"Elongin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heterotrimeric protein complex composed of 110 kDa elongin A, 18 kDa elongin B, and 15 kDa elongin C subunits. It functions as a positive regulator of RNA POLYMERASE II, increasing its rate of transcriptional elongation by suppressing transient pausing along the DNA template. Elongin A is the transcriptionally active component; elongins B and C enhance its activity.
| Descriptor ID |
D000075065
|
| MeSH Number(s) |
D12.776.260.197 D12.776.930.215
|
| Concept/Terms |
Elongin- Elongin
- SIII Elongation Factor
- Elongation Factor, SIII
- TF-SIII
- Transcription Factor SIII
- SIII, Transcription Factor
- Elongin Complex
- Complex, Elongin
|
Below are MeSH descriptors whose meaning is more general than "Elongin".
Below are MeSH descriptors whose meaning is more specific than "Elongin".
This graph shows the total number of publications written about "Elongin" by people in this website by year, and whether "Elongin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 2 | 2 |
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Below are the most recent publications written about "Elongin" by people in Profiles.
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Role of elongin-binding domain of von Hippel Lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma. Oncogene. 2005 Nov 24; 24(53):7850-8.
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The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. Nat Cell Biol. 2005 Jul; 7(7):698-705.