Interferon Regulatory Factor-1
"Interferon Regulatory Factor-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An interferon regulatory factor that binds upstream TRANSCRIPTIONAL REGULATORY ELEMENTS in the GENES for INTERFERON-ALPHA and INTERFERON-BETA. It functions as a transcriptional activator for the INTERFERON TYPE I genes.
| Descriptor ID |
D050856
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| MeSH Number(s) |
D12.644.360.024.302.124 D12.776.157.057.050.124 D12.776.260.108.374 D12.776.260.504.124 D12.776.476.024.385.124 D12.776.930.127.374 D12.776.930.332.124
|
| Concept/Terms |
Interferon Regulatory Factor-1- Interferon Regulatory Factor-1
- Interferon Regulatory Factor 1
- IRF-1 Protein
- IRF 1 Protein
- IREBF1 Transcription Factor
- Transcription Factor, IREBF1
- IREBF1 Protein
- IRF-1 Transcription Factor
- Factor, IRF-1 Transcription
- IRF 1 Transcription Factor
- Transcription Factor, IRF-1
- ISGF1 Transcription Factor
- Factor, ISGF1 Transcription
- Transcription Factor, ISGF1
- Interferon-Stimulated Gene Factor 1
- Interferon Stimulated Gene Factor 1
- MyD32 Protein
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Below are MeSH descriptors whose meaning is more general than "Interferon Regulatory Factor-1".
Below are MeSH descriptors whose meaning is more specific than "Interferon Regulatory Factor-1".
This graph shows the total number of publications written about "Interferon Regulatory Factor-1" by people in this website by year, and whether "Interferon Regulatory Factor-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 2 | 0 | 2 |
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Below are the most recent publications written about "Interferon Regulatory Factor-1" by people in Profiles.
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Interferon regulatory factor 1 regulation of oligodendrocyte injury and inflammatory demyelination. Rev Neurosci. 2012 Jan 26; 23(2):145-52.
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Overexpression of the dominant-negative form of interferon regulatory factor 1 in oligodendrocytes protects against experimental autoimmune encephalomyelitis. J Neurosci. 2011 Jun 08; 31(23):8329-41.
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IRF-1 signaling in central nervous system glial cells regulates inflammatory demyelination. J Neuroimmunol. 2011 Apr; 233(1-2):147-59.
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Central nervous system expression of interferon regulatory factor 1 regulates experimental autoimmune encephalomyelitis. J Neuroimmune Pharmacol. 2010 Jun; 5(2):260-5.
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STAT1/IRF-1 signaling pathway mediates the injurious effect of interferon-gamma on oligodendrocyte progenitor cells. Glia. 2010 Jan 15; 58(2):195-208.
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Overexpression of Bcl-2 differentially restores development of thymus-derived CD4-8+ T cells and intestinal intraepithelial T cells in IFN-regulatory factor-1-deficient mice. J Immunol. 2001 Jun 01; 166(11):6509-13.
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Human immunodeficiency virus type-1 transcription: role of the 5'-untranslated leader region (review). Int J Mol Med. 1998 May; 1(5):875-81.