 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
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| MeSH Number(s) |
G02.111.087.800 G02.149.115.800 G04.299.880
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| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
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Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 1 | 1 | 2 | | 1992 | 1 | 0 | 1 | | 1994 | 1 | 2 | 3 | | 1996 | 1 | 2 | 3 | | 1997 | 1 | 3 | 4 | | 1998 | 3 | 3 | 6 | | 1999 | 3 | 3 | 6 | | 2000 | 2 | 5 | 7 | | 2001 | 1 | 6 | 7 | | 2002 | 8 | 6 | 14 | | 2003 | 5 | 6 | 11 | | 2004 | 3 | 10 | 13 | | 2005 | 6 | 9 | 15 | | 2006 | 3 | 16 | 19 | | 2007 | 10 | 14 | 24 | | 2008 | 12 | 16 | 28 | | 2009 | 6 | 7 | 13 | | 2010 | 11 | 22 | 33 | | 2011 | 13 | 23 | 36 | | 2012 | 6 | 20 | 26 | | 2013 | 6 | 14 | 20 | | 2014 | 4 | 17 | 21 | | 2015 | 3 | 13 | 16 | | 2016 | 3 | 16 | 19 | | 2017 | 4 | 15 | 19 | | 2018 | 6 | 11 | 17 | | 2019 | 1 | 8 | 9 |
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Bianco AC, Dumitrescu A, Gereben B, Ribeiro MO, Fonseca TL, Fernandes GW, Bocco BMLC. Paradigms of Dynamic Control of Thyroid Hormone Signaling. Endocr Rev. 2019 08 01; 40(4):1000-1047.
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Turturro SB, Najor MS, Yung T, Portt L, Malarkey CS, Abukhdeir AM, Cobleigh MA. Somatic loss of PIK3R1 may sensitize breast cancer to inhibitors of the MAPK pathway. Breast Cancer Res Treat. 2019 Sep; 177(2):325-333.
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Sposito AC, de Lima-Junior JC, Moura FA, Barreto J, Bonilha I, Santana M, Virginio VW, Sun L, Carvalho LSF, Soares AAS, Nadruz W, Feinstein SB, Nofer JR, Zanotti I, Kontush A, Remaley AT. Reciprocal Multifaceted Interaction Between HDL (High-Density Lipoprotein) and Myocardial Infarction. Arterioscler Thromb Vasc Biol. 2019 08; 39(8):1550-1564.
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Voigt RM, Forsyth CB, Keshavarzian A. Circadian rhythms: a regulator of gastrointestinal health and dysfunction. Expert Rev Gastroenterol Hepatol. 2019 May; 13(5):411-424.
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Mittal N, Li L, Sheng Y, Hu C, Li F, Zhu T, Qiao X, Qian Z. A critical role of epigenetic inactivation of miR-9 in EVI1high pediatric AML. Mol Cancer. 2019 02 27; 18(1):30.
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Mishra PK, Palma M, Buechel B, Moore J, Davra V, Chu N, Millman A, Hallab NJ, Kanneganti TD, Birge RB, Behrens EM, Rivera A, Beebe KS, Benevenia J, Gause WC. Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton's tyrosine kinase-dependent pathway. Nat Mater. 2019 03; 18(3):289-297.
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Samelko L, Caicedo MS, Jacobs J, Hallab NJ. Transition from metal-DTH resistance to susceptibility is facilitated by NLRP3 inflammasome signaling induced Th17 reactivity: Implications for orthopedic implants. PLoS One. 2019; 14(1):e0210336.
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Silva DA, Yu S, Ulge UY, Spangler JB, Jude KM, Labão-Almeida C, Ali LR, Quijano-Rubio A, Ruterbusch M, Leung I, Biary T, Crowley SJ, Marcos E, Walkey CD, Weitzner BD, Pardo-Avila F, Castellanos J, Carter L, Stewart L, Riddell SR, Pepper M, Bernardes GJL, Dougan M, Garcia KC, Baker D. De novo design of potent and selective mimics of IL-2 and IL-15. Nature. 2019 01; 565(7738):186-191.
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Deng J, Liu AD, Hou GQ, Zhang X, Ren K, Chen XZ, Li SSC, Wu YS, Cao X. N-acetylcysteine decreases malignant characteristics of glioblastoma cells by inhibiting Notch2 signaling. J Exp Clin Cancer Res. 2019 Jan 03; 38(1):2.
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De Rossi P, Andrew RJ, Musial TF, Buggia-Prevot V, Xu G, Ponnusamy M, Ly H, Krause SV, Rice RC, de l'Estoile V, Valin T, Salem S, Despa F, Borchelt DR, Bindokas VP, Nicholson DA, Thinakaran G. Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models. Brain Pathol. 2019 07; 29(4):485-501.
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