NFATC Transcription Factors
"NFATC Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.
Descriptor ID |
D050778
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MeSH Number(s) |
D12.776.930.608
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Concept/Terms |
NFATC Transcription Factors- NFATC Transcription Factors
- Transcription Factors, NFATC
- Transcription Factor NF-AT
- NF-AT, Transcription Factor
- Transcription Factor NF AT
- Nuclear Factor of Activated T-Cells, Cytoplasmic
- Nuclear Factor of Activated T Cells, Cytoplasmic
- NFAT Proteins
- NFATC Proteins
- Nuclear Factors of Activated T-Cells
- Nuclear Factors of Activated T Cells
- NF-AT Proteins
- NF AT Proteins
NFAT Transcription Factor 4- NFAT Transcription Factor 4
- NFATC3 Transcription Factor
- Factor, NFATC3 Transcription
- Transcription Factor, NFATC3
- NFATx Protein
- Nuclear Factor of Activated T-Cells, Cytoplasmic 3 Protein
- Nuclear Factor of Activated T Cells, Cytoplasmic 3 Protein
- NF-AT4 Protein
- NF AT4 Protein
- NFAT4 Protein
- NFATC3 Protein
NFAT Transcription Factor 2- NFAT Transcription Factor 2
- NFAT-2 Protein
- NFAT 2 Protein
- Nuclear Factor of Activated T-Cells, Cytoplasmic 1 Protein
- Nuclear Factor of Activated T Cells, Cytoplasmic 1 Protein
- NFATC1 Protein
- NFATC1 Transcription Factor
- Factor, NFATC1 Transcription
- Transcription Factor, NFATC1
- NF-ATc1 Protein
- NF ATc1 Protein
- NFAT2 Protein
NFAT Transcription Factor 3- NFAT Transcription Factor 3
- NFATC4 Transcription Factor
- Transcription Factor, NFATC4
- NFAT3 Protein
- NFATC4 Protein
- Nuclear Factor of Activated T-Cells, Cytoplasmic 4 Protein
- Nuclear Factor of Activated T Cells, Cytoplasmic 4 Protein
- NF-AT3 Protein
- NF AT3 Protein
NFAT Transcription Factor 5- NFAT Transcription Factor 5
- Nuclear Factor of Activated T-Cells 5 Protein
- Nuclear Factor of Activated T Cells 5 Protein
- OREBP Protein
- Osmotic Response Element Binding Protein
- NFATL1 Protein
- Tonicity-Responsive Enhancer-Binding Protein
- Tonicity Responsive Enhancer Binding Protein
- NFAT5 Protein
- NFATz Protein
- TonEBP Protein
NFAT Transcription Factor 1- NFAT Transcription Factor 1
- NFATC2 Transcription Factor
- Factor, NFATC2 Transcription
- Transcription Factor, NFATC2
- NFAT1 Protein
- NFATC2 Protein
- Nuclear Factor of Activated T-Cells, Cytoplasmic 2 Protein
- Nuclear Factor of Activated T Cells, Cytoplasmic 2 Protein
- NFAT-1 Protein
- NFAT 1 Protein
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Below are MeSH descriptors whose meaning is more general than "NFATC Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "NFATC Transcription Factors".
This graph shows the total number of publications written about "NFATC Transcription Factors" by people in this website by year, and whether "NFATC Transcription Factors" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1998 | 0 | 1 | 1 | 2004 | 0 | 1 | 1 | 2006 | 1 | 0 | 1 | 2009 | 1 | 0 | 1 | 2010 | 3 | 0 | 3 | 2011 | 2 | 0 | 2 | 2012 | 1 | 0 | 1 | 2014 | 1 | 0 | 1 | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "NFATC Transcription Factors" by people in Profiles.
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Blanchard JW, Bula M, Davila-Velderrain J, Akay LA, Zhu L, Frank A, Victor MB, Bonner JM, Mathys H, Lin YT, Ko T, Bennett DA, Cam HP, Kellis M, Tsai LH. Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes. Nat Med. 2020 06; 26(6):952-963.
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Walther S, Awad S, Lonchyna VA, Blatter LA. NFAT transcription factor regulation by urocortin II in cardiac myocytes and heart failure. Am J Physiol Heart Circ Physiol. 2014 Mar; 306(6):H856-66.
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Zhang B, Shi W, Ma J, Sloan A, Faul C, Wei C, Reiser J, Yang Y, Liu S, Wang W. The calcineurin-NFAT pathway allows for urokinase receptor-mediated beta3 integrin signaling to cause podocyte injury. J Mol Med (Berl). 2012 Dec; 90(12):1407-20.
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Nijenhuis T, Sloan AJ, Hoenderop JG, Flesche J, van Goor H, Kistler AD, Bakker M, Bindels RJ, de Boer RA, M?ller CC, Hamming I, Navis G, Wetzels JF, Berden JH, Reiser J, Faul C, van der Vlag J. Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway. Am J Pathol. 2011 Oct; 179(4):1719-32.
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Orhue V, Kanaji A, Caicedo MS, Virdi AS, Sumner DR, Hallab NJ, Jahr H, Sena K. Calcineurin/nuclear factor of activated T cells (NFAT) signaling in cobalt-chromium-molybdenum (CoCrMo) particles-induced tumor necrosis factor-a (TNFa) secretion in MLO-Y4 osteocytes. J Orthop Res. 2011 Dec; 29(12):1867-73.
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Rinne A, Blatter LA. Activation of NFATc1 is directly mediated by IP3 in adult cardiac myocytes. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1701-7.
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Rinne A, Blatter LA. A fluorescence-based assay to monitor transcriptional activity of NFAT in living cells. J Physiol. 2010 Sep 01; 588(Pt 17):3211-6.
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Rinne A, Kapur N, Molkentin JD, Pogwizd SM, Bers DM, Banach K, Blatter LA. Isoform- and tissue-specific regulation of the Ca(2+)-sensitive transcription factor NFAT in cardiac myocytes and heart failure. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H2001-9.
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Rinne A, Banach K, Blatter LA. Regulation of nuclear factor of activated T cells (NFAT) in vascular endothelial cells. J Mol Cell Cardiol. 2009 Sep; 47(3):400-10.
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Managlia EZ, Landay A, Al-Harthi L. Interleukin-7 induces HIV replication in primary naive T cells through a nuclear factor of activated T cell (NFAT)-dependent pathway. Virology. 2006 Jul 05; 350(2):443-52.
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