 Substrate Specificity
"Substrate Specificity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
| Descriptor ID |
D013379
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| MeSH Number(s) |
G02.111.835
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| Concept/Terms |
Substrate Specificity- Substrate Specificity
- Specificities, Substrate
- Specificity, Substrate
- Substrate Specificities
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Below are MeSH descriptors whose meaning is more general than "Substrate Specificity".
Below are MeSH descriptors whose meaning is more specific than "Substrate Specificity".
This graph shows the total number of publications written about "Substrate Specificity" by people in this website by year, and whether "Substrate Specificity" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1984 | 0 | 1 | 1 | | 1992 | 0 | 2 | 2 | | 1993 | 0 | 2 | 2 | | 1998 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 3 | 3 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2007 | 0 | 4 | 4 | | 2008 | 0 | 2 | 2 | | 2009 | 0 | 3 | 3 | | 2011 | 0 | 3 | 3 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 3 | 3 | | 2014 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Substrate Specificity" by people in Profiles.
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França MM, German A, Fernandes GW, Liao XH, Bianco AC, Refetoff S, Dumitrescu AM. Human Type 1 Iodothyronine Deiodinase (DIO1) Mutations Cause Abnormal Thyroid Hormone Metabolism. Thyroid. 2021 02; 31(2):202-207.
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Kim Y, Liu G, Leugers CJ, Mueller JD, Francis MB, Hefti MM, Schneider JA, Lee G. Tau interacts with SHP2 in neuronal systems and in Alzheimer's disease brains. J Cell Sci. 2019 07 15; 132(14).
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Thal DM, Sun B, Feng D, Nawaratne V, Leach K, Felder CC, Bures MG, Evans DA, Weis WI, Bachhawat P, Kobilka TS, Sexton PM, Kobilka BK, Christopoulos A. Crystal structures of the M1 and M4 muscarinic acetylcholine receptors. Nature. 2016 Mar 17; 531(7594):335-40.
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Gillespie D, Xu L, Meissner G. Selecting ions by size in a calcium channel: the ryanodine receptor case study. Biophys J. 2014 Nov 18; 107(10):2263-73.
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Kaufman I, Luchinsky DG, Tindjong R, McClintock PV, Eisenberg RS. Energetics of discrete selectivity bands and mutation-induced transitions in the calcium-sodium ion channels family. Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Nov; 88(5):052712.
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Arrojo E Drigo R, Egri P, Jo S, Gereben B, Bianco AC. The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex. Mol Endocrinol. 2013 Dec; 27(12):2105-15.
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Ziniel PD, Desai J, Cass CL, Gatto C, Oldfield E, Williams DL. Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni. Antimicrob Agents Chemother. 2013 Dec; 57(12):5969-76.
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Evans DA, Adams DJ, Kwan EE. Progress toward the syntheses of (+)-GB 13, (+)-himgaline, and himandridine. new insights into intramolecular imine/enamine aldol cyclizations. J Am Chem Soc. 2012 May 16; 134(19):8162-70.
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Csányi E, Boda D, Gillespie D, Kristóf T. Current and selectivity in a model sodium channel under physiological conditions: Dynamic Monte Carlo simulations. Biochim Biophys Acta. 2012 Mar; 1818(3):592-600.
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Musset B, Smith SM, Rajan S, Morgan D, Cherny VV, Decoursey TE. Aspartate?112 is the selectivity filter of the human voltage-gated proton channel. Nature. 2011 Oct 23; 480(7376):273-7.
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