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Bryan D. James

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentInternal Medicine
Address1750 West Harrison St
Chicago IL 60612
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    Bryan D. James, PhD, is an epidemiologist with the Rush Alzheimer’s Disease Center and an assistant professor in the Department of Internal Medicine, Section of Community Epidemiologic Research. His research focuses on identifying risk factors for Alzheimer’s disease, dementia, cognitive decline and disability at the population level. In particular, he is interested in social and lifestyle factors that can protect against the clinical manifestation of disease pathology in the aging brain. He is currently funded by the National Institute on Aging to examine why hospitalization can lead to faster cognitive decline in some older persons. James received his PhD in epidemiology from the Johns Hopkins Bloomberg School of Public Health in 2009 and Master of Bioethics degree from the University of Pennsylvania in 2001. He joined the RADC in 2009. James is an active member of the Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART), the Gerontological Society of America (GSA) and the Society for Epidemiological Research (SER). He has published extensively in the areas of cognitive aging, gerontology, neuroepidemiology, and research ethics. He helps to prepare the Alzheimer’s Association Facts & Figures annual report.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lamar M, Yu L, Rubin LH, James BD, Barnes LL, Farfel JM, Gaiteri C, Buchman AS, Bennett DA, Schneider JA. APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults. Alzheimers Dement. 2018 Oct 12. PMID: 30321502.
      View in: PubMed
    2. Greenberg JA, Hohmann SF, James BD, Shah RC, Hall JB, Kress JP, David MZ. Hospital Volume of Immunosuppressed Patients with Sepsis and Sepsis Mortality. Ann Am Thorac Soc. 2018 Aug; 15(8):962-969. PMID: 29856657.
      View in: PubMed
    3. James BD, Wilson RS, Shah RC, Yu L, Arvanitakis Z, Bennett DA, Boyle PA. Association of Financial Literacy With Hospitalization in Community-dwelling Older Adults. Med Care. 2018 Jul; 56(7):596-602. PMID: 29901572.
      View in: PubMed
    4. Power MC, Mormino E, Soldan A, James BD, Yu L, Armstrong NM, Bangen KJ, Delano-Wood L, Lamar M, Lim YY, Nudelman K, Zahodne L, Gross AL, Mungas D, Widaman KF, Schneider J. Combined neuropathological pathways account for age-related risk of dementia. Ann Neurol. 2018 Jul; 84(1):10-22. PMID: 29944741.
      View in: PubMed
    5. Stewart CC, Boyle PA, James BD, Yu L, Han SD, Bennett DA. Associations of APOE e4 With Health and Financial Literacy Among Community-Based Older Adults Without Dementia. J Gerontol B Psychol Sci Soc Sci. 2018 Jun 14; 73(5):778-786. PMID: 27174891.
      View in: PubMed
    6. Kapasi A, Leurgans SE, James BD, Boyle PA, Arvanitakis Z, Nag S, Bennett DA, Buchman AS, Schneider JA. Watershed microinfarct pathology and cognition in older persons. Neurobiol Aging. 2018 Oct; 70:10-17. PMID: 29935416.
      View in: PubMed
    7. Jansen WJ, Wilson RS, Visser PJ, Nag S, Schneider JA, James BD, Leurgans SE, Capuano AW, Bennett DA, Boyle PA. Age and the association of dementia-related pathology with trajectories of cognitive decline. Neurobiol Aging. 2018 01; 61:138-145. PMID: 29078129.
      View in: PubMed
    8. Wilson RS, Capuano AW, James BD, Amofa P, Arvanitakis Z, Shah R, Bennett DA, Boyle PA. Purpose in Life and Hospitalization for Ambulatory Care-Sensitive Conditions in Old Age. Am J Geriatr Psychiatry. 2018 Mar; 26(3):364-374. PMID: 28780129.
      View in: PubMed
    9. Yarchoan M, James BD, Shah RC, Arvanitakis Z, Wilson RS, Schneider J, Bennett DA, Arnold SE. Association of Cancer History with Alzheimer's Disease Dementia and Neuropathology. J Alzheimers Dis. 2017; 56(2):699-706. PMID: 28035936.
      View in: PubMed
    10. James BD, Wilson RS, Boyle PA, Trojanowski JQ, Bennett DA, Schneider JA. TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementia. Brain. 2016 11 01; 139(11):2983-2993. PMID: 27694152.
      View in: PubMed
    11. Turner AD, James BD, Capuano AW, Aggarwal NT, Barnes LL. Perceived Stress and Cognitive Decline in Different Cognitive Domains in a Cohort of Older African Americans. Am J Geriatr Psychiatry. 2017 01; 25(1):25-34. PMID: 28231871.
      View in: PubMed
    12. Buchman AS, Leurgans SE, Yu L, Wilson RS, Lim AS, James BD, Shulman JM, Bennett DA. Incident parkinsonism in older adults without Parkinson disease. Neurology. 2016 Sep 06; 87(10):1036-44. PMID: 27488597.
      View in: PubMed
    13. Wilson RS, Yu L, James BD, Bennett DA, Boyle PA. Association of financial and health literacy with cognitive health in old age. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2017 Mar; 24(2):186-197. PMID: 27263546.
      View in: PubMed
    14. Duke Han S, Boyle PA, Yu L, Arfanakis K, James BD, Fleischman DA, Bennett DA. Grey matter correlates of susceptibility to scams in community-dwelling older adults. Brain Imaging Behav. 2016 06; 10(2):524-32. PMID: 26100658.
      View in: PubMed
    15. Hinrich AJ, Jodelka FM, Chang JL, Brutman D, Bruno AM, Briggs CA, James BD, Stutzmann GE, Bennett DA, Miller SA, Rigo F, Marr RA, Hastings ML. Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides. EMBO Mol Med. 2016 04 01; 8(4):328-45. PMID: 26902204; PMCID: PMC4818756.
    16. Han SD, Boyle PA, Arfanakis K, Fleischman D, Yu L, James BD, Bennett DA. Financial literacy is associated with white matter integrity in old age. Neuroimage. 2016 Apr 15; 130:223-229. PMID: 26899784; PMCID: PMC4808430 [Available on 04/15/17].
    17. Han SD, Boyle PA, James BD, Yu L, Bennett DA. Mild Cognitive Impairment and Susceptibility to Scams in Old Age. J Alzheimers Dis. 2016; 49(3):845-51. PMID: 26519434; PMCID: PMC4708889.
    18. Barnes LL, Leurgans S, Aggarwal NT, Shah RC, Arvanitakis Z, James BD, Buchman AS, Bennett DA, Schneider JA. Mixed pathology is more likely in black than white decedents with Alzheimer dementia. Neurology. 2015 Aug 11; 85(6):528-34. PMID: 26180136; PMCID: PMC4540250.
    19. Han SD, Boyle PA, James BD, Yu L, Barnes LL, Bennett DA. Discrepancies between cognition and decision making in older adults. Aging Clin Exp Res. 2016 Feb; 28(1):99-108. PMID: 25995167; PMCID: PMC4654982 [Available on 02/01/17].
    20. Han SD, Boyle PA, James BD, Yu L, Bennett DA. Poorer Financial and Health Literacy Among Community-Dwelling Older Adults With Mild Cognitive Impairment. J Aging Health. 2015 Sep; 27(6):1105-17. PMID: 25903976; PMCID: PMC4520748.
    21. Han SD, Boyle PA, James BD, Yu L, Bennett DA. Mild cognitive impairment is associated with poorer decision-making in community-based older persons. J Am Geriatr Soc. 2015 Apr; 63(4):676-83. PMID: 25850350; PMCID: PMC4406791.
    22. James BD, Boyle PA, Yu L, Han SD, Bennett DA. Cognitive decline is associated with risk aversion and temporal discounting in older adults without dementia. PLoS One. 2015; 10(4):e0121900. PMID: 25838074; PMCID: PMC4383618.
    23. Nadimpalli SB, James BD, Yu L, Cothran F, Barnes LL. The association between discrimination and depressive symptoms among older African Americans: the role of psychological and social factors. Exp Aging Res. 2015; 41(1):1-24. PMID: 25494668; PMCID: PMC4413914.
    24. Wilson RS, Boyle PA, James BD, Leurgans SE, Buchman AS, Bennett DA. Negative social interactions and risk of mild cognitive impairment in old age. Neuropsychology. 2015 Jul; 29(4):561-70. PMID: 25495828; PMCID: PMC4468039.
    25. James B, Leurgans S, Bennett D. Author response. Neurology. 2014 Sep 30; 83(14):1302. PMID: 25392862.
      View in: PubMed
    26. Wilson RS, Boyle PA, Yang J, James BD, Bennett DA. Early life instruction in foreign language and music and incidence of mild cognitive impairment. Neuropsychology. 2015 Mar; 29(2):292-302. PMID: 25110933; PMCID: PMC4324380.
    27. James BD, Leurgans SE, Hebert LE, Scherr PA, Yaffe K, Bennett DA. Contribution of Alzheimer disease to mortality in the United States. Neurology. 2014 Mar 25; 82(12):1045-50. PMID: 24598707; PMCID: PMC3962992.
    28. Dacks PA, Andrieu S, Blacker D, Carman AJ, Green AM, Grodstein F, Henderson VW, James BD, Lane RF, Lau J, Lin PJ, Reeves BC, Shah RC, Vellas B, Yaffe K, Yurko-Mauro K, Shineman DW, Bennett DA, Fillit HM. Dementia Prevention: optimizing the use of observational data for personal, clinical, and public health decision-making. J Prev Alzheimers Dis. 2014 Feb; 1(2):117-123. PMID: 26146610.
      View in: PubMed
    29. James BD, Boyle PA, Bennett DA. Correlates of susceptibility to scams in older adults without dementia. J Elder Abuse Negl. 2014; 26(2):107-22. PMID: 24499279; PMCID: PMC3916958.
    30. James BD, Boyle PA, Yu L, Bennett DA. Internet use and decision making in community-based older adults. Front Psychol. 2013; 4:605. PMID: 24578696; PMCID: PMC3936138.
    31. Buchman AS, Wilson RS, Yu L, James BD, Boyle PA, Bennett DA. Total daily activity declines more rapidly with increasing age in older adults. Arch Gerontol Geriatr. 2014 Jan-Feb; 58(1):74-9. PMID: 24007938; PMCID: PMC3889486.
    32. James BD, Glass TA, Caffo B, Bobb JF, Davatzikos C, Yousem D, Schwartz BS. Association of social engagement with brain volumes assessed by structural MRI. J Aging Res. 2012; 2012:512714. PMID: 22997582; PMCID: PMC3446736.
    33. James BD, Boyle PA, Bennett DA, Buchman AS. Total daily activity measured with actigraphy and motor function in community-dwelling older persons with and without dementia. Alzheimer Dis Assoc Disord. 2012 Jul-Sep; 26(3):238-45. PMID: 21946015; PMCID: PMC3251727.
    34. James BD, Boyle PA, Bennett JS, Bennett DA. The impact of health and financial literacy on decision making in community-based older adults. Gerontology. 2012; 58(6):531-9. PMID: 22739454; PMCID: PMC3491105.
    35. Bennett JS, Boyle PA, James BD, Bennett DA. Correlates of health and financial literacy in older adults without dementia. BMC Geriatr. 2012 Jun 12; 12:30. PMID: 22691341; PMCID: PMC3459814.
    36. James BD, Bennett DA, Boyle PA, Leurgans S, Schneider JA. Dementia from Alzheimer disease and mixed pathologies in the oldest old. JAMA. 2012 May 02; 307(17):1798-800. PMID: 22550192; PMCID: PMC3368581.
    37. Shah RC, Maitra K, Barnes LL, James BD, Leurgans S, Bennett DA. Relation of driving status to incident life space constriction in community-dwelling older persons: a prospective cohort study. J Gerontol A Biol Sci Med Sci. 2012 Sep; 67(9):984-9. PMID: 22546958; PMCID: PMC3436089.
    38. Huang JY, Hafez DM, James BD, Bennett DA, Marr RA. Altered NEP2 expression and activity in mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis. 2012; 28(2):433-41. PMID: 22008264; PMCID: PMC3320721.
    39. James BD, Wilson RS, Barnes LL, Bennett DA. Late-life social activity and cognitive decline in old age. J Int Neuropsychol Soc. 2011 Nov; 17(6):998-1005. PMID: 22040898; PMCID: PMC3206295.
    40. James BD, Boyle PA, Buchman AS, Barnes LL, Bennett DA. Life space and risk of Alzheimer disease, mild cognitive impairment, and cognitive decline in old age. Am J Geriatr Psychiatry. 2011 Nov; 19(11):961-9. PMID: 21430509; PMCID: PMC3123692.
    41. James BD, Caffo B, Stewart WF, Yousem D, Davatzikos C, Schwartz BS. Genetic risk factors for longitudinal changes in structural MRI in former organolead workers. J Aging Res. 2011; 2011:362189. PMID: 22028967; PMCID: PMC3199062.
    42. Lee BK, Glass TA, James BD, Bandeen-Roche K, Schwartz BS. Neighborhood psychosocial environment, apolipoprotein E genotype, and cognitive function in older adults. Arch Gen Psychiatry. 2011 Mar; 68(3):314-21. PMID: 21383266; PMCID: PMC3328419.
    43. James BD, Bennett DA. Smoking in midlife and dementia in old age: risk across the life course. Arch Neurol. 2011 Mar; 68(3):365-8. PMID: 21403022.
      View in: PubMed
    44. James BD, Boyle PA, Buchman AS, Bennett DA. Relation of late-life social activity with incident disability among community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2011 Apr; 66(4):467-73. PMID: 21300745; PMCID: PMC3055280.
    45. Buchman AS, Boyle PA, Wilson RS, James BD, Leurgans SE, Arnold SE, Bennett DA. Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort study. BMC Geriatr. 2010 Oct 22; 10:77. PMID: 20969786; PMCID: PMC2975650.
    46. Boyle PA, Buchman AS, Barnes LL, James BD, Bennett DA. Association between life space and risk of mortality in advanced age. J Am Geriatr Soc. 2010 Oct; 58(10):1925-30. PMID: 20831722; PMCID: PMC3286640.
    47. James BD, Schneider JA. Increasing incidence of dementia in the oldest old: evidence and implications. Alzheimers Res Ther. 2010 May 13; 2(3):9. PMID: 20497589; PMCID: PMC2919692.
    48. Schwartz BS, Caffo B, Stewart WF, Hedlin H, James BD, Yousem D, Davatzikos C. Evaluation of cumulative lead dose and longitudinal changes in structural magnetic resonance imaging in former organolead workers. J Occup Environ Med. 2010 Apr; 52(4):407-14. PMID: 20357679; PMCID: PMC2869464.
    49. Augustin T, Glass TA, James BD, Schwartz BS. Neighborhood psychosocial hazards and cardiovascular disease: the Baltimore Memory Study. Am J Public Health. 2008 Sep; 98(9):1664-70. PMID: 18633086; PMCID: PMC2509598.
    50. Karlawish J, Kim SY, Knopman D, van Dyck CH, James BD, Marson D. Interpreting the clinical significance of capacity scores for informed consent in Alzheimer disease clinical trials. Am J Geriatr Psychiatry. 2008 Jul; 16(7):568-74. PMID: 18556397; PMCID: PMC3936673.
    51. Karlawish J, Kim SY, Knopman D, van Dyck CH, James BD, Marson D. The views of Alzheimer disease patients and their study partners on proxy consent for clinical trial enrollment. Am J Geriatr Psychiatry. 2008 Mar; 16(3):240-7. PMID: 18310554.
      View in: PubMed
    52. Karlawish JH, Bonnie RJ, Appelbaum PS, Kane RA, Lyketsos CG, Karlan PS, James BD, Sabatino C, Lawrence T, Knopman D. Identifying the barriers and challenges to voting by residents in nursing homes and assisted living settings. J Aging Soc Policy. 2008; 20(1):65-79. PMID: 18198160.
      View in: PubMed
    53. Hirschman KB, Joyce CM, James BD, Xie SX, Casarett DJ, Karlawish JH. Would caregivers of Alzheimer disease patients involve their relative in a decision to use an AD-slowing medication? Am J Geriatr Psychiatry. 2005 Nov; 13(11):1014-21. PMID: 16286446.
      View in: PubMed
    54. Hirschman KB, Joyce CM, James BD, Xie SX, Karlawish JH. Do Alzheimer's disease patients want to participate in a treatment decision, and would their caregivers let them? Gerontologist. 2005 Jun; 45(3):381-8. PMID: 15933278.
      View in: PubMed
    55. James BD, Xie SX, Karlawish JH. How do patients with Alzheimer disease rate their overall quality of life? Am J Geriatr Psychiatry. 2005 Jun; 13(6):484-90. PMID: 15956268.
      View in: PubMed
    56. Karlawish JH, Casarett DJ, James BD, Xie SX, Kim SY. The ability of persons with Alzheimer disease (AD) to make a decision about taking an AD treatment. Neurology. 2005 May 10; 64(9):1514-9. PMID: 15883310.
      View in: PubMed
    57. Karlawish JH, Bonnie RJ, Appelbaum PS, Lyketsos C, James B, Knopman D, Patusky C, Kane RA, Karlan PS. Addressing the ethical, legal, and social issues raised by voting by persons with dementia. JAMA. 2004 Sep 15; 292(11):1345-50. PMID: 15367557.
      View in: PubMed
    58. Karlawish JH, Casarett DJ, James BD, Tenhave T, Clark CM, Asch DA. Why would caregivers not want to treat their relative's Alzheimer's disease? J Am Geriatr Soc. 2003 Oct; 51(10):1391-7. PMID: 14511158.
      View in: PubMed
    59. Karlawish JH, Casarett DJ, James BD. Alzheimer's disease patients' and caregivers' capacity, competency, and reasons to enroll in an early-phase Alzheimer's disease clinical trial. J Am Geriatr Soc. 2002 Dec; 50(12):2019-24. PMID: 12473015.
      View in: PubMed
    60. Karlawish JH, Casarett DA, James BD, Propert KJ, Asch DA. Do persons with dementia vote? Neurology. 2002 Apr 09; 58(7):1100-2. PMID: 11940701.
      View in: PubMed
    61. Karlawish JH, Casarett D, Propert KJ, James BD, Clark CM. Relationship between Alzheimer's disease severity and patient participation in decisions about their medical care. J Geriatr Psychiatry Neurol. 2002; 15(2):68-72. PMID: 12083595.
      View in: PubMed
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