 p21-Activated Kinases
"p21-Activated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.
| Descriptor ID |
D054462
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| MeSH Number(s) |
D08.811.913.696.620.682.700.596 D12.644.360.552 D12.776.476.548
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| Concept/Terms |
p21-Activated Kinases- p21-Activated Kinases
- Kinases, p21-Activated
- p21 Activated Kinases
- PAK Kinases
- Kinases, PAK
p21-Activated Kinase 3- p21-Activated Kinase 3
- p21 Activated Kinase 3
- Serine-Threonine-Protein Kinase PAK 3
- Serine Threonine Protein Kinase PAK 3
- Oligophrenin-3
- Oligophrenin 3
- PAK3 Kinase
- beta p21-Activated Kinase
- beta p21 Activated Kinase
- p21-Activated Kinase, beta
- beta-PAK
p21-Activated Kinase 1- p21-Activated Kinase 1
- p21 Activated Kinase 1
- Serine-Threonine-Protein Kinase PAK 1
- Serine Threonine Protein Kinase PAK 1
- PAK-1 Kinase
- PAK 1 Kinase
- PAK1 Kinase
- alpha p21-Activated Kinase
- alpha p21 Activated Kinase
- alpha-PAK
p21-Activated Kinase 2- p21-Activated Kinase 2
- p21 Activated Kinase 2
- p65(PAK)
- PAK65
- PAK-2 Kinase
- PAK 2 Kinase
- PAK2 Kinase
- gamma-PAK
- gamma PAK
- p65PAK Protein
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Below are MeSH descriptors whose meaning is more general than "p21-Activated Kinases".
Below are MeSH descriptors whose meaning is more specific than "p21-Activated Kinases".
This graph shows the total number of publications written about "p21-Activated Kinases" by people in this website by year, and whether "p21-Activated Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 1 | 2 | | 2013 | 3 | 0 | 3 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "p21-Activated Kinases" by people in Profiles.
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DeSantiago J, Bare DJ, Varma D, Solaro RJ, Arora R, Banach K. Loss of p21-activated kinase 1 (Pak1) promotes atrial arrhythmic activity. Heart Rhythm. 2018 08; 15(8):1233-1241.
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DeSantiago J, Bare DJ, Xiao L, Ke Y, Solaro RJ, Banach K. p21-Activated kinase1 (Pak1) is a negative regulator of NADPH-oxidase 2 in ventricular myocytes. J Mol Cell Cardiol. 2014 Feb; 67:77-85.
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Arsenault D, Dal-Pan A, Tremblay C, Bennett DA, Guitton MJ, De Koninck Y, Tonegawa S, Calon F. PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and Aß. J Neurosci. 2013 Jun 26; 33(26):10729-40.
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DeSantiago J, Bare DJ, Ke Y, Sheehan KA, Solaro RJ, Banach K. Functional integrity of the T-tubular system in cardiomyocytes depends on p21-activated kinase 1. J Mol Cell Cardiol. 2013 Jul; 60:121-8.
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Ai X, Jiang A, Ke Y, Solaro RJ, Pogwizd SM. Enhanced activation of p21-activated kinase 1 in heart failure contributes to dephosphorylation of connexin 43. Cardiovasc Res. 2011 Oct 01; 92(1):106-14.
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Forsyth CB, Tang Y, Shaikh M, Zhang L, Keshavarzian A. Role of snail activation in alcohol-induced iNOS-mediated disruption of intestinal epithelial cell permeability. Alcohol Clin Exp Res. 2011 Sep; 35(9):1635-43.
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Ke Y, Lum H, Solaro RJ. Inhibition of endothelial barrier dysfunction by P21-activated kinase-1. Can J Physiol Pharmacol. 2007 Mar-Apr; 85(3-4):281-8.
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