 Up-Regulation
"Up-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015854
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| MeSH Number(s) |
G02.111.087.880 G02.149.115.880 G05.355.315.850 G07.690.812.925 G07.700.680.925
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| Concept/Terms |
Up-Regulation- Up-Regulation
- Up Regulation
- Upregulation
- Up-Regulation (Physiology)
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Below are MeSH descriptors whose meaning is more general than "Up-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Up-Regulation".
This graph shows the total number of publications written about "Up-Regulation" by people in this website by year, and whether "Up-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 1 | 0 | 1 | | 1992 | 1 | 0 | 1 | | 1996 | 1 | 0 | 1 | | 1998 | 0 | 1 | 1 | | 2000 | 2 | 2 | 4 | | 2001 | 1 | 4 | 5 | | 2002 | 0 | 2 | 2 | | 2003 | 1 | 8 | 9 | | 2004 | 0 | 4 | 4 | | 2005 | 2 | 3 | 5 | | 2006 | 1 | 9 | 10 | | 2007 | 1 | 11 | 12 | | 2008 | 1 | 9 | 10 | | 2009 | 1 | 5 | 6 | | 2010 | 0 | 6 | 6 | | 2011 | 3 | 4 | 7 | | 2012 | 3 | 4 | 7 | | 2013 | 3 | 5 | 8 | | 2014 | 2 | 6 | 8 | | 2015 | 1 | 8 | 9 | | 2016 | 1 | 4 | 5 | | 2017 | 0 | 3 | 3 | | 2018 | 1 | 2 | 3 | | 2019 | 1 | 3 | 4 |
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Below are the most recent publications written about "Up-Regulation" by people in Profiles.
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Arakawa Y, Yokoyama K, Tasaki S, Kato J, Nakashima K, Takeyama M, Nakatani A, Suzuki M. Transgenic mice overexpressing miR-137 in the brain show schizophrenia-associated behavioral deficits and transcriptome profiles. PLoS One. 2019; 14(7):e0220389.
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Gottschalk CG, Roy A, Jana M, Kundu M, Pahan K. Activation of Peroxisome Proliferator-Activated Receptor-a Increases the Expression of Nuclear Receptor Related 1 Protein (Nurr1) in Dopaminergic Neurons. Mol Neurobiol. 2019 Nov; 56(11):7872-7887.
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Chakrabarti S, Chandra S, Roy A, Dasarathi S, Kundu M, Pahan K. Upregulation of tripeptidyl-peptidase 1 by 3-hydroxy-(2,2)-dimethyl butyrate, a brain endogenous ligand of PPARa: Implications for late-infantile Batten disease therapy. Neurobiol Dis. 2019 07; 127:362-373.
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Azher I, Kaushal A, Chang A, Cutting S, Mac Grory B, Burton T, Dakay K, Thompson B, Reznik M, Wendell L, Potter NS, Mahta A, Rao S, Paciaroni M, Elkind MSV, Jayaraman M, Atalay M, Furie K, Yaghi S. Serum Troponin Level in Acute Ischemic Stroke Identifies Patients with Visceral Infarcts. J Stroke Cerebrovasc Dis. 2019 May; 28(5):1173-1177.
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Yu Y, Blokhuis BRJ, Diks MAP, Keshavarzian A, Garssen J, Redegeld FA. Functional Inhibitory Siglec-6 Is Upregulated in Human Colorectal Cancer-Associated Mast Cells. Front Immunol. 2018; 9:2138.
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Witcher PC, Miner SE, Horan DJ, Bullock WA, Lim KE, Kang KS, Adaniya AL, Ross RD, Loots GG, Robling AG. Sclerostin neutralization unleashes the osteoanabolic effects of Dkk1 inhibition. JCI Insight. 2018 06 07; 3(11).
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Chakrabarti S, Jana M, Roy A, Pahan K. Upregulation of Suppressor of Cytokine Signaling 3 in Microglia by Cinnamic Acid. Curr Alzheimer Res. 2018; 15(10):894-904.
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Chandra G, Kundu M, Rangasamy SB, Dasarathy S, Ghosh S, Watson R, Pahan K. Increase in Mitochondrial Biogenesis in Neuronal Cells by RNS60, a Physically-Modified Saline, via Phosphatidylinositol 3-Kinase-Mediated Upregulation of PGC1a. J Neuroimmune Pharmacol. 2018 06; 13(2):143-162.
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Samman Tahhan A, Hayek SS, Sandesara P, Hajjari J, Hammadah M, O'Neal WT, Kelli HM, Alkhoder A, Ghasemzadeh N, Ko YA, Aida H, Gafeer MM, Abdelhadi N, Mohammed KH, Patel K, Arya S, Reiser J, Vaccarino V, Sperling L, Quyyumi A. Circulating soluble urokinase plasminogen activator receptor levels and peripheral arterial disease outcomes. Atherosclerosis. 2017 Sep; 264:108-114.
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Wang J, Shidfar A, Ivancic D, Ranjan M, Liu L, Choi MR, Parimi V, Gursel DB, Sullivan ME, Najor MS, Abukhdeir AM, Scholtens D, Khan SA. Overexpression of lipid metabolism genes and PBX1 in the contralateral breasts of women with estrogen receptor-negative breast cancer. Int J Cancer. 2017 06 01; 140(11):2484-2497.
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