"Smad Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins that are involved in the translocation of signals from TGF-BETA RECEPTORS; BONE MORPHOGENETIC PROTEIN RECEPTORS; and other surface receptors to the CELL NUCLEUS. They were originally identified as a class of proteins that are related to the mothers against decapentaplegic protein, Drosophila and sma proteins from CAENORHABDITIS ELEGANS.
| Descriptor ID |
D051785
|
| MeSH Number(s) |
D12.644.360.024.334 D12.776.157.057.170 D12.776.260.713 D12.776.476.024.428 D12.776.930.806
|
| Concept/Terms |
Smad Proteins- Smad Proteins
- Mothers Against Decapentaplegic Homolog
- Sma- and Mad-Related Proteins
|
Below are MeSH descriptors whose meaning is more general than "Smad Proteins".
Below are MeSH descriptors whose meaning is more specific than "Smad Proteins".
This graph shows the total number of publications written about "Smad Proteins" by people in this website by year, and whether "Smad Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2008 | 2 | 0 | 2 |
| 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "Smad Proteins" by people in Profiles.
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Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis. Ann N Y Acad Sci. 2011 Dec; 1240:61-9.
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Insulin-like growth factor 1 synergizes with bone morphogenetic protein 7-mediated anabolism in bovine intervertebral disc cells. Arthritis Rheum. 2010 Dec; 62(12):3706-15.
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Specific residues of RUNX2 are obligatory for formation of BMP2-induced RUNX2-SMAD complex to promote osteoblast differentiation. Cells Tissues Organs. 2009; 189(1-4):133-7.
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Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal. J Biol Chem. 2008 Mar 28; 283(13):8412-22.
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Transforming growth factor-beta promotes inactivation of extracellular thyroid hormones via transcriptional stimulation of type 3 iodothyronine deiodinase. Mol Endocrinol. 2005 Dec; 19(12):3126-36.
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Regulation of anabolic and catabolic gene expression in normal and osteoarthritic adult human articular chondrocytes by osteogenic protein-1. Clin Exp Rheumatol. 2004 Jan-Feb; 22(1):103-6.