 Tumor Necrosis Factor-alpha
"Tumor Necrosis Factor-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
| Descriptor ID |
D014409
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| MeSH Number(s) |
D12.644.276.374.500.800 D12.644.276.374.750.626 D12.644.276.972.626 D12.776.124.900 D12.776.395.930 D12.776.467.374.500.800 D12.776.467.374.750.626 D12.776.467.972.626 D23.529.374.500.800 D23.529.374.750.626 D23.529.972.626
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| Concept/Terms |
Tumor Necrosis Factor-alpha- Tumor Necrosis Factor-alpha
- Tumor Necrosis Factor alpha
- Cachectin-Tumor Necrosis Factor
- Cachectin Tumor Necrosis Factor
- TNFalpha
- TNF-alpha
- Tumor Necrosis Factor
- Tumor Necrosis Factor Ligand Superfamily Member 2
- Cachectin
- TNF Superfamily, Member 2
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Below are MeSH descriptors whose meaning is more general than "Tumor Necrosis Factor-alpha".
Below are MeSH descriptors whose meaning is more specific than "Tumor Necrosis Factor-alpha".
This graph shows the total number of publications written about "Tumor Necrosis Factor-alpha" by people in this website by year, and whether "Tumor Necrosis Factor-alpha" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1989 | 1 | 1 | 2 | | 1991 | 2 | 0 | 2 | | 1993 | 1 | 0 | 1 | | 1994 | 0 | 3 | 3 | | 1995 | 2 | 0 | 2 | | 1996 | 2 | 1 | 3 | | 1997 | 3 | 6 | 9 | | 1998 | 1 | 4 | 5 | | 1999 | 2 | 8 | 10 | | 2000 | 2 | 3 | 5 | | 2001 | 1 | 2 | 3 | | 2002 | 8 | 7 | 15 | | 2003 | 3 | 5 | 8 | | 2004 | 6 | 5 | 11 | | 2005 | 3 | 8 | 11 | | 2006 | 3 | 4 | 7 | | 2007 | 3 | 5 | 8 | | 2008 | 2 | 7 | 9 | | 2009 | 3 | 3 | 6 | | 2010 | 2 | 5 | 7 | | 2011 | 1 | 4 | 5 | | 2012 | 1 | 4 | 5 | | 2013 | 1 | 7 | 8 | | 2014 | 1 | 4 | 5 | | 2015 | 0 | 2 | 2 | | 2016 | 0 | 2 | 2 | | 2017 | 1 | 4 | 5 | | 2018 | 1 | 3 | 4 | | 2019 | 3 | 1 | 4 | | 2020 | 1 | 2 | 3 | | 2021 | 0 | 1 | 1 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tumor Necrosis Factor-alpha" by people in Profiles.
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Li Z, Qi X, Zhang X, Yu L, Gao L, Kong W, Chen W, Dong W, Luo L, Lu D, Zhang L, Ma Y. TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-?B/MAPK-TNF-a pathway. Animal Model Exp Med. 2022 04; 5(2):172-182.
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Yang F, Duan M, Zheng F, Yu L, Wang Y, Wang G, Lin J, Han S, Gan D, Meng Z, Zhu S. Fas signaling in adipocytes promotes low-grade inflammation and lung metastasis of colorectal cancer through interaction with Bmx. Cancer Lett. 2021 12 01; 522:93-104.
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Joers V, Masilamoni G, Kempf D, Weiss AR, Rotterman TM, Murray B, Yalcin-Cakmakli G, Voll RJ, Goodman MM, Howell L, Bachevalier J, Green SJ, Naqib A, Shaikh M, Engen PA, Keshavarzian A, Barnum CJ, Nye JA, Smith Y, Tansey MG. Microglia, inflammation and gut microbiota responses in a progressive monkey model of Parkinson's disease: A case series. Neurobiol Dis. 2020 10; 144:105027.
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Tollkuci E, Fitzpatrick P, N Seddon A, Myers R, Nathan S, Ustun C. Biosimilar infliximab administration for the management of acute graft-versus-host disease. J Oncol Pharm Pract. 2020 Dec; 26(8):2047-2051.
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Cogswell A, Ferguson N, Barker E. Presence of Inflammatory Group I and III Innate Lymphoid Cells in the Colon of Simian Immunodeficiency Virus-Infected Rhesus Macaques. J Virol. 2020 04 16; 94(9).
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Papagiannopoulos P, Devins K, Tong CCL, Yver C, Patel NN, Kuhar HN, Bosso JV, Kohanski MA, Tajudeen BA, Kuan EC, Batra PS, Cohen NA, Kennedy DW, Palmer JN, Montone K, Adappa ND. Chronic rhinosinusitis precipitated by tumor necrosis factor alpha inhibitors is the phenotype of chronic rhinosinusitis without nasal polyps. Int Forum Allergy Rhinol. 2020 01; 10(1):23-28.
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Cogswell AC, Maski K, Scammell TE, Tucker D, Orban ZS, Koralnik IJ. Children with Narcolepsy type 1 have increased T-cell responses to orexins. Ann Clin Transl Neurol. 2019 12; 6(12):2566-2572.
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Gibson FT, Amber KT. Autoimmune blistering diseases provoked during the treatment of chronic inflammatory disease with biologic agents: a systematic review. Int J Dermatol. 2020 May; 59(5):520-524.
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Saad RE, Shobar R, Mutlu EA. Collagenous colitis development occurs after long standing mucosal healing in IBD with TNF-a inhibitors, and could be due to exaggerated healing response from excess TNF-a inhibition. Med Hypotheses. 2019 Feb; 123:90-94.
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Bekhbat M, Mehta CC, Kelly SD, Vester A, Ofotokun I, Felger J, Wingood G, Anastos K, Gustafson DR, Kassaye S, Milam J, Aouizerat B, Weber K, Golub ET, Moore MF, Diclemente R, Fischl M, Kempf MC, Maki P, Neigh GN. HIV and symptoms of depression are independently associated with impaired glucocorticoid signaling. Psychoneuroendocrinology. 2018 10; 96:118-125.
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