orcid.org/0000-0003-3915-3904 My Scopus: https://www.scopus.com/authid/detail.uri?authorId=7004503402 Education: PhD, George Washington University
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Concept Potassium Channels, Voltage-Gated
Concept Smoking
Concept Absorptiometry, Photon
Concept Reverse Transcriptase Inhibitors
Concept Lymphocytes
Concept Vibrio cholerae
Concept Longitudinal Studies
Concept Cell Death
Concept Receptors, CXCR4
Concept 5' Untranslated Regions
Concept Lymphopoiesis
Concept Glycogen Synthase Kinase 3
Concept Heating
Concept Prosthodontics
Concept Glutamine
Concept rev Gene Products, Human Immunodeficiency Virus
Concept Enzyme-Linked Immunosorbent Assay
Concept Protein Binding
Concept Activities of Daily Living
Concept Apoptosis
Concept Ki-67 Antigen
Concept Interleukin-10
Concept Temperature
Concept Central Nervous System
Concept Brain Neoplasms
Concept Prefrontal Cortex
Concept RNA, Small Interfering
Concept Blood-Brain Barrier
Concept Mass Spectrometry
Concept Cell Lineage
Concept HIV Seropositivity
Concept Humans
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Concept CpG Islands
Concept Down-Regulation
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Concept Melanins
Concept Receptors, CXCR3
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Concept Methamphetamine
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Academic Article Inhibition of cytokine-driven human immunodeficiency virus type 1 replication by protease inhibitor.
Academic Article Interleukin-7 induces HIV replication in primary naive T cells through a nuclear factor of activated T cell (NFAT)-dependent pathway.
Academic Article Dynamics of cytokine expression in HIV productively infected primary CD4+ T cells.
Academic Article Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon- gamma levels.
Academic Article HIV infection of primary CD4+ Th2 cells, defined by expression of the chemoattractant receptor-homologous (CRTH2), induces a Th0 phenotype.
Academic Article Immune reconstitution after successful treatment with protease inhibitor-based and protease inhibitor-sparing antiretroviral regimens.
Academic Article Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells.
Academic Article A human immunodeficiency virus (HIV)-inducing factor from the female genital tract activates HIV-1 gene expression through the kappaB enhancer.
Academic Article Induction of HIV-1 replication by type 1-like cytokines, interleukin (IL)-12 and IL-15: effect on viral transcriptional activation, cellular proliferation, and endogenous cytokine production.
Academic Article Evaluating the impact of hepatitis C virus (HCV) on highly active antiretroviral therapy-mediated immune responses in HCV/HIV-coinfected women: role of HCV on expression of primed/memory T cells.
Academic Article Maximum suppression of HIV replication leads to the restoration of HIV-specific responses in early HIV disease.
Academic Article Entrapment of recent thymic emigrants in lymphoid tissues from HIV-infected patients: association with HIV cellular viral load.
Academic Article Activation of plasmacytoid dendritic cells with TLR9 agonists initiates invariant NKT cell-mediated cross-talk with myeloid dendritic cells.
Academic Article A potent activator of HIV-1 replication is present in the genital tract of a subset of HIV-1-infected and uninfected women.
Academic Article Trophoblasts are productively infected by CD4-independent isolate of HIV type 1.
Academic Article Rationale for immune-based therapies for HIV-1 infection.
Academic Article A menstrual cycle pattern for cytokine levels exists in HIV-positive women: implication for HIV vaginal and plasma shedding.
Academic Article Impact of class A, B and C CpG-oligodeoxynucleotides on in vitro activation of innate immune cells in human immunodeficiency virus-1 infected individuals.
Academic Article Interleukin-7-treated naive T cells can be productively infected by T-cell-adapted and primary isolates of human immunodeficiency virus 1.
Academic Article Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus.
Academic Article Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women.
Academic Article Granulocyte-macrophage colony-stimulating factor induces modest increases in plasma human immunodeficiency virus (HIV) type 1 RNA levels and CD4+ lymphocyte counts in patients with uncontrolled HIV infection.
Academic Article CD8(+) T cell activation in women coinfected with human immunodeficiency virus type 1 and hepatitis C virus.
Academic Article CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV.
Academic Article HIV in the female genital tract: viral shedding and mucosal immunity.
Academic Article T cell receptor excision circle (TREC) content following maximum HIV suppression is equivalent in HIV-infected and HIV-uninfected individuals.
Academic Article Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers.
Academic Article Bacterial vaginosis-associated microflora isolated from the female genital tract activates HIV-1 expression.
Academic Article Immune recovery in HIV disease: role of the thymus and T cell expansion in immune reconstitution strategies.
Academic Article Immunological effects of antiretroviral and immune therapies for HIV.
Academic Article CD1d-restricted natural killer T cells are potent targets for human immunodeficiency virus infection.
Academic Article Evaluation of the impact of highly active antiretroviral therapy on immune recovery in antiretroviral naive patients.
Academic Article The impact of the ovulatory cycle on cytokine production: evaluation of systemic, cervicovaginal, and salivary compartments.
Academic Article Immunophenotypic alterations in acute and early HIV infection.
Academic Article Interleukin-7 signalling is sufficient to phenotypically and functionally prime human CD4 naive T cells.
Academic Article Evaluation of thymopoiesis using T cell receptor excision circles (TRECs): differential correlation between adult and pediatric TRECs and na?ve phenotypes.
Academic Article Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA).
Academic Article Methamphetamine and HIV-1 Tat down regulate ?-catenin signaling: implications for methampetamine abuse and HIV-1 co-morbidity.
Academic Article Combined chronic blockade of hyper-active L-type calcium channels and NMDA receptors ameliorates HIV-1 associated hyper-excitability of mPFC pyramidal neurons.
Academic Article Enriching for HIV-infected cells using anti-gp41 antibodies indirectly conjugated to magnetic microbeads.
Academic Article Immune modulation of HIV replication: relevance to HIV immuno- and neuro-pathogenesis.
Academic Article Assessing thymopoiesis in patients with common variable immunodeficiency as measured by T-cell receptor excision circles.
Academic Article Gamma interferon primes productive human immunodeficiency virus infection in astrocytes.
Academic Article Multiple populations of T lymphocytes are distinguished by the level of CD4 and CD8 coexpression and require individual consideration.
Academic Article Negative-strand hepatitis C virus (HCV) RNA in peripheral blood mononuclear cells from anti-HCV-positive/HIV-infected women.
Academic Article Human immunodeficiency virus-restricted replication in astrocytes and the ability of gamma interferon to modulate this restriction are regulated by a downstream effector of the Wnt signaling pathway.
Academic Article Active beta-catenin signaling is an inhibitory pathway for human immunodeficiency virus replication in peripheral blood mononuclear cells.
Academic Article Potent HIV-specific responses are enriched in a unique subset of CD8+ T cells that coexpresses CD4 on its surface.
Academic Article Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells.
Academic Article Role of ?-catenin/TCF-4 signaling in HIV replication and pathogenesis: insights to informing novel anti-HIV molecular therapeutics.
Academic Article Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors.
Academic Article IFN-gamma mediates enhancement of HIV replication in astrocytes by inducing an antagonist of the beta-catenin pathway (DKK1) in a STAT 3-dependent manner.
Academic Article Human FasL gene is a target of ?-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions.
Academic Article Role of ?-catenin and TCF/LEF family members in transcriptional activity of HIV in astrocytes.
Academic Article NKG2D signaling on CD8? T cells represses T-bet and rescues CD4-unhelped CD8? T cell memory recall but not effector responses.
Academic Article Mechanisms of HIV-1 latency post HAART treatment area.
Academic Article Identification of novel T cell factor 4 (TCF-4) binding sites on the HIV long terminal repeat which associate with TCF-4, ?-catenin, and SMAR1 to repress HIV transcription.
Academic Article Comment on "CD4+ CD8+ T cells represent a significant portion of the anti-HIV T cell response to acute HIV infection".
Academic Article Interplay between Wnt/?-catenin signaling and HIV: virologic and biologic consequences in the CNS.
Academic Article Wnt/?-catenin and its diverse physiological cell signaling pathways in neurodegenerative and neuropsychiatric disorders.
Academic Article Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription through its intact core and cysteine-rich domains inhibits Wnt/?-catenin signaling in astrocytes: relevance to HIV neuropathogenesis.
Academic Article 17?-Estradiol inhibits HIV-1 by inducing a complex formation between ?-catenin and estrogen receptor a on the HIV promoter to suppress HIV transcription.
Academic Article Epigenetic regulation of HIV-1 latency in astrocytes.
Academic Article HIV infection accelerates gastrointestinal tumor outgrowth in NSG-HuPBL mice.
Academic Article ?-Catenin/TCF-4 signaling regulates susceptibility of macrophages and resistance of monocytes to HIV-1 productive infection.
Academic Article Dynamic interaction between astrocytes and infiltrating PBMCs in context of neuroAIDS.
Academic Article HIV Infection Leads to Redistribution of Leaky Claudin-2 in the Intestine of Humanized SCID IL-2R(-/-) Hu-PBMC Mice.
Academic Article Migration of CD8+ T Cells into the Central Nervous System Gives Rise to Highly Potent Anti-HIV CD4dimCD8bright T Cells in a Wnt Signaling-Dependent Manner.
Academic Article ?-Catenin signaling positively regulates glutamate uptake and metabolism in astrocytes.
Academic Article Plasma dickkopf-related protein 1, an antagonist of the Wnt pathway, is associated with HIV-associated neurocognitive impairment.
Academic Article Wnt7a induces a unique phenotype of monocyte-derived macrophages with lower phagocytic capacity and differential expression of pro- and anti-inflammatory cytokines.
Academic Article HIV and drug abuse mediate astrocyte senescence in a ?-catenin-dependent manner leading to neuronal toxicity.
Academic Article The periodontal restorative interface: esthetic considerations.
Academic Article Periodontal diseases in an Omani adult population: a preliminary study.
Academic Article Periodontitis among adult populations in the Arab World.
Academic Article Human immunodeficiency virus type-1 transcription: role of the 5'-untranslated leader region (review).
Academic Article Interleukin-10 enhances tumor necrosis factor-alpha activation of HIV-1 transcription in latently infected T cells.
Academic Article The cAMP-dependent protein kinase A and protein kinase C-beta pathways synergistically interact to activate HIV-1 transcription in latently infected cells of monocyte/macrophage lineage.
Academic Article Molecular inhibition of HIV type 1 by HIV type 2: effectiveness in peripheral blood mononuclear cells.
Academic Article TNFalpha cooperates with the protein kinase A pathway to synergistically increase HIV-1 LTR transcription via downstream TRE-like cAMP response elements.
Academic Article Induction of melanin biosynthesis in Vibrio cholerae.
Academic Article Aging alters voltage-gated calcium channels in prefrontal cortex pyramidal neurons in the HIV brain.
Academic Article Methamphetamine decreases K+ channel function in human fetal astrocytes by activating the trace amine-associated receptor type-1.
Academic Article Astrocytes as an HIV CNS reservoir: highlights and reflections of an NIMH-sponsored symposium.
Academic Article Letter to Editor.
Academic Article Correction to: Astrocytes as an HIV CNS reservoir: highlights and reflections of an NIMH-sponsored symposium.
Academic Article Aging and HIV-1 alter the function of specific K+ channels in prefrontal cortex pyramidal neurons.
Academic Article The far-reaching HAND of cART: cART effects on astrocytes.
Academic Article Ginkgolic acid inhibits fusion of enveloped viruses.
Academic Article Author Correction: Ginkgolic acid inhibits fusion of enveloped viruses.
Academic Article Circulating sclerostin is associated with bone mineral density independent of HIV-serostatus.
Academic Article HIV infects astrocytes in vivo and egresses from the brain to the periphery.
Academic Article ?-Catenin and TCFs/LEF signaling discordantly regulate IL-6 expression in astrocytes.
Academic Article What HIV in the Brain Can Teach Us About SARS-CoV-2 Neurological Complications?
Academic Article Negative regulation of IL-8 in human astrocytes depends on ?-catenin while positive regulation is mediated by TCFs/LEF/ATF2 interaction.
Academic Article Canonical Wnts Mediate CD8+ T Cell Noncytolytic Anti-HIV-1 Activity and Correlate with HIV-1 Clinical Status.
Academic Article CD32 is enriched on CD4dimCD8bright T cells.
Academic Article Change in Circulating Undercarboxylated Osteocalcin (ucOCN) Is Associated With Fat Accumulation in HIV-Seropositive Women.
Academic Article Placing a mask on COVID-19 patients during high-flow nasal cannula therapy reduces aerosol particle dispersion.
Academic Article Triumeq Increases Excitability of Pyramidal Neurons in the Medial Prefrontal Cortex by Facilitating Voltage-Gated Ca2+ Channel Function.
Academic Article ?-Catenin Restricts Zika Virus Internalization by Downregulating Axl.
Academic Article HIV in the Brain: Identifying Viral Reservoirs and Addressing the Challenges of an HIV Cure.
Academic Article Next-Generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire.
Academic Article ?-catenin regulates HIV latency and modulates HIV reactivation.
Academic Article Anti-HIV Drugs Cause Mitochondrial Dysfunction in Monocyte-Derived Macrophages.
Academic Article Bone Quality in Relation to HIV and Antiretroviral Drugs.
Academic Article An Efficient Humanized Mouse Model for Oral Anti-Retroviral Administration.
Academic Article Bulk IgG glycosylation predicts COVID-19 severity and vaccine antibody response.
Academic Article Brain autopsies of critically ill COVID-19 patients demonstrate heterogeneous profile of acute vascular injury, inflammation and age-linked chronic brain diseases.
Academic Article An Efficient and Cost-Effective Approach to Generate Functional Human Inducible Pluripotent Stem Cell-Derived Astrocytes.
Academic Article The Human Microbiome and Its Role in Musculoskeletal Disorders.
Academic Article CD4dim CD8bright T Cells Home to the Brain and Mediate HIV Neuroinvasion.
Academic Article HIV infection of non-classical cells in the brain.
Academic Article Wnt/?-Catenin Protects Lymphocytes from HIV-Mediated Apoptosis via Induction of Bcl-xL.
Academic Article Hyperactivity of medial prefrontal cortex pyramidal neurons occurs in a mouse model of early-stage Alzheimer's disease without ?-amyloid accumulation.
Academic Article HIV-Induced Hyperactivity of Striatal Neurons Is Associated with Dysfunction of Voltage-Gated Calcium and Potassium Channels at Middle Age.
Academic Article CD4 dim CD8 bright T cells are inversely associated with neuro-inflammatory markers among people with HIV.
Concept Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
Concept Gastrointestinal Microbiome
Concept Glycogen Synthase Kinase 3 beta
Concept CX3C Chemokine Receptor 1
Concept Transcription Factor 4
Academic Article Prevalence and correlates of depressive symptoms among people living with HIV attending tertiary care hospitals in Oman.
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