 Calcium Channels, L-Type
"Calcium Channels, L-Type" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
| Descriptor ID |
D020746
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| MeSH Number(s) |
D12.776.157.530.400.150.400 D12.776.543.550.425.150.400 D12.776.543.585.400.150.400
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| Concept/Terms |
Calcium Channels, L-Type- Calcium Channels, L-Type
- Calcium Channels, L Type
- L-Type VDCC
- L Type VDCC
- VDCC, L-Type
- L-Type Calcium Channel
- Calcium Channel, L-Type
- L Type Calcium Channel
- L-Type Voltage-Dependent Calcium Channels
- L Type Voltage Dependent Calcium Channels
- L-Type Calcium Channels
- L Type Calcium Channels
- Long-Lasting Calcium Channels
- Calcium Channels, Long-Lasting
- Long Lasting Calcium Channels
Receptors, Dihydropyridine- Receptors, Dihydropyridine
- L-Type VDCC alpha-1 Subunit
- L Type VDCC alpha 1 Subunit
- Dihydropyridine Receptor
- Receptor, Dihydropyridine
- Dihydropyridine Receptors
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Below are MeSH descriptors whose meaning is more general than "Calcium Channels, L-Type".
Below are MeSH descriptors whose meaning is more specific than "Calcium Channels, L-Type".
This graph shows the total number of publications written about "Calcium Channels, L-Type" by people in this website by year, and whether "Calcium Channels, L-Type" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 3 | 3 | | 2000 | 1 | 0 | 1 | | 2003 | 1 | 1 | 2 | | 2004 | 1 | 0 | 1 | | 2005 | 2 | 2 | 4 | | 2006 | 0 | 2 | 2 | | 2007 | 1 | 2 | 3 | | 2008 | 1 | 1 | 2 | | 2009 | 4 | 1 | 5 | | 2010 | 1 | 1 | 2 | | 2011 | 2 | 0 | 2 | | 2012 | 1 | 0 | 1 | | 2013 | 2 | 0 | 2 | | 2014 | 1 | 1 | 2 | | 2015 | 1 | 1 | 2 | | 2016 | 2 | 0 | 2 | | 2017 | 3 | 0 | 3 | | 2019 | 1 | 1 | 2 | | 2020 | 0 | 1 | 1 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Calcium Channels, L-Type" by people in Profiles.
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Manno C, Tammineni E, Figueroa L, Marty I, R?os E. Quantification of the calcium signaling deficit in muscles devoid of triadin. PLoS One. 2022; 17(2):e0264146.
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McCauley MD, Hong L, Sridhar A, Menon A, Perike S, Zhang M, da Silva IB, Yan J, Bonini MG, Ai X, Rehman J, Darbar D. Ion Channel and Structural Remodeling in Obesity-Mediated Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2020 08; 13(8):e008296.
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S?ndergaard MT, Liu Y, Brohus M, Guo W, Nani A, Carvajal C, Fill M, Overgaard MT, Chen SRW. Diminished inhibition and facilitated activation of RyR2-mediated Ca2+ release is a common defect of arrhythmogenic calmodulin mutations. FEBS J. 2019 11; 286(22):4554-4578.
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Treinys R, Kanaporis G, Fischmeister R, Jurevicius J. Metabolic Inhibition Induces Transient Increase of L-type Ca2+ Current in Human and Rat Cardiac Myocytes. Int J Mol Sci. 2019 Mar 26; 20(6).
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Khodr CE, Chen L, Al-Harthi L, Hu XT. Aging alters voltage-gated calcium channels in prefrontal cortex pyramidal neurons in the HIV brain. J Neurovirol. 2018 02; 24(1):113-118.
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Kanaporis G, Treinys R, Fischmeister R, Jurevicius J. Metabolic inhibition reduces cardiac L-type Ca2+ channel current due to acidification caused by ATP hydrolysis. PLoS One. 2017; 12(8):e0184246.
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Kanaporis G, Blatter LA. Membrane potential determines calcium alternans through modulation of SR Ca2+ load and L-type Ca2+ current. J Mol Cell Cardiol. 2017 04; 105:49-58.
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Khodr CE, Chen L, Dave S, Al-Harthi L, Hu XT. Combined chronic blockade of hyper-active L-type calcium channels and NMDA receptors ameliorates HIV-1 associated hyper-excitability of mPFC pyramidal neurons. Neurobiol Dis. 2016 Oct; 94:85-94.
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Hu XT. HIV-1 Tat-Mediated Calcium Dysregulation and Neuronal Dysfunction in Vulnerable Brain Regions. Curr Drug Targets. 2016; 17(1):4-14.
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Ramos-Franco J, Aguilar-Sanchez Y, Escobar AL. Intact Heart Loose Patch Photolysis Reveals Ionic Current Kinetics During Ventricular Action Potentials. Circ Res. 2016 Jan 22; 118(2):203-15.
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