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Michael Fill

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentPhysiology and Biophysics
AddressChicago IL 60612
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    Collapse Biography 
    Collapse awards and honors
    2016Chair of the NIH MOSS-V02 Study Section, NIH
    2015The Francis & Catherine Bard Endowed Chair of Physiology, Rush University
    2014Ad Hoc member NIH MOSS-C02 Study Section, NIH
    2014Member NIH Director’s Early Independence DP5 Award Panel, NIH
    2009Member Journal General Physiology Editorial Advisory Board, Journal General Physiology, Journal General Physiology
    2008Ad Hoc reviewer NIH Study Section, NIH

    Collapse Overview 
    Collapse overview
    Chair and The Francis N. and Catherine O. Bard Professor of Physiology, Department of Physiology & Biophysics, Rush Medical College, Rush University Medical Center.

    The research of Michael Fill, PhD, explores the local control of intracellular Ca signals mediated by the ryanodine receptor (RyR) Ca release channel in excitable cells. These control mechanisms are fundamental to many cellular phenomena and, thus, are often sites of pathological failure and potential targets for therapeutic intervention.

    Dr. Fill’s laboratory at Rush University is internationally recognized for its world-class RyR experimental expertise. The Ca signals generated by RyRs are known to modulate a myriad of physiological functions. Our lab details clinically significant structure-function attributes of single RyR function in health and disease, including local RyR control by Ca, closely regulatory proteins and post-translational modifications. This provides a strong mechanistic foundation for our group’s ongoing work toward developing new RyR-targeted drugs that will hopefully be applied to limit/treat diseases exacerbated or caused by hyperactive RyR Ca signaling.

    My Scopus ID is 7003468631.
    My NIH COMMONS name is MFILL2005.

    Research Areas:
    Ryanodine receptor calcium release channel, calcium signaling.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/michael-fill-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/physiology-and-biophysics-research/laboratory-michael-fill-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/45353019/?sort=date&direction=descending

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=7003468631

    Education:
    PhD, University of Illinois at Urbana-Champaign
    MS, University of Illinois at Urbana-Champaign
    BS, University of Illinois at Urbana-Champaign


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Uehara A, Murayama T, Yasukochi M, Fill M, Horie M, Okamoto T, Matsuura Y, Uehara K, Fujimoto T, Sakurai T, Kurebayashi N. Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+ hypersensitivity. J Gen Physiol. 2017 Feb; 149(2):199-218. PMID: 28082361.
      View in: PubMed
    2. Søndergaard MT, Liu Y, Larsen KT, Nani A, Tian X, Holt C, Wang R, Wimmer R, Van Petegem F, Fill M, Chen SR, Overgaard MT. The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+ Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor. J Biol Chem. 2017 Jan 27; 292(4):1385-1395. PMID: 27927985.
      View in: PubMed
    3. Berti C, Zsolnay V, Shannon TR, Fill M, Gillespie D. Sarcoplasmic reticulum Ca2+, Mg2+, K+, and Cl- concentrations adjust quickly as heart rate changes. J Mol Cell Cardiol. 2017 Feb; 103:31-39. PMID: 27914790.
      View in: PubMed
    4. Tan Z, Xiao Z, Wei J, Zhang J, Zhou Q, Smith CD, Nani A, Wu G, Song LS, Back TG, Fill M, Chen SR. Nebivolol suppresses cardiac ryanodine receptor-mediated spontaneous Ca2+ release and catecholaminergic polymorphic ventricular tachycardia. Biochem J. 2016 Nov 15; 473(22):4159-4172. PMID: 27623776.
      View in: PubMed
    5. Ramos-Franco J, Fill M. Approaching ryanodine receptor therapeutics from the calcin angle. J Gen Physiol. 2016 May; 147(5):369-73. PMID: 27114611; PMCID: PMC4845691 [Available on 11/01/16].
    6. Zhang J, Zhou Q, Smith CD, Chen H, Tan Z, Chen B, Nani A, Wu G, Song LS, Fill M, Back TG, Chen SR. Non-ß-blocking R-carvedilol enantiomer suppresses Ca2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure. Biochem J. 2015 Sep 01; 470(2):233-42. PMID: 26348911; PMCID: PMC4902270.
    7. Bovo E, Mazurek SR, Fill M, Zima AV. Cytosolic Ca²? buffering determines the intra-SR Ca²? concentration at which cardiac Ca²? sparks terminate. Cell Calcium. 2015 Sep; 58(3):246-53. PMID: 26095947; PMCID: PMC4550446.
    8. Zhang J, Chen B, Zhong X, Mi T, Guo A, Zhou Q, Tan Z, Wu G, Chen AW, Fill M, Song LS, Chen SR. The cardiac ryanodine receptor luminal Ca2+ sensor governs Ca2+ waves, ventricular tachyarrhythmias and cardiac hypertrophy in calsequestrin-null mice. Biochem J. 2014 Jul 01; 461(1):99-106. PMID: 24758151; PMCID: PMC4277184.
    9. Chen W, Wang R, Chen B, Zhong X, Kong H, Bai Y, Zhou Q, Xie C, Zhang J, Guo A, Tian X, Jones PP, O'Mara ML, Liu Y, Mi T, Zhang L, Bolstad J, Semeniuk L, Cheng H, Zhang J, Chen J, Tieleman DP, Gillis AM, Duff HJ, Fill M, Song LS, Chen SR. The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias. Nat Med. 2014 Feb; 20(2):184-92. PMID: 24441828; PMCID: PMC4269524.
    10. Guo T, Nani A, Shonts S, Perryman M, Chen H, Shannon T, Gillespie D, Fill M. Sarcoplasmic reticulum K(+) (TRIC) channel does not carry essential countercurrent during Ca(2+) release. Biophys J. 2013 Sep 03; 105(5):1151-60. PMID: 24010658; PMCID: PMC3762336.
    11. Sanchez EJ, Hayes RP, Barr JT, Lewis KM, Webb BN, Subramanian AK, Nissen MS, Jones JP, Shelden EA, Sorg BA, Fill M, Schenk JO, Kang C. Potential role of cardiac calsequestrin in the lethal arrhythmic effects of cocaine. Drug Alcohol Depend. 2013 Dec 01; 133(2):344-51. PMID: 23876860; PMCID: PMC4097383.
    12. Chen H, Valle G, Furlan S, Nani A, Gyorke S, Fill M, Volpe P. Mechanism of calsequestrin regulation of single cardiac ryanodine receptor in normal and pathological conditions. J Gen Physiol. 2013 Aug; 142(2):127-36. PMID: 23858002; PMCID: PMC3727306.
    13. Brunello L, Slabaugh JL, Radwanski PB, Ho HT, Belevych AE, Lou Q, Chen H, Napolitano C, Lodola F, Priori SG, Fedorov VV, Volpe P, Fill M, Janssen PM, Györke S. Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):10312-7. PMID: 23733959; PMCID: PMC3690898.
    14. Gillespie D, Fill M. Pernicious attrition and inter-RyR2 CICR current control in cardiac muscle. J Mol Cell Cardiol. 2013 May; 58:53-8. PMID: 23369697; PMCID: PMC3628281.
    15. Guo T, Gillespie D, Fill M. Ryanodine receptor current amplitude controls Ca2+ sparks in cardiac muscle. Circ Res. 2012 Jun 22; 111(1):28-36. PMID: 22628577; PMCID: PMC3417769.
    16. Gillespie D, Chen H, Fill M. Is ryanodine receptor a calcium or magnesium channel? Roles of K+ and Mg2+ during Ca2+ release. Cell Calcium. 2012 Jun; 51(6):427-33. PMID: 22387011; PMCID: PMC3361554.
    17. Tang Y, Tian X, Wang R, Fill M, Chen SR. Abnormal termination of Ca2+ release is a common defect of RyR2 mutations associated with cardiomyopathies. Circ Res. 2012 Mar 30; 110(7):968-77. PMID: 22374134; PMCID: PMC3345272.
    18. Zhou Q, Xiao J, Jiang D, Wang R, Vembaiyan K, Wang A, Smith CD, Xie C, Chen W, Zhang J, Tian X, Jones PP, Zhong X, Guo A, Chen H, Zhang L, Zhu W, Yang D, Li X, Chen J, Gillis AM, Duff HJ, Cheng H, Feldman AM, Song LS, Fill M, Back TG, Chen SR. Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat Med. 2011 Jul 10; 17(8):1003-9. PMID: 21743453; PMCID: PMC3268079.
    19. Porta M, Zima AV, Nani A, Diaz-Sylvester PL, Copello JA, Ramos-Franco J, Blatter LA, Fill M. Single ryanodine receptor channel basis of caffeine's action on Ca2+ sparks. Biophys J. 2011 Feb 16; 100(4):931-8. PMID: 21320437; PMCID: PMC3037573.
    20. Ramos-Franco J, Gomez AM, Nani A, Liu Y, Copello JA, Fill M. Ryanodol action on calcium sparks in ventricular myocytes. Pflugers Arch. 2010 Sep; 460(4):767-76. PMID: 20419313; PMCID: PMC3315696.
    21. Liu Y, Porta M, Qin J, Ramos J, Nani A, Shannon TR, Fill M. Flux regulation of cardiac ryanodine receptor channels. J Gen Physiol. 2010 Jan; 135(1):15-27. PMID: 20008518; PMCID: PMC2806413.
    22. Gillespie D, Giri J, Fill M. Reinterpreting the anomalous mole fraction effect: the ryanodine receptor case study. Biophys J. 2009 Oct 21; 97(8):2212-21. PMID: 19843453; PMCID: PMC2764102.
    23. Qin J, Valle G, Nani A, Chen H, Ramos-Franco J, Nori A, Volpe P, Fill M. Ryanodine receptor luminal Ca2+ regulation: swapping calsequestrin and channel isoforms. Biophys J. 2009 Oct 07; 97(7):1961-70. PMID: 19804727; PMCID: PMC2756356.
    24. Qin J, Zima AV, Porta M, Blatter LA, Fill M. Trifluoperazine: a rynodine receptor agonist. Pflugers Arch. 2009 Aug; 458(4):643-51. PMID: 19277699; PMCID: PMC2752966.
    25. Zima AV, Qin J, Fill M, Blatter LA. Tricyclic antidepressant amitriptyline alters sarcoplasmic reticulum calcium handling in ventricular myocytes. Am J Physiol Heart Circ Physiol. 2008 Nov; 295(5):H2008-16. PMID: 18790837; PMCID: PMC2614574.
    26. Gillespie D, Fill M. Intracellular calcium release channels mediate their own countercurrent: the ryanodine receptor case study. Biophys J. 2008 Oct; 95(8):3706-14. PMID: 18621826; PMCID: PMC2553138.
    27. Qin J, Valle G, Nani A, Nori A, Rizzi N, Priori SG, Volpe P, Fill M. Luminal Ca2+ regulation of single cardiac ryanodine receptors: insights provided by calsequestrin and its mutants. J Gen Physiol. 2008 Apr; 131(4):325-34. PMID: 18347081; PMCID: PMC2279168.
    28. Copello JA, Zima AV, Diaz-Sylvester PL, Fill M, Blatter LA. Ca2+ entry-independent effects of L-type Ca2+ channel modulators on Ca2+ sparks in ventricular myocytes. Am J Physiol Cell Physiol. 2007 Jun; 292(6):C2129-40. PMID: 17314267; PMCID: PMC2094215.
    29. García MC, Carrillo E, Galindo JM, Hernández A, Copello JA, Fill M, Sánchez JA. Short-term regulation of excitation-contraction coupling by the beta1a subunit in adult mouse skeletal muscle. Biophys J. 2005 Dec; 89(6):3976-84. PMID: 16183888; PMCID: PMC1366963.
    30. Pérez CG, Copello JA, Li Y, Karko KL, Gómez L, Ramos-Franco J, Fill M, Escobar AL, Mejía-Alvarez R. Ryanodine receptor function in newborn rat heart. Am J Physiol Heart Circ Physiol. 2005 May; 288(5):H2527-40. PMID: 15626694.
      View in: PubMed
    31. Zoghbi ME, Copello JA, Villalba-Galea CA, Vélez P, Diaz Sylvester PL, Bolaños P, Marcano A, Fill M, Escobar AL. Differential Ca2+ and Sr2+ regulation of intracellular divalent cations release in ventricular myocytes. Cell Calcium. 2004 Aug; 36(2):119-34. PMID: 15193860.
      View in: PubMed
    32. Rosales RA, Fill M, Escobar AL. Calcium regulation of single ryanodine receptor channel gating analyzed using HMM/MCMC statistical methods. J Gen Physiol. 2004 May; 123(5):533-53. PMID: 15111644; PMCID: PMC2234502.
    33. Fill M, Ramos J. Calcium regulation of single cardiac ryanodine receptor channels. J Muscle Res Cell Motil. 2004; 25(8):603-4. PMID: 16285027.
      View in: PubMed
    34. Kettlun C, González A, Ríos E, Fill M. Unitary Ca2+ current through mammalian cardiac and amphibian skeletal muscle ryanodine receptor Channels under near-physiological ionic conditions. J Gen Physiol. 2003 Oct; 122(4):407-17. PMID: 12975450; PMCID: PMC2233776.
    35. Ramos J, Jung W, Ramos-Franco J, Mignery GA, Fill M. Single channel function of inositol 1,4,5-trisphosphate receptor type-1 and -2 isoform domain-swap chimeras. J Gen Physiol. 2003 May; 121(5):399-411. PMID: 12695486; PMCID: PMC2217376.
    36. Mejía-Alvarez R, Manno C, Villalba-Galea CA, del Valle Fernández L, Costa RR, Fill M, Gharbi T, Escobar AL. Pulsed local-field fluorescence microscopy: a new approach for measuring cellular signals in the beating heart. Pflugers Arch. 2003 Mar; 445(6):747-58. PMID: 12632197.
      View in: PubMed
    37. Fill M. Mechanisms that turn-off intracellular calcium release channels. Front Biosci. 2003 Jan 01; 8:d46-54. PMID: 12456314.
      View in: PubMed
    38. Fill M, Copello JA. Ryanodine receptor calcium release channels. Physiol Rev. 2002 Oct; 82(4):893-922. PMID: 12270947.
      View in: PubMed
    39. Copello JA, Barg S, Sonnleitner A, Porta M, Diaz-Sylvester P, Fill M, Schindler H, Fleischer S. Differential activation by Ca2+, ATP and caffeine of cardiac and skeletal muscle ryanodine receptors after block by Mg2+. J Membr Biol. 2002 May 01; 187(1):51-64. PMID: 12029377.
      View in: PubMed
    40. Uehara A, Yasukochi M, Mejía-Alvarez R, Fill M, Imanaga I. Gating kinetics and ligand sensitivity modified by phosphorylation of cardiac ryanodine receptors. Pflugers Arch. 2002 May; 444(1-2):202-12. PMID: 11976933.
      View in: PubMed
    41. Fill M, Zahradníková A, Villalba-Galea CA, Zahradník I, Escobar AL, Györke S. Ryanodine receptor adaptation. J Gen Physiol. 2000 Dec; 116(6):873-82. PMID: 11099353; PMCID: PMC2231812.
    42. Olson RD, Li X, Palade P, Shadle SE, Mushlin PS, Gambliel HA, Fill M, Boucek RJ, Cusack BJ. Sarcoplasmic reticulum calcium release is stimulated and inhibited by daunorubicin and daunorubicinol. Toxicol Appl Pharmacol. 2000 Dec 01; 169(2):168-76. PMID: 11097869.
      View in: PubMed
    43. Ramos-Franco J, Bare D, Caenepeel S, Nani A, Fill M, Mignery G. Single-channel function of recombinant type 2 inositol 1,4, 5-trisphosphate receptor. Biophys J. 2000 Sep; 79(3):1388-99. PMID: 10969001; PMCID: PMC1301033.
    44. Zoghbi ME, Bolaños P, Villalba-Galea C, Marcano A, Hernández E, Fill M, Escobar AL. Spatial Ca(2+) distribution in contracting skeletal and cardiac muscle cells. Biophys J. 2000 Jan; 78(1):164-73. PMID: 10620283; PMCID: PMC1300627.
    45. Ramos-Franco J, Galvan D, Mignery GA, Fill M. Location of the permeation pathway in the recombinant type 1 inositol 1,4,5-trisphosphate receptor. J Gen Physiol. 1999 Aug; 114(2):243-50. PMID: 10436000; PMCID: PMC2230642.
    46. Fill M, Mejía-Alvarez R, Kettlun C, Escobar A. Ryanodine receptor permeation and gating: glowing cinders that underlie the Ca2+ spark. J Gen Physiol. 1999 Jul; 114(1):159-61. PMID: 10447409; PMCID: PMC2229638.
    47. Minn AJ, Kettlun CS, Liang H, Kelekar A, Vander Heiden MG, Chang BS, Fesik SW, Fill M, Thompson CB. Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms. EMBO J. 1999 Feb 01; 18(3):632-43. PMID: 9927423; PMCID: PMC1171156.
    48. Mejía-Alvarez R, Kettlun C, Ríos E, Stern M, Fill M. Unitary Ca2+ current through cardiac ryanodine receptor channels under quasi-physiological ionic conditions. J Gen Physiol. 1999 Feb; 113(2):177-86. PMID: 9925817; PMCID: PMC2223367.
    49. Satoh H, Katoh H, Velez P, Fill M, Bers DM. Bay K 8644 increases resting Ca2+ spark frequency in ferret ventricular myocytes independent of Ca influx: contrast with caffeine and ryanodine effects. Circ Res. 1998 Dec 14-28; 83(12):1192-204. PMID: 9851936.
      View in: PubMed
    50. Ramos-Franco J, Caenepeel S, Fill M, Mignery G. Single channel function of recombinant type-1 inositol 1,4,5-trisphosphate receptor ligand binding domain splice variants. Biophys J. 1998 Dec; 75(6):2783-93. PMID: 9826600; PMCID: PMC1299951.
    51. Bers DM, Fill M. Coordinated feet and the dance of ryanodine receptors. Science. 1998 Aug 07; 281(5378):790-1. PMID: 9714684.
      View in: PubMed
    52. Ramos-Franco J, Fill M, Mignery GA. Isoform-specific function of single inositol 1,4,5-trisphosphate receptor channels. Biophys J. 1998 Aug; 75(2):834-9. PMID: 9675184; PMCID: PMC1299757.
    53. Perez PJ, Ramos-Franco J, Fill M, Mignery GA. Identification and functional reconstitution of the type 2 inositol 1,4,5-trisphosphate receptor from ventricular cardiac myocytes. J Biol Chem. 1997 Sep 19; 272(38):23961-9. PMID: 9295347.
      View in: PubMed
    54. Escobar AL, Velez P, Kim AM, Cifuentes F, Fill M, Vergara JL. Kinetic properties of DM-nitrophen and calcium indicators: rapid transient response to flash photolysis. Pflugers Arch. 1997 Sep; 434(5):615-31. PMID: 9242727.
      View in: PubMed
    55. Vélez P, Györke S, Escobar AL, Vergara J, Fill M. Adaptation of single cardiac ryanodine receptor channels. Biophys J. 1997 Feb; 72(2 Pt 1):691-7. PMID: 9017196; PMCID: PMC1185594.
    56. Minn AJ, Vélez P, Schendel SL, Liang H, Muchmore SW, Fesik SW, Fill M, Thompson CB. Bcl-x(L) forms an ion channel in synthetic lipid membranes. Nature. 1997 Jan 23; 385(6614):353-7. PMID: 9002522.
      View in: PubMed
    57. Uehara A, Fill M, Vélez P, Yasukochi M, Imanaga I. Rectification of rabbit cardiac ryanodine receptor current by endogenous polyamines. Biophys J. 1996 Aug; 71(2):769-77. PMID: 8842215; PMCID: PMC1233533.
    58. Sierralta J, Fill M, Suárez-Isla BA. Functionally heterogenous ryanodine receptors in avian cerebellum. J Biol Chem. 1996 Jul 19; 271(29):17028-34. PMID: 8663321.
      View in: PubMed
    59. Cheng H, Fill M, Valdivia H, Lederer WJ. Models of Ca2+ release channel adaptation. Science. 1995 Mar 31; 267(5206):2009-10. PMID: 7701326.
      View in: PubMed
    60. Tu Q, Vélez P, Brodwick M, Fill M. Streaming potentials reveal a short ryanodine-sensitive selectivity filter in cardiac Ca2+ release channel. Biophys J. 1994 Dec; 67(6):2280-5. PMID: 7696468; PMCID: PMC1225612.
    61. Györke S, Vélez P, Suárez-Isla B, Fill M. Activation of single cardiac and skeletal ryanodine receptor channels by flash photolysis of caged Ca2+. Biophys J. 1994 Jun; 66(6):1879-86. PMID: 8075325; PMCID: PMC1275913.
    62. Tu Q, Velez P, Cortes-Gutierrez M, Fill M. Surface charge potentiates conduction through the cardiac ryanodine receptor channel. J Gen Physiol. 1994 May; 103(5):853-67. PMID: 8035165; PMCID: PMC2219216.
    63. Györke S, Fill M. Response. Science. 1994 Feb 18; 263(5149):987-8. PMID: 17758643.
      View in: PubMed
    64. Chu A, Fill M, Stefani E, Entman ML. Cytoplasmic Ca2+ does not inhibit the cardiac muscle sarcoplasmic reticulum ryanodine receptor Ca2+ channel, although Ca(2+)-induced Ca2+ inactivation of Ca2+ release is observed in native vesicles. J Membr Biol. 1993 Jul; 135(1):49-59. PMID: 8411131.
      View in: PubMed
    65. Györke S, Fill M. Ryanodine receptor adaptation: control mechanism of Ca(2+)-induced Ca2+ release in heart. Science. 1993 May 07; 260(5109):807-9. PMID: 8387229.
      View in: PubMed
    66. Shomer NH, Louis CF, Fill M, Litterer LA, Mickelson JR. Reconstitution of abnormalities in the malignant hyperthermia-susceptible pig ryanodine receptor. Am J Physiol. 1993 Jan; 264(1 Pt 1):C125-35. PMID: 7679249.
      View in: PubMed
    67. Fill M, Stefani E, Nelson TE. Abnormal human sarcoplasmic reticulum Ca2+ release channels in malignant hyperthermic skeletal muscle. Biophys J. 1991 May; 59(5):1085-90. PMID: 1651122; PMCID: PMC1281343.
    68. Mejía-Alvarez R, Fill M, Stefani E. Voltage-dependent inactivation of T-tubular skeletal calcium channels in planar lipid bilayers. J Gen Physiol. 1991 Feb; 97(2):393-412. PMID: 1849962; PMCID: PMC2216470.
    69. Fill M, Mejia-Alvarez R, Zorzato F, Volpe P, Stefani E. Antibodies as probes for ligand gating of single sarcoplasmic reticulum Ca2(+)-release channels. Biochem J. 1991 Jan 15; 273(Pt 2):449-57. PMID: 1703762; PMCID: PMC1149866.
    70. García J, Fill M, Toro L, Stefani E. Functional studies of Ca2+ channels from plasmalemma and sarcoplasmic reticulum membranes in muscle cells. Semin Cell Biol. 1990 Aug; 1(4):255-64. PMID: 1966494.
      View in: PubMed
    71. Fill M, Coronado R, Mickelson JR, Vilven J, Ma JJ, Jacobson BA, Louis CF. Abnormal ryanodine receptor channels in malignant hyperthermia. Biophys J. 1990 Mar; 57(3):471-5. PMID: 2306496; PMCID: PMC1280741.
    72. Fill M, Best PM. Effect of perchlorate on calcium release in skinned fibres stimulated by ionic substitution and caffeine. Pflugers Arch. 1990 Mar; 415(6):688-92. PMID: 2159617.
      View in: PubMed
    73. Hamilton SL, Alvarez RM, Fill M, Hawkes MJ, Brush KL, Schilling WP, Stefani E. [3H]PN200-110 and [3H]ryanodine binding and reconstitution of ion channel activity with skeletal muscle membranes. Anal Biochem. 1989 Nov 15; 183(1):31-41. PMID: 2559627.
      View in: PubMed
    74. Fill MD, Best PM. Block of contracture in skinned frog skeletal muscle fibers by calcium antagonists. J Gen Physiol. 1989 Mar; 93(3):429-49. PMID: 2539431; PMCID: PMC2216221.
    75. Fill M, Ma JJ, Knudson CM, Imagawa T, Campbell KP, Coronado R. Role of the ryanodine receptor of skeletal muscle in excitation-contraction coupling. Ann N Y Acad Sci. 1989; 560:155-62. PMID: 2662857.
      View in: PubMed
    76. Ma J, Fill M, Knudson CM, Campbell KP, Coronado R. Ryanodine receptor of skeletal muscle is a gap junction-type channel. Science. 1988 Oct 07; 242(4875):99-102. PMID: 2459777.
      View in: PubMed
    77. Fill M, Coronado R. Ryanodine receptor channel of sarcoplasmic reticulum. Trends Neurosci. 1988 Oct; 11(10):453-7. PMID: 2469164.
      View in: PubMed
    78. Smith JS, Imagawa T, Ma J, Fill M, Campbell KP, Coronado R. Purified ryanodine receptor from rabbit skeletal muscle is the calcium-release channel of sarcoplasmic reticulum. J Gen Physiol. 1988 Jul; 92(1):1-26. PMID: 2459298; PMCID: PMC2228891.
    79. Fill MD, Best PM. Contractile activation and recovery in skinned frog muscle stimulated by ionic substitution. Am J Physiol. 1988 Jan; 254(1 Pt 1):C107-14. PMID: 3257357.
      View in: PubMed
    80. Best PM, Fill M. Calcium release rate in skinned skeletal muscle fibers measured with arsenazo III. Am J Physiol. 1986 Feb; 250(2 Pt 1):C245-55. PMID: 3485383.
      View in: PubMed
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