"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015536
|
| MeSH Number(s) |
G02.111.240 G05.308.200 G07.690.773.937
|
| Concept/Terms |
Down-Regulation- Down-Regulation
- Down Regulation
- Downregulation
- Down-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Down-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".
This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 4 | 4 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 2 | 2 |
| 2000 | 1 | 0 | 1 |
| 2001 | 2 | 1 | 3 |
| 2002 | 2 | 1 | 3 |
| 2003 | 2 | 4 | 6 |
| 2004 | 1 | 3 | 4 |
| 2005 | 0 | 4 | 4 |
| 2007 | 1 | 6 | 7 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 3 | 3 |
| 2010 | 3 | 1 | 4 |
| 2011 | 1 | 3 | 4 |
| 2012 | 1 | 1 | 2 |
| 2013 | 0 | 3 | 3 |
| 2014 | 0 | 6 | 6 |
| 2015 | 1 | 2 | 3 |
| 2016 | 0 | 2 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 2 | 2 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Down-Regulation" by people in Profiles.
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Bone metastatic breast cancer cells display downregulation of PKC-? with enhanced glutamine metabolism. Gene. 2021 Apr 05; 775:145419.
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TGF-? type 2 receptor-mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis. Sci Transl Med. 2019 05 08; 11(491).
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Distinct genome-wide methylation patterns in sporadic and hereditary nonfunctioning pancreatic neuroendocrine tumors. Cancer. 2019 04 15; 125(8):1247-1257.
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HDAC1 overexpression enhances ?-cell proliferation by down-regulating Cdkn1b/p27. Biochem J. 2018 12 19; 475(24):3997-4010.
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Transcription factor Zbtb38 downregulates the expression of anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis. Biochim Biophys Acta Gene Regul Mech. 2018 11; 1861(11):1040-1047.
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Creatinine downregulates TNF-a in macrophage and T cell lines. Cytokine. 2018 Oct; 110:29-38.
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Trans-suppression of host CDH3 and LOXL4 genes during Cryptosporidium parvum infection involves nuclear delivery of parasite Cdg7_FLc_1000 RNA. Int J Parasitol. 2018 May; 48(6):423-431.
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Involvement of Cryptosporidium parvum Cdg7_FLc_1000 RNA in the Attenuation of Intestinal Epithelial Cell Migration via Trans-Suppression of Host Cell SMPD3. J Infect Dis. 2017 Dec 27; 217(1):122-133.
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Inhibition of Sp1 prevents ER homeostasis and causes cell death by lysosomal membrane permeabilization in pancreatic cancer. Sci Rep. 2017 05 08; 7(1):1564.
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Smpd3 Expression in both Chondrocytes and Osteoblasts Is Required for Normal Endochondral Bone Development. Mol Cell Biol. 2016 09 01; 36(17):2282-99.