Activating Transcription Factor 6
"Activating Transcription Factor 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response.
| Descriptor ID |
D051702
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| MeSH Number(s) |
D12.644.360.011 D12.776.260.108.061.968 D12.776.476.011 D12.776.930.127.061.968
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Activating Transcription Factor 6".
Below are MeSH descriptors whose meaning is more specific than "Activating Transcription Factor 6".
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Below are the most recent publications written about "Activating Transcription Factor 6" by people in Profiles.
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Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy. Nat Commun. 2015 Mar 10; 6:6496.