"NADPH Oxidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC.
| Descriptor ID |
D019255
|
| MeSH Number(s) |
D08.811.682.608.575 D12.776.331.894 D12.776.543.653
|
| Concept/Terms |
NADPH Oxidases- NADPH Oxidases
- Oxidases, NADPH
- NAD(P)H oxidase
- NADPH Oxidase
- Oxidase, NADPH
- Nox Proteins
- NAD(P)H Oxidases
|
Below are MeSH descriptors whose meaning is more general than "NADPH Oxidases".
Below are MeSH descriptors whose meaning is more specific than "NADPH Oxidases".
This graph shows the total number of publications written about "NADPH Oxidases" by people in this website by year, and whether "NADPH Oxidases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2001 | 3 | 0 | 3 |
| 2002 | 2 | 0 | 2 |
| 2003 | 3 | 0 | 3 |
| 2004 | 1 | 1 | 2 |
| 2005 | 2 | 0 | 2 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 1 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 3 | 3 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "NADPH Oxidases" by people in Profiles.
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Expression and function of voltage gated proton channels (Hv1) in MDA-MB-231 cells. PLoS One. 2020; 15(5):e0227522.
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Impaired phagocytosis directs human monocyte activation in response to fungal derived ?-glucan particles. Eur J Immunol. 2018 05; 48(5):757-770.
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The intimate and controversial relationship between voltage-gated proton channels and the phagocyte NADPH oxidase. Immunol Rev. 2016 09; 273(1):194-218.
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Analysis of electrophysiological properties and responses of neutrophils. Methods Mol Biol. 2014; 1124:121-58.
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p21-Activated kinase1 (Pak1) is a negative regulator of NADPH-oxidase 2 in ventricular myocytes. J Mol Cell Cardiol. 2014 Feb; 67:77-85.
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Voltage-gated proton channels. Compr Physiol. 2012 Apr; 2(2):1355-85.
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NOX5 in human spermatozoa: expression, function, and regulation. J Biol Chem. 2012 Mar 16; 287(12):9376-88.
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Strong glucose dependence of electron current in human monocytes. Am J Physiol Cell Physiol. 2012 Jan 01; 302(1):C286-95.
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Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes. Physiology (Bethesda). 2010 Feb; 25(1):27-40.
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Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes. J Biol Chem. 2010 Feb 19; 285(8):5117-21.