Structure-Activity Relationship
"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
| Descriptor ID |
D013329
|
| MeSH Number(s) |
G02.111.830 G07.690.773.997
|
| Concept/Terms |
Structure-Activity Relationship- Structure-Activity Relationship
- Relationship, Structure-Activity
- Relationships, Structure-Activity
- Structure Activity Relationship
- Structure-Activity Relationships
|
Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".
Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".
This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 3 | 3 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 3 | 3 |
| 2017 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.
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Examination of Coligands in Mefloquine-Metal Complexes Reveals the Structural Determinants of Activity against Plasmodium falciparum and Schistosoma mansoni. J Med Chem. 2026 Apr 23; 69(8):9242-9264.
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Taking Advantage of the Morpheein Behavior of Peroxiredoxin in Bionanotechnology. Bioconjug Chem. 2021 01 20; 32(1):43-62.
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CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor. Nat Commun. 2017 02 23; 8(1):7.
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Synthesis and evaluation of 1,4-naphthoquinone ether derivatives as SmTGR inhibitors and new anti-schistosomal drugs. FEBS J. 2015 Aug; 282(16):3199-217.
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Discovery of oxathiapiprolin, a new oomycete fungicide that targets an oxysterol binding protein. Bioorg Med Chem. 2016 Feb 01; 24(3):354-61.
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Antimalarial NADPH-Consuming Redox-Cyclers As Superior Glucose-6-Phosphate Dehydrogenase Deficiency Copycats. Antioxid Redox Signal. 2015 May 20; 22(15):1337-51.
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New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni. Eur J Med Chem. 2014 Sep 12; 84:135-45.
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Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets. Curr Rheumatol Rep. 2013 Aug; 15(8):350.
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1-Phenyl-4-benzoyl-1H-1,2,3-triazoles as orally bioavailable transcriptional function suppressors of estrogen-related receptor a. J Med Chem. 2013 Jun 13; 56(11):4631-40.
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Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors. J Med Chem. 2012 Jun 14; 55(11):5291-310.