Disks Large Homolog 4 Protein
"Disks Large Homolog 4 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). It localizes to the POST-SYNAPTIC DENSITY and associates with the cytoplasmic tail of NMDA RECEPTORS and SHAKER POTASSIUM CHANNELS, playing a critical role in NMDA receptor-mediated SYNAPTIC PLASTICITY.
| Descriptor ID |
D000076122
|
| MeSH Number(s) |
D08.811.913.696.650.450.750 D12.644.360.265 D12.776.476.265 D12.776.543.219 D12.776.631.224
|
| Concept/Terms |
Disks Large Homolog 4 Protein- Disks Large Homolog 4 Protein
- Postsynaptic Density Protein 95
- Discs Large Homolog 4 Protein
- SAP-90 Protein
- SAP 90 Protein
- PSD95 Protein
- PSD-95 Protein
- PSD 95 Protein
- Synapse-Associated Protein 90
- Synapse Associated Protein 90
- SAP90 Protein
|
Below are MeSH descriptors whose meaning is more general than "Disks Large Homolog 4 Protein".
Below are MeSH descriptors whose meaning is more specific than "Disks Large Homolog 4 Protein".
This graph shows the total number of publications written about "Disks Large Homolog 4 Protein" by people in this website by year, and whether "Disks Large Homolog 4 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
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Below are the most recent publications written about "Disks Large Homolog 4 Protein" by people in Profiles.
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Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial. Lancet. 2020 03 14; 395(10227):878-887.
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Flavonoids induce the expression of synaptic proteins, synaptotagmin, and postsynaptic density protein-95 in cultured rat cortical neuron. Planta Med. 2013 Dec; 79(18):1710-4.
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The clinically available NMDA receptor antagonist, memantine, exhibits relative safety in the developing rat brain. Int J Dev Neurosci. 2011 Nov; 29(7):767-73.
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Chronic corticosterone exposure alters postsynaptic protein levels of PSD-95, NR1, and synaptopodin in the mouse brain. Synapse. 2011 Aug; 65(8):763-70.
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Homeostatic synapse-driven membrane plasticity in nucleus accumbens neurons. J Neurosci. 2009 May 06; 29(18):5820-31.