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Zoe Arvanitakis

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentRush Alzheimer's Disease Center
Address
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    Collapse Biography 
    Collapse awards and honors
    2004Association of American Medical Colleges Early Career Women Faculty Professional Development Seminar, Rush Office of the Dean
    2006Association of American Medical Colleges, Mid Career Women Faculty Professional Development Seminar, Rush Office of the Dean
    2008Palatucci Advocacy Leadership Forum: training neurologists worldwide in grassroots advocacy , American Academy of Neurology
    2013 - 2014Rush Faculty Award, Excellence in Mentoring, Provost Office of Faculty Affairs, Rush University
    2015"Women in Advanced Leadership Roles" program (competitive registration), American Academy of Neurology
    2018In pool of inaugural trainees selected for the "Women's Leadership Development Program", Rush University, Rush Leadership and Learning Academy

    Collapse Overview 
    Collapse overview
    My Scopus ID is 6603251223.
    My NIH COMMONS name is ZARVANITAKIS.

    Zoe Arvanitakis, MD, MS, is the Acting Chairperson of the Department of Neurological Sciences, at the Rush Medical College of Rush University. She is the Medical Director of the Rush Memory Clinic, at the Rush Alzheimer’s Disease Center. A Professor of Neurological Sciences, she is a board-certified neurologist (certified by the American Board of Psychiatry and Neurology, with re-certification) and subspecialist in cognitive neurology and dementia, with fellowship training from the Mayo Clinic. She has more than two decades of clinical experience in cognitive clinical care, research, and education. The Rush Memory Clinic, under the leadership of Arvanitakis, provides expert subspecialty clinical care to improve the overall health and well-being of older adults with memory and cognitive-behavioral changes through expert diagnosis, care planning, and opportunities for research participation. Arvanitakis is recognized as an effective and energetic educator who teaches at the medical school and within Rush, as well as at national conferences and meetings, and has received an award from Rush for her excellence in mentoring.

    Arvanitakis is also an academic clinical neuroscientist with expertise in biomedical research, with a Master of Science (MS) in Clinical Research, and subspecialization in epidemiology. Arvanitakis is Principal Investigator of research grants from the National Institutes of Health (NIH), including investigator-initiated grants (R01s), and is Principal Investigator of clinical trials and co-investigator on several other NIH-funded and additional projects. Arvanitakis has published original research in peer-reviewed medical journals in the field of neurodegenerative, vascular, and metabolic cognitive impairment and dementia, including publications on the topics of Alzheimer’s disease and mechanisms of dementia. In addition to her many publications, Arvanitakis has also co-edited a medical textbook. Her collaborative research leverages clinical, laboratory, neuroimaging and other data, and human biospecimens, from several large, epidemiologic, longitudinal, clinical-pathologic cohort studies of aging at the Rush Alzheimer’s Disease Center. She serves on numerous national and international funding agency, scientific journal, and meeting abstract review panels. She is a member of the NIH Neurological, Aging and Musculoskeletal Epidemiology (NAME) study section. Arvanitakis is internationally recognized scientific speaker in the field of neurologic aging and dementia. She is a past chair of the Geriatric Neurology Section of the American Academy of Neurology (AAN), the largest professional organization of neurologists in the world. Arvanitakis is an elected Fellow of the American Academy of Neurology (FAAN) and an elected Fellow of the American Neurological Association (FANA).

    My Scopus ID is 6603251223.
    My NIH COMMONS name is ZARVANITAKIS.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Halloway S, Schoeny ME, Arvanitakis Z, Volgman AS, Pressler SJ, Vispute S, Wilhelm K, Borgia JA, Wilbur J, Barnes LL. A multidomain trial for cognition in women with cardiovascular disease. Alzheimers Dement. 2025 06; 21(6):e70285. PMID: 40511694; PMCID: PMC12163647.
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    2. Wang S, Li B, Li J, Cai Z, Hugo C, Sun Y, Qian L, Tcw J, Chui HC, Dikeman D, Asante I, Louie SG, Bennett DA, Arvanitakis Z, Remaley AT, Kerman BE, Yassine HN. Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD. Mol Neurodegener. 2025 02 04; 20(1):15. PMID: 39901180; PMCID: PMC11792374.
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    3. Halloway S, Volgman AS, Barnes LL, Schoeny ME, Wilbur J, Pressler SJ, Laddu D, Phillips SA, Vispute S, Hall G, Shakya S, Goodyke M, Auger C, Cagin K, Borgia JA, Arvanitakis ZA. The MindMoves Trial: Cross-Sectional Analyses of Baseline Vascular Risk and Cognition in Older Women with Cardiovascular Disease. J Alzheimers Dis. 2024; 100(4):1407-1416. PMID: 39031356.
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    4. Tong H, Capuano AW, Carmichael OT, Gwizdala KL, Bennett DA, Ahima RS, Arnold SE, Arvanitakis Z. Brain Insulin Signaling is Associated with Late-Life Cognitive Decline. Aging Dis. 2023 Nov 20. PMID: 38029396.
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    5. Sachdev A, Moges Y, Rubin M, Sremac AC, Arvanitakis Z, McCarthy RJ. Early incident and subsyndromal delirium in older patients undergoing elective surgical procedures: a randomized clinical trial of an avoid delirium protocol. Front Anesthesiol. 2023; 2. PMID: 38650976; PMCID: PMC11034801.
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    6. Sood A, Capuano AW, Wilson RS, Barnes LL, Kapasi A, Bennett DA, Arvanitakis Z. Metformin, age-related cognitive decline, and brain pathology. Neurobiol Aging. 2024 Jan; 133:99-106. PMID: 37931533.
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    7. Halloway S, Wagner M, Tangney C, Lange-Maia BS, Bennett DA, Arvanitakis Z, Schoeny ME. Profiles of lifestyle health behaviors and cognitive decline in older adults. Alzheimers Dement. 2023 Sep 07. PMID: 37676928.
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    8. Kim AB, Arvanitakis Z. Insulin resistance, cognition, and Alzheimer disease. Obesity (Silver Spring). 2023 06; 31(6):1486-1498. PMID: 37203336.
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    9. Beadell AV, Zhang Z, Capuano AW, Bennett DA, He C, Zhang W, Arvanitakis Z. Genome-Wide Mapping Implicates 5-Hydroxymethylcytosines in Diabetes Mellitus and Alzheimer's Disease. J Alzheimers Dis. 2023; 93(3):1135-1151. PMID: 37182870.
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    10. Ebright B, Assante I, Poblete RA, Wang S, Duro MV, Bennett DA, Arvanitakis Z, Louie SG, Yassine HN. Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer's dementia. Alzheimers Res Ther. 2022 10 11; 14(1):152. PMID: 36217192.
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    11. Laughlin M, Cooke B, Boutelle K, Savage CR, Kravitz A, Small D, Arvanitakis Z, Martin A, Stoeckel LE. Correction to: Neuroimaging and modulation in obesity and diabetes research: 10th anniversary meeting. Int J Obes (Lond). 2022 Apr; 46(4):889. PMID: 35046495.
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    12. Wang S, Li B, Solomon V, Fonteh A, Rapoport SI, Bennett DA, Arvanitakis Z, Chui HC, Miller C, Sullivan PM, Wang HY, Yassine HN. Retraction Note: Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4. Mol Neurodegener. 2022 02 04; 17(1):14. PMID: 35115039.
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    13. Laughlin M, Cooke B, Boutelle K, Savage CR, Kravitz A, Small D, Arvanitakis Z, Martin A, Stoeckel LE. Neuroimaging and modulation in obesity and diabetes research: 10th anniversary meeting. Int J Obes (Lond). 2022 04; 46(4):718-725. PMID: 34934178.
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    14. Oveisgharan S, Capuano AW, Nag S, Agrawal S, Barnes LL, Bennett DA, Arvanitakis Z, Schneider JA. Association of Hemoglobin A1C With TDP-43 Pathology in Community-Based Elders. Neurology. 2021 May 31; 96(22):e2694-e2703. PMID: 33853892.
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    15. Oveisgharan S, Yu L, Capuano A, Arvanitakis Z, Barnes LL, Schneider JA, Bennett DA, Buchman AS. Late-Life Vascular Risk Score in Association With Postmortem Cerebrovascular Disease Brain Pathologies. Stroke. 2021 06; 52(6):2060-2067. PMID: 33840227.
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    16. Kapasi A, Leurgans SE, Arvanitakis Z, Barnes LL, Bennett DA, Schneider JA. A? (Amyloid Beta) and Tau Tangle Pathology Modifies the Association Between Small Vessel Disease and Cortical Microinfarcts. Stroke. 2021 03; 52(3):1012-1021. PMID: 33567873.
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    17. Halloway S, Schoeny ME, Barnes LL, Arvanitakis Z, Pressler SJ, Braun LT, Volgman AS, Gamboa C, Wilbur J. A study protocol for MindMoves: A lifestyle physical activity and cognitive training intervention to prevent cognitive impairment in older women with cardiovascular disease. Contemp Clin Trials. 2021 02; 101:106254. PMID: 33383230.
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    18. Arvanitakis Z, Tatavarthy M, Bennett DA. The Relation of Diabetes to Memory Function. Curr Neurol Neurosci Rep. 2020 11 05; 20(12):64. PMID: 33150490.
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    19. Aiken-Morgan AT, Capuano AW, Arvanitakis Z, Barnes LL. Changes in Body Mass Index Are Related to Faster Cognitive Decline Among African American Older Adults. J Am Geriatr Soc. 2020 11; 68(11):2662-2667. PMID: 32978794.
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    20. Hill NL, Mogle J, Bhargava S, Whitaker E, Bhang I, Capuano AW, Arvanitakis Z, Bennett DA, Barnes LL. Differences in the Associations Between Memory Complaints and Depressive Symptoms Among Black and White Older Adults. J Gerontol B Psychol Sci Soc Sci. 2020 03 09; 75(4):783-791. PMID: 30102393.
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    21. Arvanitakis Z, Shah RC, Bennett DA. Diagnosis and Management of Dementia: Review. JAMA. 2019 10 22; 322(16):1589-1599. PMID: 31638686.
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    22. Wang HY, Capuano AW, Khan A, Pei Z, Lee KC, Bennett DA, Ahima RS, Arnold SE, Arvanitakis Z. Insulin and adipokine signaling and their cross-regulation in postmortem human brain. Neurobiol Aging. 2019 12; 84:119-130. PMID: 31539648.
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    23. Arvanitakis Z, Capuano AW, Brey R, Fleischman DA, Arfanakis K, Buchman AS, Schneider JA, Levine SR, Bennett DA. Antiphospholipid Antibodies: Cognitive and Motor Decline, Neuroimaging and Neuropathology. Neuroepidemiology. 2019; 53(1-2):100-107. PMID: 31067547.
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    24. Arvanitakis Z, Capuano AW. Author response: Late-life blood pressure association with cerebrovascular and Alzheimer disease pathology. Neurology. 2019 04 09; 92(15):732. PMID: 30962305.
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    25. Capuano AW, Wilson RS, Honer WG, Petyuk VA, Leurgans SE, Yu L, Gatchel JR, Arnold S, Bennett DA, Arvanitakis Z. Brain IGFBP-5 modifies the relation of depressive symptoms to decline in cognition in older persons. J Affect Disord. 2019 05 01; 250:313-318. PMID: 30875674.
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    26. Oveisgharan S, Arvanitakis Z, Yu L, Farfel J, Schneider JA, Bennett DA. Sex differences in Alzheimer's disease and common neuropathologies of aging. Acta Neuropathol. 2018 12; 136(6):887-900. PMID: 30334074.
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    27. Arvanitakis Z, Capuano AW, Lamar M, Shah RC, Barnes LL, Bennett DA, Schneider JA. Late-life blood pressure association with cerebrovascular and Alzheimer disease pathology. Neurology. 2018 08 07; 91(6):e517-e525. PMID: 29997190.
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    28. James BD, Wilson RS, Shah RC, Yu L, Arvanitakis Z, Bennett DA, Boyle PA. Association of Financial Literacy With Hospitalization in Community-dwelling Older Adults. Med Care. 2018 07; 56(7):596-602. PMID: 29901572.
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    29. Kapasi A, Leurgans SE, James BD, Boyle PA, Arvanitakis Z, Nag S, Bennett DA, Buchman AS, Schneider JA. Watershed microinfarct pathology and cognition in older persons. Neurobiol Aging. 2018 10; 70:10-17. PMID: 29935416.
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    30. Arvanitakis Z, Leurgans SE, Fleischman DA, Schneider JA, Rajan KB, Pruzin JJ, Shah RC, Evans DA, Barnes LL, Bennett DA. Memory complaints, dementia, and neuropathology in older blacks and whites. Ann Neurol. 2018 04; 83(4):718-729. PMID: 29466839.
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    31. Pruzin JJ, Nelson PT, Abner EL, Arvanitakis Z. Review: Relationship of type 2 diabetes to human brain pathology. Neuropathol Appl Neurobiol. 2018 06; 44(4):347-362. PMID: 29424027.
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    32. Arnold SE, Arvanitakis Z, Macauley-Rambach SL, Koenig AM, Wang HY, Ahima RS, Craft S, Gandy S, Buettner C, Stoeckel LE, Holtzman DM, Nathan DM. Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums. Nat Rev Neurol. 2018 03; 14(3):168-181. PMID: 29377010.
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    33. Wilson RS, Capuano AW, James BD, Amofa P, Arvanitakis Z, Shah R, Bennett DA, Boyle PA. Purpose in Life and Hospitalization for Ambulatory Care-Sensitive Conditions in Old Age. Am J Geriatr Psychiatry. 2018 03; 26(3):364-374. PMID: 28780129.
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    34. Yarchoan M, James BD, Shah RC, Arvanitakis Z, Wilson RS, Schneider J, Bennett DA, Arnold SE. Association of Cancer History with Alzheimer's Disease Dementia and Neuropathology. J Alzheimers Dis. 2017; 56(2):699-706. PMID: 28035936.
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    35. Rajan KB, Arvanitakis Z, Lynch EB, McAninch EA, Wilson RS, Weuve J, Barnes LL, Bianco AC, Evans DA. Cognitive decline following incident and preexisting diabetes mellitus in a population sample. Neurology. 2016 Oct 18; 87(16):1681-1687. PMID: 27655734.
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    36. Boyle PA, Yu L, Fleischman DA, Leurgans S, Yang J, Wilson RS, Schneider JA, Arvanitakis Z, Arfanakis K, Bennett DA. White matter hyperintensities, incident mild cognitive impairment, and cognitive decline in old age. Ann Clin Transl Neurol. 2016 10; 3(10):791-800. PMID: 27752514.
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    37. Arvanitakis Z, Capuano AW, Leurgans SE, Buchman AS, Bennett DA, Schneider JA. The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts. Brain Pathol. 2017 01; 27(1):77-85. PMID: 26844934.
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    38. Felsky D, De Jager PL, Schneider JA, Arfanakis K, Fleischman DA, Arvanitakis Z, Honer WG, Pouget JG, Mizrahi R, Pollock BG, Kennedy JL, Bennett DA, Voineskos AN. Cerebrovascular and microglial states are not altered by functional neuroinflammatory gene variant. J Cereb Blood Flow Metab. 2016 Apr; 36(4):819-30. PMID: 26762507.
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    39. Yu L, Boyle PA, Nag S, Leurgans S, Buchman AS, Wilson RS, Arvanitakis Z, Farfel JM, De Jager PL, Bennett DA, Schneider JA. APOE and cerebral amyloid angiopathy in community-dwelling older persons. Neurobiol Aging. 2015 Nov; 36(11):2946-2953. PMID: 26341746.
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    40. Fleischman DA, Yang J, Arfanakis K, Arvanitakis Z, Leurgans SE, Turner AD, Barnes LL, Bennett DA, Buchman AS. Physical activity, motor function, and white matter hyperintensity burden in healthy older adults. Neurology. 2015 Mar 31; 84(13):1294-300. PMID: 25762710.
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    41. Arvanitakis Z, Brey RL, Rand JH, Schneider JA, Capuano AW, Yu L, Leurgans SE, Bennett DA, Levine SR. Relation of antiphospholipid antibodies to postmortem brain infarcts in older people. Circulation. 2015 Jan 13; 131(2):182-9. PMID: 25301832.
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    42. Arvanitakis Z, Brey RL, Rand JH, Schneider JA, Leurgans SE, Yu L, Buchman AS, Arfanakis K, Fleischman DA, Boyle PA, Bennett DA, Levine SR. Antiphospholipid antibodies, brain infarcts, and cognitive and motor decline in aging (ABICMA): design of a community-based, longitudinal, clinical-pathological study. Neuroepidemiology. 2013; 40(2):73-84. PMID: 23095514.
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    43. Schneider JA, Arvanitakis Z, Yu L, Boyle PA, Leurgans SE, Bennett DA. Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies. Brain. 2012 Oct; 135(Pt 10):3005-14. PMID: 23065790.
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    44. Bennett DA, Schneider JA, Arvanitakis Z, Wilson RS. Overview and findings from the religious orders study. Curr Alzheimer Res. 2012 Jul; 9(6):628-45. PMID: 22471860.
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    45. Arvanitakis Z, Leurgans SE, Barnes LL, Bennett DA, Schneider JA. Microinfarct pathology, dementia, and cognitive systems. Stroke. 2011 Mar; 42(3):722-7. PMID: 21212395.
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    46. Arvanitakis Z, Leurgans SE, Wang Z, Wilson RS, Bennett DA, Schneider JA. Cerebral amyloid angiopathy pathology and cognitive domains in older persons. Ann Neurol. 2011 Feb; 69(2):320-7. PMID: 21387377.
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    47. Arvanitakis Z, Bennett DA, Wilson RS, Barnes LL. Diabetes and cognitive systems in older black and white persons. Alzheimer Dis Assoc Disord. 2010 Jan-Mar; 24(1):37-42. PMID: 19568148.
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    48. Schneider JA, Arvanitakis Z, Leurgans SE, Bennett DA. The neuropathology of probable Alzheimer disease and mild cognitive impairment. Ann Neurol. 2009 Aug; 66(2):200-8. PMID: 19743450.
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    49. Hascalovici JR, Vaya J, Khatib S, Holcroft CA, Zukor H, Song W, Arvanitakis Z, Bennett DA, Schipper HM. Brain sterol dysregulation in sporadic AD and MCI: relationship to heme oxygenase-1. J Neurochem. 2009 Aug; 110(4):1241-53. PMID: 19522732.
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    50. Arvanitakis Z, Grodstein F, Bienias JL, Schneider JA, Wilson RS, Kelly JF, Evans DA, Bennett DA. Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology. Neurology. 2008 Jun 03; 70(23):2219-25. PMID: 18519870.
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    51. Schneider JA, Arvanitakis Z, Bang W, Bennett DA. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology. 2007 Dec 11; 69(24):2197-204. PMID: 17568013.
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    52. Assaraf MI, Diaz Z, Liberman A, Miller WH, Arvanitakis Z, Li Y, Bennett DA, Schipper HM. Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairment. J Neuropathol Exp Neurol. 2007 May; 66(5):389-98. PMID: 17483696.
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    53. Arvanitakis Z, Wilson RS, Bienias JL, Bennett DA. Diabetes and parkinsonian signs in older persons. Alzheimer Dis Assoc Disord. 2007 Apr-Jun; 21(2):144-9. PMID: 17545740.
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    54. Arvanitakis Z, Witte RJ, Dickson DW, Tsuboi Y, Uitti RJ, Slowinski J, Hutton ML, Lin SC, Boeve BF, Cheshire WP, Pooley RA, Liss JM, Caviness JN, Strongosky AJ, Wszolek ZK. Clinical-pathologic study of biomarkers in FTDP-17 (PPND family with N279K tau mutation). Parkinsonism Relat Disord. 2007 May; 13(4):230-9. PMID: 17196872.
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    55. Bennett DA, Schneider JA, Aggarwal NT, Arvanitakis Z, Shah RC, Kelly JF, Fox JH, Cochran EJ, Arends D, Treinkman AD, Wilson RS. Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study. Neuroepidemiology. 2006; 27(3):169-76. PMID: 17035694.
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    56. Bennett DA, Schneider JA, Arvanitakis Z, Kelly JF, Aggarwal NT, Shah RC, Wilson RS. Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology. 2006 Jun 27; 66(12):1837-44. PMID: 16801647.
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    57. Boyle PA, Wilson RS, Aggarwal NT, Arvanitakis Z, Kelly J, Bienias JL, Bennett DA. Parkinsonian signs in subjects with mild cognitive impairment. Neurology. 2005 Dec 27; 65(12):1901-6. PMID: 16380610.
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    58. Shah RC, Wilson RS, Bienias JL, Arvanitakis Z, Evans DA, Bennett DA. Relation of blood pressure to risk of incident Alzheimer's disease and change in global cognitive function in older persons. Neuroepidemiology. 2006; 26(1):30-6. PMID: 16254451.
      Citations:    
    59. Buracchio T, Arvanitakis Z, Gorbien M. Dementia with Lewy bodies: current concepts. Dement Geriatr Cogn Disord. 2005; 20(5):306-20. PMID: 16174977.
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    60. Schipper HM, Bennett DA, Liberman A, Bienias JL, Schneider JA, Kelly J, Arvanitakis Z. Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment. Neurobiol Aging. 2006 Feb; 27(2):252-61. PMID: 16399210.
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    61. Arvanitakis Z, Wilson RS, Bienias JL, Evans DA, Bennett DA. Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol. 2004 May; 61(5):661-6. PMID: 15148141.
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    62. Arvanitakis Z, Lucas JA, Younkin LH, Younkin SG, Graff-Radford NR. Serum creatinine levels correlate with plasma amyloid Beta protein. Alzheimer Dis Assoc Disord. 2002 Jul-Sep; 16(3):187-90. PMID: 12218650.
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    63. Arvanitakis Z, Wszolek ZK. Recent advances in the understanding of tau protein and movement disorders. Curr Opin Neurol. 2001 Aug; 14(4):491-7. PMID: 11470966.
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    64. Arvanitakis Z, Graff-Radford N. Focal degenerative dementia syndromes. Clin Geriatr Med. 2001 May; 17(2):303-18. PMID: 11375137.
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    65. Suarez SV, Stankoff B, Conquy L, Rosenblum O, Seilhean D, Arvanitakis Z, Lazarini F, Bricaire F, Lubetzki C, Hauw JJ, Dubois B. Similar subcortical pattern of cognitive impairment in AIDS patients with and without dementia. Eur J Neurol. 2000 Mar; 7(2):151-8. PMID: 10809935.
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    66. Arvanitakis Z, Tounsi H, Pillon B, Dubois B. [Fronto-temporal dementia: a clinical approach]. Rev Neurol (Paris). 1999 Feb; 155(2):113-9. PMID: 10226314.
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    67. Arvanitakis Z, Long RL, Hershfield ES, Manfreda J, Kabani A, Kunimoto D, Power C. M. tuberculosis molecular variation in CNS infection: evidence for strain-dependent neurovirulence. Neurology. 1998 Jun; 50(6):1827-32. PMID: 9633735.
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