NLR Family, Pyrin Domain-Containing 3 Protein
"NLR Family, Pyrin Domain-Containing 3 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.
| Descriptor ID |
D000071199
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| MeSH Number(s) |
D12.644.360.539.250
|
| Concept/Terms |
NLR Family, Pyrin Domain-Containing 3 Protein- NLR Family, Pyrin Domain-Containing 3 Protein
- NLR Family, Pyrin Domain Containing 3 Protein
- Cold Autoinflammatory Syndrome 1 Protein
- NACHT, LRR and PYD Domains-Containing Protein 3
- NACHT, LRR and PYD Domains Containing Protein 3
- NLRP3 Protein
|
Below are MeSH descriptors whose meaning is more general than "NLR Family, Pyrin Domain-Containing 3 Protein".
Below are MeSH descriptors whose meaning is more specific than "NLR Family, Pyrin Domain-Containing 3 Protein".
This graph shows the total number of publications written about "NLR Family, Pyrin Domain-Containing 3 Protein" by people in this website by year, and whether "NLR Family, Pyrin Domain-Containing 3 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "NLR Family, Pyrin Domain-Containing 3 Protein" by people in Profiles.
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Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form. Nat Immunol. 2023 03; 24(3):412-413.
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Metal-induced delayed type hypersensitivity responses potentiate particle induced osteolysis in a sex and age dependent manner. PLoS One. 2021; 16(5):e0251885.
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Inflammasome expression is higher in ovarian tumors than in normal ovary. PLoS One. 2020; 15(1):e0227081.
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Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation. Nat Immunol. 2020 01; 21(1):30-41.
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Transition from metal-DTH resistance to susceptibility is facilitated by NLRP3 inflammasome signaling induced Th17 reactivity: Implications for orthopedic implants. PLoS One. 2019; 14(1):e0210336.
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Impaired phagocytosis directs human monocyte activation in response to fungal derived ?-glucan particles. Eur J Immunol. 2018 05; 48(5):757-770.
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Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms. J Orthop Res. 2013 Oct; 31(10):1633-42.
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Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity. J Orthop Res. 2009 Jul; 27(7):847-54.