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David L Williams

TitleAssociate Professor
InstitutionRush University, Rush Medical College
DepartmentMicrobial Pathogens and Immunity
AddressChicago IL 60612
Phone312-942-1375
Fax312-942-2808
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    Collapse Overview 
    Collapse overview
    My Scopus ID is 55574201569.
    My NIH COMMONS name is DLWILLI.

    Research Areas:
    Schistosomiasis, redox biology, drug development.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/david-l-williams-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/microbial-pathogens-and-immunity-research/laboratory-david-l-williams-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/pubmed/?term=David+L+Williams

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=55574201569

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Petukhova VZ, Aboagye SY, Ardini M, Lullo RP, Fata F, Byrne ME, Gabriele F, Martin LM, Harding LNM, Gone V, Dangi B, Lantvit DD, Nikolic D, Ippoliti R, Effantin G, Ling WL, Johnson JJ, Thatcher GRJ, Angelucci F, Williams DL, Petukhov PA. Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo. Nat Commun. 2023 06 22; 14(1):3737. PMID: 37349300.
      Citations:    
    2. Smith MM, Alt TB, Williams DL, Moran GR. Descriptive Analysis of Transient-State Observations for Thioredoxin/Glutathione Reductase (Sec597Cys) from Schistosoma mansoni. Biochemistry. 2023 05 02; 62(9):1497-1508. PMID: 37071546.
      Citations:    
    3. Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I. An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity. Cell. 2022 02 17; 185(4):614-629.e21. PMID: 35148840.
      Citations:    
    4. Lyu H, Petukhov PA, Banta PR, Jadhav A, Lea WA, Cheng Q, Arn?r ESJ, Simeonov A, Thatcher GRJ, Angelucci F, Williams DL. Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis. ACS Infect Dis. 2020 03 13; 6(3):393-405. PMID: 31939288.
      Citations:    
    5. Silvestri I, Lyu H, Fata F, Banta PR, Mattei B, Ippoliti R, Bellelli A, Pitari G, Ardini M, Petukhova V, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F. Ectopic suicide inhibition of thioredoxin glutathione reductase. Free Radic Biol Med. 2020 02 01; 147:200-211. PMID: 31870799.
      Citations:    
    6. Hoyer FF, Naxerova K, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M. Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge. Immunity. 2019 11 19; 51(5):899-914.e7. PMID: 31732166.
      Citations:    
    7. Ziniel PD, Karumudi B, Barnard AH, Fisher EM, Thatcher GR, Podust LM, Williams DL. The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development. PLoS Negl Trop Dis. 2015 Dec; 9(12):e0004279. PMID: 26713732.
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    8. Li T, Ziniel PD, He PQ, Kommer VP, Crowther GJ, He M, Liu Q, Van Voorhis WC, Williams DL, Wang MW. High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis. Infect Dis Poverty. 2015 Aug 31; 4:40. PMID: 26341081.
      Citations:    
    9. Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rasc?n AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari JA. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003534. PMID: 25700363.
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    10. Wang YT, Piyankarage SC, Williams DL, Thatcher GR. Proteomic profiling of nitrosative stress: protein S-oxidation accompanies S-nitrosylation. ACS Chem Biol. 2014 Mar 21; 9(3):821-30. PMID: 24397869.
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    11. Ziniel PD, Desai J, Cass CL, Gatto C, Oldfield E, Williams DL. Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni. Antimicrob Agents Chemother. 2013 Dec; 57(12):5969-76. PMID: 24041901.
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    12. Rigouin C, Vermeire JJ, Nylin E, Williams DL. Characterization of the phytochelatin synthase from the human parasitic nematode Ancylostoma ceylanicum. Mol Biochem Parasitol. 2013 Sep; 191(1):1-6. PMID: 23916800.
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    13. Rigouin C, Nylin E, Cogswell AA, Schauml?ffel D, Dobritzsch D, Williams DL. Towards an understanding of the function of the phytochelatin synthase of Schistosoma mansoni. PLoS Negl Trop Dis. 2013; 7(1):e2037. PMID: 23383357.
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    14. Cogswell AA, Kommer VP, Williams DL. Transcriptional analysis of a unique set of genes involved in Schistosoma mansoni female reproductive biology. PLoS Negl Trop Dis. 2012; 6(11):e1907. PMID: 23166854.
      Citations:    
    15. Williams DL, Bonilla M, Gladyshev VN, Salinas G. Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites. Antioxid Redox Signal. 2013 Sep 01; 19(7):735-45. PMID: 22909029.
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    16. Treger RS, Cook AG, Rai G, Maloney DJ, Simeonov A, Jadhav A, Thomas CJ, Williams DL, Cappello M, Vermeire JJ. Oxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione reductase is not the primary target. Int J Parasitol Drugs Drug Resist. 2012 Dec 01; 2:171-177. PMID: 22844653.
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    17. Saccoccia F, Di Micco P, Boumis G, Brunori M, Koutris I, Miele AE, Morea V, Sriratana P, Williams DL, Bellelli A, Angelucci F. Moonlighting by different stressors: crystal structure of the chaperone species of a 2-Cys peroxiredoxin. Structure. 2012 Mar 07; 20(3):429-39. PMID: 22405002.
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    18. Huang HH, Rigouin C, Williams DL. The redox biology of schistosome parasites and applications for drug development. Curr Pharm Des. 2012; 18(24):3595-611. PMID: 22607149.
      Citations:    
    19. Huang HH, Day L, Cass CL, Ballou DP, Williams CH, Williams DL. Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni. Biochemistry. 2011 Jul 05; 50(26):5870-82. PMID: 21630672.
      Citations:    
    20. Ray D, Williams DL. Characterization of the phytochelatin synthase of Schistosoma mansoni. PLoS Negl Trop Dis. 2011 May; 5(5):e1168. PMID: 21629724.
      Citations:    
    21. Cogswell AA, Collins JJ, Newmark PA, Williams DL. Whole mount in situ hybridization methodology for Schistosoma mansoni. Mol Biochem Parasitol. 2011 Jul-Aug; 178(1-2):46-50. PMID: 21397637.
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    22. Collins JJ, King RS, Cogswell A, Williams DL, Newmark PA. An atlas for Schistosoma mansoni organs and life-cycle stages using cell type-specific markers and confocal microscopy. PLoS Negl Trop Dis. 2011 Mar 08; 5(3):e1009. PMID: 21408085.
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    23. Oke TT, Moskovitz J, Williams DL. Characterization of the methionine sulfoxide reductases of Schistosoma mansoni. J Parasitol. 2009 Dec; 95(6):1421-8. PMID: 19604033.
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    24. Sayed AA, Simeonov A, Thomas CJ, Inglese J, Austin CP, Williams DL. Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nat Med. 2008 Apr; 14(4):407-12. PMID: 18345010.
      Citations:    
    25. Cass CL, Johnson JR, Califf LL, Xu T, Hernandez HJ, Stadecker MJ, Yates JR, Williams DL. Proteomic analysis of Schistosoma mansoni egg secretions. Mol Biochem Parasitol. 2007 Oct; 155(2):84-93. PMID: 17644200.
      Citations:    
    26. Kuntz AN, Davioud-Charvet E, Sayed AA, Califf LL, Dessolin J, Arn?r ES, Williams DL. Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target. PLoS Med. 2007 Jun; 4(6):e206. PMID: 17579510.
      Citations:    
    27. Williams DL, Sayed AA, Bernier J, Birkeland SR, Cipriano MJ, Papa AR, McArthur AG, Taft A, Vermeire JJ, Yoshino TP. Profiling Schistosoma mansoni development using serial analysis of gene expression (SAGE). Exp Parasitol. 2007 Nov; 117(3):246-58. PMID: 17577588.
      Citations:    
    28. Williams DL, Sayed AA, Ray D, McArthur AG. Schistosoma mansoni albumin, a major defense against oxidative damage, was acquired by lateral gene transfer from a mammalian host. Mol Biochem Parasitol. 2006 Dec; 150(2):359-63. PMID: 16934344.
      Citations:    
    29. Sayed AA, Cook SK, Williams DL. Redox balance mechanisms in Schistosoma mansoni rely on peroxiredoxins and albumin and implicate peroxiredoxins as novel drug targets. J Biol Chem. 2006 Jun 23; 281(25):17001-17010. PMID: 16606626.
      Citations:    
    30. Williams DL, Asahi H, Oke TT, Lopes da Rosa J, Stadecker MJ. Murine immune responses to a novel schistosome egg antigen, SmEP25. Int J Parasitol. 2005 Jul; 35(8):875-82. PMID: 15970293.
      Citations:    
    31. Sayed AA, Williams DL. Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni. J Biol Chem. 2004 Jun 18; 279(25):26159-66. PMID: 15075328.
      Citations:    
    32. Vermeire JJ, Osman A, LoVerde PT, Williams DL. Characterisation of a Rho homologue of Schistosoma mansoni. Int J Parasitol. 2003 Jul; 33(7):721-31. PMID: 12814652.
      Citations:    
    33. B?niguel L, Diallo TO, Remou? F, Williams DL, Cognasse F, Charrier-Mze N, N'Diaye AA, Perraut R, Capron M, Riveau G, Garraud O. Differential production in vitro of antigen specific IgG1, IgG3 and IgA: a study in Schistosoma haematobium infected individuals. Parasite Immunol. 2003 Jan; 25(1):39-44. PMID: 12753436.
      Citations:    
    34. Foulk BW, Pappas G, Hirai Y, Hirai H, Williams DL. Adenylosuccinate lyase of Schistosoma mansoni: gene structure, mRNA expression, and analysis of the predicted peptide structure of a potential chemotherapeutic target. Int J Parasitol. 2002 Nov; 32(12):1487-95. PMID: 12392914.
      Citations:    
    35. Alger HM, Sayed AA, Stadecker MJ, Williams DL. Molecular and enzymatic characterisation of Schistosoma mansoni thioredoxin. Int J Parasitol. 2002 Sep; 32(10):1285-92. PMID: 12204228.
      Citations:    
    36. Alger HM, Williams DL. The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase. Mol Biochem Parasitol. 2002 Apr 30; 121(1):129-39. PMID: 11985869.
      Citations:    
    37. Williams DL, Asahi H, Botkin DJ, Stadecker MJ. Schistosome infection stimulates host CD4(+) T helper cell and B-cell responses against a novel egg antigen, thioredoxin peroxidase. Infect Immun. 2001 Feb; 69(2):1134-41. PMID: 11160011.
      Citations:    
    38. Kwatia MA, Botkin DJ, Williams DL. Molecular and enzymatic characterization of Schistosoma mansoni thioredoxin peroxidase. J Parasitol. 2000 Oct; 86(5):908-15. PMID: 11128509.
      Citations:    
    39. Le Paslier MC, Pierce RJ, Merlin F, Hirai H, Wu W, Williams DL, Johnston D, LoVerde PT, Le Paslier D. Construction and characterization of a Schistosoma mansoni bacterial artificial chromosome library. Genomics. 2000 Apr 15; 65(2):87-94. PMID: 10783255.
      Citations:    
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