"Microtubules" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.
| Descriptor ID |
D008870
|
| MeSH Number(s) |
A11.284.430.214.190.750.602
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Microtubules".
Below are MeSH descriptors whose meaning is more specific than "Microtubules".
This graph shows the total number of publications written about "Microtubules" by people in this website by year, and whether "Microtubules" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 1 | 2 |
| 2001 | 2 | 1 | 3 |
| 2002 | 3 | 0 | 3 |
| 2003 | 3 | 0 | 3 |
| 2004 | 1 | 0 | 1 |
| 2007 | 0 | 2 | 2 |
| 2013 | 1 | 0 | 1 |
| 2017 | 0 | 2 | 2 |
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Below are the most recent publications written about "Microtubules" by people in Profiles.
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High-content screening assay-based discovery of paullones as novel podocyte-protective agents. Am J Physiol Renal Physiol. 2018 02 01; 314(2):F280-F292.
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The role of Runx2 in facilitating autophagy in metastatic breast cancer cells. J Cell Physiol. 2018 Jan; 233(1):559-571.
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Lymphocytes with cytotoxic activity induce rapid microtubule axonal destabilization independently and before signs of neuronal death. ASN Neuro. 2013 Feb 06; 5(1):e00105.
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The zebrafish fleer gene encodes an essential regulator of cilia tubulin polyglutamylation. Mol Biol Cell. 2007 Nov; 18(11):4353-64.
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The significance of Pin1 in the development of Alzheimer's disease. J Alzheimers Dis. 2007 Mar; 11(1):13-23.
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Critical role of the atypical {lambda} isoform of protein kinase C (PKC-{lambda}) in oxidant-induced disruption of the microtubule cytoskeleton and barrier function of intestinal epithelium. J Pharmacol Exp Ther. 2005 Feb; 312(2):458-71.
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Zeta isoform of protein kinase C prevents oxidant-induced nuclear factor-kappaB activation and I-kappaBalpha degradation: a fundamental mechanism for epidermal growth factor protection of the microtubule cytoskeleton and intestinal barrier integrity. J Pharmacol Exp Ther. 2003 Oct; 307(1):53-66.
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Evidence that nuclear factor-kappa B activation is critical in oxidant-induced disruption of the microtubule cytoskeleton and barrier integrity and that its inactivation is essential in epidermal growth factor-mediated protection of the monolayers of intestinal epithelia. J Pharmacol Exp Ther. 2003 Jul; 306(1):13-28.
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The delta-isoform of protein kinase C causes inducible nitric-oxide synthase and nitric oxide up-regulation: key mechanism for oxidant-induced carbonylation, nitration, and disassembly of the microtubule cytoskeleton and hyperpermeability of barrier of intestinal epithelia. J Pharmacol Exp Ther. 2003 May; 305(2):482-94.
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PKC-zeta prevents oxidant-induced iNOS upregulation and protects the microtubules and gut barrier integrity. Am J Physiol Gastrointest Liver Physiol. 2002 Oct; 283(4):G909-22.