Inositol 1,4,5-Trisphosphate
"Inositol 1,4,5-Trisphosphate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.
| Descriptor ID |
D015544
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| MeSH Number(s) |
D02.033.800.519.400.350 D09.853.519.400.350 D09.894.480.350
|
| Concept/Terms |
Inositol 1,4,5-Trisphosphate- Inositol 1,4,5-Trisphosphate
- Inositol 1,4,5-Triphosphate
- Myoinositol 1,4,5-Triphosphate
- 1,4,5-InsP3
- 1,4,5-IP3
- Myo-Inositol 1,4,5-Trisphosphate
|
Below are MeSH descriptors whose meaning is more general than "Inositol 1,4,5-Trisphosphate".
Below are MeSH descriptors whose meaning is more specific than "Inositol 1,4,5-Trisphosphate".
This graph shows the total number of publications written about "Inositol 1,4,5-Trisphosphate" by people in this website by year, and whether "Inositol 1,4,5-Trisphosphate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 0 | 2 | 2 |
| 1998 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
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Below are the most recent publications written about "Inositol 1,4,5-Trisphosphate" by people in Profiles.
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Increased Risk for Atrial Alternans in Rabbit Heart Failure: The Role of Ca2+/Calmodulin-Dependent Kinase II and Inositol-1,4,5-trisphosphate Signaling. Biomolecules. 2023 Dec 30; 14(1).
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Biosensors to measure inositol 1,4,5-trisphosphate concentration in living cells with spatiotemporal resolution. J Biol Chem. 2006 Jan 06; 281(1):608-16.
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Astrocytes in adult rat brain express type 2 inositol 1,4,5-trisphosphate receptors. Glia. 2002 Jul; 39(1):69-84.
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Single-channel function of recombinant type 2 inositol 1,4, 5-trisphosphate receptor. Biophys J. 2000 Sep; 79(3):1388-99.
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Isoform-specific function of single inositol 1,4,5-trisphosphate receptor channels. Biophys J. 1998 Aug; 75(2):834-9.
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Identification and functional reconstitution of the type 2 inositol 1,4,5-trisphosphate receptor from ventricular cardiac myocytes. J Biol Chem. 1997 Sep 19; 272(38):23961-9.
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'Quantal' calcium release operated by membrane voltage in frog skeletal muscle. J Physiol. 1997 Jun 01; 501 ( Pt 2):289-303.
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Functionally heterogenous ryanodine receptors in avian cerebellum. J Biol Chem. 1996 Jul 19; 271(29):17028-34.
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Ryanodine receptor adaptation: control mechanism of Ca(2+)-induced Ca2+ release in heart. Science. 1993 May 07; 260(5109):807-9.
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The mechanical hypothesis of excitation-contraction (EC) coupling in skeletal muscle. J Muscle Res Cell Motil. 1991 Apr; 12(2):127-35.