"Neuropil Threads" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.
| Descriptor ID |
D019600
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| MeSH Number(s) |
A08.637.500.550 A08.675.703.550 A11.284.430.214.190.750.602.620 A11.650.500.550 A11.671.685.550
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Neuropil Threads".
Below are MeSH descriptors whose meaning is more specific than "Neuropil Threads".
This graph shows the total number of publications written about "Neuropil Threads" by people in this website by year, and whether "Neuropil Threads" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "Neuropil Threads" by people in Profiles.
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Activation of caspase-6 in aging and mild cognitive impairment. Am J Pathol. 2007 Apr; 170(4):1200-9.
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Improved detection of substantia nigra pathology in Alzheimer's disease. J Histochem Cytochem. 2002 Jan; 50(1):99-106.
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Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment. J Histochem Cytochem. 2000 Dec; 48(12):1627-38.