Core Binding Factor Alpha 1 Subunit
"Core Binding Factor Alpha 1 Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
| Descriptor ID |
D050659
|
| MeSH Number(s) |
D12.776.930.155.200.100
|
| Concept/Terms |
Core Binding Factor Alpha 1 Subunit- Core Binding Factor Alpha 1 Subunit
- AML3 Transcription Factor
- CBFA-1 Protein
- CBFA 1 Protein
- CBFA1 Protein
- CBFalpha Runt Domain Transcription Factor 1
- Osf2 Transcription Factor
- PEBP2alphaA Protein
- Runx2 Protein
- SEF1 Protein
- SL3-3 Enhancer Factor 1
- SL3 3 Enhancer Factor 1
- Acute Myeloid Leukemia 3 Protein
- CBFalpha1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Core Binding Factor Alpha 1 Subunit".
Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor Alpha 1 Subunit".
This graph shows the total number of publications written about "Core Binding Factor Alpha 1 Subunit" by people in this website by year, and whether "Core Binding Factor Alpha 1 Subunit" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Core Binding Factor Alpha 1 Subunit" by people in Profiles.
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Deletion of Runx2 in condylar chondrocytes disrupts TMJ tissue homeostasis. J Cell Physiol. 2019 Apr; 234(4):3436-3444.
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The role of Runx2 in facilitating autophagy in metastatic breast cancer cells. J Cell Physiol. 2018 Jan; 233(1):559-571.
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Role of Runx2 in IGF-1R?/Akt- and AMPK/Erk-dependent growth, survival and sensitivity towards metformin in breast cancer bone metastasis. Oncogene. 2016 09 08; 35(36):4730-40.
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Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1. Stem Cells. 2011 Oct; 29(10):1601-10.