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Bryan D James

TitleAssociate Professor
InstitutionRush University, Rush Medical College
DepartmentCommunity Epidemiology
Address1750 West Harrison St
Chicago IL 60612
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    Collapse Biography 
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    2010International Conference on Alzheimer's Disease 2010 Travel Fellowship, Alzheimer's Association, Chicago, IL
    2004 - 2009Fellow, Epidemiology and Biostatistics of Aging Training Grant , Center on Aging and Health, JHSPH, Baltimore MD
    2008Louis I. and Thomas D. Dublin Award for the Advancement of Epidemiology and Biostatistics, JHSPH, Baltimore, MD
    2005Emerging Scholar and Professional Organization Poster (ESPO) Award, Annual Meeting of the Gerontological Society of America
    2008Emerging Scholar and Professional Organization Poster (ESPO) Award, Annual Meeting of the Gerontological Society of America
    2008Behavioral and Social Science (BSS) Student Travel Award, Annual Meeting of the Gerontological Society of America
    2008Second place poster, Research on Aging Showcase, Johns Hopkins Gerontology Interest Group JHSPH, Baltimore, MD
    2006Marcia Pines Award in Bioethics and Public Health, JHSPH, Baltimore, MD
    1999Dean's list, University of Pennsylvania, Philadelphia, PA

    Collapse Overview 
    Collapse overview
    Bryan D. James, PhD, is an epidemiologist with the Rush Alzheimer’s Disease Center and an associate professor in the Department of Internal Medicine, Section of Epidemiology Research. His research focuses on identifying risk factors for Alzheimer’s disease, dementia, cognitive decline and disability at the population level. In particular, he is interested in social and lifestyle factors that can protect against the clinical manifestation of disease pathology in the aging brain. He is currently funded by the National Institute on Aging to examine why hospitalization can lead to cognitive problems in some older persons. James received his PhD in epidemiology from the Johns Hopkins Bloomberg School of Public Health in 2009 and Master of Bioethics degree from the University of Pennsylvania in 2001. He joined the RADC in 2009. James is an active member of the Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART), the Gerontological Society of America (GSA), and the Society for Epidemiological Research (SER), for which he co-chairs the Publications Committee and leads the SER Podcast initiative, “Epidemiology Counts”. He has published extensively in the areas of cognitive aging, gerontology, neuroepidemiology, and research ethics. Since 2011, Dr. James has contributed to the Alzheimer’s Association Facts & Figures annual report.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dhana K, Agarwal P, James BD, Leurgans SE, Rajan KB, Aggarwal NT, Barnes LL, Bennett DA, Schneider JA. Healthy Lifestyle and Cognition in Older Adults With Common Neuropathologies of Dementia. JAMA Neurol. 2024 Mar 01; 81(3):233-239. PMID: 38315471; PMCID: PMC10845037.
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    2. Power MC, Willens V, Prather C, Moghtaderi A, Chen Y, Gianattasio KZ, Grodstein F, Shah RC, James BD. Risks and Benefits of Clinical Diagnosis Around the Time of Dementia Onset. Gerontol Geriatr Med. 2023 Jan-Dec; 9:23337214231213185. PMID: 38026091.
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    3. Shea MK, Barger K, Dawson-Hughes B, Leurgans SE, Fu X, James BD, Holland TM, Agarwal P, Wang J, Matuszek G, Heger NE, Schneider JA, Booth SL. Brain vitamin D forms, cognitive decline, and neuropathology in community-dwelling older adults. Alzheimers Dement. 2023 06; 19(6):2389-2396. PMID: 36479814.
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    4. Willroth EC, James BD, Graham EK, Kapasi A, Bennett DA, Mroczek DK. Well-Being and Cognitive Resilience to Dementia-Related Neuropathology. Psychol Sci. 2023 03; 34(3):283-297. PMID: 36473124.
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    5. Agarwal P, Holland TM, James BD, Cherian LJ, Aggarwal NT, Leurgans SE, Bennett DA, Schneider JA. Pelargonidin and Berry Intake Association with Alzheimer's Disease Neuropathology: A Community-Based Study. J Alzheimers Dis. 2022; 88(2):653-661. PMID: 35694918.
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    6. Dawe RJ, Yu L, Leurgans SE, James BD, Poole VN, Arfanakis K, Schneider JA, Bennett DA, Buchman AS. Physical activity, brain tissue microstructure, and cognition in older adults. PLoS One. 2021; 16(7):e0253484. PMID: 34232955.
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    7. Graham EK, James BD, Jackson KL, Willroth EC, Boyle P, Wilson R, Bennett DA, Mroczek DK. Associations Between Personality Traits and Cognitive Resilience in Older Adults. J Gerontol B Psychol Sci Soc Sci. 2021 01 01; 76(1):6-19. PMID: 32969474.
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    8. Mielke MM, James BD. Women who participated in the paid labor force have lower rates of memory decline: Working to remember. Neurology. 2020 12 08; 95(23):1027-1028. PMID: 33148812.
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    9. Weston SJ, Graham EK, Turiano NA, Aschwanden D, Booth T, Harrison F, James BD, Lewis NA, Makkar SR, Mueller S, Wisniewski KM, Yoneda T, Zhaoyang R, Spiro A, Drewelies J, Wagner GG, Steinhagen-Thiessen E, Demuth I, Willis S, Schaie KW, Sliwinski M, Lipton RA, Katz M, Deary IJ, Zelinski EM, Bennett DA, Sachdev PS, Brodaty H, Trollor JN, Ames D, Wright MJ, Gerstorf D, Allemand M, Muniz-Terrera G, Piccinin AM, Hofer SM, Mroczek DK. Is Healthy Neuroticism Associated with Chronic Conditions? A Coordinated Integrative Data Analysis. Collabra Psychol. 2020; 6(1). PMID: 33073161.
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    10. Turiano NA, Graham EK, Weston SJ, Booth T, Harrison F, James BD, Lewis NA, Makkar SR, Mueller S, Wisniewski KM, Zhaoyang R, Spiro A, Willis S, Schaie KW, Lipton RB, Katz M, Sliwinski M, Deary IJ, Zelinski EM, Bennett DA, Sachdev PS, Brodaty H, Trollor JN, Ames D, Wright MJ, Gerstorf D, Muniz-Terrera G, Piccinin AM, Hofer SM, Mroczek DK. Is Healthy Neuroticism Associated with Longevity? A Coordinated Integrative Data Analysis. Collabra Psychol. 2020; 6(1). PMID: 33354648.
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    11. Graham EK, Weston SJ, Turiano NA, Aschwanden D, Booth T, Harrison F, James BD, Lewis NA, Makkar SR, Mueller S, Wisniewski KM, Yoneda T, Zhaoyang R, Spiro A, Willis S, Schaie KW, Sliwinski M, Lipton RA, Katz MJ, Deary IJ, Zelinski EM, Bennett DA, Sachdev PS, Brodaty H, Trollor JN, Ames D, Wright MJ, Gerstorf D, Allemand M, Drewelies J, Wagner GG, Muniz-Terrera G, Piccinin AM, Hofer SM, Mroczek DK. Is Healthy Neuroticism Associated with Health Behaviors? A Coordinated Integrative Data Analysis. Collabra Psychol. 2020; 6(1). PMID: 33354649.
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    12. Glover CM, CoCroft S, James BD, Barnes LL. Perceptions of Risk Factors for Alzheimer Disease Among Community-Dwelling, Nondemented Older African Americans. Alzheimer Dis Assoc Disord. 2019 Jul-Sep; 33(3):254-259. PMID: 31058682.
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    13. James BD, Wilson RS, Capuano AW, Boyle PA, Shah RC, Lamar M, Ely EW, Bennett DA, Schneider JA. Cognitive decline after elective and nonelective hospitalizations in older adults. Neurology. 2019 02 12; 92(7):e690-e699. PMID: 30635482.
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    14. Lamar M, Yu L, Rubin LH, James BD, Barnes LL, Farfel JM, Gaiteri C, Buchman AS, Bennett DA, Schneider JA. APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults. Alzheimers Dement. 2019 02; 15(2):258-266. PMID: 30321502.
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    15. Greenberg JA, Hohmann SF, James BD, Shah RC, Hall JB, Kress JP, David MZ. Hospital Volume of Immunosuppressed Patients with Sepsis and Sepsis Mortality. Ann Am Thorac Soc. 2018 08; 15(8):962-969. PMID: 29856657.
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    16. James BD, Wilson RS, Shah RC, Yu L, Arvanitakis Z, Bennett DA, Boyle PA. Association of Financial Literacy With Hospitalization in Community-dwelling Older Adults. Med Care. 2018 07; 56(7):596-602. PMID: 29901572.
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    17. Power MC, Mormino E, Soldan A, James BD, Yu L, Armstrong NM, Bangen KJ, Delano-Wood L, Lamar M, Lim YY, Nudelman K, Zahodne L, Gross AL, Mungas D, Widaman KF, Schneider J. Combined neuropathological pathways account for age-related risk of dementia. Ann Neurol. 2018 07; 84(1):10-22. PMID: 29944741.
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    18. Kapasi A, Leurgans SE, James BD, Boyle PA, Arvanitakis Z, Nag S, Bennett DA, Buchman AS, Schneider JA. Watershed microinfarct pathology and cognition in older persons. Neurobiol Aging. 2018 10; 70:10-17. PMID: 29935416.
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    19. Jansen WJ, Wilson RS, Visser PJ, Nag S, Schneider JA, James BD, Leurgans SE, Capuano AW, Bennett DA, Boyle PA. Age and the association of dementia-related pathology with trajectories of cognitive decline. Neurobiol Aging. 2018 01; 61:138-145. PMID: 29078129.
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    20. Wilson RS, Capuano AW, James BD, Amofa P, Arvanitakis Z, Shah R, Bennett DA, Boyle PA. Purpose in Life and Hospitalization for Ambulatory Care-Sensitive Conditions in Old Age. Am J Geriatr Psychiatry. 2018 03; 26(3):364-374. PMID: 28780129.
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    21. Yarchoan M, James BD, Shah RC, Arvanitakis Z, Wilson RS, Schneider J, Bennett DA, Arnold SE. Association of Cancer History with Alzheimer's Disease Dementia and Neuropathology. J Alzheimers Dis. 2017; 56(2):699-706. PMID: 28035936.
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    22. James BD, Wilson RS, Boyle PA, Trojanowski JQ, Bennett DA, Schneider JA. TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementia. Brain. 2016 11 01; 139(11):2983-2993. PMID: 27694152.
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    23. Buchman AS, Leurgans SE, Yu L, Wilson RS, Lim AS, James BD, Shulman JM, Bennett DA. Incident parkinsonism in older adults without Parkinson disease. Neurology. 2016 Sep 06; 87(10):1036-44. PMID: 27488597.
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    24. Wilson RS, Yu L, James BD, Bennett DA, Boyle PA. Association of financial and health literacy with cognitive health in old age. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2017 Mar; 24(2):186-197. PMID: 27263546.
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    25. Han SD, Boyle PA, Arfanakis K, Fleischman D, Yu L, James BD, Bennett DA. Financial literacy is associated with white matter integrity in old age. Neuroimage. 2016 Apr 15; 130:223-229. PMID: 26899784.
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    26. Han SD, Boyle PA, James BD, Yu L, Barnes LL, Bennett DA. Discrepancies between cognition and decision making in older adults. Aging Clin Exp Res. 2016 Feb; 28(1):99-108. PMID: 25995167.
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    27. Wilson RS, Boyle PA, James BD, Leurgans SE, Buchman AS, Bennett DA. Negative social interactions and risk of mild cognitive impairment in old age. Neuropsychology. 2015 Jul; 29(4):561-70. PMID: 25495828.
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    28. James BD, Leurgans SE, Hebert LE, Scherr PA, Yaffe K, Bennett DA. Contribution of Alzheimer disease to mortality in the United States. Neurology. 2014 Mar 25; 82(12):1045-50. PMID: 24598707.
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    29. Dacks PA, Andrieu S, Blacker D, Carman AJ, Green AM, Grodstein F, Henderson VW, James BD, Lane RF, Lau J, Lin PJ, Reeves BC, Shah RC, Vellas B, Yaffe K, Yurko-Mauro K, Shineman DW, Bennett DA, Fillit HM. Dementia Prevention: optimizing the use of observational data for personal, clinical, and public health decision-making. J Prev Alzheimers Dis. 2014 Feb; 1(2):117-123. PMID: 26146610.
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    30. James BD, Boyle PA, Yu L, Bennett DA. Internet use and decision making in community-based older adults. Front Psychol. 2013; 4:605. PMID: 24578696.
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    31. Buchman AS, Wilson RS, Yu L, James BD, Boyle PA, Bennett DA. Total daily activity declines more rapidly with increasing age in older adults. Arch Gerontol Geriatr. 2014 Jan-Feb; 58(1):74-9. PMID: 24007938.
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    32. Bennett JS, Boyle PA, James BD, Bennett DA. Correlates of health and financial literacy in older adults without dementia. BMC Geriatr. 2012 Jun 12; 12:30. PMID: 22691341.
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    33. James BD, Wilson RS, Barnes LL, Bennett DA. Late-life social activity and cognitive decline in old age. J Int Neuropsychol Soc. 2011 Nov; 17(6):998-1005. PMID: 22040898.
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    34. James BD, Caffo B, Stewart WF, Yousem D, Davatzikos C, Schwartz BS. Genetic risk factors for longitudinal changes in structural MRI in former organolead workers. J Aging Res. 2011; 2011:362189. PMID: 22028967.
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    35. Lee BK, Glass TA, James BD, Bandeen-Roche K, Schwartz BS. Neighborhood psychosocial environment, apolipoprotein E genotype, and cognitive function in older adults. Arch Gen Psychiatry. 2011 Mar; 68(3):314-21. PMID: 21383266.
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    36. James BD, Boyle PA, Buchman AS, Bennett DA. Relation of late-life social activity with incident disability among community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2011 Apr; 66(4):467-73. PMID: 21300745.
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    37. James BD, Schneider JA. Increasing incidence of dementia in the oldest old: evidence and implications. Alzheimers Res Ther. 2010 May 13; 2(3):9. PMID: 20497589.
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    38. Schwartz BS, Caffo B, Stewart WF, Hedlin H, James BD, Yousem D, Davatzikos C. Evaluation of cumulative lead dose and longitudinal changes in structural magnetic resonance imaging in former organolead workers. J Occup Environ Med. 2010 Apr; 52(4):407-14. PMID: 20357679.
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    39. Karlawish J, Kim SY, Knopman D, van Dyck CH, James BD, Marson D. Interpreting the clinical significance of capacity scores for informed consent in Alzheimer disease clinical trials. Am J Geriatr Psychiatry. 2008 Jul; 16(7):568-74. PMID: 18556397.
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    40. Karlawish JH, Bonnie RJ, Appelbaum PS, Kane RA, Lyketsos CG, Karlan PS, James BD, Sabatino C, Lawrence T, Knopman D. Identifying the barriers and challenges to voting by residents in nursing homes and assisted living settings. J Aging Soc Policy. 2008; 20(1):65-79. PMID: 18198160.
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    41. James BD, Xie SX, Karlawish JH. How do patients with Alzheimer disease rate their overall quality of life? Am J Geriatr Psychiatry. 2005 Jun; 13(6):484-90. PMID: 15956268.
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    42. Karlawish JH, Casarett DJ, James BD, Xie SX, Kim SY. The ability of persons with Alzheimer disease (AD) to make a decision about taking an AD treatment. Neurology. 2005 May 10; 64(9):1514-9. PMID: 15883310.
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    43. Karlawish JH, Bonnie RJ, Appelbaum PS, Lyketsos C, James B, Knopman D, Patusky C, Kane RA, Karlan PS. Addressing the ethical, legal, and social issues raised by voting by persons with dementia. JAMA. 2004 Sep 15; 292(11):1345-50. PMID: 15367557.
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    44. Karlawish JH, Casarett DJ, James BD. Alzheimer's disease patients' and caregivers' capacity, competency, and reasons to enroll in an early-phase Alzheimer's disease clinical trial. J Am Geriatr Soc. 2002 Dec; 50(12):2019-24. PMID: 12473015.
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    45. Karlawish JH, Casarett DA, James BD, Propert KJ, Asch DA. Do persons with dementia vote? Neurology. 2002 Apr 09; 58(7):1100-2. PMID: 11940701.
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