"Drug Tolerance" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
| Descriptor ID |
D004361
|
| MeSH Number(s) |
G07.690.773.992
|
| Concept/Terms |
Drug Tolerance- Drug Tolerance
- Drug Tolerances
- Tolerance, Drug
- Tolerances, Drug
|
Below are MeSH descriptors whose meaning is more general than "Drug Tolerance".
Below are MeSH descriptors whose meaning is more specific than "Drug Tolerance".
This graph shows the total number of publications written about "Drug Tolerance" by people in this website by year, and whether "Drug Tolerance" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
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Below are the most recent publications written about "Drug Tolerance" by people in Profiles.
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Open-label flexible-dose pilot study to evaluate the safety and tolerability of aripiprazole in patients with psychosis associated with Parkinson's disease. Mov Disord. 2006 Dec; 21(12):2078-81.
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Benzodiazepines in clinical practice: consideration of their long-term use and alternative agents. J Clin Psychiatry. 2005; 66 Suppl 2:21-7.
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A comparison of the efficacy, safety, and tolerability of divalproex sodium and olanzapine in the treatment of bipolar disorder. J Clin Psychiatry. 2002 Dec; 63(12):1148-55.
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Antinociceptive potentiation and attenuation of tolerance by intrathecal co-infusion of magnesium sulfate and morphine in rats. Anesth Analg. 1998 Apr; 86(4):830-6.
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Carboplatin/etoposide/radiation plus escalating doses of paclitaxel in stage III non-small cell lung cancer: a preliminary report. Semin Oncol. 1995 Aug; 22(4 Suppl 9):42-7.
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Treatment of patients with advanced HIV infection and zidovudine intolerance with dideoxyinosine. AIDS. 1992 Jul; 6(7):748-9.
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Long-term management of panic disorder. J Clin Psychiatry. 1990 May; 51 Suppl:11-3; discussion 50-3.
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LSD and other related hallucinogens elicit myoclonic jumping behavior in the guinea pig. Prog Neuropsychopharmacol Biol Psychiatry. 1989; 13(1-2):199-210.
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Drug signals enhance morphine tolerance development in hypophysectomized rats. Psychopharmacology (Berl). 1983; 79(1):84-5.
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Alprazolam: pharmacokinetics, clinical efficacy, and mechanism of action. Pharmacotherapy. 1982 Sep-Oct; 2(5):243-54.