 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
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| MeSH Number(s) |
G02.111.087.800 G02.149.115.800 G04.299.880
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| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
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Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1991 | 1 | 1 | 2 | | 1992 | 1 | 0 | 1 | | 1994 | 1 | 2 | 3 | | 1996 | 1 | 2 | 3 | | 1997 | 1 | 3 | 4 | | 1998 | 3 | 3 | 6 | | 1999 | 3 | 3 | 6 | | 2000 | 2 | 5 | 7 | | 2001 | 1 | 6 | 7 | | 2002 | 8 | 6 | 14 | | 2003 | 5 | 6 | 11 | | 2004 | 2 | 9 | 11 | | 2005 | 5 | 9 | 14 | | 2006 | 3 | 15 | 18 | | 2007 | 10 | 13 | 23 | | 2008 | 11 | 15 | 26 | | 2009 | 6 | 7 | 13 | | 2010 | 10 | 20 | 30 | | 2011 | 13 | 23 | 36 | | 2012 | 6 | 20 | 26 | | 2013 | 6 | 14 | 20 | | 2014 | 4 | 16 | 20 | | 2015 | 4 | 16 | 20 | | 2016 | 3 | 17 | 20 | | 2017 | 4 | 15 | 19 | | 2018 | 7 | 11 | 18 | | 2019 | 2 | 18 | 20 | | 2020 | 4 | 9 | 13 | | 2021 | 3 | 10 | 13 |
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Deng J, Huang M, Wu H. Protective effect of limonin against doxorubicin-induced cardiotoxicity via activating nuclear factor - like 2 and Sirtuin 2 signaling pathways. Bioengineered. 2021 12; 12(1):7975-7984.
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Duan L, Calhoun S, Shim D, Perez RE, Blatter LA, Maki CG. Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells. J Mol Cell Biol. 2021 09 11; 13(6):433-444.
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Dutta D, Jana M, Majumder M, Mondal S, Roy A, Pahan K. Selective targeting of the TLR2/MyD88/NF-?B pathway reduces a-synuclein spreading in vitro and in vivo. Nat Commun. 2021 09 10; 12(1):5382.
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Andersen JB, Hultqvist LD, Jansen CU, Jakobsen TH, Nilsson M, Rybtke M, Uhd J, Fritz BG, Seifert R, Berthelsen J, Nielsen TE, Qvortrup K, Givskov M, Tolker-Nielsen T. Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms. NPJ Biofilms Microbiomes. 2021 07 09; 7(1):59.
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Russo ML, Molina-Campos E, Ybarra N, Rogalsky AE, Musial TF, Jimenez V, Haddad LG, Voskobiynyk Y, D'Souza GX, Carballo G, Neuman KM, Chetkovich DM, Oh MM, Disterhoft JF, Nicholson DA. Variability in sub-threshold signaling linked to Alzheimer's disease emerges with age and amyloid plaque deposition in mouse ventral CA1 pyramidal neurons. Neurobiol Aging. 2021 10; 106:207-222.
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Napolitano A, Ostler AE, Jones RL, Huang PH. Fibroblast Growth Factor Receptor (FGFR) Signaling in GIST and Soft Tissue Sarcomas. Cells. 2021 06 17; 10(6).
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Roehle K, Qiang L, Ventre KS, Heid D, Ali LR, Lenehan P, Heckler M, Crowley SJ, Stump CT, Ro G, Godicelj A, Bhuiyan AM, Yang A, Quiles Del Rey M, Biary T, Luoma AM, Bruck PT, Tegethoff JF, Nopper SL, Li J, Byrne KT, Pelletier M, Wucherpfennig KW, Stanger BZ, Akin JJ, Mancias JD, Agudo J, Dougan M, Dougan SK. cIAP1/2 antagonism eliminates MHC class I-negative tumors through T cell-dependent reprogramming of mononuclear phagocytes. Sci Transl Med. 2021 05 19; 13(594).
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Arvanitakis Z, Capuano AW, Wang HY, Schneider JA, Kapasi A, Bennett DA, Ahima RS, Arnold SE. Brain insulin signaling and cerebrovascular disease in human postmortem brain. Acta Neuropathol Commun. 2021 04 15; 9(1):71.
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Raj N, McEachin ZT, Harousseau W, Zhou Y, Zhang F, Merritt-Garza ME, Taliaferro JM, Kalinowska M, Marro SG, Hales CM, Berry-Kravis E, Wolf-Ochoa MW, Martinez-Cerdeño V, Wernig M, Chen L, Klann E, Warren ST, Jin P, Wen Z, Bassell GJ. Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis. Cell Rep. 2021 04 13; 35(2):108991.
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Arif M, Alam P, Ahmed RP, Pandey R, Faridi HM, Sadayappan S. Upregulated Angiogenesis Is Incompetent to Rescue Dilated Cardiomyopathy Phenotype in Mice. Cells. 2021 03 31; 10(4).
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