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Tom Shannon

TitleAssociate Professor
InstitutionRush University, Rush Medical College
DepartmentPhysiology and Biophysics
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    Collapse Overview 
    Collapse overview
    My Scopus ID is 7005554863.
    My NIH COMMONS name is TSHANNON.

    Research Areas:
    Ionic channels, voltage gated ionic channels, fluorescence signal detection and electrophysiology, particularly as they relate to excitation-contraction coupling in striated muscle. Shannon uses multiple biochemical, biophysical and molecular approaches to study the control of the concentration of calcium in the storage organelle (the sarcoplasmic reticulum) of normal and abnormal cells of the heart.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/thomas-shannon-dvm-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/physiology-and-biophysics-research/laboratory-thomas-r-shannon-dvm-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/pubmed/?term=Shannon+TR

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=7005554863

    Education:
    PhD, Univeristy of Missouri
    DVM, University of Missouri


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Pereira L, Bare DJ, Galice S, Shannon TR, Bers DM. ß-Adrenergic induced SR Ca2+ leak is mediated by an Epac-NOS pathway. J Mol Cell Cardiol. 2017 Jul; 108:8-16. PMID: 28476660.
      View in: PubMed
    2. Berti C, Zsolnay V, Shannon TR, Fill M, Gillespie D. Sarcoplasmic reticulum Ca2+, Mg2+, K+, and Cl- concentrations adjust quickly as heart rate changes. J Mol Cell Cardiol. 2017 Feb; 103:31-39. PMID: 27914790.
      View in: PubMed
    3. Hegyi B, Bányász T, Shannon TR, Chen-Izu Y, Izu LT. Electrophysiological Determination of Submembrane Na(+) Concentration in Cardiac Myocytes. Biophys J. 2016 Sep 20; 111(6):1304-1315. PMID: 27653489.
      View in: PubMed
    4. Sato D, Shannon TR, Bers DM. Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks. Biophys J. 2016 Jan 19; 110(2):382-90. PMID: 26789761; PMCID: PMC4724649 [Available on 01/19/17].
    5. Curran J, Tang L, Roof SR, Velmurugan S, Millard A, Shonts S, Wang H, Santiago D, Ahmad U, Perryman M, Bers DM, Mohler PJ, Ziolo MT, Shannon TR. Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation. PLoS One. 2014; 9(2):e87495. PMID: 24498331; PMCID: PMC3911966.
    6. Santiago DJ, Ríos E, Shannon TR. Isoproterenol increases the fraction of spark-dependent RyR-mediated leak in ventricular myocytes. Biophys J. 2013 Mar 05; 104(5):976-85. PMID: 23473480; PMCID: PMC3591256.
    7. Bers DM, Shannon TR. Calcium movements inside the sarcoplasmic reticulum of cardiac myocytes. J Mol Cell Cardiol. 2013 May; 58:59-66. PMID: 23321551; PMCID: PMC3628081.
    8. Edwards JN, Cully TR, Shannon TR, Stephenson DG, Launikonis BS. Longitudinal and transversal propagation of excitation along the tubular system of rat fast-twitch muscle fibres studied by high speed confocal microscopy. J Physiol. 2012 Feb 01; 590(3):475-92. PMID: 22155929; PMCID: PMC3379695.
    9. Roof SR, Shannon TR, Janssen PM, Ziolo MT. Effects of increased systolic Ca²? and phospholamban phosphorylation during ß-adrenergic stimulation on Ca²? transient kinetics in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1570-8. PMID: 21765055; PMCID: PMC3197371.
    10. Picht E, Zima AV, Shannon TR, Duncan AM, Blatter LA, Bers DM. Dynamic calcium movement inside cardiac sarcoplasmic reticulum during release. Circ Res. 2011 Apr 01; 108(7):847-56. PMID: 21311044; PMCID: PMC3084972.
    11. Santiago DJ, Curran JW, Bers DM, Lederer WJ, Stern MD, Ríos E, Shannon TR. Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes. Biophys J. 2010 May 19; 98(10):2111-20. PMID: 20483318; PMCID: PMC2872235.
    12. Curran J, Brown KH, Santiago DJ, Pogwizd S, Bers DM, Shannon TR. Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase II. J Mol Cell Cardiol. 2010 Jul; 49(1):25-32. PMID: 20353795; PMCID: PMC2883657.
    13. Liu Y, Porta M, Qin J, Ramos J, Nani A, Shannon TR, Fill M. Flux regulation of cardiac ryanodine receptor channels. J Gen Physiol. 2010 Jan; 135(1):15-27. PMID: 20008518; PMCID: PMC2806413.
    14. Shannon TR. Ryanodine receptor Ca2+ sensitivity and excitation-contraction coupling in muscular dystrophy and heart failure: similar and yet different. Am J Physiol Heart Circ Physiol. 2009 Dec; 297(6):H1965-6. PMID: 19837948.
      View in: PubMed
    15. Shannon TR, Lew WY. Diastolic release of calcium from the sarcoplasmic reticulum: a potential target for treating triggered arrhythmias and heart failure. J Am Coll Cardiol. 2009 May 26; 53(21):2006-8. PMID: 19460615.
      View in: PubMed
    16. Shannon TR. Linking calsequestrin to lumenal control of SR Ca2+ release. Circ Res. 2007 Sep 14; 101(6):539-41. PMID: 17872471.
      View in: PubMed
    17. Guo T, Ai X, Shannon TR, Pogwizd SM, Bers DM. Intra-sarcoplasmic reticulum free [Ca2+] and buffering in arrhythmogenic failing rabbit heart. Circ Res. 2007 Oct 12; 101(8):802-10. PMID: 17704210.
      View in: PubMed
    18. Curran J, Hinton MJ, Ríos E, Bers DM, Shannon TR. Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ Res. 2007 Feb 16; 100(3):391-8. PMID: 17234966.
      View in: PubMed
    19. Launikonis BS, Zhou J, Royer L, Shannon TR, Brum G, Ríos E. Depletion "skraps" and dynamic buffering inside the cellular calcium store. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2982-7. PMID: 16473932; PMCID: PMC1413852.
    20. Ai X, Curran JW, Shannon TR, Bers DM, Pogwizd SM. Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res. 2005 Dec 09; 97(12):1314-22. PMID: 16269653.
      View in: PubMed
    21. Shannon TR, Bers DM, Blatter LA, Niggli E. Confocal imaging of CICR events from isolated and immobilized SR vesicles. Cell Calcium. 2005 Nov; 38(5):497-505. PMID: 16122794.
      View in: PubMed
    22. Shannon TR, Wang F, Bers DM. Regulation of cardiac sarcoplasmic reticulum Ca release by luminal [Ca] and altered gating assessed with a mathematical model. Biophys J. 2005 Dec; 89(6):4096-110. PMID: 16169970; PMCID: PMC1366975.
    23. Launikonis BS, Zhou J, Royer L, Shannon TR, Brum G, Ríos E. Confocal imaging of [Ca2+] in cellular organelles by SEER, shifted excitation and emission ratioing of fluorescence. J Physiol. 2005 Sep 01; 567(Pt 2):523-43. PMID: 15946962; PMCID: PMC1474212.
    24. Shannon TR, Wang F, Puglisi J, Weber C, Bers DM. A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J. 2004 Nov; 87(5):3351-71. PMID: 15347581; PMCID: PMC1304803.
    25. Shannon TR, Bers DM. Integrated Ca2+ management in cardiac myocytes. Ann N Y Acad Sci. 2004 May; 1015:28-38. PMID: 15201147.
      View in: PubMed
    26. Shannon TR, Pogwizd SM, Bers DM. Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure. Circ Res. 2003 Oct 03; 93(7):592-4. PMID: 12946948.
      View in: PubMed
    27. Shannon TR, Guo T, Bers DM. Ca2+ scraps: local depletions of free [Ca2+] in cardiac sarcoplasmic reticulum during contractions leave substantial Ca2+ reserve. Circ Res. 2003 Jul 11; 93(1):40-5. PMID: 12791706.
      View in: PubMed
    28. Shannon TR, Ginsburg KS, Bers DM. Quantitative assessment of the SR Ca2+ leak-load relationship. Circ Res. 2002 Oct 04; 91(7):594-600. PMID: 12364387.
      View in: PubMed
    29. Weber CR, Ginsburg KS, Philipson KD, Shannon TR, Bers DM. Allosteric regulation of Na/Ca exchange current by cytosolic Ca in intact cardiac myocytes. J Gen Physiol. 2001 Feb; 117(2):119-31. PMID: 11158165; PMCID: PMC2217247.
    30. Frank K, Tilgmann C, Shannon TR, Bers DM, Kranias EG. Regulatory role of phospholamban in the efficiency of cardiac sarcoplasmic reticulum Ca2+ transport. Biochemistry. 2000 Nov 21; 39(46):14176-82. PMID: 11087366.
      View in: PubMed
    31. Shannon TR, Chu G, Kranias EG, Bers DM. Phospholamban decreases the energetic efficiency of the sarcoplasmic reticulum Ca pump. J Biol Chem. 2001 Mar 09; 276(10):7195-201. PMID: 11087739.
      View in: PubMed
    32. Shannon TR, Ginsburg KS, Bers DM. Potentiation of fractional sarcoplasmic reticulum calcium release by total and free intra-sarcoplasmic reticulum calcium concentration. Biophys J. 2000 Jan; 78(1):334-43. PMID: 10620297; PMCID: PMC1300641.
    33. Shannon TR, Ginsburg KS, Bers DM. Reverse mode of the sarcoplasmic reticulum calcium pump and load-dependent cytosolic calcium decline in voltage-clamped cardiac ventricular myocytes. Biophys J. 2000 Jan; 78(1):322-33. PMID: 10620296; PMCID: PMC1300640.
    34. Cadre BM, Qi M, Eble DM, Shannon TR, Bers DM, Samarel AM. Cyclic stretch down-regulates calcium transporter gene expression in neonatal rat ventricular myocytes. J Mol Cell Cardiol. 1998 Nov; 30(11):2247-59. PMID: 9925362.
      View in: PubMed
    35. Shannon TR, Ginsburg KS, Bers DM. Reverse mode of the sarcoplasmic reticulum Ca pump limits sarcoplasmic reticulum Ca uptake in permeabilized and voltage-clamped myocytes. Ann N Y Acad Sci. 1998 Sep 16; 853:350-2. PMID: 10603977.
      View in: PubMed
    36. Bassani RA, Shannon TR, Bers DM. Passive Ca2+ binding in ventricular myocardium of neonatal and adult rats. Cell Calcium. 1998 Jun; 23(6):433-42. PMID: 9924635.
      View in: PubMed
    37. McCall E, Ginsburg KS, Bassani RA, Shannon TR, Qi M, Samarel AM, Bers DM. Ca flux, contractility, and excitation-contraction coupling in hypertrophic rat ventricular myocytes. Am J Physiol. 1998 Apr; 274(4 Pt 2):H1348-60. PMID: 9575940.
      View in: PubMed
    38. Shannon TR, Bers DM. Assessment of intra-SR free [Ca] and buffering in rat heart. Biophys J. 1997 Sep; 73(3):1524-31. PMID: 9284319; PMCID: PMC1181051.
    39. Qi M, Shannon TR, Euler DE, Bers DM, Samarel AM. Downregulation of sarcoplasmic reticulum Ca(2+)-ATPase during progression of left ventricular hypertrophy. Am J Physiol. 1997 May; 272(5 Pt 2):H2416-24. PMID: 9176313.
      View in: PubMed
    40. McCall E, Li L, Satoh H, Shannon TR, Blatter LA, Bers DM. Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes. Circ Res. 1996 Dec; 79(6):1110-21. PMID: 8943949.
      View in: PubMed
    41. Shannon TR, Hale CC, Milanick MA. Interaction of cardiac Na-Ca exchanger and exchange inhibitory peptide with membrane phospholipids. Am J Physiol. 1994 May; 266(5 Pt 1):C1350-6. PMID: 8203499.
      View in: PubMed
    42. Shannon TR, Hale CC. Identification of a 65 kDa endothelin receptor in bovine cardiac sarcolemmal vesicles. Eur J Pharmacol. 1994 Apr 15; 267(2):233-8. PMID: 8050483.
      View in: PubMed
    43. SHANNON TR. Antihistaminic drug in the prevention of spinal headache. N Y State J Med. 1950 May 15; 50(10):1259-60. PMID: 15416957.
      View in: PubMed
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