Core Binding Factor alpha Subunits
"Core Binding Factor alpha Subunits" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.
| Descriptor ID |
D050657
|
| MeSH Number(s) |
D12.776.930.155.200
|
| Concept/Terms |
Core Binding Factor alpha Subunits- Core Binding Factor alpha Subunits
- Core Binding Factor alpha Proteins
- Runx Proteins
- Polyomavirus Enhancer A Binding Protein 2
- Polyomavirus Enhancer Binding Protein 2, Alpha Subunit
- Runt Domain Factor
- Acute Myeloid Leukemia Proteins
- PEBP2A Transcription Factors
- Transcription Factors, PEBP2A
|
Below are MeSH descriptors whose meaning is more general than "Core Binding Factor alpha Subunits".
Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor alpha Subunits".
This graph shows the total number of publications written about "Core Binding Factor alpha Subunits" by people in this website by year, and whether "Core Binding Factor alpha Subunits" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 2 | 2 |
| 2005 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "Core Binding Factor alpha Subunits" by people in Profiles.
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Nuclear microenvironments in biological control and cancer. Nat Rev Cancer. 2007 Jun; 7(6):454-63.
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Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer. Adv Enzyme Regul. 2005; 45:136-54.
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Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1454-9.
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Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer. Blood Cells Mol Dis. 2003 Mar-Apr; 30(2):170-6.
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Temporal and spatial parameters of skeletal gene expression: targeting RUNX factors and their coregulatory proteins to subnuclear domains. Connect Tissue Res. 2003; 44 Suppl 1:149-53.