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Frank C. Ko

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentAnatomy and Cell Biology
AddressChicago IL 60612
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    Collapse overview
    Frank C. Ko, PhD, completed his graduate training in musculoskeletal biomechanics at Cornell University. He subsequently pursued postdoctoral training at Massachusetts General Hospital and Beth Israel Deaconess Medical Center in musculoskeletal biology and mechanics. Dr. Ko’s current interest is in determining the molecular basis of intramembranous bone regeneration. He is a member of Orthopaedic Research Society and American Society for Bone and Mineral Research.

    Research Areas:
    Musculoskeletal homeostasis, disease, and repair.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/frank-c-ko-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/anatomy-cell-biology-research/laboratory-frank-ko-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/myncbi/1dqanars5t55i/bibliography/public/

    Education:
    PhD, Cornell University

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wilson BM, Ko FC, Moran MM, Adra A, Rasmussen MB, Thymann T, Sangild PT, Sumner DR. Skeletal consequences of preterm birth in pigs as a model for preterm infants. J Bone Miner Res. 2024 Jul 23; 39(6):791-803. PMID: 38655758.
      Citations:    
    2. Ko FC, Xie R, Willis B, Herdman ZG, Dulion BA, Lee H, Oh CD, Chen D, Sumner DR, Ko FC, Xie R, Willis B, Herdman ZG, Dulion BA, Lee H, Oh CD, Chen D, Sumner DR. Cells transiently expressing periostin are required for intramedullary intramembranous bone regeneration. Bone. 2024 01; 178:116934. PMID: 37839663; PMCID: PMC10841632.
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    3. Anderson KD, Beckmann C, Heermant S, Ko FC, Dulion B, Tarhoni I, Borgia JA, Virdi AS, Wimmer MA, Sumner DR, Ross RD, Anderson KD, Beckmann C, Heermant S, Ko FC, Dulion B, Tarhoni I, Borgia JA, Virdi AS, Wimmer MA, Sumner DR, Ross RD. Zucker Diabetic-Sprague Dawley Rats Have Impaired Peri-Implant Bone Formation, Matrix Composition, and Implant Fixation Strength. JBMR Plus. 2023 Nov; 7(11):e10819. PMID: 38025036; PMCID: PMC10652173.
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    4. Jochum SB, Engen PA, Shaikh M, Naqib A, Wilber S, Raeisi S, Zhang L, Song S, Sanzo G, Chouhan V, Ko F, Post Z, Tran L, Ramirez V, Green SJ, Khazaie K, Hayden DM, Brown MJ, Voigt RM, Forsyth CB, Keshavarzian A, Swanson GR. Colonic Epithelial Circadian Disruption Worsens Dextran Sulfate Sodium-Induced Colitis. Inflamm Bowel Dis. 2023 03 01; 29(3):444-457. PMID: 36287037.
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    5. Qiao Y, Li J, Yuh C, Ko F, Mercuri LG, Alkhudari J, Pourzal R, Oh CD. Chemokine Regulation in Temporomandibular Joint Disease: A Comprehensive Review. Genes (Basel). 2023 02 04; 14(2). PMID: 36833336.
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    6. Ko FC, Jochum SB, Wilson BM, Adra A, Patel N, Lee H, Wilber S, Shaikh M, Forsyth C, Keshavarzian A, Swanson GR, Sumner DR, Ko FC, Jochum SB, Wilson BM, Adra A, Patel N, Lee H, Wilber S, Shaikh M, Forsyth C, Keshavarzian A, Swanson GR, Sumner DR. Colon epithelial cell-specific Bmal1 deletion impairs bone formation in mice. Bone. 2023 03; 168:116650. PMID: 36584784; PMCID: PMC9911378.
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    7. Moran MM, Ko FC, Mesner LD, Calabrese GM, Al-Barghouthi BM, Farber CR, Sumner DR, Moran MM, Ko FC, Mesner LD, Calabrese GM, Al-Barghouthi BM, Farber CR, Sumner DR. Intramembranous bone regeneration in diversity outbred mice is heritable. Bone. 2022 11; 164:116524. PMID: 36028119; PMCID: PMC9798271.
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    8. Wilson BM, Witkiewics BR, Voigt RM, Forysth CB, Keshavarzian A, Ko FC, Virdi AS, Sumner DR, Wilson BM, Witkiewics BR, Voigt RM, Forysth CB, Keshavarzian A, Ko FC, Virdi AS, Sumner DR. Alcohol and Circadian Disruption Minimally Impact Bone Properties in Two Cohorts of Male Mice While Between-Cohort Differences Predominate: Association With Season of Birth? JBMR Plus. 2022 Mar; 6(3):e10591. PMID: 35309863; PMCID: PMC8914150.
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    9. Ko FC, Moran MM, Ross RD, Sumner DR, Ko FC, Moran MM, Ross RD, Sumner DR. Activation of canonical Wnt signaling accelerates intramembranous bone regeneration in male mice. J Orthop Res. 2022 08; 40(8):1834-1843. PMID: 34811780; PMCID: PMC9124233.
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    10. Spatz JM, Ko FC, Ayturk UM, Warman ML, Bouxsein ML. RNAseq and RNA molecular barcoding reveal differential gene expression in cortical bone following hindlimb unloading in female mice. PLoS One. 2021; 16(10):e0250715. PMID: 34637435.
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    11. Carpenter KA, Davison R, Shakthivel S, Anderson KD, Ko FC, Ross RD, Carpenter KA, Davison R, Shakthivel S, Anderson KD, Ko FC, Ross RD. Sclerostin antibody improves phosphate metabolism hormones, bone formation rates, and bone mass in adult Hyp mice. Bone. 2022 01; 154:116201. PMID: 34537437; PMCID: PMC8671249.
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    12. Anderson KD, Ko FC, Fullam S, Virdi AS, Wimmer MA, Sumner DR, Ross RD, Anderson KD, Ko FC, Fullam S, Virdi AS, Wimmer MA, Sumner DR, Ross RD. The relative contribution of bone microarchitecture and matrix composition to implant fixation strength in rats. J Orthop Res. 2022 04; 40(4):862-870. PMID: 34061392; PMCID: PMC8633073.
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    13. Ko FC, Kobelski MM, Zhang W, Grenga GM, Martins JS, Demay MB. Phosphate restriction impairs mTORC1 signaling leading to increased bone marrow adipose tissue and decreased bone in growing mice. J Bone Miner Res. 2021 08; 36(8):1510-1520. PMID: 33900666.
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    14. Copello FM, Silveira AM, Castro ACR, Lopes RT, Ko F, Sumner DR, Sant'Anna EF, Copello FM, Silveira AM, Castro ACR, Lopes RT, Ko F, Sumner DR, Sant'Anna EF. In-vitro trabecular bone damage following mono- and bicortical mini implants anchorage in mini-implant assisted rapid palatal expansion (MARPE). Int Orthod. 2021 Jun; 19(2):243-251. PMID: 33811012.
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    15. Anderson KD, Ko FC, Virdi AS, Sumner DR, Ross RD, Anderson KD, Ko FC, Virdi AS, Sumner DR, Ross RD. Biomechanics of Implant Fixation in Osteoporotic Bone. Curr Osteoporos Rep. 2020 10; 18(5):577-586. PMID: 32734511; PMCID: PMC7541774.
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    16. Ko FC, Sumner DR, Ko FC, Sumner DR. How faithfully does intramembranous bone regeneration recapitulate embryonic skeletal development? Dev Dyn. 2021 03; 250(3):377-392. PMID: 32813296.
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    17. Ko FC, Mortreux M, Riveros D, Nagy JA, Rutkove SB, Bouxsein ML. Dose-dependent skeletal deficits due to varied reductions in mechanical loading in rats. NPJ Microgravity. 2020; 6:15. PMID: 32435691.
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    18. Wang W, Li J, Ko FC, Zhao X, Qiao Y, Lu RS, Sumner DR, Wang T, Chen D. CHIP regulates skeletal development and postnatal bone growth. J Cell Physiol. 2020 06; 235(6):5378-5385. PMID: 31898815.
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    19. Ko FC, Meagher MJ, Mashiatulla M, Ross RD, Virdi AS, Sumner DR. Implant surface alters compartmental-specific contributions to fixation strength in rats. J Orthop Res. 2020 06; 38(6):1208-1215. PMID: 31821588.
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    20. Morse A, Ko FC, McDonald MM, Lee LR, Schindeler A, van der Meulen MCH, Little DG. Increased anabolic bone response in Dkk1 KO mice following tibial compressive loading. Bone. 2020 02; 131:115054. PMID: 31521827.
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    21. Mortreux M, Ko FC, Riveros D, Bouxsein ML, Rutkove SB. Longitudinal time course of muscle impairments during partial weight-bearing in rats. NPJ Microgravity. 2019; 5:20. PMID: 31453318.
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    22. Kuehn F, Adiliaghdam F, Hamarneh SR, Vasan R, Liu E, Liu Y, Ramirez JM, Hoda RS, Munoz AR, Ko FC, Armanini M, Brooks DJ, Bouxsein ML, Demay MB, Hodin RA. Loss of Intestinal Alkaline Phosphatase Leads to Distinct Chronic Changes in Bone Phenotype. J Surg Res. 2018 12; 232:325-331. PMID: 30463736.
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    23. Ko FC, Li J, Brooks DJ, Rutkove SB, Bouxsein ML. Structural and functional properties of bone are compromised in amyotrophic lateral sclerosis mice. Amyotroph Lateral Scler Frontotemporal Degener. 2018 08; 19(5-6):457-462. PMID: 29569488.
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    24. Mortreux M, Nagy JA, Ko FC, Bouxsein ML, Rutkove SB. A novel partial gravity ground-based analog for rats via quadrupedal unloading. J Appl Physiol (1985). 2018 07 01; 125(1):175-182. PMID: 29565773.
      Citations:    
    25. Ko FC, Van Vliet M, Ellman R, Grasso D, Brooks DJ, Spatz JM, Conlon C, Aguirre JI, Wronski TJ, Bouxsein ML. Treatment With a Soluble Bone Morphogenetic Protein Type 1A Receptor (BMPR1A) Fusion Protein Increases Bone Mass and Bone Formation in Mice Subjected to Hindlimb Unloading. JBMR Plus. 2017 Oct; 1(2):66-72. PMID: 30283882.
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    26. Adebayo OO, Ko FC, Wan PT, Goldring SR, Goldring MB, Wright TM, van der Meulen MCH. Role of subchondral bone properties and changes in development of load-induced osteoarthritis in mice. Osteoarthritis Cartilage. 2017 12; 25(12):2108-2118. PMID: 28919430.
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    27. Ko FC, Karim L, Brooks DJ, Bouxsein ML, Demay MB. Bisphosphonate Withdrawal: Effects on Bone Formation and Bone Resorption in Maturing Male Mice. J Bone Miner Res. 2017 04; 32(4):814-820. PMID: 27925290.
      Citations:    
    28. Ko FC, Martins JS, Reddy P, Bragdon B, Hussein AI, Gerstenfeld LC, Demay MB. Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice. J Bone Miner Res. 2016 12; 31(12):2204-2214. PMID: 27324177.
      Citations:    
    29. Adebayo OO, Ko FC, Goldring SR, Goldring MB, Wright TM, van der Meulen MC. Kinematics of meniscal- and ACL-transected mouse knees during controlled tibial compressive loading captured using roentgen stereophotogrammetry. J Orthop Res. 2017 02; 35(2):353-360. PMID: 27153222.
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    30. Ko FC, Dragomir CL, Plumb DA, Hsia AW, Adebayo OO, Goldring SR, Wright TM, Goldring MB, van der Meulen MC. Progressive cell-mediated changes in articular cartilage and bone in mice are initiated by a single session of controlled cyclic compressive loading. J Orthop Res. 2016 11; 34(11):1941-1949. PMID: 26896841.
      Citations:    
    31. Ko FC, Dragomir C, Plumb DA, Goldring SR, Wright TM, Goldring MB, van der Meulen MC. In vivo cyclic compression causes cartilage degeneration and subchondral bone changes in mouse tibiae. Arthritis Rheum. 2013 Jun; 65(6):1569-78. PMID: 23436303.
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    32. Fahlgren A, Yang X, Ciani C, Ryan JA, Kelly N, Ko FC, van der Meulen MC, Bostrom MP. The effects of PTH, loading and surgical insult on cancellous bone at the bone-implant interface in the rabbit. Bone. 2013 Feb; 52(2):718-24. PMID: 22613252.
      Citations:    
    33. Tse EY, Ko FC, Tung EK, Chan LK, Lee TK, Ngan ES, Man K, Wong AS, Ng IO, Yam JW. Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis. J Pathol. 2012 Mar; 226(4):645-53. PMID: 22072235.
      Citations:    
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