TCF Transcription Factors
"TCF Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of DNA-binding proteins that are primarily expressed in T-LYMPHOCYTES. They interact with BETA CATENIN and serve as transcriptional activators and repressors in a variety of developmental processes.
| Descriptor ID |
D051820
|
| MeSH Number(s) |
D12.776.260.730 D12.776.660.235.400.800 D12.776.664.235.400.800 D12.776.930.875
|
| Concept/Terms |
TCF Transcription Factors- TCF Transcription Factors
- Transcription Factors, TCF
- Lymphoid Enhancer Factors
- T-Cell Factors
- T Cell Factors
- LEF Transcription Factors
- Transcription Factors, LEF
|
Below are MeSH descriptors whose meaning is more general than "TCF Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "TCF Transcription Factors".
This graph shows the total number of publications written about "TCF Transcription Factors" by people in this website by year, and whether "TCF Transcription Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "TCF Transcription Factors" by people in Profiles.
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Negative regulation of IL-8 in human astrocytes depends on ?-catenin while positive regulation is mediated by TCFs/LEF/ATF2 interaction. Cytokine. 2020 12; 136:155252.
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?-Catenin signaling positively regulates glutamate uptake and metabolism in astrocytes. J Neuroinflammation. 2016 09 10; 13(1):242.
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Identification of novel T cell factor 4 (TCF-4) binding sites on the HIV long terminal repeat which associate with TCF-4, ?-catenin, and SMAR1 to repress HIV transcription. J Virol. 2012 Sep; 86(17):9495-503.
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Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells. J Immunol. 2010 Aug 15; 185(4):2013-9.
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Human immunodeficiency virus-restricted replication in astrocytes and the ability of gamma interferon to modulate this restriction are regulated by a downstream effector of the Wnt signaling pathway. J Virol. 2007 Jun; 81(11):5864-71.
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Ionomycin downregulates beta-catenin/Tcf signaling in colon cancer cell line. Carcinogenesis. 2005 Nov; 26(11):1929-33.
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Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. Biochem Biophys Res Commun. 2005 Mar 04; 328(1):227-34.