"NADPH Oxidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC.
| Descriptor ID |
D019255
|
| MeSH Number(s) |
D08.811.682.608.575 D12.776.331.894 D12.776.543.653
|
| Concept/Terms |
NADPH Oxidases- NADPH Oxidases
- Oxidases, NADPH
- NAD(P)H oxidase
- NADPH Oxidase
- Oxidase, NADPH
- Nox Proteins
- NAD(P)H Oxidases
|
Below are MeSH descriptors whose meaning is more general than "NADPH Oxidases".
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This graph shows the total number of publications written about "NADPH Oxidases" by people in this website by year, and whether "NADPH Oxidases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "NADPH Oxidases" by people in Profiles.
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Expression and function of voltage gated proton channels (Hv1) in MDA-MB-231 cells. PLoS One. 2020; 15(5):e0227522.
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p21-Activated kinase1 (Pak1) is a negative regulator of NADPH-oxidase 2 in ventricular myocytes. J Mol Cell Cardiol. 2014 Feb; 67:77-85.
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Strong glucose dependence of electron current in human monocytes. Am J Physiol Cell Physiol. 2012 Jan 01; 302(1):C286-95.
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Innate immune and chemically triggered oxidative stress modifies translational fidelity. Nature. 2009 Nov 26; 462(7272):522-6.
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Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):18022-7.
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The pH dependence of NADPH oxidase in human eosinophils. J Physiol. 2005 Dec 01; 569(Pt 2):419-31.
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Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase. J Neurosci. 2004 Oct 27; 24(43):9531-40.