"Cocaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
| Descriptor ID |
D003042
|
| MeSH Number(s) |
D02.145.074.722.388 D03.132.889.354 D03.605.084.500.722.388 D03.605.869.388
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cocaine".
Below are MeSH descriptors whose meaning is more specific than "Cocaine".
This graph shows the total number of publications written about "Cocaine" by people in this website by year, and whether "Cocaine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 0 | 2 |
| 1998 | 2 | 0 | 2 |
| 1999 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2004 | 2 | 0 | 2 |
| 2005 | 3 | 0 | 3 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 2 | 1 | 3 |
| 2011 | 3 | 0 | 3 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 3 | 0 | 3 |
| 2017 | 0 | 1 | 1 |
| 2021 | 2 | 0 | 2 |
| 2022 | 3 | 0 | 3 |
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Below are the most recent publications written about "Cocaine" by people in Profiles.
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Associations between drug and alcohol use, smoking, and frailty among people with HIV across the United States in the current era of antiretroviral treatment. Drug Alcohol Depend. 2022 11 01; 240:109649.
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Cocaine Self-Administration Influences Central Nervous System Immune Responses in Male HIV-1 Transgenic Rats. Cells. 2022 08 04; 11(15).
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Impaired verbal memory in individuals living with HIV and cocaine dependence. J Clin Exp Neuropsychol. 2022 03; 44(2):134-145.
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GluN3-Containing NMDA Receptors in the Rat Nucleus Accumbens Core Contribute to Incubation of Cocaine Craving. J Neurosci. 2021 09 29; 41(39):8262-8277.
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Effects of cocaine and HIV on decision-making abilities. J Neurovirol. 2021 06; 27(3):422-433.
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Impact on Cortical Function of Cocaine Abuse Co-Occurring with HIV. Neuropsychopharmacology. 2017 01; 42(1):365.
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HIV-1 Transgenic Rat Prefrontal Cortex Hyper-Excitability is Enhanced by Cocaine Self-Administration. Neuropsychopharmacology. 2016 07; 41(8):1965-73.
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Cocaine self-administration enhances excitatory responses of pyramidal neurons in the rat medial prefrontal cortex to human immunodeficiency virus-1 Tat. Eur J Neurosci. 2015 May; 41(9):1195-206.
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Cortical consequences of HIV-1 Tat exposure in rats are enhanced by chronic cocaine. Curr HIV Res. 2015; 13(1):80-7.
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MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity. J Neurosci. 2014 Mar 26; 34(13):4519-27.