eIF-2 Kinase
"eIF-2 Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
Descriptor ID |
D019892
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MeSH Number(s) |
D08.811.913.696.620.682.700.300 D12.644.360.275 D12.776.476.275
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Concept/Terms |
eIF-2 Kinase- eIF-2 Kinase
- Kinase, eIF-2
- eIF 2 Kinase
- Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase
- Double Stranded RNA Dependent eIF 2 alpha Protein Kinase
- Double Stranded RNA-Dependent Kinase (dsl)
- dsRNA-Activated Inhibitor
- Inhibitor, dsRNA-Activated
- dsRNA Activated Inhibitor
- DSRNA-Dep Protein Kinase
- DSRNA Dep Protein Kinase
- Kinase, DSRNA-Dep Protein
- Protein Kinase, DSRNA-Dep
- eIF-2alpha Kinase
- Kinase, eIF-2alpha
- eIF 2alpha Kinase
- eRF, eIF-2 Recycling Factor
- eRF, eIF 2 Recycling Factor
- Eukaryotic Initiation Factor 2alpha Kinase
- Heme Controlled Repressor
- Controlled Repressor, Heme
- Repressor, Heme Controlled
- Heme-Controlled Inhibitor
- Heme Controlled Inhibitor
- Inhibitor, Heme-Controlled
- Heme-Controlled Translational Repressor
- Heme Controlled Translational Repressor
- Repressor, Heme-Controlled Translational
- Translational Repressor, Heme-Controlled
- Heme-Regulated eIF-2alpha Kinase
- Heme Regulated eIF 2alpha Kinase
- Kinase, Heme-Regulated eIF-2alpha
- eIF-2alpha Kinase, Heme-Regulated
- Hemin Controlled Repressor
- Controlled Repressor, Hemin
- Repressor, Hemin Controlled
- Hemin-Controlled Translational Repressor
- Hemin Controlled Translational Repressor
- Repressor, Hemin-Controlled Translational
- Translational Repressor, Hemin-Controlled
- p65 Kinase
- Kinase, p65
- p68 Kinase
- Kinase, p68
- P68 Protein Kinase
- Kinase, P68 Protein
- Protein Kinase, P68
- Protein Kinase PKR
- Kinase PKR, Protein
- PKR, Protein Kinase
- Protein Kinase, RNA Activated
- RNA-Dependent Protein Kinase
- Kinase, RNA-Dependent Protein
- Protein Kinase, RNA-Dependent
- RNA Dependent Protein Kinase
- Self-Phosphorylating Protein Kinase
- Kinase, Self-Phosphorylating Protein
- Protein Kinase, Self-Phosphorylating
- Self Phosphorylating Protein Kinase
- TIK Kinase
- Kinase, TIK
- DAI Protein Kinase
- Kinase, DAI Protein
- Protein Kinase, DAI
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Below are MeSH descriptors whose meaning is more general than "eIF-2 Kinase".
Below are MeSH descriptors whose meaning is more specific than "eIF-2 Kinase".
This graph shows the total number of publications written about "eIF-2 Kinase" by people in this website by year, and whether "eIF-2 Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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2002 | 0 | 1 | 1 | 2004 | 1 | 0 | 1 | 2008 | 0 | 1 | 1 | 2010 | 0 | 1 | 1 | 2015 | 0 | 1 | 1 | 2018 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "eIF-2 Kinase" by people in Profiles.
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Ohene-Nyako M, Persons AL, Napier TC. Region-specific changes in markers of neuroplasticity revealed in HIV-1 transgenic rats by low-dose methamphetamine. Brain Struct Funct. 2018 Sep; 223(7):3503-3513.
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Wang S, Chen XA, Hu J, Jiang JK, Li Y, Chan-Salis KY, Gu Y, Chen G, Thomas C, Pugh BF, Wang Y. ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells. Mol Cancer Ther. 2015 Apr; 14(4):877-88.
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Wang Y, Ren Z, Tao D, Tilwalli S, Goswami R, Balabanov R. STAT1/IRF-1 signaling pathway mediates the injurious effect of interferon-gamma on oligodendrocyte progenitor cells. Glia. 2010 Jan 15; 58(2):195-208.
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O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, H?bert SS, De Strooper B, Haass C, Bennett DA, Vassar R. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 2008 Dec 26; 60(6):988-1009.
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Auch CJ, Saha RN, Sheikh FG, Liu X, Jacobs BL, Pahan K. Role of protein kinase R in double-stranded RNA-induced expression of nitric oxide synthase in human astroglia. FEBS Lett. 2004 Apr 09; 563(1-3):223-8.
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Liu X, Jana M, Dasgupta S, Koka S, He J, Wood C, Pahan K. Human immunodeficiency virus type 1 (HIV-1) tat induces nitric-oxide synthase in human astroglia. J Biol Chem. 2002 Oct 18; 277(42):39312-9.
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