"Synapsins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of synaptic vesicle-associated proteins involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this family, links SYNAPTIC VESICLES to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible PHOSPHORYLATION of synapsin I through various signal transduction pathways. The protein is also a substrate for cAMP- and CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. It is believed that these functional properties are also shared by synapsin II.
| Descriptor ID |
D016704
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| MeSH Number(s) |
D12.776.631.750 D12.776.744.840
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Synapsins".
Below are MeSH descriptors whose meaning is more specific than "Synapsins".
This graph shows the total number of publications written about "Synapsins" by people in this website by year, and whether "Synapsins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Synapsins" by people in Profiles.
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Microglial Correlates of Late Life Physical Activity: Relationship with Synaptic and Cognitive Aging in Older Adults. J Neurosci. 2022 01 12; 42(2):288-298.
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Selective lowering of synapsins induced by oligomeric a-synuclein exacerbates memory deficits. Proc Natl Acad Sci U S A. 2017 06 06; 114(23):E4648-E4657.
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The clinically available NMDA receptor antagonist, memantine, exhibits relative safety in the developing rat brain. Int J Dev Neurosci. 2011 Nov; 29(7):767-73.