"Activin Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity.
| Descriptor ID |
D029404
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.062 D12.776.543.750.750.400.820.500
|
| Concept/Terms |
Activin Receptors- Activin Receptors
- Receptor, Activin
- Activin Receptor-Like Kinases
- Activin Receptor like Kinases
- Kinases, Activin Receptor-like
- Receptor-like Kinases, Activin
- Activin Receptor
- Activin Receptor-like Kinase
- Activin Receptor like Kinase
- Kinase, Activin Receptor-like
- Receptor-like Kinase, Activin
|
Below are MeSH descriptors whose meaning is more general than "Activin Receptors".
Below are MeSH descriptors whose meaning is more specific than "Activin Receptors".
This graph shows the total number of publications written about "Activin Receptors" by people in this website by year, and whether "Activin Receptors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Activin Receptors" by people in Profiles.
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The relationship between fibrogenic TGF?1 signaling in the joint and cartilage degradation in post-injury osteoarthritis. Osteoarthritis Cartilage. 2011 Sep; 19(9):1081-90.