Core Binding Factor Alpha 1 Subunit
"Core Binding Factor Alpha 1 Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
| Descriptor ID |
D050659
|
| MeSH Number(s) |
D12.776.930.155.200.100
|
| Concept/Terms |
Core Binding Factor Alpha 1 Subunit- Core Binding Factor Alpha 1 Subunit
- AML3 Transcription Factor
- CBFA-1 Protein
- CBFA 1 Protein
- CBFA1 Protein
- CBFalpha Runt Domain Transcription Factor 1
- Osf2 Transcription Factor
- PEBP2alphaA Protein
- Runx2 Protein
- SEF1 Protein
- SL3-3 Enhancer Factor 1
- SL3 3 Enhancer Factor 1
- Acute Myeloid Leukemia 3 Protein
- CBFalpha1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Core Binding Factor Alpha 1 Subunit".
Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor Alpha 1 Subunit".
This graph shows the total number of publications written about "Core Binding Factor Alpha 1 Subunit" by people in this website by year, and whether "Core Binding Factor Alpha 1 Subunit" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 2 | 2 |
| 2005 | 1 | 5 | 6 |
| 2006 | 1 | 0 | 1 |
| 2007 | 3 | 0 | 3 |
| 2008 | 5 | 0 | 5 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 2 | 0 | 2 |
| 2019 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Core Binding Factor Alpha 1 Subunit" by people in Profiles.
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Loss of miR-204 and miR-211 shifts osteochondral balance and causes temporomandibular joint osteoarthritis. J Cell Physiol. 2023 Nov; 238(11):2668-2678.
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The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression. Nat Commun. 2019 06 28; 10(1):2876.
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Deletion of Runx2 in condylar chondrocytes disrupts TMJ tissue homeostasis. J Cell Physiol. 2019 Apr; 234(4):3436-3444.
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Runx2 is required for postnatal intervertebral disc tissue growth and development. J Cell Physiol. 2019 05; 234(5):6679-6687.
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Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice. Sci Rep. 2017 05 24; 7(1):2371.
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The role of Runx2 in facilitating autophagy in metastatic breast cancer cells. J Cell Physiol. 2018 Jan; 233(1):559-571.
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Role of Runx2 in IGF-1R?/Akt- and AMPK/Erk-dependent growth, survival and sensitivity towards metformin in breast cancer bone metastasis. Oncogene. 2016 09 08; 35(36):4730-40.
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Environmental disruption of circadian rhythm predisposes mice to osteoarthritis-like changes in knee joint. J Cell Physiol. 2015 Sep; 230(9):2174-2183.
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Role of Runx2 in crosstalk between Mek/Erk and PI3K/Akt signaling in MCF-10A cells. J Cell Biochem. 2014 Dec; 115(12):2208-17.
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Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells. Breast Cancer Res. 2014 Jan 30; 16(1):R16.