Chromatin Immunoprecipitation
"Chromatin Immunoprecipitation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.
| Descriptor ID |
D047369
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| MeSH Number(s) |
E05.393.170 E05.478.605.160
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Chromatin Immunoprecipitation".
Below are MeSH descriptors whose meaning is more specific than "Chromatin Immunoprecipitation".
This graph shows the total number of publications written about "Chromatin Immunoprecipitation" by people in this website by year, and whether "Chromatin Immunoprecipitation" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 5 | 5 |
| 2008 | 1 | 0 | 1 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 2 | 2 |
| 2016 | 0 | 2 | 2 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Chromatin Immunoprecipitation" by people in Profiles.
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Amelioration of Autoimmune Arthritis in Mice Treated With the DNA Methyltransferase Inhibitor 5'-Azacytidine. Arthritis Rheumatol. 2019 08; 71(8):1265-1275.
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A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research. Sci Data. 2018 08 07; 5:180142.
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?-Catenin signaling positively regulates glutamate uptake and metabolism in astrocytes. J Neuroinflammation. 2016 09 10; 13(1):242.
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GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium. Aging Cell. 2016 10; 15(5):792-800.
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CEBPD amplification and overexpression in urothelial carcinoma: a driver of tumor metastasis indicating adverse prognosis. Oncotarget. 2015 Oct 13; 6(31):31069-84.
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ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells. Mol Cancer Ther. 2015 Apr; 14(4):877-88.
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SOX9 regulates multiple genes in chondrocytes, including genes encoding ECM proteins, ECM modification enzymes, receptors, and transporters. PLoS One. 2014; 9(9):e107577.
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REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014 03 27; 507(7493):448-54.
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CMGRN: a web server for constructing multilevel gene regulatory networks using ChIP-seq and gene expression data. Bioinformatics. 2014 04 15; 30(8):1190-1192.
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Chromatin immunoprecipitation assays: application of ChIP-on-chip for defining dynamic transcriptional mechanisms in bone cells. Methods Mol Biol. 2008; 455:165-76.