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Frank C. Ko

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentAnatomy and Cell Biology
AddressChicago IL 60612
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    Frank C. Ko, PhD, completed his graduate training in musculoskeletal biomechanics at Cornell University. He subsequently pursued postdoctoral training at Massachusetts General Hospital and Beth Israel Deaconess Medical Center in musculoskeletal biology and mechanics. Dr. Ko’s current interest is in determining the molecular basis of intramembranous bone regeneration. He is a member of Orthopaedic Research Society and American Society for Bone and Mineral Research.

    Research Areas:
    Musculoskeletal homeostasis, disease, and repair.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/frank-c-ko-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/anatomy-cell-biology-research/laboratory-frank-ko-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/myncbi/1dqanars5t55i/bibliography/public/

    Education:
    PhD, Cornell University


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Ko FC, Xie R, Willis B, Herdman ZG, Dulion BA, Lee H, Oh CD, Chen D, Sumner DR. Cells transiently expressing periostin are required for intramedullary intramembranous bone regeneration. Bone. 2024 Jan; 178:116934. PMID: 37839663.
      View in: PubMed
    2. Jochum SB, Engen PA, Shaikh M, Naqib A, Wilber S, Raeisi S, Zhang L, Song S, Sanzo G, Chouhan V, Ko F, Post Z, Tran L, Ramirez V, Green SJ, Khazaie K, Hayden DM, Brown MJ, Voigt RM, Forsyth CB, Keshavarzian A, Swanson GR. Colonic Epithelial Circadian Disruption Worsens Dextran Sulfate Sodium-Induced Colitis. Inflamm Bowel Dis. 2023 03 01; 29(3):444-457. PMID: 36287037.
      View in: PubMed
    3. Qiao Y, Li J, Yuh C, Ko F, Mercuri LG, Alkhudari J, Pourzal R, Oh CD. Chemokine Regulation in Temporomandibular Joint Disease: A Comprehensive Review. Genes (Basel). 2023 02 04; 14(2). PMID: 36833336.
      View in: PubMed
    4. Ko FC, Jochum SB, Wilson BM, Adra A, Patel N, Lee H, Wilber S, Shaikh M, Forsyth C, Keshavarzian A, Swanson GR, Sumner DR. Colon epithelial cell-specific Bmal1 deletion impairs bone formation in mice. Bone. 2023 03; 168:116650. PMID: 36584784.
      View in: PubMed
    5. Moran MM, Ko FC, Mesner LD, Calabrese GM, Al-Barghouthi BM, Farber CR, Sumner DR. Intramembranous bone regeneration in diversity outbred mice is heritable. Bone. 2022 11; 164:116524. PMID: 36028119.
      View in: PubMed
    6. Wilson BM, Witkiewics BR, Voigt RM, Forysth CB, Keshavarzian A, Ko FC, Virdi AS, Sumner DR. Alcohol and Circadian Disruption Minimally Impact Bone Properties in Two Cohorts of Male Mice While Between-Cohort Differences Predominate: Association With Season of Birth? JBMR Plus. 2022 Mar; 6(3):e10591. PMID: 35309863.
      View in: PubMed
    7. Ko FC, Moran MM, Ross RD, Sumner DR. Activation of canonical Wnt signaling accelerates intramembranous bone regeneration in male mice. J Orthop Res. 2022 08; 40(8):1834-1843. PMID: 34811780.
      View in: PubMed
    8. Spatz JM, Ko FC, Ayturk UM, Warman ML, Bouxsein ML. RNAseq and RNA molecular barcoding reveal differential gene expression in cortical bone following hindlimb unloading in female mice. PLoS One. 2021; 16(10):e0250715. PMID: 34637435.
      View in: PubMed
    9. Carpenter KA, Davison R, Shakthivel S, Anderson KD, Ko FC, Ross RD. Sclerostin antibody improves phosphate metabolism hormones, bone formation rates, and bone mass in adult Hyp mice. Bone. 2022 01; 154:116201. PMID: 34537437.
      View in: PubMed
    10. Anderson KD, Ko FC, Fullam S, Virdi AS, Wimmer MA, Sumner DR, Ross RD. The relative contribution of bone microarchitecture and matrix composition to implant fixation strength in rats. J Orthop Res. 2022 04; 40(4):862-870. PMID: 34061392.
      View in: PubMed
    11. Ko FC, Kobelski MM, Zhang W, Grenga GM, Martins JS, Demay MB. Phosphate restriction impairs mTORC1 signaling leading to increased bone marrow adipose tissue and decreased bone in growing mice. J Bone Miner Res. 2021 08; 36(8):1510-1520. PMID: 33900666.
      View in: PubMed
    12. Copello FM, Silveira AM, Castro ACR, Lopes RT, Ko F, Sumner DR, Sant'Anna EF. In-vitro trabecular bone damage following mono- and bicortical mini implants anchorage in mini-implant assisted rapid palatal expansion (MARPE). Int Orthod. 2021 Jun; 19(2):243-251. PMID: 33811012.
      View in: PubMed
    13. Anderson KD, Ko FC, Virdi AS, Sumner DR, Ross RD. Biomechanics of Implant Fixation in Osteoporotic Bone. Curr Osteoporos Rep. 2020 10; 18(5):577-586. PMID: 32734511.
      View in: PubMed
    14. Ko FC, Sumner DR. How faithfully does intramembranous bone regeneration recapitulate embryonic skeletal development? Dev Dyn. 2021 03; 250(3):377-392. PMID: 32813296.
      View in: PubMed
    15. Ko FC, Mortreux M, Riveros D, Nagy JA, Rutkove SB, Bouxsein ML. Dose-dependent skeletal deficits due to varied reductions in mechanical loading in rats. NPJ Microgravity. 2020; 6:15. PMID: 32435691.
      View in: PubMed
    16. Wang W, Li J, Ko FC, Zhao X, Qiao Y, Lu RS, Sumner DR, Wang T, Chen D. CHIP regulates skeletal development and postnatal bone growth. J Cell Physiol. 2020 06; 235(6):5378-5385. PMID: 31898815.
      View in: PubMed
    17. Ko FC, Meagher MJ, Mashiatulla M, Ross RD, Virdi AS, Sumner DR. Implant surface alters compartmental-specific contributions to fixation strength in rats. J Orthop Res. 2020 06; 38(6):1208-1215. PMID: 31821588.
      View in: PubMed
    18. Morse A, Ko FC, McDonald MM, Lee LR, Schindeler A, van der Meulen MCH, Little DG. Increased anabolic bone response in Dkk1 KO mice following tibial compressive loading. Bone. 2020 02; 131:115054. PMID: 31521827.
      View in: PubMed
    19. Mortreux M, Ko FC, Riveros D, Bouxsein ML, Rutkove SB. Longitudinal time course of muscle impairments during partial weight-bearing in rats. NPJ Microgravity. 2019; 5:20. PMID: 31453318.
      View in: PubMed
    20. Kuehn F, Adiliaghdam F, Hamarneh SR, Vasan R, Liu E, Liu Y, Ramirez JM, Hoda RS, Munoz AR, Ko FC, Armanini M, Brooks DJ, Bouxsein ML, Demay MB, Hodin RA. Loss of Intestinal Alkaline Phosphatase Leads to Distinct Chronic Changes in Bone Phenotype. J Surg Res. 2018 12; 232:325-331. PMID: 30463736.
      View in: PubMed
    21. Ko FC, Li J, Brooks DJ, Rutkove SB, Bouxsein ML. Structural and functional properties of bone are compromised in amyotrophic lateral sclerosis mice. Amyotroph Lateral Scler Frontotemporal Degener. 2018 08; 19(5-6):457-462. PMID: 29569488.
      View in: PubMed
    22. Mortreux M, Nagy JA, Ko FC, Bouxsein ML, Rutkove SB. A novel partial gravity ground-based analog for rats via quadrupedal unloading. J Appl Physiol (1985). 2018 07 01; 125(1):175-182. PMID: 29565773.
      View in: PubMed
    23. Ko FC, Van Vliet M, Ellman R, Grasso D, Brooks DJ, Spatz JM, Conlon C, Aguirre JI, Wronski TJ, Bouxsein ML. Treatment With a Soluble Bone Morphogenetic Protein Type 1A Receptor (BMPR1A) Fusion Protein Increases Bone Mass and Bone Formation in Mice Subjected to Hindlimb Unloading. JBMR Plus. 2017 Oct; 1(2):66-72. PMID: 30283882.
      View in: PubMed
    24. Adebayo OO, Ko FC, Wan PT, Goldring SR, Goldring MB, Wright TM, van der Meulen MCH. Role of subchondral bone properties and changes in development of load-induced osteoarthritis in mice. Osteoarthritis Cartilage. 2017 12; 25(12):2108-2118. PMID: 28919430.
      View in: PubMed
    25. Ko FC, Karim L, Brooks DJ, Bouxsein ML, Demay MB. Bisphosphonate Withdrawal: Effects on Bone Formation and Bone Resorption in Maturing Male Mice. J Bone Miner Res. 2017 04; 32(4):814-820. PMID: 27925290.
      View in: PubMed
    26. Ko FC, Martins JS, Reddy P, Bragdon B, Hussein AI, Gerstenfeld LC, Demay MB. Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice. J Bone Miner Res. 2016 12; 31(12):2204-2214. PMID: 27324177.
      View in: PubMed
    27. Adebayo OO, Ko FC, Goldring SR, Goldring MB, Wright TM, van der Meulen MC. Kinematics of meniscal- and ACL-transected mouse knees during controlled tibial compressive loading captured using roentgen stereophotogrammetry. J Orthop Res. 2017 02; 35(2):353-360. PMID: 27153222.
      View in: PubMed
    28. Ko FC, Dragomir CL, Plumb DA, Hsia AW, Adebayo OO, Goldring SR, Wright TM, Goldring MB, van der Meulen MC. Progressive cell-mediated changes in articular cartilage and bone in mice are initiated by a single session of controlled cyclic compressive loading. J Orthop Res. 2016 11; 34(11):1941-1949. PMID: 26896841.
      View in: PubMed
    29. Ko FC, Dragomir C, Plumb DA, Goldring SR, Wright TM, Goldring MB, van der Meulen MC. In vivo cyclic compression causes cartilage degeneration and subchondral bone changes in mouse tibiae. Arthritis Rheum. 2013 Jun; 65(6):1569-78. PMID: 23436303.
      View in: PubMed
    30. Fahlgren A, Yang X, Ciani C, Ryan JA, Kelly N, Ko FC, van der Meulen MC, Bostrom MP. The effects of PTH, loading and surgical insult on cancellous bone at the bone-implant interface in the rabbit. Bone. 2013 Feb; 52(2):718-24. PMID: 22613252.
      View in: PubMed
    31. Tse EY, Ko FC, Tung EK, Chan LK, Lee TK, Ngan ES, Man K, Wong AS, Ng IO, Yam JW. Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis. J Pathol. 2012 Mar; 226(4):645-53. PMID: 22072235.
      View in: PubMed
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